BotVax庐 B
Clostridium Botulinum Type B Toxoid
Indications
For prevention of Botulism due to Clostridium botulinum Type B in
healthy horses.
Research has demonstrated that pregnant mares immunized during the
third trimester of gestation, with the third dose (booster) given 2-4 weeks
before parturition, respond with antibody. This antibody is concentrated in
colostrum and results in significant passively acquired antibody in normal
suckling foals.
Directions For Use
Inject 2 mL intramuscularly, using aseptic technique, at monthly
intervals for a total of 3 doses. Booster annually with a single 2 mL
Description intramuscular dose. Shake well before use.
Caution
BotVax B is a monovalent product for prevention of disease caused
by Clostridium botulinum Type B. This product does not confer For veterinary use only.
protection against other strains of C. botulinum. Do not vaccinate food-producing animals within 21 days
of slaughter.
Ingredients Transitory tissue reaction at the injection site, such as heat and minor
swelling, may occur.
Anaphylactoid reactions may occur. Epinephrine is antidotal.
Purified botulinum type B toxoid, aluminum phosphate absorbed
Use the entire contents of the container when first opened. Do not
Thimerosal (as preservative) 0.01%
store opened vials.
鈮?0.02%
Formaldehyde (as inactivating solution)
For animal use only.
Storage
Store unopened vials at 2掳-7掳C (35掳 to 45掳F). Do not freeze.
Presentation
#200180 10 mL vial (5 doses per vial) 12 vials per case
ADMINISTRATION: Inject intra-
INDICATIONS: For the prevention
CLOSTRIDIUM muscularly using aseptic technique.
of equine botulism due to
BOTULINUM Shake well before use.
Clostridium botulinum Type B in healthy
TYPE mL - 5 TOXOID
B Doses CAUTIONS: Transitory local reactions
horses.
10
BotVax庐 B at the injection site such as heat and
DOSAGE: Inject 2.0 mL
intramuscularly at monthly minor swelling may occur.
intervals for a total of 3 doses. Anaphylactoid reactions may occur.
Purified botulinum type B toxoid
Booster annually with a single 2.0 Epinephrine is antidotal. Store at 2-
aluminum phosphate absorbed.
mL intramuscular dose. 7掳C (35-45掳F). Do not freeze. Use
Preservative: 0.01% Thimerosal.
Research has demonstrated that entire contents when opened.
Contains no more than 0.2%
pregnant mares immunized Do not vaccinate food producing
formaldehyde as inactivating
during the third trimester of animals within 21 days of
gestation, with the third dose solution. slaughter.
(booster) given 2 - 4 weeks before U.S. Vet. Lic. No. 302 This is a conditionally licensed
parturition, respond with antibody. vaccine. Efficacy and potency have
This antibody is concentrated in not been determined. These
Serial No.
colostrum and results in studies are in progress.
Tampa, FL USA 33610
significant passively acquired
Exp.
FOR VETERINARY USE ONLY
antibody in normal suckling foals. 800/525-2022 聲 606/254-1221 L309-0699
L309-0300
Neogen Corporation 聲 628 Winchester Rd. 聲 Lexington, KY 40505 USA 聲 800/525-2022 聲 859/254-1221 聲 Fax: 859/255-5532 聲 www.neogen.com 聲 e-mail: inform@neogen.com
BotVax庐 B
Clostridium botulinum Type B Toxoid
Botulism B is a rapidly progressive, neurological paralyzing When diagnosed, treatment of the horse consists of giving an
disease that is nearly 100% fatal in horses. Botulism is sometimes expensive antitoxin that binds to any circulating toxins. The cost
referred to as 鈥淔orage Poisoning鈥? in adult horses and 鈥淪haker Foal of antitoxin alone for foals is $1,000 to $1,500 and about
Syndrome鈥? in foals. $2,000 for adult horses.
Symptoms include: With the addition of antibiotics and intensive care, the cost of
鈥? Muscular tremors, stilted gate treatment is even higher. Prevention is simple and inexpensive
鈥? Difficulty eating or swallowing with the USDA approved vaccine, BotVax B.
鈥? Decreased tongue and tail tone; loose (falling)
tongue is very common
Immunization of Pregnant Mares
鈥? Progressive muscular weakness, recumbency
Revaccinate annually with a single 2 mL dose 2-4 weeks before
鈥? Respiratory paralysis and generally death within
parturition.
48 to 72 hours
Newborn foals are highly susceptible to Shaker Foal Syndrome.
Proper vaccination of mares with BotVax B will protect the foal
through colostral antibodies, until maternal immunity begins to
wane (8-10 weeks).
Vaccination of Foals, Weanlings and
Yearlings
All young horses are susceptible to equine botulism and should
be given the proper 3 dose series. A yearly booster with BotVax B
is needed to protect the horse from botulism throughout its adult
life. Foals from properly vaccinated mares should begin their
series at 10-12 weeks of age. For a foal from a non-immunized
mare, the 3 dose series should begin a week to 10 days following
Type B equine botulism and Shaker Foal Syndrome are caused
birth.
by a toxin produced by soilborne bacteria named Clostridium
botulinum. C. botulinum, whose serotype is B, produces extremely
Important Note: The mobility of both horses and feedstuffs puts
stable spores that have been found in soil samples around the
many horses at risk. The spores of C. botulinum Type B can be
world and remain viable for many years. The toxins that are
found almost everywhere and can live in the soil for years. When
produced by C. botulinum, once the spores germinate and
the conditions are right, the toxin these bacteria produce can
produce active bacterial growth, are some of the most potent
cause botulism. If a horse has value, economic or otherwise, it
known to man.
should be vaccinated against botulism.
Any horse, at any age, is susceptible to botulism, which may
occur in three ways:
鈥? Botulinum toxin is produced repeatedly and rapidly in the
horse鈥檚 gut (toxicoinfectious botulism).
鈥? A wound infection that becomes contaminated with C.
botulinum spores, which grow and produce the toxin in
tissue. Contamination of the navel may cause the same
result.
鈥? As a forage poisoning in which botulinum toxin develops in
feed or hay before it is consumed by the horse. Also, spores
ingested from hay contaminated with C. botulinum
(bacteria/toxin) infected dead animal(s) 鈥渞olled up鈥? in the
hay harvest. These spores then may germinate in a minor
gut lesion.
To order call 800/525-2022 USA/Canada or 859/254-1221 鈥? Fax: 800/255-1168 USA/Canada or 859/255-5532 鈥? e-mail: inform@neogen.com
漏Neogen Corporation, 2003. Neogen庐 and BotVax庐 are registered trademarks of Neogen Corp., Lansing, MI. L383-0203
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