===================== Product Identification =====================
MSDS NAME:ACETONE, 99.9+%, HPLC GRADE, 270725
NIIN:00N014193
Status Code:A
MSDS Number: CJQPZ
=== Responsible Party ===
Company:ALDRICH CHEMICAL CO INC
Address:1001 W ST PAUL
City:MILWAUKEE
State:WI
ZIP:53233
Country:US
Info Phone Num:414-273-3850
Emergency Phone Num:414-273-3850
CAGE:60928
=== Contractor Identification ===
Company:ALDRICH CHEMICAL CO INC
Address:1001 WEST ST PAUL AVE
Box:355
City:MILWAUKEE
State:WI
ZIP:53233
Country:US
Phone:414-273-3850
CAGE:60928
============= Composition/Information on Ingredients =============
Name:ACETONE. LD50:(ORAL,RAT) 5800 MG/KG.
CAS:67-64-1
RTECS #:AL3150000
> Wt:99.9
OSHA PEL:2400 MG/M3;1000 PPM
ACGIH TLV:1780 MG/M3;750 PPM
ACGIH STEL:2380 MG/M3;1000 PPM
EPA Rpt Qty:5000 LBS
DOT Rpt Qty:5000 LBS
===================== Hazards Identification =====================
LD50 LC50 Mixture:SEE INGREDIENT & TOXICOLOGICAL INFO.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INHALATION,
INGESTION OR SKIN ABSORPTION. CAUSES SEVERE EYE IRRITATION. CAUSES
SKIN IRRITATION. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND
UPPER RESPIRATORY TRACT, CAUSES DERMATITIS. TARGET ORGAN(S):
LIVER, KIDNEYS. TARGET ORGAN DATA: BRAIN AND COVERINGS (RECORDINGS
FROM SPECIFIC AREA OF CENTRAL NERVOUS SYSTEM); SENSE ORGANS AND
SPECIAL SENSES (OTHER OLFACTION EFFECTS; CONJUNCTIVA IRRITATION);
BEHAVIORAL (GENERAL ANESTHETIC; MUSCLE WEAKNESS; MUSCLE CONTRACTION
OR SPASTICITY); LUNGS, THORAX OR RESPIRATION (RESPIRATORY
DEPRESSION; OTHER CHANGES); KIDNEY, URETER, BLAD DER (RENAL
FUNCTION (EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZS: TESTS DEPRESSED); EFFECTS ON
FERTILITY (POST-IMPLANTATION MORTALITY).
======================= First Aid Measures =======================
Eyes: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT
LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING EYELIDS
WITH FINGERS. SKIN: FLUSH WITH WATER. REMOVE AND WASH CONTAMINATED
CLOTHIN G PROMPTLY. INHALATION: REMOVE TO FRESH AIR. IF NOT
BREATHING GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT,
GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON
IS CONSCIOUS. CA LL MD.
===================== Fire Fighting Measures =====================
Flash Point:=-17.2C, 1.F
Autoignition Temp:=465.C, 869.F
Lower Limits:2%
Upper Limits:13%
Extinguishing Media:CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE
FOAM. WATER MAY BE EFFECTIVE FOR COOLING, BUT MAY NOT EFFECT
EXTINGUISHMENT.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:EXTREMELY FLAMMABLE. VAPOR MAY TRAVEL
CONSIDERABLE DISTANCE TO SOURCE OF IGNITION AND FLASH BACK.
================== Accidental Release Measures ==================
Spill Release Procedures:EVACUATE AREA. SHUT OFF ALL SOURCES OF
IGNITION. WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS,
RUBBER BOOTS AND HEAVY RUBBER GLOVES. COVER WITH AN ACTIVATED
CARBON ADSORBENT, TAKE UP AND PLA CE IN CLOSED CONTAINERS.
TRANSPORT OUTDOORS. VENTILATE AREA AND WASH SPILL SITE AFTER
MATERIAL PICKUP IS COMPLETE.
====================== Handling and Storage ======================
Handling and Storage Precautions:DO NOT BREATHE VAPOR. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
SEVERE EYE IRRITANT. KEEP AWAY FROM HEAT, SPARKS AND OPEN FLAME.
STORE IN A COOL, DRY PLACE.
Other Precautions:FLAMMABLE. IRRITANT. RISK OF SERIOUS DAMAGE TO EYES.
KEEP AWAY FROM SOURCES OF IGNITION - NO SMOKING. TAKE PRECAUTIONARY
MEASURES AGAINST STATIC DISCHARGES. KEEP CONTAINER TIGHTLY CLOSED
IN A COOL, WE LL-VENTILATED PLACE.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:COMPATIBLE CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES & FULL LENGTH
FACESHIELD .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
WEAR SUITABLE PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
MFR INFO: MF: CEH6O. EC NO: 200-662-2. -- OTHER INFO:10H TWA 250 PPM -
NIOSH* DHHS #92-100,1992. NOHS 1974: HZD 02820; NIS 350; TNF 99713;
NOS 188; TNE 1287794. NOES 1983: HZD 02820; NIS 358; TNF 9734 2;
NOS 215; TNE 1740164; TFE 540313. EPA GENETOX PROGRAM 1988, NEG:
(SHE-CLONAL ASSAY; CELL (TRANSPORTATION INFO)
================== Physical/Chemical Properties ==================
Boiling Pt:=56.C, 132.8F
Melt/Freeze Pt:=-94.C, -137.2F
Vapor Pres:184MM @ 20C;400MM @ 39.5C
Vapor Density:2
Spec Gravity:0.791
Appearance and Odor:COLORLESS LIQUID.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
BASES, OXIDIZING AGENTS, REDUCING AGENTS.
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
CARBON DIOXIDE.
=================== Toxicological Information ===================
Toxicological Information:IRRIT DATA:EYE-HMN 500 PPM - JHITAB
25,282,1943. SKIN-RBT 395 MG OPEN MLD - UCDS** 5/7/1970. SKIN-RBT
500 MG/24H MLD - 85JCAE -,280,1986. EYE-RBT 20 MG SEV - AJOPAA
29,1363,1946. EYE-RBT 20 MG/24H MOD - 85JCAE -,280,1986. TOX
DATA:LDL0:(UNR,MAN) 1150 MG/KG - 85DCAI 2,73,1970. LD50:(ORL,RAT)
5800 MG/KG - JTEHD6 15,609,1985. LC50:(IHL,RAT) 50100 MG/M3/8H -
AIHAAP 20,364,1959. LD50:(IVN,RAT) 5500 MG/ KG - NPIRI* 1,1,1974.
LD50:(ORL,MUS) 3 GM/KG - PCJOAU 14,162,1980. LC50:(IHL,MUS) 44
GM/M3 4H - CUTOEX 1,47,1993. LD50:(IPR,MUS) 1297 MG/KG - SCCUR*
-,1,1961. LD50:(ORL,RBT) 5340 MG/KG - FAONAU 48A,86 ,1970.
(ECOLOGICAL INFO)
===================== Ecological Information =====================
Ecological:DATA NOT YET AVAILABLE. -- TOX INFO: LD50:(SKIN,GPG) >9400
UL/KG - TXAPA9 7,559,1965. ONLY SELECTED REGISTRY OF TOXIC EFFECTS
OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL
ENTRY IN RTECS FOR COMPLETE INFORMATION.
==================== Disposal Considerations ====================
Waste Disposal Methods:BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER BUT EXERT EXTRA CARE IN IGNITING AS THIS
MATERIAL IS HIGHLY FLAMMABLE. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGUL ATIONS. RCRA WASTE NUMBER: U002.
=================== MSDS Transport Information ===================
Transport Information:CONTACT ALDRICH CHEMICAL COMPANY FOR
TRANSPORTATION INFORMATION. -- SUPP DATA:TRANSFORM.-MOUSE EMBRYO),
(CELL TRANSFORM.-RLV F344 RAT EMBRYO), (IN VITRO
CYTOGENETICS-NONHUMAN), (HISTIDINE REVERSION-AM ES TEST; IN VITRO
SCE-NONHUMAN). EPA TSCA SECTION 8 (B): CHEM INVENTORY. EPA TSCA
SECTION 8 (D) UNPUBLISHED HLTH/SFTY STUDIES ON EPA IRIS DATABASE.
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, DECEMBE R 1998. NIOSH
ANALYTICAL METHOD, 1994: KETONES I, 1300. NIOSH ANALYTICAL METHOD,
1996: VOLAT ORGANIC CMPD, 2549. NTP TOX STUDIES, RPT# TOX-03, NOV
1998. OSHA ANALYTICAL METHOD #ID-69.
===================== Regulatory Information =====================
Federal Regulatory Information:EUROPEAN INFO: EC INDEX NO:
606-001-00-8. HIGHLY FLAMM; IRRIT; R 11 - HIGHLY FLAMM; S 9 - KEEP
CNTNR IN WELL-VENTED PLACE; S 16 - KEEP AWAY FROM SOURCES OF IGNIT
- NO SMOKING; S 23 - DO NOT BREATHE VA P; S 33 - TAKE PRECAUTIONARY
MEASURES AGAINST STATIC DISCHARGES. REVIEWS, STDS & REGS: OEL=MAK.
ACGIH TLV-NOT CLASSIFIABLE AS HUMAN CARCIN; STEL 1782 MG/M3 (750
PPM); TWA 1188 MG/M3 (500 PPM) - DTLVS* TLV/BEI,1997. EPA FIFRA
1988 PESTICIDE SUBJECT TO REGISTRATION/RE-REGISTRATION - FEREAC
54,7740,198 9. MSHA STD-AIR:TWA 1000 PPM (2400 MG/M3) - DTLVS*
3,3,1971. OSHA PEL (GEN INDU):8H TWA 1000 PPM (2400 MG/M3) - (STATE
REGULATORY INFO)
State Regulatory Information:FED REGULATORY: CFRGBR 29, 1910.1000,1994.
OSHA PEL (CONSTRUC):8H TWA 1000 PPM (2400 MG/M3) - CFRGBR
29,1926.55,1994. OSHA PEL (SHIPYARD):8H TWA 1000 PPM (2400 MG/M3) -
CFRGBR 29,1915.1000,1993. OSHA PEL (FED CONT):8H TWA 1000 PPM
(2400 MG/M3) - CFRGBR 41,50-204.50,1994. OEL-AUSTRALIA:TWA 500 PPM
(1185 MG/M3); STEL 1000 PPM JAN 1993. OEL-AUSTRIA, THE NETHERLANDS,
SWITZERLAND:TWA 750 PPM (1780 MG/M 3) JAN 1993. OEL-BELGIUM:TWA 750
PPM (1780 MG/M3) STEL 1000 PPM JAN 1993. OEL-DENMARK:TWA 250 PPM (6
00 MG/M3) JAN 1993. OEL-FINLAND:TWA 500 PPM (1200 MG/M3); STEL 625
PPM (1500 MG/M3) JAN 1993. OEL-FRANCE:TWA 750 PPM (OTHER INFO)
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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