**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 1327-53-3 |Arsenic trioxide | 100.0 | 215-481-4 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T+ N
Risk Phrases: 28 34 45 50/53
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Very toxic if swallowed. Causes burns. May cause cancer. Very toxic
to aquatic organisms, may cause long-term adverse effects in the
aquatic environment.
Potential Health Effects
Eye:
Contact produces irritation, tearing, and burning pain. May cause
conjunctivitis.
Skin:
Causes irritation with burning pain, itching, and redness. May cause
dermatitis. Exposure to arsenic compounds may produce
hyperpigmentation of the skin and hyperkeratoses of plantar and
palmar surfaces as well as both primary irritation and sensitization
types.
Ingestion:
May be fatal if swallowed. Causes severe digestive tract burns with
abdominal pain, vomiting, and possible death. May cause hemorrhaging
of the digestive tract. Ingestion of arsenical compounds may cause
burning of the lips, throat constriction, swallowing difficulties,
severe abdominal pain, severe nausea, projectile vomiting, and
profuse diarrhea. Ingestion of arsenic compounds can produce
convulsions, coma, and possibly death within 24 hours.
Inhalation:
May cause severe irritation of the respiratory tract with sore
throat, coughing, shortness of breath and delayed lung edema.
Inhalation of arsenic compounds may lead to irritation of the
respiratory tract and to possible nasal perforation. Long-term
exposure to arsenic compounds may produce impairment of peripheral
circulation.
Chronic:
May cause liver and kidney damage. Chronic inhalation may cause
nasal septum ulceration and perforation. May cause anemia and other
blood cell abnormalities. Chronic skin effects include: cracking,
thickening, pigmentation, and drying of the skin. Arsenic trioxide
can cause cancer in humans. Other long term effects include: anemia,
liver and kidney damage. Chronic exposure to arsenical dust may cause
shortness of breath, nausea, chest pains, and garlic odor.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use
extinguishing media appropriate to the surrounding fire. Substance is
noncombustible.
Extinguishing Media:
Substance is noncombustible; use agent most appropriate to
extinguish surrounding fire. Do NOT get water inside containers.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Avoid runoff into storm sewers and ditches which lead to
waterways. Clean up spills immediately, observing precautions in the
Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation. Do not get water inside containers.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Minimize dust generation and accumulation. Avoid
contact with eyes, skin, and clothing. Avoid ingestion and
inhalation. Do not allow contact with water. Use only with adequate
ventilation or respiratory protection.
Storage:
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances. Do not store
in metal containers.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits. See 29CFR
1910.1018 for regulatory requirements pertaining to all occupational
exposures to inorganic arsenic.
Exposure Limits
CAS# 1327-53-3:
United Kingdom, WEL - TWA: (listed as arsenic compounds, n.o.s.):
mg/m3 TWA (except arsine, as As)
United Kingdom, WEL - STEL: (listed as arsenic compounds, n.o.s.)
0.3 mg/m3 STEL (except arsine, as As)
United States OSHA: 0.5 mg/m3 TWA (listed under Arsenic).5 ??g/m3
Action Level (as As); 10 ??g/m3 PEL (as As. Cancer hazard - see 2
CFR 1 910.1018. Arsine excepted) (listed under Arsenic, inorgani
compounds).
Belgium - TWA: (listed as arsenic, inorganic compounds): 0.01 mg/
VLE (as As)
France - VME: 0.2 mg/m3 VME (as As)
Germany: 0.1 mg/m3 TWA (inhalable fraction)
Japan: (listed as arsenic compounds, n.o.s.): 3 ??g/m3 OEL (refere
value, as As)
Malaysia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 TW
(as As, except arsine)
Netherlands: (listed as arsenic, inorganic compounds): 0.1 mg/m3
(as As)
Netherlands: (listed as arsenic, inorganic compounds): 0.050 mg/m
MAC (as As)
Russia: (listed as arsenic, inorganic compounds): 0.04 mg/m3 TWA
As)
Russia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 STEL
As)
Spain: 0.1 mg/m3 VLA-ED (as As)
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Solid
Color: white
Odor: odorless
pH: Not available.
Vapor Pressure: 66 mm Hg @ 312C
Viscosity: Not available.
Boiling Point: 465 deg C
Freezing/Melting Point: 312 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: 3.7% in water.
Specific Gravity/Density: 3.738
Molecular Formula: As2O3
Molecular Weight: 197.8414
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, moisture, metals, excess heat.
Incompatibilities with Other Materials:
Incompatible with chlorine trifluoride, fluorine, hydrogen fluoride,
oxygen difluoride, and sodium chlorate. Can generate arsine, which
is an extremely poisonous gas, when arsenic compounds contact acid,
alkalies, or water in the presence of an active metal (zinc,
aluminum, magnesium, manganese, sodium, iron, etc).
Hazardous Decomposition Products:
Irritating and toxic fumes and gases, oxides of arsenic, arsine.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 1327-53-3: CG3325000
LD50/LC50:
CAS# 1327-53-3: Oral, mouse: LD50 = 20 mg/kg; Oral, rabbit: LD50 =
20190 ug/kg; Oral, rat: LD50 = 10 mg/kg.
Carcinogenicity:
Arsenic trioxide -
California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorg
NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
IARC: Group 1 carcinogen (listed as Arsenic).
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Water flea Daphnia: LC50 = 0.038 mg/L; 24 Hr.; UnspecifiedBacteria:
Phytobacterium phosphoreum: EC50 = 31.43-73.73 mg/L; 5,15,30 minutes;
Microtox test
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Products which are considered hazardous for supply are classified as Special
Waste and the disposal of such chemicals is covered by regulations which may
vary according to location. Contact a specialist disposal company or the local
waste regulator for advice. Empty containers must be decontaminated before
returning for recycling.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: ARSENIC TRIOXIDE
Hazard Class: 6.1
UN Number: 1561
Packing Group: II
IMO
Shipping Name: ARSENIC TRIOXIDE
Hazard Class: 6.1
UN Number: 1561
Packing Group: II
RID/ADR
Shipping Name: ARSENIC TRIOXIDE
Hazard Class: 6.1
UN Number: 1561
Packing group: II
USA RQ: CAS# 1327-53-3: 1 lb final RQ; 0.454 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ N
Risk Phrases:
R 45 May cause cancer.
R 28 Very toxic if swallowed.
R 34 Causes burns.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 1327-53-3: 3
Canada
CAS# 1327-53-3 is listed on Canada's DSL List.
CAS# 1327-53-3 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1327-53-3 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 6/21/1999 Revision #5 Date: 1/03/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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