Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 1 of 5
1. IDENTIFICATION OF SUBSTANCE
Name: DUKE PEDIATRIC EYE MIXTURE
Manufacturer: Department of Pharmacy
Duke University Medical Center
Box 3089
Durham, NC 27710
919-684-5125
Information Department: Occupational and Environmental Safety Office
Duke University Medical Center
Box 3914
Durham, NC 27710
919-684-5996
Emergency Information: Regional Poison Control Center
800-848-6946
2. COMPOSITION/INFORMATION ON INGREDIENTS
Chemical Characterization/Description: Phenylephrine hydrochloride (HCl),
cyclopentolate HCl, and sodium phosphate solution
Synonym(s): Phenylephrine HCl: Neo-synephrine HCl;
Cyclopentolate HCl: cyclogyl
Dangerous Components (CAS#, Hazardous Chemical, Percent):
61-76-7 Phenylephrine hydrochloride 2.5%
5870-29-1 Cyclopentolate hydrochloride 1%
7558-79-4 Sodium phosphate 16-17%
1310-73-2 Sodium hydroxide (pH adjustment as needed) Varies
7647-01-0 Hydrochloric acid (pH adjustment as needed) Varies
7732-18-5 Water Balance
3. HAZARDS IDENTIFICATION
Hazard Description:
Phenylephrine HCl may cause adverse CNS and cardiovascular reactions and is a
poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular
routes. Sodium phosphate is a caustic substance that is moderately toxic by
intravenous route. (Hazard description based on concentrated constituents; this
product is an aqueous solution.)
NFPA Ratings (scale 0-4):
1
Health
0
Fire:
0
Reactivity:
Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 2 of 5
TRADE NAME: DUKE PEDIATRIC EYE MIXTURE
4. FIRST AID MEASURES
Inhalation:
Remove victim to fresh air. Give oxygen or artificial respiration if necessary.
Skin Contact:
IMMEDIATELY flood affected skin with water while removing and isolating all
contaminated clothing. Gently wash all affected skin areas thoroughly with soap
and water. Seek medical attention if warranted.
Eye Contact:
First check the victim for contact lenses and remove if present. Flush victim's
eyes with water or normal saline solution for 20 to 30 minutes while
simultaneously calling a hospital or poison control center. Do not put any
ointments, oils, or medication in the victim's eyes without specific instructions
from a physician. IMMEDIATELY transport the victim after flushing eyes to a
hospital even if no symptoms (such as redness or irritation) develop.
Ingestion:
DO NOT INDUCE VOMITING.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute
the chemical and IMMEDIATELY call a hospital or poison control center.
IMMEDIATELY transport the victim to a hospital.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure
that the victim's airway is open, and lay the victim on his/her side with the head
lower than the body. Transport the victim IMMEDIATELY to a hospital.
Printed on 05/03/00 Reviewed on 05/03/00
Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 3 of 5
TRADE NAME: DUKE PEDIATRIC EYE MIXTURE
5. FIRE-FIGHTING MEASURES
Suitable Extinguishing Agents:
Use appropriate extinguishing media for surrounding fire.
Protective Equipment:
Self-contained breathing apparatus and protective equipment for fire fighting.
6. ACCIDENTAL RELEASE MEASURES
Personnel Precautions:
Wear gloves (disposable surgical) and eye protection (chemical splash goggles).
Environmental Precautions:
None necessary under normal conditions of use.
Measures for Cleaning/Collection:
Use absorbent paper to pick up all liquid spill material. Seal the absorbent paper,
as well as contaminated clothing, in a vapor-tight plastic bag for eventual
disposal. Wash all contaminated surfaces with a soap and water solution.
7. HANDLING AND STORAGE
Handling:
Wear PPE when handling this material. Wash hands after handling.
Storage:
Store in a cool, dry, well-ventilated location.
Printed on 05/03/00 Reviewed on 05/03/00
Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 4 of 5
TRADE NAME: DUKE PEDIATRIC EYE MIXTURE
8. EXPOSURE CONTROLS AND PERSONAL PROTECTION
Engineering Controls:
None necessary under conditions of normal use.
Control Parameters:
Chemical Limit Reference
Phenylephrine hydrochloride N/A N/A
Cyclopentolate hydrochloride N/A N/A
Sodium phosphate N/A N/A
2 mg/m3
Sodium hydroxide Hydrochloric ACGIH TLV-Ceiling
acid 5 ppm ACGIH TLV-Ceiling
Personal Protective Equipment:
Respiratory Protection
None necessary under conditions of normal use.
Skin Protection
Wear disposable surgical gloves when using this chemical. If this chemical
comes into contact with your gloves, or if a tear/puncture develops, remove
gloves at once and wash hands.
Eye Protection
Splash-proof safety goggles should be worn while handling this chemical.
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid Color and Odor: Colorless to yellow,
odorless
pH: 5.0
Boiling/Freezing Points (掳C):
Approx. same as water.
Flashpoint (掳C): N/A Autoignition Temperature (掳C): N/A
Explosion Properties: N/A
Vapor Pressure (mm Hg): N/A Vapor Density (air = 1): N/A
Specific Gravity (water = 1): Solubility: Soluble in water (aqueous
Approx. same as water. solution).
Printed on 05/03/00 Reviewed on 05/03/00
Material Safety Data Sheet
According to ISO 11014-1:1994(E)
Page 5 of 5
TRADE NAME: DUKE PEDIATRIC EYE MIXTURE
10. STABILITY AND REACTIVITY
General: This product is considered stable.
Materials to Avoid: Acids, acid chlorides, acid anhydrides, butacine, alkalies,
ferric salts, and oxidizing agents.
Hazardous Decomposition Products: When heated to decomposition, this
product may emit very toxic fumes of POx , Na2O, HCl , and NOx .
11. TOXICOLOGICAL INFORMATION
Acute Toxicity: Phenylephrine HCl may cause adverse CNS and cardiovascular
reactions. It is a poison by ingestion, intraperitoneal, subcutaneous, intravenous,
and intramuscular routes and can cause skin irritation. There have been rare
reports of serious cardiovascular arrhythmias and myocardial infarctions. The
oral LD50 for phenylephrine HCl is 120 mg/kg (mouse). Cyclopentolate HCl is a
poison by intravenous and intraperitoneal routes and is moderately toxic by
ingestion. Human systemic effects by subcutaneous route include convulsions.
Sodium phosphate is a caustic substance that is moderately toxic by intravenous
route. It is an irritant to the skin and eyes.
Signs/Symptoms of Overexposure: Headache, reflex bradycardia, excitability,
and restlessness have been reported due to overexposure to phenylephrine HCl.
Cyclopentolate HCl can cause dilated pupils, blurring of vision, increased heart
rate, dry mouth, disorientation, fever, convulsion, and coma.
Chronic Toxicity: This product is not considered a carcinogen by NTP, IARC or
OSHA.
12. ECOLOGICAL EFFECTS
None anticipated under normal conditions of use.
13. DISPOSAL CONSIDERATIONS
Dispose of all waste and contaminated materials associated with this chemical as
specified by existing local, state and federal regulations concerning hazardous
waste disposal. Contact the Occupational and Environmental Safety Office for
specific guidance.
14. TRANSPORT INFORMATION
Proper shipping name (DOT): Not regulated by this mode of transportation.
15. REGULATORY INFORMATION
Reported in EPA TSCA Inventory.
16. OTHER INFORMATION
This information is based on our present knowledge; however this shall not
constitute a guarantee for any specific product features. No toxicity data are
available on this specific formulation; this health hazard assessment is based on
information that is available for its components.
Printed on 05/03/00 Reviewed on 05/03/00
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