Creation Date: 07-23-2004
Revision Date: 10-12-2004
Material Safety Data Sheet
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1. Chemical Product and Company Identification
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Material Name QRFP-43, [125I]-
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01
Version #
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NEX408000MC
Item #
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PerkinElmer Life and Analytical Sciences
Identification Of The
710 Bridgeport Avenue
Company/Undertaking
Shelton, CT 06484
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Technical Support 800-762-4000
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CHEMTREC 800-424-9300
Emergency Telephone
Emergency Phone 800-762-4000
Number
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2. Composition / Information on Ingredients
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Hazardous component(s) CAS # Percent PEL TLV
ACETONITRILE 75-05-8 20 - 40 40 ppm 20
1-PROPANOL 71-23-8 10 - 20 200 ppm 200
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Non-hazardous component(s) CAS # Percent
WATER 7732-18-5 40 - 60
ALBUMIN, BOVINE FRACTION V 9048-46-8 0.1 - 1
(POWDER)
QRFR-43, [125I] 0.01 - 0.1
TRIFLUOROACETIC ACID 76-05-1 0.01 - 0.1
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3. Hazards Identification
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Emergency Overview
Highly flammable.
Risk of serious damage to eyes.
Severe eye irritation
Harmful by inhalation, in contact with skin and if swallowed.
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Target Organs
Central nervous system, Eyes, Liver
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4. First Aid Measures
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General advice
In case of feeling unwell: Call a physician immediately.
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First Aid
Skin contact
Wash off immediately with soap and plenty of water removing all contaminated clothes and
shoes.
Material ID 14304 Material Name QRFP-43, [125I]-
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Eye contact
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Consult a
physician.
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Inhalation
Move to fresh air. Oxygen or artificial respiration if needed.
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Ingestion
Clean mouth with water and drink afterwards plenty of water. Never give anything by mouth to
an unconscious person.
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5. Fire Fighting Measures
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Suitable extinguishing media
carbon dioxide (CO2), dry powder or foam
Water may be ineffective.
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Specific hazards
In the event of fire toxic fumes may be formed.
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Special protective equipment for firefighters
In the event of fire, wear self contained breathing apparatus.
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6. Accidental Release Measures
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Evacuation Procedures
Evacuate personnel to safe areas.
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Personal precautions
Remove all sources of ignition. Ensure adequate ventilation. Use personal protective equipment.
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Environmental precautions
Do not let product enter drains.
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Methods for cleaning up
Neutralise with dry-lime, sand, or soda ash. Clean contaminated surface thoroughly. Keep in
suitable and closed containers for disposal.
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7. Handling and Storage
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Handling
Container may be opened only under exhaust ventilation hood. Keep away from heat and sources
of ignition. Wear personal protective equipment. Do not breathe vapours/dust. Avoid contact with
skin and eyes.
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Storage
Keep tightly closed in a dry and cool place. Keep away from heat.
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8. Exposure Controls / Personal Protection
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Exposure Limit Values
ACGIH - Occupational Exposure Limits - TWAs
1-PROPANOL 71-23-8 200 ppm TWA
ACETONITRILE 75-05-8 20 ppm TWA
OSHA - Final PELs - Time Weighted Averages (TWAs)
1-PROPANOL 71-23-8 200 ppm TWA; 500 mg/m3 TWA
ACETONITRILE 75-05-8 40 ppm TWA; 70 mg/m3 TWA
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Exposure Controls
Engineering measures to reduce exposure
Provide adequate ventilation.
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Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Contaminated work
clothing should not be allowed out of the workplace. Keep away from food and drink. Avoid
contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
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Respiratory protection
No personal respiratory protective equipment normally required.
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Hand protection
solvent-resistant gloves
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Eye protection
safety glasses with side-shields
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Skin and body protection
lab coat
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9. Physical & Chemical Properties
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General Information
Form
liquid
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Color
colorless, clear
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Odor
none
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Important health, safety and environmental information
2
pH
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10. Chemical Stability & Reactivity Information
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Stability
Stable
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Hazardous decomposition products
carbon oxides
nitrogen oxides (NOx)
hydrogen cyanide (hydrocyanic acid)
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Incompatibility
acids, bases, oxidizing agents, reducing agents, alkaline metals
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Hazardous Polymerization
Will not occur.
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11. Toxicological Information
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Acute Toxicity
Harmful by inhalation, in contact with skin and if swallowed.
Risk of serious damage to eyes.
Severe eye irritation
May cause skin irritation.
May cause irritation of respiratory tract.
Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting.
NIOSH - Selected LD50s and LC50s
1-PROPANOL 71-23-8 Inhalation LC50 Mouse: 48 gm/m3; Oral LD50 Rat:
1870 mg/kg; Oral LD50 Mouse: 6800 mg/kg; Dermal
LD50 Rabbit: 4060 mg/kg
ACETONITRILE 75-05-8 Inhalation LC50 Rat: 7551 ppm/8H; Inhalation LC50
Mouse: 2693 ppm/1H; Oral LD50 Rat: 2460 mg/kg;
Oral LD50 Mouse: 269 mg/kg; Dermal LD50 Rabbit:
1250 uL/kg
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Carcinogenicity Data
ACETONITRILE
Ingredient(s)
- ACGIH Not Classified Carcinogen
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Symptoms and Target Organs
NIOSH - Pocket Guide - Target Organs
1-PROPANOL 71-23-8 skin, eyes, respiratory system, GI tract, CNS
ACETONITRILE 75-05-8 kidneys, liver, CVS, CNS, respiratory system
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12. Ecological Information
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Ecotoxicity
Ecotoxicity - Freshwater Fish Species Data
1-PROPANOL 71-23-8 96 Hr LC50 fathead minnow: 4480 mg/L
(flow-through)
ACETONITRILE 75-05-8 96 Hr LC50 fathead minnow: 1640 mg/L
(flow-through)
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Aquatic Toxicity
Ecotoxicity - Freshwater Fish Species Data
1-PROPANOL 71-23-8 96 Hr LC50 fathead minnow: 4480 mg/L
(flow-through)
ACETONITRILE 75-05-8 96 Hr LC50 fathead minnow: 1640 mg/L
(flow-through)
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Ecological Information
No information available
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13. Disposal Considerations
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Disposal Instructions
In accordance with local and national regulations.
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Waste from residues / unused products
In accordance with local and national regulations.
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14. Transportation Information
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US DOT
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Material ID 14304 Material Name QRFP-43, [125I]-
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15. Regulatory Information
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CERCLA/SARA Section 313
ACETONITRILE
Ingredient(s)
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US Federal Regulations
CERCLA/SARA - Hazardous Substances and their Reportable Quantities
ACETONITRILE 75-05-8 5000 lb final RQ; 2270 kg final RQ
CERCLA/SARA - Section 313 - Emission Reporting
ACETONITRILE 75-05-8 1.0 percent de minimis concentration
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State Regulations
Massachusetts - Right To Know List
1-PROPANOL 71-23-8 [present]
ACETONITRILE 75-05-8 [present]
Massachusetts - Toxics Use Reduction Act
ACETONITRILE 75-05-8 CERCLA and 313 chemical
New Jersey - Department of Health RTK List
1-PROPANOL 71-23-8 sn 1605
ACETONITRILE 75-05-8 sn 0008
Pennsylvania - RTK (Right to Know) List
1-PROPANOL 71-23-8 Present
ACETONITRILE 75-05-8 environmental hazard
Rhode Island - Hazardous Substance List
1-PROPANOL 71-23-8 Toxic; skin
ACETONITRILE 75-05-8 Toxic, Flammable
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International Regulations
Canada - WHMIS - Ingredient Disclosure
1-PROPANOL 71-23-8 1%; English Item 1355; French Item 187
ACETONITRILE 75-05-8 0.1%; English Item 12; French Item 43
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16. Other Information
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Recommended use
For research use only.
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Disclaimer
The information provided in this Material Safety Data Sheet is based on our present knowledge,
and believed to be correct at the date of publication. However, no representation is made
concerning its accuracy and completeness. It is intended as guidance only, and is not to be
considered a warranty or quality specification. All materials may present unknown hazards, and
should be used with caution. Although certain hazards are described, we cannot guarantee that
these are the only hazards which exist. PerkinElmer Life and Analytical Sciences shall not be held
liable for any damage resulting from handling or from contact with the product.
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Material ID 14304 Material Name QRFP-43, [125I]-
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MSDS US
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