===================== Product Identification =====================
MSDS NAME:CHLORAMPHENICOL CRYSTALLINE, C0378
NIIN:00N092456
Status Code:A
MSDS Number: CJVSL
=== Responsible Party ===
Company:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076
============= Composition/Information on Ingredients =============
Name:CHLORAMPHENICOL (CRYSTALLINE)
CAS:56-75-7
RTECS #:AB6825000
Other REC Limits:N/K
OSHA PEL:N/K
OSHA STEL:N/K
ACGIH TLV:N/K
ACGIH STEL:N/K
===================== Hazards Identification =====================
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFFECTS: MAY BE HARMFUL BY
INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CAUSE EYE
IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING
TO MUCOUS MEMBRANES AND UPPER RESPIRATOR Y TRACT. MAY CAUSE
ALLERGIC REACTION. EXPOSURE CAN CAUSE: NAUSEA, HEADACHE AND
VOMITING. CHRONIC EFFECTS: THIS PRODUCT IS OR CONTAINS A
COMPONENT THAT HAS BEEN REPORTED TO BE PROBABLY CARCINOGENIC BASED
ON ITS IARC, OSHA, ACGIH, NTP OR EPA CLASSIFICATION. MAY ALTER
GENETIC MATL. POSSIBLE RISK OF CONGENITAL MALFORMATION IN THE
FETUS. TARGET ORGAN(S): BLOOD, BONE MARROW, NERVES, LIVER.
Explanation of Carcinogenicity:CHLORAMPHENICOL: IARC MONOGRAPHS, VOL
50, PAGE 169, 1990: GROUP 2A. HUMAN-BLOOD-LEUKEMIA.
Effects of Overexposure:SEE HEALTH HAZARDS.
======================= First Aid Measures =======================
First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND
SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE
ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE.
===================== Fire Fighting Measures =====================
Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
================== Accidental Release Measures ==================
Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPROVED
SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER
GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID
RAISING DUST. VENTILATE AREA AN D WASH SPILL SITE AFTER MATERIAL
PICKUP IS COMPLETE.
====================== Handling and Storage ======================
Handling and Storage Precautions:AVOID INHALATION. DO NOT GET IN EYES,
ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP
TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
SHOWER . WEAR OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
TOX INFO: JCINAO 28, 943, 1949. IVN-RBT LD50: 117 MG/KG; JCINAO 28,
943, 1949. ORL-GPG LD50: 500 MG/KG; FRPSAX 10, 3, 1955. IVN-GPG
LD50: 560 MG/KG; FRPSAX 9, 21, 1954. TARGET ORGAN DATA: BEHAVIORAL
( SOMNOLENCE, CONVLS/EFT ON SEIZURE THRESHOLD, ATAXIA, COMA); CARD
(CARD OUTPUT); VASCULAR (BP LOWERING NOT (OTHER INFO)
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:>148.C, 298.4F
M.P/F.P Text:148C - 150C
Appearance and Odor:WHITE POWDER.
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
ACIDS, ACID CHLORIDES, ACID ANHYDRIDES, OXIDIZING AGENTS.
Hazardous Decomposition Products:CARBON MONOXIDE, CARBON DIOXIDE,
NITROGEN OXIDES, HYDROGEN CHLORIDE GAS.
=================== Toxicological Information ===================
Toxicological Information:RTECS #: AB6825000 ACETAMIDE-
2,2-DICHLORO-N-(BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-P-NITROPHENETHYL
)-, D-(-)-THREO-. TOXICITY DATA: ORL-WMN LDLO: 400 MG/KG; JAMAAP
234, 149, 1975. IVN-INF LDLO: 30 MG/KG /3D-I; JOPDAB 103, 487,
1983. UNR-INF LDLO: 200 MG/KG/4D-I; LANCAO 1, 555, 1986. ORL-RAT
LD50: 2500 MG/KG; FRPSAX 10, 3, 1955. IPR-RAT LD50: 1811 MG/KG;
TXAPA9 18, 185, 1971. SCU-RAT LD50: 5 GM/KG; TX APA9 9, 445, 1966.
IVN-RAT LD50: 171 MG/KG; JCINAO 28, 943, 1949. ORL-MUS LD50: 1500
MG/KG; ARZNAD 5, 1, 1955. IPR-MUS LD50: 1100 MG/KG; DIPHAH 14, 21,
1962. SCU-MUS LD50: 400 MG/KG; 85ERAY 1, 493, 19 78. IVN-MUS LD50:
110 MG/KG; (SUP DAT)
===================== Ecological Information =====================
Ecological:DATA NOT YET AVAILABLE. OTHER INFO: TUMORIGENIC (CARCIN BY
RTECS CRITERIA). ONLY SELECTED REGISTRY OF TOX EFTS OF CHEM
SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN
RTECS FOR COMPLETE INFO.
==================== Disposal Considerations ====================
Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.
=================== MSDS Transport Information ===================
Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.
===================== Regulatory Information =====================
SARA Title III Information:FED REGS: IMEMDT 50, 169, 1990. OEL-RUSSIA:
STEL 1 MG/M3 JAN 1993. NOHS 1974: HZD 84396; NIS 1; TNF 165; NOS 6;
TNE 11365. NOES 1983: HZD 84396; NIS 3; TNF 2358; NOS 19; TNE
35571; TFE 23544. EPA GENE TOX PROGRAM 1988, POS: RODENT DOMINANT
LETHAL. EPA GENETOX PROGRAM 1988, NEG: B SUBTILIS REC ASSAY; E COLI
POLA W/OUT S9. EPA GENETOX PROGRAM 1988, NEG: E COLI POLA W/OUT S9;
HISTIDINE REVERSION-AMES TEST. EPA GENETOX PROGRAM 1988, NEG: TRP
REVERSION. EPA GENETOX PROGRAM 1988, INCONCLUSIVE:
CARCIN-MOUSE/RAT; B SUBTILIS REC ASSAY. EPA GENETOX PROGRAM 1988,
INCONCLUSIVE: D MELANOGASTER SEX-LINKED LE THAL. EPA TSCA SECTION 8
(B) INVENTORY.
Federal Regulatory Information:EU INFO: TOX. R45: MAY CAUSE CANCER.
R46: MAY CAUSE HERITABLE GENETIC DMG. R63: POSS RISK OF HARM TO
UNBORN CHILD. R42/43: MAY CAUSE SENSIT BY INHAL & SKIN CONT. S45:
IN CASE OF ACCIDENT/YOU FEEL UNWE LL, SEEK MED ADVICE IMMED (SHOW
LABEL WHERE POSS). S36/37/39: WEAR SUITABLE PROT CLTHG, GLOVES &
EYE/FACE PROT. REVIEWS, STDS, & REGS: OEL=MAK. IARC CANCER REVIEW:
HUMAN LIM EVIDENCE; IMEMDT 10, 85, 1 976. IARC CANCER REVIEW: HUMAN
LIM EVIDENCE; IMEMDT 50, 169, 1990. IARC CANCER REVIEW: ANIMAL
INADEQ EVIDENCE; IMEMDT 10, 85, 1976. IARC CANCER REVIEW: ANIMAL
INADEQ EVIDENCE; IMEMDT 50, 169, 1990. IARC CANCER REVIEW: GRP 2A;
(SARA REGS)
State Regulatory Information:CALIFORNIA PROPOSITION 65: THIS PRODUCT
CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE
CANCER.
======================= Other Information =======================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
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