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Biomolecules for research MATERIAL SAFETY DATA SHEET
Section 1 : Substance Identification
Clindamycin Phosphate
Name: CAS Number: 24729-96-2
Catalog Number: A-192 Chemical Formula: C18H34ClN2O8PS
Chemical Name: 7(S)-Chloro-7-deoxylincomycin-2-phosphate
Synonyms: U-28,508E
Chemical Class: Antibiotic
Company Identification: BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting PA 19462-1202 USA
(610) 941-0430 (9am-5pm ET)
Section 2 : Health Hazard Data
Acute Health Effects: May be harmful if ingested, inhaled, or absorbed through the skin. Symptoms
of overexposure may include: nausea, vomiting, diarrhea, abdominal pain, colitis, esophagitis, skin
rash, neutropenia, thrombocytopenia, juandice or abnormalities in liver function. May be irritating
to skin, eyes, mucous membranes or upper respiratory tract. People who have experienced adverse
reactions to lincomycin, clindamycin or related families of antibiotics should exercise care when
handling this product.
Chronic Health Effects: unknown
Section 3 : First Aid Measures
Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15
minutes separating eyelids. Seek medical attention immediately.
Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes.
Seek medical attention immediately.
Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops,
administer artificial respiration. Seek medical attention immediately. Provide chemical label
and MSDS if possible.
Ingestion: Remove dentures and clear mouth. If person is conscious, rinse mouth with water. Call
physician or poison control immediately. Provide chemical label and MSDS information if
possible.
Section 4 : Fire and Explosion Data
Flammability: Not Available
Flash Point: Not Available
Combustion Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides,
Hydrochloric acid, Phosphorous oxides
Extinguishing Media: Carbon Dioxide, Dry chemical powder, polymer foam, water spray
Special Firefighting Procedures: Use self-contained breathing apparatus and protective clothing to
prevent contact with skin and eyes.
Unusual Fire/Explosion Hazards: None known
Section 5 : Spill or Leak Procedures
Cleanup Procedures: Wearing appropriate protective gear as outlined under 鈥淧rotective equipment鈥?
wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate
the area and wash spill site after material has been removed.
Waste Disposal Method: Observe all Federal, State and Local regulations concerning the disposal of
this product.
Section 6 : Storage and Handling Precautions
Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber
gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or
NIOSH/MSHA approved respirator is required.
Storage and Handling: This product should be stored at 0掳C. It should be kept in a tightly
closed container. This product should be handled only by qualified experienced professionals.
Wash thoroughly after handling this material.
Section 7 : Physical Data
Appearance: White solid Odor: None
Molecular Weight: 505.0 Taste: Not Available
Boiling Point: Not Available Melting Point: 202-204掳C
Solubility: DMSO, Water Vapor Density: Not Available
Specific Gravity: Not Available Vapor Pressure: Not Available
Volatility: Negligible
Section 8 : Stability and Reactivity Data
Stability: This material is stable if stored as directed
Conditions to Avoid: None known
Incompatibles: None known
Section 9 : Toxicity Data
RTECS#: Not Available
I.V. LD50: Rat : 321mg/kg Mouse : 820mg/kg
Oral LD50: Rat : 1832mg/kg Mouse : 2359mg/kg
I.P. LD50: Rat : 745mg/kg Mouse : 784mg/kg
Scu. LD50: Rat : 3861mg/kg Mouse : 1036mg/kg
Section 10 : Ecological Data
Environmental Fate:
Mobility: This compound has no measurable vapor pressure, therefore it is not expected to enter
the air. The compound is freely soluble in water. Based on solubility data, this compound
is expected to be relatively mobile, and to migrate to the aquatic compartment.
Persistence / Degradability: This compound is hydrolyzed at environmental pH. Half-lives are
131 days at pH 9, 262 days at pH 7, and 363 days at pH 5. The compound mineralized
in three soil types: sandy loam, loam, and silty clay loam. Mineralization ratio ranged
from 3.47 to 9.34 in aerobic incubation test systems after 64 days.
Bioaccumulative Potential: The octanol / water partition coefficient of this compound is not
known. However, based on it鈥檚 water solubility, it would be expected to be less then 3,
and thus would have a low potential to bioaccumulate in aquatic organisms.
Abiotic Potential: This compound did not inhibit respiration in activated sewage sludge
suspensions when tested at concentrations of ranging from 6.5 to 528 mg/l
The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of
safe use of this material rests entirely with the user.
Emergency Contact:
BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting, PA 19462 USA
(610) 941-0430
Last Revised : 1/7/04
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