ImmunoRegulin
庐
Immunostimulant
An adjunct to antibiotic
therapy in the treatment
of acute and chronically
recurring canine pyoderma
What is ImmunoRegulin?
In extensive stability testing, unrefrigerated unopened Immu-
ImmunoRegulin is an immune stimulant that has been
noRegulin retained its potency. Practitioners who leave their
developed for canine use in the treatment of the immune-
medicine on the counter before use don鈥檛 have to worry about
compromising disease Staph. Pyoderma. The product stim-
ImmunoRegulin deteriorating or the integrity of the product
ulates an immune response in animals. Propionibacterium
being compromised with normal warming. Unused portions
acnes, the active ingredient of ImmunoRegulin, is one of the
of opened vials should be refrigerated.
best characterized biological response modi铿乪rs inducing
immunostimulatory activity.
ImmunoRegulin has been used safely in millions of animals.
Because ImmunoRegulin acts primarily on the cell-mediated
How does ImmunoRegulin work? side of the immune response, it does not have a high potential
for causing anaphylaxis. Anaphylaxis is primarily a humoral
ImmunoRegulin is an inactivated bacterin. Once it鈥檚 injected
or B-cell involvement.
intravenously (IV), it travels to the lungs, liver and spleen
where it activates the aureus system or the reticulonendothe-
Valued.
lial (RES) cell system. Taken up quickly by macrophages, Im-
munoRegulin triggers the phagocytic action of macrophages
With ImmunoRegulin therapy you can get by with less dosage
to eliminate invading microbes. Concurrently, ImmunoReg-
and less frequency of antibiotic treatment. A concurrent anti-
ulin activates the messenger system of the macrophages to
biotic that is usually given two to three times a day may be cut
begin a cascade of immunological events that 铿乬ht bacterial
back to only once a day when using ImmunoRegulin.
involvement and viral infection. Interferon production is also
increased which hastens the production of interleukins and
Supported.
natural killer cells. These natural killer cells indiscriminately
attack invading microbes and abnormal cells, which assists
Clinical trials demonstrated an 80% rate of healing when
the antibiotic in bringing the infection to a quick conclusion.
ImmunoRegulin was used in conjunction with antibiotics.
A responsive patient鈥檚 haircoat will return quickly, usually
Trusted. within 5鈥?10 days of ImmunoRegulin therapy. Pustules will
clear quickly as will the in铿俛mmation and itching tendencies.
ImmunoRegulin is an extremely stable product. The USDA
An enhanced immune system will allow chosen antibiotics to
has given approval for the storage of unopened vials of Im-
more e铿?ectively eliminate the persistent infection quickly and
munoRegulin at room temperature. Suspended in 12.5% eth-
more e铿僣iently.
anol and saline, ImmunoRegulin doesn鈥檛 contain albumins
like many biologics.
Summary of Clinical Trials
with ImmunoRegulin and Antibiotics
in Canine Pyoderma
Clinical Appearance Response by Group
of Lesions Field Study
12 Week Controlled Study
Avg. 7 Injections
14 Injections per Treatment
ImmunoRegulin/ Antibiotic ImmunoRegulin/
Antibiotics Controls Antibiotics
(N=15) (N=13) (N=68)
Clinical Response 80% 38% 83%
(Remissions and Improvement)
Complete Remissions 53% 31% 31%
Clinical Improvement 27% 7% 52%
No Response 20% 62% 17%
References on 铿乴e, Neogen Corporation
ImmunoRegulin Use Schedule Dosage Schedule
1. Two IV injections per week for 2 weeks Weight of Dog Dose (IV)
2. One IV injection per week until de铿乶ite
up to 15 lbs. 0.25 mL
improvement is noted
16鈥?45 lbs. 0.50 mL
3. One IV injection per month to avoid relapse and
46鈥?75 lbs. 1.00 mL
to maintain clinical improvement
over 75 lbs. 2.00 mL
Testimonials
鈥淲e鈥檝e found that if we start using ImmunoRegulin early, along
鈥淲ith the nature of some diseases like chronic recurring pyoderma,
with shampoos and proper antibiotics, the patient responds
I think ImmunoRegulin therapy is a lifetime endeavor. I鈥檝e main-
quicker and will usually reduce the reoccurrence rate. Timing is
tained some chronic recurring pyoderma dogs on ImmunoRegu-
everything when treating acute pyoderma. The longer you let the
lin maintenance for over six years with no side e铿?ects. I鈥檝e had the
disease go, the longer the treatment is going to take and the higher
biggest success with ImmunoRegulin in dogs that are habitual ste-
the reoccurrence.鈥?
roid鈥攁 chronic cortisone or prednisone dog. Where we鈥檙e looking
for something that will improve the long-term overall health of that 鈥擡ddie Garcia, DVM
animal, we鈥檒l initiate the program. We start them out at one dose,
twice a week. Usually in 10 days we鈥檒l see the pustules drying up,
鈥淭he Staph.-speci铿乧 product seems to work as well as the Immu-
the redness will be gone and the haircoat will start to come back.
noRegulin, but in the long run, it鈥檚 more expensive to manage. We
Then we鈥檒l maintain them on one dose every couple of weeks.鈥?
start using the Staph.-speci铿乧 product a couple of doses a week,
鈥擬ike Lies, DVM but are required to stay at a higher dose a lot longer. With Im-
munoRegulin we 铿乶d that we can gradually space out the dosage
much further apart.鈥?
鈥淚鈥檓 not only seeing a quicker and better response to the antibiotics
and shampoos, I鈥檓 also using less antibiotics. I don鈥檛 see relapses as 鈥擥race Robinson, DVM
soon after therapy as I was seeing when using antibiotics alone.鈥?
鈥擱onald Hulslander, DVM
944 Nandino Blvd. 鈥? Lexington, KY 40511 USA
800/525-2022 鈥? 859/254-1221 鈥? Fax 877/228-7229
inform@neogen.com 鈥? www.neogen.com
AN054-0805
漏 2005, Neogen Corporation. Neogen and ImmunoRegulin are registered trademarks of Neogen Corporation, Lansing, MI 48912.
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