MATERIAL SAFETY DATA SHEET
Date Printed: 02/23/2006
Date Updated: 02/01/2006
Version 1.8
Section 1 - Product and Company Information
Product Name COPPER(II) SULFATE PENTAHYDRATE,
98+%, A.C.S. REAGENT
Product Number 209198
Brand SIAL
Company World Precision Instruments, Inc.
Street Address 175 Sarasota Center Blvd.
City, State, Zip, Country Sarasota FL 34240 US
Technical Phone: 941-371-1003
Emergency Phone: 941-371-1003
Fax: 941-377-5428
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
COPPER (II) SULFATE PENTAHYDRATE 7758-99-8 Yes
Formula CuSO4.5H2O
Synonyms Blue copper AS * Copper(II) sulfate pentahydrate
* Copper(2+) sulfate pentahydrate * Cupric
sulfate pentahydrate * Kupfersulfat-pentahydrat
(German) * Kupfervitriol (German) * Salzburg
vitriol * Sulfuric acid, copper(2+) salt,
pentahydrate * Sulfuric acid copper(2+) salt
(1:1), pentahydrate (8CI,9CI) * Vencedor
RTECS Number: GL8900000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic (USA) Harmful (EU). Dangerous for the environment.
Harmful if swallowed. Irritating to eyes and skin. Very toxic to
aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
Possible sensitizer. Target organ(s): Liver. Kidneys.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 0
REACTIVITY: 1
NFPA RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Handle and store under argon.
Store in a cool dry place.
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SPECIAL REQUIREMENTS
Air sensitive. Hygroscopic. Handle and store under inert gas.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a dust mask type N95 (US) or type P1 (EN 143)
respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Color: Blue
Form: Crystals
Property Value At Temperature or Pressure
Molecular Weight 249.68 AMU
pH 3.7 - 4.5
BP/BP Range N/A
MP/MP Range 110 掳C
Freezing Point N/A
Vapor Pressure 7.3 mmHg 25 掳C
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 2.284 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
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Stable: Stable.
Conditions to Avoid: Air sensitive. Hygroscopic.
Materials to Avoid: Finely powdered metals Anhydrous copper(II)
sulfate reacts violently with: hydroxylamine, magnesium.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Copper oxide, Sulfur oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
SENSITIZATION
Skin: Prolonged or repeated exposure may cause allergic
reactions in certain sensitive individuals.
TARGET ORGAN(S) OR SYSTEM(S)
Blood. Liver. Kidneys.
SIGNS AND SYMPTOMS OF EXPOSURE
Chronic copper poisoning is typified by hepatic cirrhosis, brain
damage and demyelination, kidney defects, and copper deposition
in the cornea as exemplified by humans with Wilson's disease. It
has also been reported that copper poisoning has lead to
hemolytic anemia and accelerates arteriosclerosis. To the best
of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Human
1088 mg/kg
LDLO
Remarks: Behavioral:Coma. Liver:Jaundice (or hyperbilirubinemia)
hepatocellular. Blood:Other hemolysis with or withot anemia.
Oral
Rat
300 mg/kg
LD50
Skin
Rat
> 2000 mg/kg
LD50
Intraperitoneal
Rat
18700 UG/KG
LD50
Intraperitoneal
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Mouse
33 MG/KG
LD50
Intraperitoneal
Mammal
7500 UG/KG
LD50
Remarks: Gastrointestinal:Changes in structure or function of
salivary glands. Behavioral:Somnolence (general depressed
activity). Gastrointestinal:Nausea or vomiting.
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 76 UMOL/L
Cell Type: lymphocyte
Mutation test: DNA inhibition
Species: Rat
Dose: 31 UMOL/L
Cell Type: liver
Mutation test: Unscheduled DNA synthesis
Species: Rat
Dose: 300 MG/KG
Cell Type: Ascites tumor
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 5 MG/KG
Mutation test: Micronucleus test
Species: Mouse
Route: Intraperitoneal
Dose: 1100 UG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intraperitoneal
Dose: 5 MG/KG
Exposure Time: 5D
Mutation test: sperm
Species: Chicken
Route: Intraperitoneal
Dose: 7500 UG/KG
Mutation test: Micronucleus test
Species: Chicken
Route: Oral
Dose: 10 MG/KG
Mutation test: Micronucleus test
Species: Chicken
Route: Oral
Dose: 10 MG/KG
Mutation test: Cytogenetic analysis
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Species: Chicken
Route: Intraperitoneal
Dose: 7500 UG/KG
Mutation test: Cytogenetic analysis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Section 12 - Ecological Information
No data available.
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Time: 96 h
Value: 1.0 - 2.5 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 0.024 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Environmentally hazardous
substances, solid, n.o.s.
UN#: 3077
Class: 9
Packing Group: Packing Group III
Hazard Label: Class 9
PIH: Not PIH
IATA
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
IATA UN Number: 3077
Hazard Class: 9
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xn-N
Indication of Danger: Harmful. Dangerous for the environment.
R: 22-36/38-50/53
Risk Statements: Harmful if swallowed. Irritating to eyes and
skin. Very toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
S: 22-60-61
Safety Statements: Do not breathe dust. This material and its
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container must be disposed of as hazardous waste. Avoid release
to the environment. Refer to special instructions/safety data
sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Toxic (USA) Harmful (EU). Dangerous for
the environment.
Risk Statements: Harmful if swallowed. Irritating to eyes and
skin. Very toxic to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
Safety Statements: Do not breathe dust. This material and its
container must be disposed of as hazardous waste. Avoid release
to the environment. Refer to special instructions/safety data
sheets.
US Statements: Possible sensitizer. Target organ(s): Liver.
Kidneys.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
NOTES: This product is subject to SARA section 313 reporting
requirements - copper compounds.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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