MSDS Number: P2017 * * * * * Effective Date: 01/16/06 * * * * * Supercedes: 05/07/03
PHENOLPHTHALEIN SOLUTIONS
1. Product Identification
Synonyms: 3,3-Bis(p-hydroxyphenyl) phthalide indicator solutions;
Phenolphthalein 1% in 95% alcohol; Phenolphthalein 0.5% in 50%
alcohol; Phenolthalein TS
CAS No.: Not applicable to mixtures.
Molecular Weight: Not applicable to mixtures.
Chemical Formula: Not applicable to mixtures.
Product Codes:
J.T. Baker: 5927
Mallinckrodt: H297, H306
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------------ ---------
Phenolphthalein 77-09-8 0.5 - 1% Yes
Ethyl Alcohol 64-17-5 50 - 95% Yes
Methyl Alcohol 67-56-1 1 - 2% Yes
Isopropyl Alcohol 67-63-0 1 - 2% Yes
3. Hazards Identification
Emergency Overview
--------------------------
DANGER! MAY BE FATAL IF SWALLOWED. HARMFUL IF
INHALED OR ABSORBED THROUGH SKIN. VAPOR
HARMFUL. FLAMMABLE LIQUID AND VAPOR. AFFECTS
CENTRAL NERVOUS SYSTEM. MAY CAUSE BLINDNESS.
CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY
TRACT. MAY AFFECT LIVER, BLOOD, REPRODUCTIVE
SYSTEM. SUSPECT CANCER HAZARD. CONTAINS
PHENOLPHTHALEIN WHICH MAY CAUSE CANCER. Risk of
cancer depends on level and duration of exposure.
SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 2 - Moderate (Cancer)
Flammability Rating: 3 - Severe (Flammable)
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe (Life)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON;
VENT HOOD; PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
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Potential Health Effects
----------------------------------
Inhalation:
Exposure may cause irritation to the mucous membranes of the upper
respiratory tract. Prolonged exposures to high concentrations may cause
drowsiness, loss of appetite and inability to concentrate.
Ingestion:
For alcohol components: Cause headaches, gastritis, intoxication,
blindness and, in acute cases, death. For phenolphthalein component:
Cathartic. Very active, even in small amounts (30-100 mg). May cause
purging, collapse, and fall of blood pressure or an itching skin rash that
can become ulcerous. Other systemic effects are not well known.
Skin Contact:
For alcohol components: Causes skin irritation, cracking or flaking due to
dehydration and defatting action. May be absorbed through the skin with
possible systemic effects. Phenolphthalein may be absorbed via moist or
oily surfaces. Symptoms may resemble those from ingestion exposure.
Eye Contact:
Can cause eye irritation. Splashes may cause temporary pain and blurred
vision.
Chronic Exposure:
Prolonged skin contact causes drying and cracking of skin. May affect the
nervous system. May affect liver, blood, reproductive system. Continued
ingestion of small amounts could result in blindness. Suspect cancer
hazard; contains phenolphthalein which may cause cancer. Risk of cancer
depends on level and duration of exposure.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or eye problems or impaired
respiratory function, or impaired liver or kidney function may be more
susceptible to the effects of the substance.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical attention.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never
give anything by mouth to an unconscious person.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Wash clothing before reuse.
Thoroughly clean shoes before reuse. Get medical attention if symptoms
occur.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting
lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire:
Flash point: 13C (55F) CC
Autoignition temperature: 363C (685F)
Flammable limits in air % by volume:
lel: 3.3; uel: 19
Flammable liquid and vapor!
Dangerous fire hazard when exposed to heat or flame.
Listed fire data is for Ethyl Alcohol (major component).
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable
limits noted above. Vapors can flow along surfaces to distant ignition
source and flash back. Sealed containers may rupture when heated.
Sensitive to static discharge.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide. Water may be
ineffective.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode. Water spray can be used
to extinguish fires and cool fire-exposed containers. Water may be used to
flush spills away from exposures and to dilute spills to non-flammable
mixtures.
6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition. Wear
appropriate personal protective equipment as specified in Section 8.
Isolate hazard area. Keep unnecessary and unprotected personnel from
entering. Contain and recover liquid when possible. Use non-sparking
tools and equipment. Collect liquid in an appropriate container or absorb
with an inert material (e. g., vermiculite, dry sand, earth), and place in a
chemical waste container. Do not use combustible materials, such as saw
dust. Do not flush to sewer! If a leak or spill has not ignited, use water
spray to disperse the vapors, to protect personnel attempting to stop leak,
and to flush spills away from exposures. US Regulations (CERCLA)
require reporting spills and releases to soil, water and air in excess of
reportable quantities. The toll free number for the US Coast Guard
National Response Center is (800) 424-8802.
7. Handling and Storage
Protect against physical damage. Store in a cool, dry well-ventilated
location, away from any area where the fire hazard may be acute. Outside
or detached storage is preferred. Separate from incompatibles. Containers
should be bonded and grounded for transfers to avoid static sparks.
Storage and use areas should be No Smoking areas. Use non-sparking type
tools and equipment, including explosion proof ventilation. Containers of
this material may be hazardous when empty since they retain product
residues (vapors, liquid); observe all warnings and precautions listed for
the product. Do Not attempt to clean empty containers since residue is
difficult to remove. Do not pressurize, cut, weld, braze, solder, drill, grind
or expose such containers to heat, sparks, flame, static electricity or other
sources of ignition: they may explode and cause injury or death.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
- OSHA Permissible Exposure Limit (PEL):
1000 ppm (TWA) for ethyl alcohol
400 ppm (TWA) for isopropyl alcohol
200 ppm (TWA) for methyl alcohol
- ACGIH Threshold Limit Value (TLV):
1000 ppm (TWA), A4 - not classifiable as a human carcinogen for ethyl
alcohol
200 ppm (TWA), 400 ppm (STEL), A4 - not classifiable as a human
carcinogen for isopropyl alcohol
200 ppm (TWA), 250 ppm (STEL) skin, for methyl alcohol
Ventilation System:
A system of local and/or general exhaust is recommended to keep
employee exposures below the Airborne Exposure Limits. Local exhaust
ventilation is generally preferred because it can control the emissions of
the contaminant at its source, preventing dispersion of it into the general
work area. Please refer to the ACGIH document, Industrial Ventilation, A
Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded and engineering controls are not feasible,
wear a supplied air, full-facepiece respirator, airlined hood, or full-
facepiece self-contained breathing apparatus. Breathing air quality must
meet the requirements of the OSHA respiratory protection standard
(29CFR1910.134). Where respirators are required, you must have a
written program covering the basic requirements in the OSHA respirator
standard. These include training, fit testing, medical approval, cleaning,
maintenance, cartridge change schedules, etc. See 29CFR1910.134 for
details.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat,
apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is
possible. Maintain eye wash fountain and quick-drench facilities in work
area.
9. Physical and Chemical Properties
Appearance:
Clear, colorless liquid.
Odor:
Alcohol odor.
Solubility:
Miscible in water.
Density:
0.8
pH:
No information found.
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
< 100C (< 212F)
Melting Point:
0C (32F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
Like ethanol.
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Carbon dioxide and carbon monoxide may form when heated to
decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidants, silver salts, acid chlorides, alkali metals, metal hydrides,
hydrazine, and many other substances.
Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.
11. Toxicological Information
Toxicological Data:
Ethyl alcohol: oral rat LD50: 7060 mg/kg; inhalation rat LC50: 20,000
ppm/10H; Irritation data, eye, rabbit: 500 mg/24H moderate; Investigated
as a tumorigen, mutagen, reproductive effector. Methyl alcohol: oral rat
LD50: 5628 mg/kg; inhalation rat LC50: 64000 ppm/4H; skin rabbit
LD50: 15800 mg/kg; Irritation data,skin,rabbit: 20 mg/24H, Moderate;
Investigated as a tumorigen, mutagen, reproductive effector. Isopropyl
alcohol: oral rat LD50: 5045 mg/kg; skin rabbit LD50: 12.8 gm/kg;
inhalation, rat: 16,000 ppm 8 hr. Investigated as a mutagen, tumorigen,
reproductive effector. Phenolphthalein: Investigated as a tumorigen and
mutagen.
Reproductive Toxicity:
Ethanol has been linked to birth defects in humans.
Carcinogenicity:
Ethanol has been linked to cancer in humans. Chronic ethanol ingestion is
associated with liver cancer. Most industrial ethanol contains denaturants
that render it undesirable to drink.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Phenolphthalein (77-09-8) No Yes None
Ethyl Alcohol (64-17-5) No No None
Methyl Alcohol (67-56-1) No No None
Isopropyl Alcohol (67-63-0) No No 3
12. Ecological Information
Environmental Fate:
Following data for ethanol: When released into the soil, this material is
expected to readily biodegrade. When released into the soil, this material
is expected to leach into groundwater. When released into the soil, this
material is expected to quickly evaporate. When released into water, this
material is expected to readily biodegrade. When released into water, this
material may evaporate to a moderate extent. This material is not expected
to significantly bioaccumulate. When released into the air, this material is
expected to be readily degraded by reaction with photochemically
produced hydroxyl radicals. When released into the air, this material is
expected to be readily removed from the atmosphere by dry and wet
deposition. When released into the air, this material is expected to have a
half-life between 1 and 10 days.
Environmental Toxicity:
This material is not expected to be toxic to aquatic life. The LC50/96-hour
values for fish are over 100 mg/l.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as
hazardous waste and sent to a RCRA approved incinerator or disposed in a
RCRA approved waste facility. Processing, use or contamination of this
product may change the waste management options. State and local
disposal regulations may differ from federal disposal regulations. Dispose
of container and unused contents in accordance with federal, state and
local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: ETHANOL SOLUTIONS
Hazard Class: 3
UN/NA: UN1170
Packing Group: II
Information reported for product/size: 1L
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: ETHANOL SOLUTIONS
Hazard Class: 3
UN/NA: UN1170
Packing Group: II
Information reported for product/size: 1L
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Phenolphthalein (77-09-8) Yes Yes Yes Yes
Ethyl Alcohol (64-17-5) Yes Yes Yes Yes
Methyl Alcohol (67-56-1) Yes Yes Yes Yes
Isopropyl Alcohol (67-63-0) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Phenolphthalein (77-09-8) Yes Yes No Yes
Ethyl Alcohol (64-17-5) Yes Yes No Yes
Methyl Alcohol (67-56-1) Yes Yes No Yes
Isopropyl Alcohol (67-63-0) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Phenolphthalein (77-09-8) No No No No
Ethyl Alcohol (64-17-5) No No No No
Methyl Alcohol (67-56-1) No No Yes No
Isopropyl Alcohol (67-63-0) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Phenolphthalein (77-09-8) No No No
Ethyl Alcohol (64-17-5) No No No
Methyl Alcohol (67-56-1) 5000 U154 No
Isopropyl Alcohol (67-63-0) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: Yes
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No
Reactivity: No (Mixture / Liquid)
WARNING:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE
STATE OF CALIFORNIA TO CAUSE CANCER.
Australian Hazchem Code: 2[S]E
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the
Controlled Products Regulations (CPR) and the MSDS contains all of the
information required by the CPR.
16. Other Information
NFPA Ratings: Health: 2 Flammability: 3 Reactivity: 0
Label Hazard Warning:
DANGER! MAY BE FATAL IF SWALLOWED. HARMFUL IF
INHALED OR ABSORBED THROUGH SKIN. VAPOR HARMFUL.
FLAMMABLE LIQUID AND VAPOR. AFFECTS CENTRAL
NERVOUS SYSTEM. MAY CAUSE BLINDNESS. CAUSES
IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. MAY
AFFECT LIVER, BLOOD, REPRODUCTIVE SYSTEM. SUSPECT
CANCER HAZARD. CONTAINS PHENOLPHTHALEIN WHICH
MAY CAUSE CANCER. Risk of cancer depends on level and duration of
exposure.
Label Precautions:
Wash thoroughly after handling.
Do not breathe vapor.
Avoid contact with eyes, skin and clothing.
Keep container closed.
Use only with adequate ventilation.
Keep away from heat, sparks and flame.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical
personnel. Never give anything by mouth to an unconscious person. If
inhaled, remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact, immediately flush
eyes or skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes. Wash clothing before reuse. Get medical
attention.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 3.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in
good faith but makes no representation as to its comprehensiveness or
accuracy. This document is intended only as a guide to the
appropriate precautionary handling of the material by a properly
trained person using this product. Individuals receiving the
information must exercise their independent judgment in determining
its appropriateness for a particular purpose. MALLINCKRODT
BAKER, INC. MAKES NO REPRESENTATIONS OR
WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING
WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR
PURPOSE WITH RESPECT TO THE INFORMATION SET
FORTH HEREIN OR THE PRODUCT TO WHICH THE
INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT
BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES
RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)
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