Product # (s) 6702
MATERIAL SAFETY DATA SHEET
Section 1. Company Identification and Product Information
庐
Product Name or Identity: GENE-TRAK Salmonella DLP Assay
Manufacturer鈥檚 Name: Neogen Corporation Emergency Phone No.: 517/372-9200
620 Lesher Place Fax No.: 517/372-0108
Lansing, MI 48912 e-mail: foodsafety@neogen.com
Date Prepared or Revised: July 2008 Chemtrec: (800) 424-9300
Outside US and Canada: (703) 527-3887
Section 2. Composition / Information on Hazardous Ingredients
This product is a mixture of the substances listed below with the addition of nonhazardous materials.
Hazardous Components CAS-No. % Concentration Hazard Symbol
Specific Chemical Identity:
Sulfuric Acid (Stop Solution) 7664-93-9 11% T (Toxic), C (Corrosive)
Formamide (Hybridization Solution) 75-12-7 > 99% Xi (Irritant)
Proteninase K (Lysis Reagent) 39450-01-6 N/A N/A
Section 3. Health Hazard Identification
Health Hazards: Information pertaining to particular dangers for man and environment.
(Acute and R 35 Corrosive. Causes severe burns. May be fatal if swallowed or contact with skin. (Sulfuric Acid)
Chronic)
R 60, 61 May impair fertility. May cause harm to the unborn child. (Formamide)
R 20 Harmful by inhalation. (Formamide, Proteninase K)
R 36, 37, 38 Irritating to eyes, respiratory system, and skin. (Sulfuric Acid, Formamide, Proteninase K)
R 42, 43 May cause sensitization by inhalation and skin contact. (Proteninase K)
Section 4. First Aid Measures
Emergency / General Information: Effects should be less severe than from exposure to higher concentrations of
First Aid sulfuric acid.
Procedures: Ingestion: DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth
to an unconscious person. Call a physician immediately, show product label or MSDS.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen. Call a physician immediately.
Eye Contact: Immediately rinse opened eye for at least 15 minutes under running water, lifting lower and
upper eyelids occasionally. Remove contact lenses if able. Seek medical attention immediately.
Skin Contact: Immediately wash with plenty of soap and water for at least 15 minutes while removing
contaminated clothing. Wash clothing before reuse. Seek medical attention. Excess acid on skin can be
neutralized with a 2% solution of bicarbonate of soda.
Section 5. Fire and Explosion Hazard Data
Flammable Limits: LEL 鈥? N/A
Flash Point (Method Used): 150掳C (Formamide)
UEL 鈥? N/A
Closed Cup
Extinguishing Media: Use water spray, dry powder, or carbon dioxide. Concentrated solutions of Sulfuric Acid are water
reactive.
Protective Equipment: Firefighters should wear full protective equipment and self-contained breathing apparatus.
Unusual Fire and Explosion Hazards: Contacts with metals causes formation of flammable and explosive hydrogen gas.
Hazardous Combustion Products: Sulfuric Acid is not combustible, but it is a strong oxidizer and its heat of reaction with
reducing agents or combustibles may cause ignition. Formamide emits toxic fumes under fire conditions.
Product # (s) 6702
Section 6. Accidental Release Measures
Personal Precautions: Consider need for evacuation. Avoid inhalation of vapors and contact with skin and eyes. Wear
suitable protective clothing, gloves, and eye protection. Wear self-containing breathing apparatus, rubber boots, and heavy
rubber gloves. Place contaminated material in a chemical waste container.
Environmental Precautions: Prevent dispersion of material. Avoid discharge into drains, water courses or onto the
ground. Inform authorities if large amounts are involved. Do not flush into sewer.
Clean-up Methods: Contain and recover liquid when possible. Neutralize with alkaline material, then absorb with an inert
material and place into chemical waste container. Contact safety officer if questions arise and ventilate area.
Section 7. Handling and Storage
Handling: Avoid inhalation of vapors and contact with skin and eyes. Wear appropriate personal protective equipment. Do
not taste or swallow. Protect against physical damage. Ensure good ventilation / exhaustion and do not breathe vapor.
Avoid prolonged or repeated exposure. Do not use if skin is cut or scratched.
Storage: Keep container tightly closed in a well-ventilated place. Store in closed original container in a dry place. Keep
away from heat, sparks, flame, and incompatible materials. Protect from physical damage.
Other Precautions: Keep respiratory protective device available. Containers may be hazardous when empty since they
retain product residues.
Section 8. Exposure Controls / Personal Protection
Components with limit values that require monitoring: Sulfuric Acid (7664-93-9), Formamide (75-12-7)
Chemical Name Source Type Exposure Limits
3
Sulfuric Acid US ACGIH TLV TWA 0.2 mg/m
3
Sulfuric Acid US OSHA -1 PEL TWA 1 mg/m
3
Formamide US OSHA TWA 18 mg/m
Engineering Controls: Provide adequate ventilation. Observe occupational exposure limits and minimize the risk of
inhalation of vapors and mist.
Respiratory Protection: Respiratory protection must be used if air contamination exceeds acceptable level. If engineering
controls do not maintain airborne concentrations below recommended exposure limits (where applicable) or to an
acceptable level (in countries where exposure limits have not been established), an approved respirator must be worn. In
the US, if respirators are used a program should be instituted to assure compliance with OSHA Standard 63 FR 1152,
January 8, 1998. Use a NIOSH-approved respirator (See 29 CRF 1910.134, respiratory protection standard). Respirator
type: Air-purifying respirator with an appropriate, government approved (where applicable), air-purifying filter, cartridge or
canister. Contact health and safety professional or manufacturer for specific information.
Personal Protective Equipment: Personal Protection listed below are general requirements for laboratory personnel.
Follow the usual precautionary measures for handling chemicals / powder. Avoid contact with eyes, skin, and clothing.
Proper ventilation required. Safety shower and eye bath required.
Keep away from food, beverages, and feed.
Wash hands before and after entering laboratory.
Immediately remove all soiled and contaminated clothing.
Avoid contact with eyes and skin.
Breathing Equipment: In case of brief exposure, use a chemical fume hood or a NIOSH / MSHA-approved respiratory.
Hand Protection: Use chemical resistant gloves. Be aware that the liquid may penetrate gloves.
Eye Protection: Wear approved safety goggles.
Body Protection: Wear lab coat or other protective work clothing.
Environmental Exposure Controls: Environmental manager must be informed of all major spillages.
Product # (s) 6702
Section 9. Physical and Chemical Properties
Appearance and Odor: Not determined Evaporation Rate: No data available.
Boiling Point: Not determined Vapor Pressure: No data available.
Melting Point: Not determined Vapor Density (Air=1): No data available.
Density: Not determined Specific Gravity: No data available.
Solubility in Water: Not determined Viscosity: No data available.
Section 10. Stability and Reactivity
Stability: Unstable
Stable X Conditions to Avoid: Stable under normal conditions of use and storage.
Incompatibility (Materials to Avoid): Incompatible with strong oxidizing agents, potassium permanganate, halogens,
metals, and reducing agents.
Hazardous Decomposition or Byproducts: Carbon monoxide, Carbon dioxide, and Nitrogen oxides. Sulfuric Acid reacts
with carbonates to generate Carbon dioxide gas.
Hazardous Polymerization: May Occur Conditions to Avoid: Heat, sparks, open flame, and incompatible
materials.
Will Not Occur X
Section 11. Toxicological Information
LD/LC50 values that are relevant:
LD50: ORL-RAT, 2140 mg/kg, Sulfuric Acid
3
LC50: INH-RAT, 510 mg/m , Sulfuric Acid
LD50: ORL-RAT, 5577 mg/kg, Formamide
Carcinogenicity Classification:
IARC (International Agency for Research on Cancer) 鈥? Category 1 as 鈥渟trong inorganic acid mists containing Sulfuric
Acid. This classification applies only to mists containing Sulfuric Acid and not to Sulfuric Acid or Sulfuric Acid solutions.
NTP (National Toxicology Program) - Not Listed
Eye: Produces eye irritation. Exposed individuals may experience blurred vision, redness, pain, and burns to eye tissue.
Concentrated solutions can cause blindness.
Ingestion: Symptoms may include severe burns of the mouth, throat, and stomach. Circulatory collapse with clammy skin,
weak and rapid pulse, shallow respirations, and scanty urine may follow ingestion or skin contact. Circulatory shock can
occur. May cause sore throat, vomiting, and diarrhea.
Inhalation: Symptoms may include irritation of the nose and throat, labored breathing, as well as lung edema, damage to
the mucous membranes and upper respiratory tract.
Skin: Symptoms may include redness, pain, and burns to the skin. Circulatory collapse with clammy skin, weak and rapid
pulse, shallow respirations, and scanty urine may follow ingestion or skin contact. The full extent of tissue damage may not
be exhibited for 12 鈥? 24 hours after exposure to Formamide.
Chronic: Long term exposure to mist or vapors may cause damage to teeth. Chronic exposure to mists containing Sulfuric
Acid is a cancer hazard. Risk of cancer depends on duration and level of exposure. Chronic exposure to Formamide may
cause congenital malformation in the fetus.
Target Organs: Eye, Skin, Lungs, Central Nervous System, Liver, Kidneys
Section 12. Ecological Information
Ecotoxicity Tests: When released into the soil, this material may leach into groundwater. This material (Sulfuric acid) may
be toxic to aquatic life.
LC50: Flounder 100 鈥? 330 mg/L / 48 hours aerated water.
Product # (s)_6702
Section 13. Disposal Considerations
Waste Disposal Method: Disposal recommendations are based on material as supplied. Disposal must be in accordance
with current applicable laws and regulations, and material characteristics at time of disposal. Contact safety officer if
questions arise and ventilate area. Dispose in accordance with all applicable federal (40 CFR 261.3), state, and local
environmental regulations.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Contact a licensed professional waste disposal service to dispose of this material if questions arise.
Container Information: Do not remove labels from containers until they have been cleaned. Since emptied containers
retain product residue, follow label warnings even after container is emptied.
Section 14. Transport Information
DOT Regulations:
UN No. 3316
Proper Shipping name: Sulfuric Acid (11% acid)
Class 8
Packing Group: II
Label: Corrosive
Land Transport ADR/RID/TDG (cross-border):
UN No. 3316
Proper Shipping name: Sulfuric Acid (11% acid)
Class 8
Packing Group: II
Label: Corrosive
Maritime Transport IMDG:
UN No. 3316
Proper Shipping name: Sulfuric Acid (11% acid)
Class 8
Packing Group: II
Label: Corrosive
Marine Pollutant: Not determined
Air Transport ICAO-TI and IATA-DGR:
UN No. 3316
Proper Shipping name: Sulfuric Acid (11% acid)
Class 8
Packing Group: II
Label: Corrosive
Section 15. Regulatory Information
EU Regulations, Hazard Symbol(s):
Sulfuric Acid, C (Corrosive), T (Toxic)
Formamide, Xi (Irritant)
Risk Phrases:
R 35 Corrosive. Causes severe burns. May be fatal if swallowed or contact with skin. (Sulfuric Acid)
R 60, 61 May impair fertility. May cause harm to the unborn child. (Formamide)
R 20 Harmful by inhalation. (Formamide, Proteninase K)
R 36, 37, 38 Irritating to eyes, respiratory system, and skin. (Sulfuric Acid, Formamide, Proteninase K)
R 42, 43 May cause sensitization by inhalation and skin contact. (Proteninase K)
Rev 04, July 2008
Product # (s)_6702
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36, 37, 39 Wear suitable protective clothing, gloves, and eye/face protection.
S 45 In case of accident or if you feel unwell, seek medical advice immediately.
Section 16. Other Information
This document is believed to be correct, but does not purport to be all inclusive and shall be used only as a guide. Neogen
Corporation shall not be held liable for any damage resulting from handling or from contact with the above product. These
suggestions should not be confused with state, municipal or insurance requirements, and constitute NO WARRANTY.
Rev 04, July 2008
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