**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 1303-28-2 |Arsenic(V) oxide | >99.9 | 215-116-9 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T N
Risk Phrases: 23/25 45 50/53
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed. May cause cancer. Very toxic
to aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
Potential Health Effects
Eye:
May cause eye irritation. May result in corneal injury.
Skin:
May cause skin irritation. May cause skin sensitization, an allergic
reaction, which becomes evident upon re-exposure to this material.
Ingestion:
May cause liver damage. Can cause nervous system damage. Ingestion
of arsenical compounds may cause burning of the lips, throat
constriction, swallowing difficulties, severe abdominal pain, severe
nausea, projectile vomiting, and profuse diarrhea. All soluble
arsenic (As) compounds are considered to be poisonous to humans.
Inorganic arsenic is more toxic than organic arsenic. Organic arsenic
is excreted more rapidly than inorganic arsenic. Arsenic 5+ is
excreted more rapidly than arsenic 3+. Arsenic inhibits enzymes
required for cellular respiration and also competes with phosphorus
for incorporation into ATP, depleting cellular energy stores and
leading to cell death.
Inhalation:
Causes respiratory tract irritation. May cause effects similar to
those described for ingestion. Inhalation of arsenic compounds may
lead to irritation of the respiratory tract and to possible nasal
perforation.
Chronic:
Chronic ingestion is characterized by weakness, anorexia,
gastrointestinal disturbances, impairment of cognitive function,
peripheral neuropathy, and skin disorders. Chronic ingestion may
cause fetal effects. Inorganic arsenic compounds may cause skin and
lung cancers in humans.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
Use water spray to cool fire-exposed containers.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Avoid generating dusty conditions. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Do not get in eyes, on skin, or on clothing. Do
not ingest or inhale. Use only with adequate ventilation or
respiratory protection.
Storage:
Poison room locked.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits. See 29CFR
1910.1018 for regulatory requirements pertaining to all occupational
exposures to inorganic arsenic.
Exposure Limits
CAS# 1303-28-2:
United Kingdom, WEL - TWA: (listed as arsenic compounds, n.o.s.):
mg/m3 TWA (except arsine, as As)
United Kingdom, WEL - STEL: (listed as arsenic compounds, n.o.s.)
0.3 mg/m3 STEL (except arsine, as As)
United States OSHA: 5 ??g/m3 Action Level (as As); 10 ??g/m3 PEL (a
As. Cancer hazard - see 29 CFR 1 910.1018. Arsine excepted)
(listed under Arsenic, inorganic compounds).
Belgium - TWA: (listed as arsenic, inorganic compounds): 0.01 mg/
VLE (as As)
Germany: 0.1 mg/m3 TWA (inhalable fraction)
Japan: (listed as arsenic compounds, n.o.s.): 3 ??g/m3 OEL (refere
value, as As)
Malaysia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 TW
(as As, except arsine)
Netherlands: (listed as arsenic, inorganic compounds): 0.1 mg/m3
(as As)
Netherlands: (listed as arsenic, inorganic compounds): 0.050 mg/m
MAC (as As)
Russia: (listed as arsenic, inorganic compounds): 0.04 mg/m3 TWA
As)
Russia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 STEL
As)
Spain: 0.1 mg/m3 VLA-ED (as As)
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Solid
Color: white
Odor: odorless
pH: acidic in soln
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 315 deg C (dec)
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 315 deg C
Solubility in water: Soluble.
Specific Gravity/Density:
Molecular Formula: As2O5
Molecular Weight: 229.84
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Excess heat, moist air.
Incompatibilities with Other Materials:
Acids, aluminum, halogens, zinc, rubidium carbide.
Hazardous Decomposition Products:
Oxides of arsenic.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 1303-28-2: CG2275000
LD50/LC50:
CAS# 1303-28-2: Oral, mouse: LD50 = 55 mg/kg; Oral, rat: LD50 = 8
mg/kg.
Carcinogenicity:
Arsenic(V) oxide -
California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorg
NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
IARC: Group 1 carcinogen (listed as Arsenic compounds, n.o.s.).
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Other
No information available.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: ARSENIC PENTOXIDE
Hazard Class: 6.1
UN Number: 1559
Packing Group: II
IMO
Shipping Name: ARSENIC PENTOXIDE
Hazard Class: 6.1
UN Number: 1559
Packing Group: II
RID/ADR
Shipping Name: ARSENIC PENTOXIDE
Hazard Class: 6.1
UN Number: 1559
Packing group: II
USA RQ: CAS# 1303-28-2: 1 lb final RQ; 0.454 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 45 May cause cancer.
R 23/25 Toxic by inhalation and if swallowed.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 1303-28-2: 3
Canada
CAS# 1303-28-2 is listed on Canada's DSL List.
CAS# 1303-28-2 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1303-28-2 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 9/02/1997 Revision #4 Date: 6/01/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
--------------------------------------------------------------------------------
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|
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DL-N-Benzoyl-2-Isobutylserine
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