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Material Safety Data Sheet
Bioclear - Tissue clearing agent
1: Chemical Product and Company Identification
Product Name: Bioclear - Tissue clearing agent
Contact information:
Catalog Code: 710162, 710163
bioWORLD
CAS#: 5989-27-5
4150 Tuller Rd
Suite 228, Dublin, OH 43017, USA
RTECS: GW6360000
For information, call: 614-792-8680
TSCA: TSCA 8(b) inventory : Components were listed.
Fax Number: 614-792-8685
Order Online:www.bio-world.com
CI#: Not available.
E-mail : save@bio-world.com
Synonym: Carvene; (+)-4-Isopropenyl-1-methylcyclohexene; (+)-
R-Limonene; (R)-1-Methyl-4-(1-methylethenyl)cyclohexene; D-(+)-
In case of a chemical emergency, contact local
Limonene; d-Limonene; d-p-Mentha-1,8-diene; optically active
hospital.
terpene
For non-emergency assistance,call: 1-800-860-9729
Chemical Name: Bioclear - Tissue clearing agent
Chemical Formula: C10H16
2: Composition and Information on Ingredients
Composition:
Name CAS# % by Weight
d-Limonene 5989-27-5
-
Butylated hydroxyanisole 25013-16-5
Toxicological Data on Ingredients:
d-Limonene
LD50 (Oral, Mouse): 5600 mg/kg
LD50 (Oral, Rat): 4400 mg/kg
Butylated hydroxyanisole
LD50 (Oral, Mouse): 1100 mg/kg
LD50 (Oral, Rat): 2 gm/kg
3: Hazards Identification
Potential Acute Health Effects: Flammable liquid and vapor. May cause respiratory tract irritation. May cause allergic
skin reaction. Causes eye and skin irritation.
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Target Organs: Skin.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
4: First Aid Measures
Eye Contact: In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.
Skin Contact: In case of contact, immediately wash skin with soap and copious amounts of water.
Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek
medical attention.
Inhalation: If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
Serious Inhalation: Not available.
Ingestion: If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Serious Ingestion: Not available.
5: Fire and Explosion Data
Flammability of the Product: Flammable liquid and vapor.
Auto-Ignition Temperature: 255 潞C ( 491.00 潞F)
Flash Points: 48 潞 C ( 118.40 潞 F)
Flammable Limits: 0.70 - 6.10 %
Product of Combustion: Carbon monoxide, carbon dioxide.
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Dry chemical powder.
LARGE FIRE: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.
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6: Accidental Release Measures
Small Spill: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Forms
smooth, slippery surfaces on floors, posing an accident risk. Remove all sources of ignition. Provide ventilation.
Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface and allow to evacuate through the sanitary system.
7: Handling and Storage
Precautions: Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep away from heat, sparks and flame.
Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only
with adequate ventilation. Avoid breathing vapor or mist.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool, dry, well-ventilated
area away from incompatible substances. Flammables-area. Separate from oxidizing materials. Partially filled containers
should be blanketed with nitrogen.
8: Exposure Controls/Personal Protection
Engineering Controls: Safety shower and eye bath. Mechanical exhaust required.
Personal Protection: Respiratory : Government approved respirator.
Hand: Chemical resistant gloves.
Eye: Safety glasses.
Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Boots. Dust respirator. Gloves.
Exposure Limits: Not available.
9: Physical and Chemical Properties
Physical State and Appearance: Liquid
Odor: Citrus-like odor
Taste: Not available.
Molecular Weight: 136.24 g/mole
Color: Clear almost colorless
pH(1% soln/water): Not available.
Boiling Point: 175-176 潞 C
Melting Point: -74 潞 C
Critical Temperature: Not available.
Specific Gravity: 0.84
Vapour Pressure: 1.98
Vapor Density: 4.7
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff: Not available.
Ionicity (in Water): Not available.
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Dispersion Properties: Not available.
Solubility: Insoluble in water.
10: Stability and Reactivity Data
Stability: Stable.
Instability Temperature: Not available.
Conditions of Instability: Ignition sources, excess heat, prolonged exposure to air.
Incompatibility with various substances: Strong oxidizing agents.
Corrosivity: Not available.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
11:Toxicological Information
Routes of Entry: Skin contact. Eye contact. Ingestion. Inhalation.
Toxicity to Animals:
d-Limonene
LD50 (Oral, Mouse): 5600 mg/kg
LD50 (Oral, Rat): 4400 mg/kg
LD50 (Skin, Rabbit): >5 gm/kg
Butylated hydroxyanisole
LD50 (Oral, Mouse): 1100 mg/kg
LD50 (Oral, Rabbit): 2100 mg/kg
LD50 (Oral, Rat): 2 gm/kg
Chronic Effects on Humans: In 2-year gavage studies, there was clear evidence of carcinogenic activity of d-limonene for
male rats, as shown by increased incidences of tubular cell hyperplasia, adenomas, and adenocarcinomas of the kidney.
There was NO evidence of carcinogenic activity of d-limonene for female rats, for male mice, or for female mice.
Butylated hydroxyanisole [NTP: Suspect carcinogen & IARC: Group 2B carcinogen ]
Other Toxic Effects on Humans: Eye: Causes eye irritation.
Skin: Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to
this material. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis.
Ingestion: May cause digestive tract disturbances.
Inhalation: May cause respiratory tract irritation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.
12: Ecological Information
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Ecotoxicity: Not available.
BOD5 and COD: Not available.
Product of Biodegradation: Not available.
Toxicity of the Products of Biodegradation: Not available.
Special Remarks on the Products of Biodegradation: Not available.
13: Disposal Considerations
Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.
14: Transport Information
DOT Classification: Class: 3
Identification: UN#:2052
Packing Group: III
Special Provisions for Transport: Not available.
15: Other Regulatory Information
Federal and State Regulations: TSCA 8(b) inventory : d-Limonene; Butylated hydroxyanisole
Other Regulations: Hazard Symbols: XI N
Risk Phrases:
R 10: Flammable.
R 38: Irritating to skin.
R 43: May cause sensitization by skin contact.
R 50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Phrases:
S 24: Avoid contact with skin.
S 37: Wear suitable gloves.
S 60: This material and its container must be disposed of as hazardous waste.
S 61: Avoid release to the environment. Refer to special instructions/safety data sheets.
Other Classifications:
WHMIS(Canada): This product has a WHMIS classification of B3, D2B.
DSCL(EEC): Not available.
HMIS(U.S.A):
Health Hazard: 2
Fire Hazard: 2
Reactivity: 0
Personal Protection:
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National Fire Protection Association (U.S.A):
Health: 2
Flammability: 2
Reactivity: 0
Specific hazard:
Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Safety goggles.
16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/04/2007 10:19:42 AM
Last Updated: 10/04/2007 10:19:42 AM
Disclaimer
This product is offered by bioWORLD for research, laboratory or further manufacturing use. Not for human use or
consumption.
The information above is believed to be accurate and represents the best information currently available to us. However,we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we
assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the
information for their particular purposes.In no event shall Bio-World.com be liable for any claims, losses, or damages of any
third party or for lost profits or any special, indirect,incidental,consequential or exemplary damages, howsoever arising,
even if Bio-World.com has been advised of the possibility of such damages.
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