=====================  Product Identification  =====================

MSDS NAME:PROCARBAZINE HYDROCHLORIDE
NIIN:00-175-6061
MSDS Number: CGDSL
=== Responsible Party ===
Company:HOFFMANN-LAROCHE INC
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07710-1199
Country:US
Info Phone Num:201-235-3729
Emergency Phone Num:201-235-6660
CAGE:KO441
=== Contractor Identification ===
Company:HOFFMAN-LA ROCHE INC
Address:340 KINGSLAND ST
City:NUTLEY
State:NJ
ZIP:07110-1141
Country:US
Phone:201-235-2323
CAGE:04493
Company:HOFFMANN-LAROCHE INC
Address:340 KINGSLAND ST
Box:City:NUTLEY
State:NJ
ZIP:07710-1199
Country:US
Phone:201-235-3729
CAGE:KO441

=============  Composition/Information on Ingredients  =============

Name:P-TOLUAMIDE, N-ISOPROPYL-ALPHA- (2-METHYLHYDRAZINO)-,
    MONOHYDROCHLORIDE; (PROCARBAZINE HYDROCHLORIDE)
CAS:366-70-1
RTECS #:XS4725000

Name:SUPDAT: DOSE, SINGLE INTRAPERITONEAL DOSE, MULTIPLE ORAL
    DOSES, MULTIPLE INTRAPERITONEAL DOSES & MULTIPLE IV (ING 3)

Name:ING 2: DOSES. LUNG CANCER, MAMMARY CANCER, NERVOUS SYS
    CANCER & LEUKEMIA MOST FREQUENTLY REPORTED. STUDIES IN (ING 4)

Name:ING 3: MONKEYS SUGGEST PROCARBAZINE HYDROCHLORIDE PRDCES
    LEUKEMIA & MALIGNANT NEOPLASMS (SOLID TUMORS) WHEN (ING 5)

Name:ING 4: ADMIN BY MULTIPLE ROUTES. SINGLE INTRAPERITONEAL
    INJECTIONS IN PREGNANT RATS OF 5-550 MG/KG BODY WT CAUSED(ING 6)

Name:ING 5: FETAL DEATHS &/OR FETAL MALFORMATIONS EG, TAIL &
    APPENDAGE DEFECTS, BRAIN INJURY, FACIAL CLEFTS, CLEFT (ING 7)

Name:ING 6: PALATES & SHORTENED JAWS. MUTAGENIC EFTS OBSERVED IN
    VARIETY OF STUDIES IN BACTERIAL, INSECT & MAMMALIAN (ING 8)

Name:ING 7: TEST SYS. SPERMATOCYTE DEATH OBSERVED IN MICE & RATS
    TREATED W/MATL. OTHER STUDIES W/MALE MICE SHOW MATL (ING 9)

Name:ING 8: AFFECTS NORM DEVELOPMENT OF ALL SPERMATOGENIC CELL
    TYPES EXCEPT FOR LATE PERMATIDS & MATURE SPERMATOZOA (ING 10)

Name:ING 9: & SIGNIFICANTLY DECRD FERTILITY THRUOUT 55-DAY
    PERIOD. MALE REPRO SYS EFTS, EG, TESTICULAR ATROPHY & NO (ING 11)

Name:ING 10: EVID OF SPERMATOGENESIS, WERE OBSERVED IN THREE
    DIFFERENT SPECIES OF MONKEYS.

Name:MED CNDTNS: & REDDENING OF FACE AS WELL AS W/CERTAIN FOODS
    & CERTAIN OTHER DRUGS. NOTE:SINCE MATL MAY AFFECT (ING 13)

Name:ING 12:MALE REPRO CAPABILITY & DEVELOPING FETUS,
    MALES/FEMALES PLANNING TO HAVE CHILDREN & PREGNANT WOMEN SHOULD(ING
    14)

Name:ING 13: EXERCISE CAUTION REGARDING POTNTL EXPOS. NURSING
    MOTHERS SHOULD ALSO EXERCISE CAUTION REGARDING POTNTL EXPOS.

Name:SPILL PROC: & DO NOT RETURN UNLESS WEARING NIOSH APPRVD
    SCBA & PPE. SHUT OFF LEAK/SPILL SOURCE IF SAFE TO DO SO.(ING 16)

Name:ING 15: AVOID SKIN CNTCT/BRTHG DUSTS. SCOOP/SHOVEL SPILL
    MATL INTO SUITABLE LABELED OPEN-HEAD DRUM. SECURE DRUM (ING 17)

Name:ING 16: COVER & MOVE CNTNR TO SAFE HOLDING AREA. CLEAN AREA
    THOROUGHLY. DECONTAM/DISPOSE OF ALL PROT EQUIP.

Name:HNDLG/STOR PRECS: & COPPER). DEGRADES RAPIDLY IN ALCOHOLIC
    MEDIA. BEST STABILITY IS IN AQ ACID. VERY SENSITIVE (ING 19)

Name:ING 18:TO UV LIGHT. AVOID CNTCT W/AIR & LIGHT. ALL
    OPERATIONS MUST BE CARRIED OUT UNDER NITROGEN. STORE AT ROOM (ING
    20)

Name:ING 19: TEMP IN DRY PLACE IN TIGHTLY CLSD CNTNRS UNDER
    NITROGEN OR IN AMBER BOTTLES.

Name:PROT GLOVES: (DO NOT USE PVC. INSPECT FREQUENTLY & DISCARD
    WHEN THEY SHOW CUTS, TEARS, PINHOLES OR SIGNS OF WEAR.)

Name:OTHER PROT EQUIP: ONLY. FOR PRODUCTION OPERATIONS, WEAR
    FULL BODY SUIT INCL HEAD & FOOT COVER W/SLEEVES TUCKED (ING 23)

Name:ING 22: UNDER GLOVES & TAPED. FOR LAB OPERATIONS, WEAR
    FULLY FASTENED DISPOSABLE LAB COAT/JUMPSUIT. LAB WORK (ING 24)

Name:ING 23: SURFS SHOULD BE COVERED W/STAINLESS STEEL, PLASTIC
    TRAYS, DRY ABSORB PLASTIC BACKED PAPER OR OTHER (ING 25)

Name:ING 24: IMPERVIOUS MATL. DECONTAM WORK SURFS & DISPOSE OF
    PROT CLTHG OR SURFACE COVERING PROPERLY.

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:LD50: (ORAL, RAT) 785 MG/KG
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:YES    IARC:YES	  OSHA:NO
Health Hazards Acute and Chronic:BASED ON SYMPS ASSOC W/THERAPEUTIC USE
    OF THIS MATL, MOST COMMON EFTS ARE BLOOD CHGS, IE, DECR IN NUMBER
    OF WHITE CELLS & PLATELETS; GI EFTS, EG, NAUS & VOMIT. OTHER
    REPORTED EFTS INCL: CENTRAL & PERI PHERAL NERVOUS SYS EFTS, EG,
    NUMB & TINGLING SENSATIONS, DIZZ; PSYCHO-MOTOR EFTS, EG, WEAK &
    FATG, (EFTS OF OVEREXP)
Explanation of Carcinogenicity:PROCARBAZINE HYDROCHLORIDE: IARC MONO,
    SUPP, VOL 7, PG 327, 1987:GROUP 2A. NTP 7TH ANNUAL REPORT ON
    CARCINS, (SUPDAT)
Effects of Overexposure:HLTH HAZ: DROW, HDCH; SKIN RXNS, EG, DERM &
    ITCH; MUSC EFTS, EG, JOINT PAIN; RESP EFTS, EG, FLUID BUILD-UP IN
    PERITONEAL & PLEURAL CAVITY, EDEMA, DFCLTY BRTHG, COUGH; TEMP
    ABNORMS, EG, CHILLS, FEVER;  BLEEDING TENDENCY, EG, INTRADERMAL
    HEMORR, NOSEBLEEDS. MAY CAUSE CANCER & TERATOGENIC EFTS. MAY AFFECT
    MALE (SUPDAT)
Medical Cond Aggravated by Exposure:PROCARBAZINE HYDROCHLORIDE ALLERGY
    HISTORY, IMPAIRED LIVER OR KIDNEY FUNC; BLOOD DISTURBS; BASED ON
    THERAPEUTIC USE OF MATL, ADVERSE RXNS MAY OCCUR W/ALCOHOLIC
    BEVERAGES, EG INTENSE WARMTH (ING 12)

=======================  First Aid Measures  =======================

Eyes: FLUSH W/PLENTY OF WATER. IF EYES ARE IRRITATED, GET MED
    ATTN. SKIN: FLUSH W/PLENTY OF WATER & WASH CNTCT AREA W/SOAP &
    WATER. IF SKIN IS IRRITATED, GET MED ATTN. REMOVE CONTAMD CLTHG &
    SHOES & W ASH BEFORE REUSE. INHAL: REMOVE TO FRESH AIR. IF
    DISCOMFORT OCCURS/PERSISTS, GET MED ATTN. INGEST: INDUCE VOMIT AS
    DIRECTED BY MED PERS. NEVER GIVE ANYTHING BY MOUTH TO UNCON PERSON.
    GET MED ATTN.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:AS APPROPRIATE FOR FIRE IN SURROUNDING MATERIALS.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
    EQUIPMENT . USE WATER TO KEEP FIRE-EXPOSED CONTAINERS COOL.
Unusual Fire/Explosion Hazard:UNKNOWN.

==================  Accidental Release Measures  ==================

Spill Release Procedures:NO STD SET BY US EPA REGARDING RELS QTYS FOR
    THIS MATL WHICH MUST BE REPORTED. HOWEVER, SPILLS/RELS WHICH MAY
    ENDANGER PUBLIC HLTH/ENVIRONMENT/MAY CAUSE COMPLAINTS SHOULD BE
    REPORTED TO APPROP STATE A GENCY, LOC OFFICIALS & NRC. EVACUATE
    AREA (ING 15)
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:UNDERGOES OXIDATION BY ATMOSPHERIC
    OXYGEN IN PRESENCE OF MOISTURE/IN AQ SOLN (THIS AUTOOXIDATION MAY
    BE CATALYZED BY METAL IONS, EG, MANGANESE(ING 18)
Other Precautions:AVOID ALL PERSONAL CONTACT. DO NOT GET IN EYES, ON
    SKIN OR ON CLTHG. DO NOT BREATHE DUST. AVOID CREATING DUST WHEN
    HNDLG. USE ONLY W/ADEQ VENT. WHEN HNDLG, WEAR PROPER NIOSH APPRVD
    RESP & OTHER PPE. F ULL BODY SUIT RECOMMENDED.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NIOSH APPROVED SUPPLIED-AIR POSITIVE-PRESSURE
    FULL FACEPIECE RESPIRATOR OR SUPPLIED-AIR HOOD.
Ventilation:LOCAL EXHAUST: SPECIFIC VENTILATION REQUIRED. MECHANICAL
    (GENERAL): REQUIRED. OTHER: LAB-TYPE HOOD.
Protective Gloves:DISPOSABLE SURGICAL LATEX. (ING 21)
Eye Protection:ANSI APPRVD CHEM WORKERS GOGGLES .
Other Protective Equipment:ANSI APPRVD EYE WASH & DELUGE SHOWER . SIGN
    SHOULD BE POSTED IN WORK AREAS LIMITING ACCESS TO AUTH PERS (ING
    22)
Work Hygienic Practices:WASH THOROUGYLY OR SHOWER AFTER HANDLING. KEEP
    CONTAINER TIGHTLY CLOSED WHEN NOT IN USE.
Supplemental Safety and Health
PH (5% IN WATER): 3-4. SOL IN H*2O: VERY SOLUBLE (200 MG/ML) BUT
    DECOMPOSES. EXPLAN OF CARCIN: 1994:ANTIC TO BE CARCIN. EFTS OF
    OVEREXP: FERTILITY. EXPERIMENTAL TOXICOLOGY: NUMEROUS STUDIES IN
    MICE &  RATS HAVE INDICATED PROCARBOZINE HYDROCHLORIDE IS CARCIN
    USING FOLLOWING ROUTES OF ADMIN: SINGLE ORAL (ING 2)

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:>433F,>223C
pH:SUPDAT
Solubility in Water:SUPDAT
Appearance and Odor:WHITE TO PALE YELLOW CRYSTALLINE POWDER; SLIGHT
    CHARACTERISTIC ODOR.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
NOT APPLICABLE.
Stability Condition to Avoid:NOT APPLICABLE.
Hazardous Decomposition Products:TOXIC FUMES OF OXIDES OF NITROGEN AND
    HYDROGEN CHLORIDE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF CONTAINED MATERIAL, SOAKED ABSORBENT
    AND DISCARDED CLOTHNG IN AN INCINERATOR WHICH HAS SUITABLE LOCAL,
    STATE AND FEDERAL PERMITS.

 ======================================================================
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 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

*** END OF RECORD ***