PRODUCT #: C0750 NAME: CAFFEINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 4:17PM
Sigma Chemical Co. Aldrich Chemical Co., Inc. Fluka Chemical Corp.
P.O. Box 14508 1001 West St. Paul 1001 West St. Paul
St. Louis, MO 63178 Milwaukee, WI 53233 Milwaukee, WI 53233
Phone: 314-771-5765 Phone: 414-273-3850 Phone: 414-273-3850
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: C0750
NAME: CAFFEINE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 58-08-2
MF: C8H10N4O2
EC NO: 200-362-1
SYNONYMS
ANHYDROUS CAFFEINE * CAFFEIN * CAFFEINA (ITALIAN) * COFFEIN (GERMAN) *
COFFEINE * COFFEINUM * 3,7-DIHYDRO-1,3,7-TRIMETHYL-1H-PURINE-2,6-
DIONE * ELDIATRIC C * GUARANINE * KOFEIN (CZECH) * KOFFEIN (GERMAN) *
METHYLTHEOBROMIDE * NCI-C02733 * NO-DOZ * ORGANEX * 1H-PURINE-2,6-
DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL- * THEIN * THEINE * THEOBROMINE, 1-
METHYL- * THEOPHYLLINE, 7-METHYL * 1,3,7-TRIMETHYL-2,6-DIOXOPURINE *
1,3,7-TRIMETHYLXANTHINE * XANTHINE, 1,3,7-TRIMETHYL *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
TOXIC
TOXIC IF SWALLOWED.
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
POSSIBLE RISK OF IRREVERSIBLE EFFECTS.
TARGET ORGAN(S):
CENTRAL NERVOUS SYSTEM
HEART
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION.
DO NOT BREATHE DUST.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
CLOTHING AND SHOES.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
WASH CONTAMINATED CLOTHING BEFORE REUSE.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
CARBON DIOXIDE.
DRY CHEMICAL POWDER.
WATER SPRAY.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
Page 1
PRODUCT #: C0750 NAME: CAFFEINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 4:17PM
WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
USE ONLY IN A CHEMICAL FUME HOOD.
SAFETY SHOWER AND EYE BATH.
DO NOT BREATHE DUST.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
WASH THOROUGHLY AFTER HANDLING.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
WHITE POWDER
PHYSICAL PROPERTIES
MELTING POINT: 234 C TO 236.5 C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
INCOMPATIBILITIES
STRONG OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
THERMAL DECOMPOSITION MAY PRODUCE CARBON MONOXIDE, CARBON DIOXIDE,
AND NITROGEN OXIDES.
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
HARMFUL IF SWALLOWED.
MAY BE HARMFUL IF INHALED.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
CAUSES EYE AND SKIN IRRITATION.
MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
OVEREXPOSURE BY INGESTION MAY RESULT IN NERVOUSNESS, TREMORS
AND INSOMNIA.
HEADACHE, DIZZINESS, DROWSINESS, INCOORDINATION, SLOWED REACTION TIME,
SLURRED SPEECH, GIDDINESS AND UNCONSCIOUSNESS.
LETHARGY AND CONVULSIONS
NAUSEA, VOMITING, DIARRHEA
NEUROTOXIC EFFECTS
ATAXIA
CNS STIMULATION
CONVULSIONS
PROLONGED OR REPEATED EXPOSURE CAN LEAD TO HABITUATION OR ADDICTION.
MUSCLE CRAMPS/SPASMS
CHRONIC EFFECTS
LABORATORY EXPERIMENTS HAVE SHOWN MUTAGENIC EFFECTS.
TARGET ORGAN(S):
CENTRAL NERVOUS SYSTEM
Page 2
PRODUCT #: C0750 NAME: CAFFEINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 4:17PM
HEART
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS #: EV6475000
CAFFEINE
TOXICITY DATA
ORL-HMN LDLO:192 MG/KG JNDRAK 5,252,1965
ORL-CHD LDLO:320 MG/KG FNSCA6 3,275,1974
ORL-WMN LDLO:1 GM/KG BIATDR -,6,1973
IVN-WMN LDLO:57 MG/KG APTOA6 15,331,1959
ORL-RAT LD50:192 MG/KG JNDRAK 5,252,1965
IPR-RAT LD50:240 MG/KG ZERNAL 15,64,1976
SCU-RAT LD50:170 MG/KG JCPHB8 7,131,1967
IVN-RAT LD50:105 MG/KG JPETAB 82,89,1944
REC-RAT LD50:300 MG/KG JCPHB8 7,131,1967
ORL-MUS LD50:127 MG/KG TXAPA9 44,1,1978
IPR-MUS LD50:168 MG/KG CPBTAL 22,1459,1974
SCU-MUS LD50:242 MG/KG ARZNAD 6,601,1956
IVN-MUS LD50:62 MG/KG TOLED5 29,25,1985
UNR-MUS LD50:251 MG/KG NYKZAU 53,2S,1957
ORL-DOG LD50:140 MG/KG NIIRDN 6,174,1982
SCU-DOG LD50:100 MG/KG NIIRDN 6,174,1982
ORL-RBT LD50:224 MG/KG TXAPA9 44,1,1978
IVN-RBT LD50:58 MG/KG KSRNAM 13,791,1979
ORL-GPG LD50:230 MG/KG TXAPA9 2,23,1960
ORL-HAM LD50:230 MG/KG TXAPA9 44,1,1978
ORL-BWD LD50:316 MG/KG AECTCV 12,355,1983
TARGET ORGAN DATA
BRAIN AND COVERINGS (OTHER DEGENERATIVE CHANGES)
BEHAVIORAL (SOMNOLENCE)
BEHAVIORAL (HALLUCINATIONS, DISTORTED PERCEPTIONS)
BEHAVIORAL (TOXIC PSYCHOSIS)
BEHAVIORAL (TREMOR)
BEHAVIORAL (CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD)
BEHAVIORAL (CHANGE IN MOTOR ACTIVITY)
BEHAVIORAL (ATAXIA)
BEHAVIORAL (STIFFNESS)
BEHAVIORAL (MUSCLE CONTRACTION OR SPASTICITY)
BEHAVIORAL (WITHDRAWAL)
BEHAVIORAL (AGGRESSION)
CARDIAC (PULSE RATE INCREASED WITHOUT FALL IN BP)
CARDIAC (CHANGE IN RATE)
CARDIAC (OTHER CHANGES)
VASCULAR (BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION)
LUNGS, THORAX OR RESPIRATION (ACUTE PULMONARY EDEMA)
LUNGS, THORAX OR RESPIRATION (DYSPNAE)
LUNGS, THORAX OR RESPIRATION (CYANOSIS)
LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION)
GASTROINTESTINAL (HYPERMOTILITY, DIARRHEA)
GASTROINTESTINAL (NAUSEA OR VOMITING)
KIDNEY, URETER, BLADDER (CHANGES IN TUBULES)
KIDNEY, URETER, BLADDER (INTERSTITIAL NEPHRITIS)
KIDNEY, URETER, BLADDER (URINE VOLUME INCREASED)
KIDNEY, URETER, BLADDER (STRUCTURAL OR FUNCTIONAL CHANGE IN URETER)
BLOOD (HEMORRHAGE)
MUSCULO-SKELETAL (TUMORS)
EFFECTS ON FERTILITY (FEMALE FERTILITY INDEX)
Page 3
PRODUCT #: C0750 NAME: CAFFEINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 4:17PM
EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
EFFECTS ON FERTILITY (LITTER SIZE)
EFFECTS ON FERTILITY (ABORTION)
EFFECTS ON EMBRYO OR FETUS (EXTRA EMBRYONIC STRUCTURES)
EFFECTS ON EMBRYO OR FETUS (MATERNAL-FETAL EXCHANGE)
EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
EFFECTS ON EMBRYO OR FETUS (FETAL DEATH)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (EYE, EAR)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (CRANIOFACIAL)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (SKIN AND SKIN APPENDAGES)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (BLOOD AND LYMPHATIC SYSTEMS)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (GASTROINTESTINAL SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (UROGENITAL SYSTEM)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (HOMEOSTASIS)
SPECIFIC DEVELOPMENTAL ABNORMALITIES (OTHER DEVELOPMENTAL ABNORMALITIES)
EFFECTS ON NEWBORN (VIABILITY INDEX)
EFFECTS ON NEWBORN (WEANING OR LACTATION INDEX)
EFFECTS ON NEWBORN (GROWTH STATISTICS)
EFFECTS ON NEWBORN (BIOCHEMICAL AND METABOLIC)
EFFECTS ON NEWBORN (BEHAVIORAL)
EFFECTS ON NEWBORN (PHYSICAL)
EFFECTS ON NEWBORN (OTHER POSTNATAL MEASURES OR EFFECTS)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
EC INDEX NO: 613-086-00-5
TOXIC
R 22
HARMFUL IF SWALLOWED.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
IARC CANCER REVIEW:HUMAN INADEQUATE EVIDENCE IMEMDT 51,291,1991
IARC CANCER REVIEW:ANIMAL INADEQUATE EVIDENCE IMEMDT 51,291,1991
IARC CANCER REVIEW:GROUP 3 IMEMDT 51,291,1991
OEL-RUSSIA:STEL 0.5 MG/M3 JAN 1993
NOHS 1974: HZD M1132; NIS 6; TNF 893; NOS 7; TNE 5715
NOES 1983: HZD M1132; NIS 19; TNF 1707; NOS 23; TNE 19593; TFE 11199
NOES 1983: HZD X9210; NIS 2; TNF 38; NOS 5; TNE 373; TFE 92
EPA GENETOX PROGRAM 1988, POSITIVE: CELL TRANSFORM.-SA7/SHE; IN VITRO
CYTOGENETICS-NONHUMAN
EPA GENETOX PROGRAM 1988, POSITIVE: D MELANOGASTER-WHOLE SEX CHROM.
LOSS
EPA GENETOX PROGRAM 1988, POSITIVE: D MELANOGASTER-NONDISJUNCTION; N
CRASSA-ANEUPLOIDY
EPA GENETOX PROGRAM 1988, POSITIVE: E COLI POLA WITHOUT S9; IN VITRO
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PRODUCT #: C0750 NAME: CAFFEINE
MATERIAL SAFETY DATA SHEET, Valid 11/97 - 1/98
Printed Monday, March 10, 1903 4:17PM
SCE-HUMAN
EPA GENETOX PROGRAM 1988, POSITIVE: D MELANOGASTER SEX-LINKED LETHAL; S
CEREVISIAE-ANEUPLOIDY
EPA GENETOX PROGRAM 1988, POSITIVE/DOSE RESPONSE: IN VITRO
CYTOGENETICS-HUMAN LYMPHOCYTE
EPA GENETOX PROGRAM 1988, NEGATIVE: SHE-CLONAL ASSAY; RODENT DOMINANT
LETHAL
EPA GENETOX PROGRAM 1988, NEGATIVE: HISTIDINE REVERSION-AMES TEST; IN
VITRO SCE-NONHUMAN
EPA GENETOX PROGRAM 1988, NEGATIVE: MOUSE SPECIFIC LOCUS; SPERM
MORPHOLOGY-MOUSE
EPA GENETOX PROGRAM 1988, NEGATIVE: UDS IN MOUSE GERM CELLS; V79 CELL
CULTURE-GENE MUTATION
EPA GENETOX PROGRAM 1988, NEGATIVE: TRP REVERSION
EPA GENETOX PROGRAM 1988, NEGATIVE/LIMITED: CARCINOGENICITY-MOUSE/RAT
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: IN VIVO CYTOGENETICS-NONHUMAN
BONE MARROW
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: CYTOGENETICS-MALE GERM CELL
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: RODENT HERITABLE TRANSLOCATION;
MAMMALIAN MICRONUCLEUS
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: MOUSE SPOT TEST; B SUBTILIS REC
ASSAY
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: IN VITRO SCE-HUMAN LYMPHOCYTES;
IN VIVO SCE-NONHUMAN
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, APRIL 1997
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 1997 SIGMA CHEMICAL CO., ALDRICH CHEMICAL CO., INC.,
FLUKA CHEMIE AG
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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