**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 98-95-3 |Nitrobenzene | > 99.0 | 202-716-0 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T N
Risk Phrases: 23/24/25 40 48/23/24 62 51/53
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed. Limited
evidence of a carcinogenic effect. Toxic : danger of serious damage
to health by prolonged exposure through inhalation and in contact
with skin. Possible risk of impaired fertility. Toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment.
Potential Health Effects
Eye:
May cause eye irritation. Vapors may cause eye irritation. May
cause eye injury.
Skin:
May cause skin irritation. Substance is rapidly absorbed through the
skin. If absorbed, may cause symptoms similar to those for ingestion.
Ingestion:
May cause methemoglobinemia, cyanosis (bluish discoloration of skin
due to deficient oxygenation of the blood), convulsions, and death.
Effects may be delayed 2 to 4 hours. Methemoglobinemia is
characterized by dizziness, drowsiness, headache, shortness of
breath, cyanosis (bluish discoloration of skin due to deficient
oxygenation of the blood), rapid heart rate and chocolate-brown
colored blood.
Inhalation:
May cause effects similar to those described for ingestion.
Chronic:
Prolonged or repeated exposure may cause adverse reproductive
effects. May cause liver and kidney damage. May cause bone marrow
abnormalities with damage to blood forming tissues. May cause fetal
effects. May cause anemia and other blood cell abnormalities.
Repeated exposure may cause central nervous system damage. Repeated
exposure may cause damage to the spleen.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at
least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
Absorption of this product into the body may cause cyanosis (bluish
discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive
measures: bed rest and oxygen inhalation. For methemoglobinemia,
administer oxygen alone or with Methylene Blue depending on the
methemoglobin concentration in the blood. Cleansing of the entire
contaminated area of the body is of utmost importance.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water
spray to keep fire-exposed containers cool. Approach fire from
upwind to avoid hazardous vapors and toxic decomposition products.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Wear a self contained breathing
apparatus and appropriate personal protection. (See Exposure
Controls, Personal Protection section). Remove all sources of
ignition. A vapor suppressing foam may be used to reduce vapors.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Use spark-proof tools and explosion proof equipment. Do not
get in eyes, on skin, or on clothing. Empty containers retain product
residue, (liquid and/or vapor), and can be dangerous. Keep container
tightly closed. Do not ingest or inhale. Do not pressurize, cut,
weld, braze, solder, drill, grind, or expose empty containers to
heat, sparks or open flames. Use only with adequate ventilation.
Storage:
Keep away from sources of ignition. Do not store in direct sunlight.
Store in a cool, dry, well-ventilated area away from incompatible
substances.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits.
Exposure Limits
CAS# 98-95-3:
United Kingdom, WEL - TWA: 1 ppm TWA; 5.1 mg/m3 TWA
United Kingdom, WEL - STEL: 2 ppm STEL; 10 mg/m3 STEL
United States OSHA: 1 ppm TWA; 5 mg/m3 TWA
Belgium - TWA: 1 ppm VLE; 5 mg/m3 VLE
France - VME: 1 ppm VME; 5 mg/m3 VME
Germany: 1 ppm TWA; 5 mg/m3 TWA
Germany: Skin absorber
Japan: 1 ppm OEL; 5 mg/m3 OEL
Malaysia: 1 ppm TWA; 5 mg/m3 TWA
Netherlands: 1 ppm MAC; 5 mg/m3 MAC
Russia: 3 mg/m3 TWA
Spain: 1 ppm VLA-ED; 5 mg/m3 VLA-ED
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: colorless to pale yellow
Odor: almond-like
pH: Not available.
Vapor Pressure: < 1 mm Hg @ 20 deg C
Viscosity: Not available.
Boiling Point: 210 - 211 deg C @ 760mmHg
Freezing/Melting Point: 5 - 6 deg C
Autoignition Temperature: 496 deg C ( 924.80 deg F)
Flash Point: 87 deg C ( 188.60 deg F)
Explosion Limits, lower: 1.8%
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Insoluble.
Specific Gravity/Density: 1.2 g/cm3
Molecular Formula: C6H5NO2
Molecular Weight: 123.11
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Substance can dangerously react with nitric acid, phenol, aluminum
chloride, aniline, glycerine, silver perchlorate, dinitrogen
tetroxide, caustics, tin, and zinc.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 98-95-3: DA6475000
LD50/LC50:
CAS# 98-95-3: Draize test, rabbit, eye: 500 mg/24H Mild; Draize
test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 556
ppm/4H; Oral, mouse: LD50 = 590 mg/kg; Oral, rat: LD50 = 349 mg/kg;
Skin, rat: LD50 = 2100 mg/kg.
Oral human LDLo: 35 mg/kg.
Carcinogenicity:
Nitrobenzene -
ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to
California: carcinogen, initial date 8/26/97
NTP: Suspect carcinogen
IARC: Group 2B carcinogen
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Zebrafish: LC50 = 112.5mg/L/96H Minnow (distilled water): LC50 =
20-24mg/L/6H Water flea: LC50 = 62mg/L/24H, 27mg/L/48H
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: NITROBENZENE
Hazard Class: 6.1
UN Number: 1662
Packing Group: II
IMO
Shipping Name: NITROBENZENE
Hazard Class: 6.1
UN Number: 1662
Packing Group: II
RID/ADR
Shipping Name: NITROBENZENE
Hazard Class: 6.1
UN Number: 1662
Packing group: II
USA RQ: CAS# 98-95-3: 1000 lb final RQ; 454 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 40 Limited evidence of a carcinogenic effect.
R 48/23/24 Toxic : danger of serious damage to
health by prolonged exposure through inhalation and in
contact with skin.
R 51/53 Toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
R 62 Possible risk of impaired fertility.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 98-95-3: 2
Canada
CAS# 98-95-3 is listed on Canada's DSL List.
CAS# 98-95-3 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 98-95-3 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 12/12/1997 Revision #4 Date: 12/03/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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