Updated February 18, 2008
Alpha Arbutin
Material Safety Data Sheet ( MSDS)
1. Product Identification 7. Hazards Identification
Product Name: Alpha-Arbutin Eye: None identified.
INCI Name: Alpha-Arbutin Skin: None identified.
Chemistry: 4-Hydroxyphenyl-a-D-glucopyranoside Inhalation: None identified.
CAS Number: 84380-01-8 Ingestion: Harmful by acute oral exposure.
EINECS Number: 440-470-8 Signs and Symptoms: Not indicated.
Cancer: No data available.
2. Physical & Chemical Properties Target Organs: No data available.
201 oC
Melting Point: Developmental: No data available.
Boiling Point: Test material and/or decomp products Pre-existing Medical Conditions: None known.
285oC
Non-Volatiles: no data available 8. First Aid Measures
Viscosity: no data available Eyes: Immediately flush eyes with plenty of water and seek medical
attention if irritation develops.
Specific Gravity: not determined
151g/l at 20oC (pH of solution 5.8)
Solubility in water: Skin: Immediately wash affected area with soap and water. Seek
medical attention if irritation develops
Refractive Index: no data available
Appearance & Odor: White powder with unknown odor. Inhalation: Remove victim to fresh air. Seek medical attention if
symptoms occur.
3. Stability & Reactivity Ingestion: Drink fluids to dilute. Seek medical attention.
Chemical Stability: Stable under normal conditions of storage and
handling. 9. Fire Fighting Measures
Conditions to Avoid: Not known Flash Point: Not applicable.
Incompatible Materials: Not known. Extinguishing Media: Water, carbon dioxide, foam, dry powder.
Hazardous Decomposition Products: Not known. Fire Fighting Procedures: No special precaution and measures
necessary. The substance will burn if involved in a fire, evolving
Hazardous Polymerization: Not known.
noxious fumes e.g. carbon oxides.
4. Handling & Storage
Handling precautions: Substance should be handled under conditions 10. Toxicological Information
of good industrial hygiene and in conformity with any local regulations The substance is harmful by acute oral exposure. Rat LD50 is be-
in order to avoid unnecessary exposure. tween 300 and 500mg/kg. The substance is not irritation to rabbit
skin or eyes. The substance is not a skin sensitizer (1/10 sensitized)
Storage Precautions: Store in a cool, dry, well-ventilated area. Keep
containers tightly closed when not in use. in a Magnusson and Kligman maximization study in the guinea pig.
An Ames test was negative. The test material, at a maximum con-
Other Precautions: Engineering controls such as LEV are necessary
to reduce exposure to the substance. centration of 10% w/w produced no evidence of photo toxicity or
photo allergenicity. The test material, in a fourteen day repeat appli-
cation dermal irritation study in the guinea pig, produced a maximum
5. Accidental Release Measures
Weekly Mean Irritation Index of 0.03 and was considered to be prac-
Personal Precautions: Evacuate personnel from immediate vicinity.
Wear eye protection (e.g. goggles), chemical resistant gloves, protec- tically non-irritant to guinea pig skin under the conditions of the test.
tive clothing (e.g. an impervious apron) and a dust mask conforming to
standard EN149 FFP1. 11. Disposal Consideration
Dispose of by incineration or landfill in accordance with local regula-
Environmental Precautions: Avoid release to drains.
tions. Stack gases should be scrubbed.
Cleanup Procedure: Absorb spillage with a suitable inert material (e.g.
sand or soil). Transfer the spillage to waste containers labeled in the
same way as the original containers. Clean the spillage area with water 12. Transport Information
and detergent. DOT Shipping Name: not regulated
ADR/RIC Code: not regulated
6. Exposure Controls & Personal Protection Sea Transport IMDG Code: not regulated
Respiratory Protection: Based upon current information and in the Air Transport IATA: not regulated
absence of occupational exposure limits the use of a dust mask to a
minimum standard of EN149 FFP 1S is recommended. 13. Disclaimer
This information relates only to the specific material designated and
Protective Clothing: Chemical protective gloves to a Standard EN 374
should be provided. Usage periods should not exceed the break- may not be valid for such material used in combination with any
through times for the chemical stated by the manufacturer of the glove. other materials or in any other process. Such information is to be the
Eye protection should be used when handling the substance. Protec- best of the company s knowledge and believed accurate and reliable
tion should be capable of giving chemical protection as classified in as of the date indicated. However, no representation, war-ranty or
EN166. Handling of the material should be done wearing chemical guarantee of any kind, express or implied, is made as to its
protective clothing suitable for protection against the chemical as clas- accuracy, reliability or completeness and we assume no respon-
sified by Standard EN368. sibility for any loss, damage or expense, direct or consequential,
arising out of use. It is the user s responsibility to satisfy himself as
Other Protective Measures: Engineering controls such as LEV are
recommended to reduce exposure to the substance. to the suitableness & completeness of such information for his own
particular use.
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