=====================  Product Identification  =====================

MSDS NAME:RIFAMPICIN CRYSTALLINE, R3501
NIIN:00N092680
Status Code:A
MSDS Number: CJVQC
=== Responsible Party ===
Company:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Name:RIFAMPICIN CRYSTALLINE
CAS:13292-46-1
RTECS #:VJ7000000
= Wt:100.

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:LD50: (ORAL,RAT) 1570 MG/KG
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED, INHALED,
    OR ABSORBED THROUGH SKIN. CAUSES EYE AND SKIN IRRITATION. MATERIAL
    IS IRRITATING TO MUCOUS MEMRANES AND UPPER RESPIRATORY TRACT.
    EXPOSURE CAN CAUSE ANOREXIA, NAUS EA, VOMITING AND INFLUENZA-LIKE
    SYNDROME. BLOOD EFFECTS. OTHER SYMPTOMS OF EXPOSURE MAY INCLUDE
    DROWSINESS, ALLERGIC RHINITIS, CONJUNCTIVITIS, AND SKIN RASH.
    CHRONIC: POSSIBLE TERATOGEN. OVEREXPOSURE  MAY CAUSE REPRODUCTIVE
    DISORDER(S) BASED ON TESTS WITH LABORATORY ANIMALS. THIS PRODUCT IS
    OR CONTAINS A COMPONENT THAT IS NOT CLASSIFIABLE AS TO ITS
    CARCINOGENICITY BASED ON ITS (EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZS: IARC, ACGIH, NTP OR EPA
    CLASSIFICATION. TARGET ORGAN(S): LIVER, KIDNEYS, BLOOD. ADDITIONAL
    INFORMATION: EXPOSURE TO AND/OR CONSUMPTION OF ALCOHOL MAY INCREASE
    TOXIC EFFECTS.

=======================  First Aid Measures  =======================

First Aid:IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
    CONSCIOUS. CALL A PHYSICIAN. IN CASE OF SKIN CONTACT, FLUSH WITH
    COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. REMOVE
    CONTAMINATED CLOTHN G AND SHOES. CALL A PHYSICIAN. IF INHALED,
    REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT, CALL A
    PHYSICIAN. IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS
    OF WATER FOR AT LEAST 15 MINU TES. ASSURE ADEQUATE FLUSHING BY
    SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR
    APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
    APPARATUS AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND
    EYES.
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPRVD SCBA, RUBBER
    BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD
    FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH
    SPILL SITE AFTER MATERIAL  PICKUP IS COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
    EYES, ON SKIN, ON CLOTHING. AVOID PRNGD/RPTD EXPOSURE. POSSIBLE
    TERATOGEN. REPRODUCTIVE HAZARD. HARMFUL SOLID. IRRITANT. KEEP
    TIGHTLY CLOSED. STORE IN A COOL DRY PLA CE. IN CASE OF ACCIDENT/IF
    YOU FEEL UNWELL, SEEK MED ADVICE IMMED (SHOW LABEL WHERE POSSIBLE).
Other Precautions:LABEL PRECAUTIONARY STATEMENTS: TOXIC. MAY IMPAIR
    FERTILITY. POSS RISK OF HARM TO UNBORN CHILD. HARMFUL BY INHAL, IN
    CONT W/SKIN & IF SWALLOWED. IRRITATING TO EYES, RESP SYS & SKIN.
    TARGET ORGAN(S): L IVER, KIDNEYS. AVOID EXPOS-OBTAIN SPEC
    INSTRUCTION BEFORE USE. WEAR SUITABLE PROT CLTHG, GLOVES & EY
    E/FACE PROTECTION.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
    OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
SOLUBILITY IN H*2O: CHLOROFORM-SOLUBLE. METHANOL-SOLUBLE. TOX INFO:
    IPR-GPG LD50:639 MG/KG. ACHTA6 16,316,1970. TARGET ORGAN DATA:
    SENSE ORGANS & SPEC SENSES (CONJUNCTIVA IRRIT), (IRITIS), (OTHER
    EYE  EFTS). BEHAVIORAL (MUSCLE WEAK). LUNGS, THORAX/RESPIRATON
    (DYSPNAE). (OTHER INFO)

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:>183.C, 361.4F
M.P/F.P Text:183-188C
Solubility in Water:SUPDAT
Appearance and Odor:SOLID.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:PROTECT FROM LIGHT.
Hazardous Decomposition Products:CARBON MONOXIDE, CARBON DIOXIDE,
    NITROGEN OXIDES.

===================  Toxicological Information	===================

Toxicological Information:ADDNL INFO: EXPOSURE TO AND/OR CONSUMPTION OF
    ALCOHOL MAY INCR TOXIC EFTS. RTECS #: VJ7000000. RIFOMYCIN SV,
    8-(N-(4-METHYL-1-PIPERAZINYL)FORMIDOYL)-. TOX DATA: ORL-MAN
    LDLO:857 MG/KG. JAMAAP 240,2283 ,1978. ORL-RAT LD50:1570 MG/KG.
    JJANAX 23,257,1970. IRP-RAT LD50:511 MG/KG. JJANAX 23,257,1970.
    SCU-RAT LD50:534 MG/KG. JJANAX 23,242,1970. ORL-MUS LD50:500 MG/KG.
    CHDDAT 269,2147,1969. IPR-MUS LD50:4 16 MG/KG. CMTRAG 12,155,1967.
    SCU-MUS LD50:621 MG/KG. JJANAX 23,242,1970. IVN-MUS LD50:260 MG/KG.
    ACHTA6 16,316,1970. ORL-RBT LD50:2120 MG/KG. ACHTA6 16,316,1970.
    (SUPDAT)

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:EUROPEAN INFO: TOXIC. R 60. MAY IMPAIR
    FERTILITY. R 63. POSSIBLE RISK OF HARM TO UNBORN CHILD. R 20/21/22.
    HARMFUL BY INHAL, IN CONT W/SKIN & IF SWALLOWED. R 36/37/38.
    IRRITATING TO EYES, RESP SYS & S KIN. S 53. AVOID EXPO-OBTAIN SPEC
    INSTRUCTIONS BEFORE REUSE. S 45. IN CASE OF ACCIDENT/IF YOU FEEL
    UNWELL, SEEK MED ADVICE IMMED (SHOW LABEL WHERE POSSIBLE). S
    36/37/39. WEAR SUITABLE PROT CLTHG, GLOV ES & EYE/FACE PROT. S 22.
    DO NOT BREATHE DUST. REVIEWS, STDS, & REGS. OEL=MAK. IARC CANCER
    REVIEW:AN IMAL LIMITED EVIDENCE. IMEMDT 24,243,1980. IARC CANCER
    REVIEW: HUMAN NO ADEQ DATA. (OTHER INFO)

=======================  Other Information  =======================

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.

*** END OF RECORD ***