PRODUCT #: 18460        NAME: BROMOTHYMOL BLUE

                      MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98

                          Printed Monday, March 10, 1903 3:34PM



Sigma Chemical Co.          Aldrich Chemical Co., Inc.    Fluka Chemical Corp.

P.O. Box 14508              1001 West St. Paul            1001 West St. Paul

St. Louis, MO 63178         Milwaukee, WI 53233           Milwaukee, WI 53233

Phone: 314-771-5765         Phone: 414-273-3850           Phone: 414-273-3850









SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -

    CATALOG #:            18460

    NAME:                 BROMOTHYMOL BLUE

SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -

    CAS #:     76-59-5

    MF: C27H28BR2O5S

    EC NO: 200-971-2

  SYNONYMS

    BROMTHYMOL BLUE * BROMOTHYMOL BLUE * DIBROMOTHYMOLSULFOPHTHALEIN * 3,

    3'-DIBROMOTHYMOLSULFONPHTHALEIN * THYMOL, 6,6'-(3H-2,1-BENZOXATHIOL-3-

    YLIDENE)BIS(2-BROMO-, S,S-DIOXIDE (8CI) *

SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -

  LABEL PRECAUTIONARY STATEMENTS

    CAUTION:

    AVOID CONTACT AND INHALATION.

SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -

    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.

    CALL A PHYSICIAN.

    IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER

    FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND

    SHOES. CALL A PHYSICIAN.

    IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,

    CALL A PHYSICIAN.

    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER

    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING

    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -

  EXTINGUISHING MEDIA

    WATER SPRAY.

    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.

  SPECIAL FIREFIGHTING PROCEDURES

    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO

    PREVENT CONTACT WITH SKIN AND EYES.

  UNUSUAL FIRE AND EXPLOSIONS HAZARDS

    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -

    WEAR PROTECTIVE EQUIPMENT.

    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.

    AVOID RAISING DUST.

    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.

SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -

    REFER TO SECTION 8.

SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -

    WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT

    GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.

    MECHANICAL EXHAUST REQUIRED.

SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -

  APPEARANCE AND ODOR

    LIGHT-PINK POWDER



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                     PRODUCT #: 18460        NAME: BROMOTHYMOL BLUE

                     MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98

                         Printed Monday, March 10, 1903 3:34PM



  PHYSICAL PROPERTIES

    MELTING POINT:       204 TO 208C

SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -

  STABILITY

    STABLE.

  INCOMPATIBILITIES

    STRONG OXIDIZING AGENTS

  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS

    TOXIC FUMES OF:

    CARBON MONOXIDE, CARBON DIOXIDE

    SULFUR OXIDES

    HYDROGEN BROMIDE GAS

  HAZARDOUS POLYMERIZATION

    WILL NOT OCCUR.

SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -

  ACUTE EFFECTS

    MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION.

    MAY CAUSE IRRITATION.

    THE TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY

    INVESTIGATED.

  RTECS #: SJ7450000

    PHENOL,

     4,4'-(3H-2,1-BENZOXATHIOL-3-YLIDENE)BIS(2-BROMO-3-METHYL-6-(1-METHYLETH

    S,S-DIOXIDE

    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES

    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR

    COMPLETE INFORMATION.

SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -

    DATA NOT YET AVAILABLE.

SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -

    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A

    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.

    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.

SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -

    CONTACT FLUKA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.

SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -

  REVIEWS, STANDARDS, AND REGULATIONS

    OEL=MAK

    NOHS 1974: HZD 81736; NIS 24; TNF 721; NOS 20; TNE 10734

    NOES 1983: HZD X9061; NIS 1; TNF 4; NOS 1; TNE 13

    NOES 1983: HZD 81736; NIS 23; TNF 2239; NOS 32; TNE 43893; TFE 30922

    EPA GENETOX PROGRAM 1988, INCONCLUSIVE: B SUBTILIS REC ASSAY

    EPA TSCA SECTION 8(B) CHEMICAL INVENTORY

SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -

    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO

    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,

    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING

    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR

    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.

    COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,

    FLUKA CHEMIE AG

    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY









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