===================== Product Identification =====================
MSDS NAME:N,N-DIMETHYLFORMAMIDE, 99%, D119
NIIN:00-890-1888
MSDS Number: CJQPC
=== Responsible Party ===
Company:FISHER SCIENTIFIC
Address:1 REAGENT LANE
City:FAIRLAWN
State:NJ
ZIP:07410
Country:US
Info Phone Num:201-796-7100
Emergency Phone Num:(800)424-9300
Chemtrec Ind/Phone:(800)424-9300
CAGE:1B464
=== Contractor Identification ===
Company:FISHER SCIENTIFIC CO. CHEMICAL MFG DIV
Address:1 REAGENT LANE
Box:City:FAIRLAWN
State:NJ
ZIP:07410-2802
Country:US
Phone:201-796-7100
CAGE:1B464
============= Composition/Information on Ingredients =============
Name:N,N-DIMETHYLFORMAMIDE LD50: (ORAL, RAT) 2800 MG/KG
CAS:68-12-2
RTECS #:LQ2100000
= Wt:100.
OSHA PEL:30 MG/M3;10 PPM
ACGIH TLV:30 MG/M3;10 PPM
EPA Rpt Qty:1 LB
DOT Rpt Qty:1 LB
===================== Hazards Identification =====================
LD50 LC50 Mixture:SEE INGREDIENT
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:EYE: CAUSES SEVERE EYE IRRITATION.
VAPORS MAY CAUSE EYE IRRITATION. SKIN: PROLONGED AND/OR REPEATED
CONTACT MAY CAUSE IRRITATION AND/OR DERMATITIS. SUBSTANCE IS
RAPIDLY ABSORBED THROUGH THE SKIN. IF A BSORBED, CAUSES SYMPTOMS
SIMILAR TO INHALATION. STRONG IRRITANT OF THE SKIN. INGESTION: MAY
CAUSE IRRITATION OF THE DIGESTIVE TRACT. MAY CAUSE EFFECTS SIMILAR
TO THOSE FOR INHALATION EXPOSURE. INHALAT ION: MAY CAUSE
RESPIRATORY TRACT IRRITATION. MAY CAUSE KIDNEY DAMAGE. MAY BE
HARMFUL IF INHALED. INHALATION MAY PRODUCE NAUSEA, VOMITING,
ANOREXIA, COLIC, HIGH BLOOD PRESSURE, HEPATOMEGALY, JAUNDICE A ND
(EFFECTS OF OVEREXPOSURE)
Explanation of Carcinogenicity:DIMETHYLFORMAMIDE: IARC MONOGRAPHS ON
EVALUATION OF CARCINOGENIC RISK OF CHEMICALS TO MAN, VOLUME 47,
PAGE 171, 1989:GROUP 2B.
Effects of Overexposure:HEALTH HAZARDS: ALTERED LIVER FUNCTION.
CHRONIC: POSSIBLE CANCER HAZARD BASED ON TESTS WITH LABORATORY
ANIMALS. PROLONGED OR REPEATED SKIN CONTACT MAY CAUSE DERMATITIS.
======================= First Aid Measures =======================
Eyes: IMMEDIATELY FLUSH EYES W/PLENTY OF WATER FOR AT LEAST
15 MINUTES, OCCASIONALLY LIFTING UPPER & LOWER LIDS. GET MEDICAL
AID IMMEDIATELY. SKIN: GET MEDICAL AID IMMEDIATELY. IMMEDIATELY
FLUSH SKIN W/PLENTY OF SOAP & WATER FOR AT LEAST 15 MINUTES WHILE
REMOVING CONTAMINATED CLOTHING & SHOES. INGEST: IF VICTIM IS
CONSCIOUS & ALERT, GIVE 2-4 CUPFULS OF MILK OR WATER. NEVER GIVE
ANYTHING BY MOUTH T O UNCONSCIOUS PERSON. GET MEDICAL AID
IMMEDIATELY. INHAL: GET MEDICAL AID IMMEDIATELY. REMOVE FROM
EXPOSURE TO FRESH AIR IMMEDIATELY. IF NOT BREATHING, GIVE
ARTIFICIAL RESPIRATION. IF BREATHING IS DIF FICULT, GIVE OXYGEN.
NOTES TO MD: NONE.
===================== Fire Fighting Measures =====================
Flash Point:=58.C, 136.4F
Autoignition Temp:=445.C, 833.F
Lower Limits:2.2%
Upper Limits:15.2%
Extinguishing Media:FOR SMALL FIRES, USE DRY CHEM, CARBON DIOXIDE,
WATER SPRAY OR ALCOHOL-RESIST FOAM. USE WATER SPRAY TO COOL
FIRE-EXPOSED CNTNRS. WATER MAY BE INEFTIVE. FOR LARGE FIRES, USE
(SUPDAT)
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT . CONTACT PROFESSIONAL FIRE-FIGHTERS IMMEDIATELY. COOL
CONTAINERS W/FLOODING QUANTITIES OF WATER UNTIL WELL AFTER FIRE IS
OUT. NFPA RATING: HEALTH-1; FLAMMABILITY-2; REACTIVITY-0.
Unusual Fire/Explosion Hazard:VAPORS CAN TRAVEL TO SOURCE OF IGNITION &
FLASH BACK. USE WATER SPRAY TO KEEP FIRE-EXPOSED CONTAINERS COOL.
FLAMMABLE LIQUID. VAPORS MAY BE HEAVIER THAN AIR. THEY CAN SPREAD
ALONG GROUND & COLLECT IN LOW OR CONFINED AREAS. VAPORS MAY FORM
AN EXPLOSIVE MIXTURE W/AIR. CONTAINERS MAY EXPLODE WHEN HEATED.
================== Accidental Release Measures ==================
Spill Release Procedures:USE PROPER PERSONAL PROTECTIVE EQUIPMENT AS
INDICATED IN EXPOSURE CONTROLS, PERSONAL PROTECTION. ABSORB SPILL
W/INERT MATERIAL (EG, DRY SAND OR EARTH), THEN PLACE INTO CHEMICAL
WASTE CONTAINER. DO NOT FLUSH INTO A SEWER. REMOVE ALL SOURCES OF
IGNIT. A VAPOR SUPPRESSING FOAM MAY BE USED TO REDUCE VAPORS. WATER
SPRAY MAY REDUCE VAPOR BUT MAY NOT PREVENT IGNITION IN CLOSED
SPACES.
====================== Handling and Storage ======================
Handling and Storage Precautions:KEEP AWAY FROM HEAT, SPARKS & FLAME.
KEEP AWAY FROM SOURCES OF IGNIT. STORE IN TIGHTLY CLOSED CNTNR.
KEEP FROM CONTACT W/OXIDIZING MATLS. STORE IN A COOL, DRY,
WELL-VENTD AREA AWAY FROM INCOMPATIBLE S UBSTANCES. WASH THOROUGHLY
AFTER HNDLG. REMOVE CONTAM CLTHG & WASH BEFORE REUSE. USE W/ADEQ
VENT.
Other Precautions:GROUND & BOND CNTNRS WHEN TRANSFERRING MATL. AVOID
CNTCT W/EYES, SKIN & CLTHG. EMPTY CNTNRS RETAIN PROD RESIDUE (LIQ
&/OR VAP) & CAN BE DANGEROUS. KEEP CNTNR TIGHTLY CLSD. AVOID CNTCT
W/HEAT, SPKS & F LAME. AVOID INGEST & INHAL. DO NOT PRESSURIZE,
CUT, WELD, BRAZE, SOLDER, DRILL, GRIND/EXPOSE EMPTY C NTNRS TO
(SUPDAT)
============= Exposure Controls/Personal Protection =============
Respiratory Protection:FOLLOW THE OSHA RESPIRATOR REGULATIONS FOUND IN
29 CFR 1910.134 OR EUROPEAN STANDARD EN 149. ALWAYS USE A NIOSH OR
EUROPEAN STANDARD EN 149 APPROVED RESPIRATOR WHEN NECESSARY.
Ventilation:USE ADEQUATE GENERAL OR LOCAL EXHAUST VENTILATION TO KEEP
AIRBORNE CONCENTRATIONS BELOW THE PERMISSIBLE EXPOSURE LIMITS.
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH AND DELUGE SHOWER .
WEAR APPROPRIATE PROTECTIVE CLOTHING TO MINIMIZE CONTACT WITH SKIN.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING. REMOVE
CONTAMINATED CLOTHES AND WASH BEFORE REUSE.
Supplemental Safety and Health
EXTING MEDIA: WATER SPRAY, FOG OR ALCOHOL-RESISTANT FOAM. DO NOT USE
STRAIGHT STREAMS OF WATER. OTHER PRECS: SPKS/OPEN FLAMES. EXPOS
LIMITS: N,N-DIMETHYLFORMAMIDE - ACGIH: 10 PPM; 30 MG/M3; SKIN-POTNT
L FOR CUTANEOUS ABSORPTION. NIOSH: 10 PPM TWA; 30 MG/M3 TWA 500 PPM
IDLH. OSHA-FINAL PELS: 10 PPM TWA; 30 MG/M3 TWA.
================== Physical/Chemical Properties ==================
Boiling Pt:B.P. Text:153760C
Melt/Freeze Pt:=-61.C, -77.8F
Decomp Temp:=350.C, 662.F
Vapor Pres:3.725 MM HG
Vapor Density:2.5(AIR=1)
Spec Gravity:0.9450
pH:6.7
Viscosity:0.8 MPAS 20 DEG
Solubility in Water:SOLUBLE
Appearance and Odor:CLEAR, COLORLESS TO PALE YELLOW LIQUID - CLEAR;
AMINE-LIKE ODOR.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
ACIDS (MINERAL, NON-OXIDIZING, EG HYDROCHLORIC ACID, HYDROFLUORIC ACID,
MURIATIC ACID, PHOSOPHORIC ACID), ACIDS (MINERAL, OXIDIZING, EG
CHROMIC ACID, HYPOCHLOROUS ACID, NITRIC ACID, SULFURIC ACID),
METALS (ALKALI & ALKALINE
Stability Condition to Avoid:INCOMPATIBLE MATERIALS, IGNITION SOURCES,
STRONG OXIDANTS.
Hazardous Decomposition Products:CARBON MONOXIDE, OXIDES OF NITROGEN,
CARBON DIOXIDE.
=================== Toxicological Information ===================
Toxicological Information:CAS # 68-12-2. LD50/LC50: INHALATION, MOUSE:
LC50 = 9400 MG/M3/2H; ORAL, MOUSE: LD50 = 3700 MG/KG; SKIN, RABBIT:
LD50 = 4720 MG/KG. CARCINOGENICITY: ACGIH: A4 - NOT CLASSIFIABLE AS
HUMAN CARCINOGEN. O SHA: POSSIBLE SELECT CARCINOGEN. IARC:GROUP 2B
CARCINOGEN. EPIDEMIOLOGY: A SIGNIFICANT EXCESS OF PROSTATE CANCER
WAS OBSERVED AMONG WORKERS EXPOSED TO DMF AND ACRYLONITRILE.
TERATOGENICITY: EXPERIMENT AL TERATOGEN EFFECTS HAVE BEEN REPORTED.
REPRODUCTIVE EFFECTS: EXPERIMENTAL REPRODUCTIVE EFFECTS HAVE BEEN
REPORTED. NEUROTOXICITY: NO DATA AVAILABLE. MUTAGENICITY: HUMAN
MUTATION DATA REPORTED. OTHER STUDIES: NO DATA AVAILABLE.
===================== Ecological Information =====================
Ecological:EXOTOXICITY: NOT AVAIL. ENVIRONMENTAL FATE: SUBSTANCE
EXPECTED TO BIODEGRADE RAPIDLY IN ENVIRONMENT & SHOULD BE HIGHLY
MOBILE IN SOIL. PHYSICAL/CHEM:NOT AVAIL. OTHER:NOT AVAIL. --FED REG
INFO:POLLUTAN TS UNDER CWA. NONE OF CHEMS IN PROD CONSIDERED HIGHLY
HAZ BY OSHA. EUROPEAN INTERNATIONAL REGS - EUROPEAN LABELING I/A/W
EC DIRECTIVES. HAZ SYMBOLS: T. RISK PHRASES: R 20/21 HARMFUL BY
INHAL & IN CNTC T W/SKIN. R 36 IRRIT TO EYES. R 61 MAY CAUSE HARM
TO UNBORN CHILD. SFTY PHRASES: S 45 IN CASE OF ACCIDENT/IF YOU FEEL
UNWELL, SEEK MED ADVICE IMMED (SHOW LABEL WHERE POSS). S 53 AVOID
EXPOS - OBTAIN S PEC INSTRUCTIONS (TRANSPORT INFO)
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IN A MANNER CONSISTENT WITH FEDERAL,
STATE AND LOCAL REGULATIONS. RCRA D-SERIES MAXIMUM CONCENTRATION OF
CONTAMINANTS: NONE LISTED. RCRA D-SERIES CHRONIC TOXICITY REFERENCE
LEVELS: NONE LIS TED. RCRA F-SERIES: NONE LISTED. RCRA P-SERIES:
NONE LISTED. RCRA U-SERIES: NONE LISTED.
=================== MSDS Transport Information ===================
Transport Information:SHIPPING NAME - US DOT: N,N-DIMETHYLFORMAMIDE,
IATA:NO INFO AVAIL, RID/ADR:NO INFO AVAIL, IMO:NO INFO AVAIL,
CANADA TDG: N,N-DIMETHYLFORMAMIDE. HAZ CLASS - US DOT:3; CANADA
TDG:3. UN NUMBER: US DOT:UN 2265; CANADA TDG:UN2265. PACKING
GROUP-US DOT:III; CANADA TDG:III. ADDNL INFO: CANADA TDG: FL PT
58C. --ECOLOGICAL INFO: BEFORE USE. WGK (WATER DANGER/PROT) - CAS
#68-12-2:1. CANADA - CAS #68-12-2 LIS TED ON CANADA'S DSL/NDSL
LIST. PROD HAS WHMIS CLASSIFICATION OF B3, D2B. NOT LISTED ON
CANADA'S INGRED DISCLOSURE LIST. EXPOS LIMS: CAS #68-12-2:
OEL-AUSTRALIA:TWA 10PPM (30MG/M3); SKIN OEL-BELGIUM: T WA 10PPM
(30MG/M3); (SARA REG INFO)
===================== Regulatory Information =====================
SARA Title III Information:SECTION 302 (RQ):NONE OF THE CHEMS IN MATL
HAVE RQ. SECTION 302 (TPQ):NONE OF CHEMS IN PROD HAVE TPQ. SARA
CODES CAS #68-12-2; ACUTE, FLAM. SECTION 313: MATL CONTAINS
N,N-DIMETHYLFORMAMIDE (CAS #68-12 -2, 100%), WHICH IS SUBJECT TO
REPORTINGREQS OF SECTION 313 OF SARA TITLE III & 40 CFR PART 373.
--TRANSPORT INFO: SKIN OEL-CZECHOSLOVAKIA:TWA 30MG/M3; STEL 60
MG/M3 OEL-DENMARK:TWA 10PPM (30MG/M3); S KIN OEL-FINLAND:TWA 10PPM
(30MG/M3); STEL 20PPM (60MG/M3); SKIN OEL-FRANCE:TWA 10PPM
(30MG/M3); SKIN OEL-GERMANY:TWA 20PPM (60MG/M3); SKIN
OEL-HUNGARY:TWA 10MG/M3; STEL 20MG/M3; SKIN OEL-JAPAN:TWA 10P PM
(30MG/M3); SKIN OEL- (STATE REG INFO)
Federal Regulatory Information:CAS #68-12-2 - LISTED ON THE TSCA
INVENTORY. HLTH & SAFETY REPORTING LIST: EFTIVE DATE: APRIL
13,1989; SUNSET DATE: 12/19/1995. CHEM TEST RULES:NONE OF CHEMS IN
PROD ARE UNDER CHEM TEST RULE. NONE OF CHEMS ARE LISTED UNDER TSCA
SECTION 12B. NONE OF CHEMS IN MATL HAVE SNUR UNDER TSCA. CLEAN AIR
ACT: #68-12-2 IS LISTED AS HAZ AIR POLLUTANT. THIS MATL DOES NOT
CNTN ANY CLASS 1 OZONE DEPLETORS. MATL D OES NOT CNTN ANY CLASS 2
OZONE DEPLETORS. CLEAN WATER ACT: NONE OF CHEMS IN PROD ARE LISTED
AS HAZ S UBSTANCES UNDER CWA. NONE OF CHEMS ARE LISTED AS PRIORITY
POLLUTANTS UNDER CWA. NONE OF CHEMS IN PROD LISTED AS TOXIC
(ECOLOGICAL INFO)
State Regulatory Information:CAS #68-12-2 CAN BE FOUND ON FOLLOWING
STATE RIGHT TO KNOW LISTS: CA, NJ, FL, PA, MN, MA. CA NO
SIGNIFICANT RISK LEVEL:NONE OF CHEMS IN PROD LISTED. --SARA TITLE
III: NETHERLANDS:TWA 10PPM (30MG/M3); SKIN OEL-PHILLIPPINES:TWA
10PPM (30MG/M3); SKIN OEL-POLAND:TWA 10MG/M3 OEL-RUSSIA:TWA 10PPM;
STEL 10MG/M3; SKIN OEL-SWEDEN:TWA 10PPM (30MG/M3); STEL 15PPM
(45MG/M3); SKIN OEL-SWITZERLAND:TWA 10PPM 930 MG/M3); STEL 20PPM;
SKIN OEL-TURKEY:TWA 10PPM (30MG/M3); SKIN OEL-UNITED KINGDOM:TWA
10PPM (30MG/M3) ; STEL 20PPM; SKIN OEL BULGARIA, COLOMBIA, JORDAN,
KOREA CHECK ACGIH TLV. OEL NEW ZEALAND, SINGAPORE, VIETNAM CHECK
ACGIH TLV.
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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