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Biomolecules for research MATERIAL SAFETY DATA SHEET
Section 1 : Substance Identification
SIRT1 Fluorescent Activity Assay/Drug Discovery Kit
Name:
Catalog Number: AK-555
Company Identification: BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting PA 19462-1202 USA
(610) 941-0430 (9am-5pm ET)
Section 2 : Components
Vial # Name: Contents: Quantity
SIRT1 (Sirtuin 1, hSir2SIRT1)
SE-239 Enzyme dissolved in 50 mM Tris, 100 U
(human, recombinant) pH 7.5, 100 mM NaCl, and 10% glycerol
Fluor de Lys-SIRT1
KI-177 5 mM in 25 mM Tris/Cl, pH 8.0, 100 碌l
Deacetylase Substrate 137 mM NaCl, 2.7 mM KCl,
1 mM MgCl2
Fluor de Lys鈩? Developer II
KI-176 5X Stock Solution 5 x 250 碌l
Concentrate (5X)
NAD+
KI-282 50 mM in 25 mM Tris/Cl, pH 8.0 500 碌l
(Sirtuin Substrate) 137 mM NaCl, 2.7 mM KCl,
1 mM MgCl2
*See Attached MSDS for this component
KI-283 Nicotinamide 50 mM in 25 mM Tris/Cl, pH 8.0 500 碌l
(Sirtuin Inhibitor) 137 mM NaCl, 2.7 mM KCl,
1 mM MgCl2
*See Attached MSDS for this component
KI-284 Resveratrol Solid 10 mg
(Sirtuin Activator)
*See Attached MSDS for this component
KI-285 Suramin sodium Solid 10 mg
(Sirtuin Inhibitor)
*See Attached MSDS for this component
Fluor de Lys鈩? Deacetylated Standard
KI-142 10 mM in DMSO 30碌l
KI-286 SIRT1 Assay Buffer 25 mM Tris/Cl, ph 8.0, 137 mM 20ml
NaCl, 2.7 mM KCl, 1 mM MgCl2
1 mg/ml BSA
AK-555 Instruction Booklet 1 booklet
KI-101 陆 Volume Microplate 陆 Volume 96-well plate 1 plate
KI-110 陆 Volume White Microplate White 陆 Volume 96-well plate 1 plate
Section 3 : Health Hazards
Please be advised that the physical, chemical and toxicological properties of many of these components
have not yet been fully investigated. It is therefore advised that all laboratory personnel handling this
product follow standard laboratory safety procedures. It is recommended that personnel wear safety
goggles, gloves, and protective clothing at all times, and avoid direct contact with the reagents supplied in
this kit.
Section 4 : First Aid
Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15
minutes separating eyelids. Seek medical attention immediately
Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes.
If irritation or discomfort develops, seek medical attention.
Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops,
administer artificial respiration. Seek medical attention if patient feels unwell or develops any
respiratory symptoms. Provide chemical label and MSDS if possible.
Ingestion: Remove dentures and clear mouth. If person is conscious, rinse mouth with water. Call
physician or poison control immediately. Provide chemical label and MSDS information if
possible.
Section 5 : Fire / Flammability Information
None of the components of this kit pose a significant risk in case of fire. Fire fighting media should be
selected to suit other materials involved in the fire. It is recommended that firefighters wear protective gear
and self contained breathing apparatus to limit exposure.
Section 6 : Spill or Leak Procedures.
Cleanup Procedures: Wearing appropriate protective gear as outlined under 鈥淧rotective equipment鈥?
wipe up spill area and rinse residue down the drain with plenty of water. Wash spill site with soap
and water.
Waste Disposal Method: Dilute waste solutions and reagents with water and dispose of in accordance
with federal, state, and local regulations.
Section 7 : Storage and Handling Precautions
Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber
gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or
NIOSH/MSHA approved respirator is recommended is the spill involves one of the kit reagents
supplied in solid form. .
Storage and Handling: The components of this kit should be stored 鈥?70掳C with the exception of the
96-well plates, and the instruction booklet which can be stored at room temperature. All
components should be kept in tightly closed containers. This product should be handled only by
qualified experienced professionals. Avoid raising dust when handling components supplied in
solid form. Wash thoroughly after handling the materials included in this kit.
Section 8 : Stability and Reactivity Data
Stability: These materials are stable if stored as directed.
Conditions to Avoid: Avoid repeated freeze/thaw of Enzyme and Developer components.
Incompatibles: Not available
Section 10 : Ecological Data
Ecotoxicological Information: None Available
The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of
safe use of this material rests entirely with the user.
Emergency Contact:
BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting, PA 19462 USA
(610) 941-0430
Last Revised : 1/8/04
庐
Biomolecules for research MATERIAL SAFETY DATA SHEET
Section 1 : Substance Identification
Resveratrol
Name: CAS Number: 501-36-0
Component Number: KI-284 Chemical Formula: C14H12O3
Chemical Name: Trans 2,4鈥?,5-trihydroxy stilbene
Chemical Class: Stilbene derivative
Company Identification: BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting PA 19462-1202 USA
(610) 941-0430 (9am-5pm ET)
Section 2 : Health Hazard Data
Acute Health Effects: May be harmful if ingested, inhaled, or absorbed through the skin. May cause
eye or skin irritation. To the best of our knowledge, the toxicological properties of this compound
have not been fully investigated. All uncharacterized chemicals should be treated as suspected
toxins.
Chronic Health Effects: unknown
Pharmacological Action: Antioxident, Natural product found in grapes.
Section 3 : First Aid Measures
Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15
minutes separating eyelids. Seek medical attention immediately.
Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes.
Seek medical attention immediately.
Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops,
administer artificial respiration. Seek medical attention immediately. Provide chemical label
and MSDS if possible.
Ingestion: Remove dentures and clear mouth. Do NOT induce vomiting. If person is conscious, have
him/her rinse mouth with water and drink serveral glasses of water. Call physician or poison
control immediately. Provide chemical label and MSDS information if possible.
Section 4 : Fire and Explosion Data
Flammability: Not Available
Flash Point: Not Available
Combustion Products: Carbon monoxide, Carbon dioxide
Extinguishing Media: Carbon Dioxide, Dry chemical powder, polymer foam, water spray
Special Firefighting Procedures: Use self-contained breathing apparatus and protective clothing to
prevent contact with skin and eyes.
Unusual Fire/Explosion Hazards: None known
Section 5 : Spill or Leak Procedures
Cleanup Procedures: Wearing appropriate protective gear as outlined under 鈥淧rotective equipment鈥?
wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate
the area and wash spill site after material has been removed.
Waste Disposal Method: Observe all Federal, State and Local regulations concerning the disposal of
this product.
Section 6 : Storage and Handling Precautions
Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber
gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or
NIOSH/MSHA approved respirator is required.
Storage and Handling: This product should be stored at 鈥?20掳C or colder. It should be kept in a tightly
closed container. This product should be handled only by qualified experienced professionals.
Wash thoroughly after handling this material.
Section 7 : Physical Data
Appearance: White solid Odor: Not Available
Molecular Weight: 228.2 Taste: Not Available
Boiling Point: Not Available Melting Point: 260-262掳C
Solubility: DMSO Vapor Density: Not Available
Specific Gravity: Not Available Vapor Pressure: Not Available
Volatility: Not Available
Section 8 : Stability and Reactivity Data
Stability: This material is stable if stored as directed
Conditions to Avoid: None known
Incompatibles: Not Available
Section 9 : Toxicity Data
RTECS#: Not Available
Section 10 : Ecological Data
Ecotoxicological Information: None Available
The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of
safe use of this material rests entirely with the user.
Emergency Contact:
BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting, PA 19462 USA
(610) 941-0430
Last Revised : 10/14/03
庐
Biomolecules for research MATERIAL SAFETY DATA SHEET
Section 1 : Substance Identification
Suramin Sodium
Name: CAS Number: 129-46-4
C51H34N6O23S6鈥a6
Component Number: KI-285 Chemical Formula:
Chemical Name: 8,8鈥?-[carbonylbis[imino-3,1-Phenylenecarbonylimino(4-methyl-3,1-
phenylene)carbonyl-imino]]-bis-1,3,5-Naphthalenetrisulfonic acid hexasodium
salt
Synonyms: Germanin
Chemical Class: Naphthalene Derivative
Company Identification: BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting PA 19462-1202 USA
(610) 941-0430 (9am-5pm ET)
Section 2 : Health Hazard Data
Acute Health Effects: To the best of our knowledge, the toxicological properties of this compound
have not been fully investigated. Exercise appropriate precautions to prevent opportunities for
inhalation, and to prevent direct contact with skin and eyes. All uncharacterized chemicals should
be treated as suspected toxins.
Chronic Health Effects: unknown
Section 3 : First Aid Measures
Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15
minutes separating eyelids. Seek medical attention immediately.
Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes.
Seek medical attention immediately.
Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops,
administer artificial respiration. Seek medical attention immediately. Provide chemical label
and MSDS if possible.
Ingestion: Remove dentures and clear mouth. If person is conscious, rinse mouth with water. Call
physician or poison control immediately. Provide chemical label and MSDS information if
possible.
Section 4 : Fire and Explosion Data
Flammability: Flammable
Flash Point: Not Available
Combustion Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides
Extinguishing Media: Carbon Dioxide, Dry chemical powder, polymer foam, water spray
Special Firefighting Procedures: Use self-contained breathing apparatus and protective clothing to
prevent contact with skin and eyes.
Unusual Fire/Explosion Hazards: None known
Section 5 : Spill or Leak Procedures
Cleanup Procedures: EVACUATE AREA Wearing appropriate protective gear as outlined under
鈥淧rotective equipment鈥? wipe up spill and place in sealed container and hold for disposal. Avoid
raising dust. Ventilate the area and wash spill site after material has been removed.
Waste Disposal Method: Observe all Federal, State and Local regulations concerning the disposal of
this product.
Section 6 : Storage and Handling Precautions
Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber
gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or
NIOSH/MSHA approved respirator is required.
Storage and Handling: This product should be stored at room temperature or colder. It should be kept in
a tightly closed container. This product should be handled only by qualified experienced
professionals. Wash thoroughly after handling this material.
Section 7 : Physical Data
Appearance: White or off-white solid Odor: Negligible
Molecular Weight: 1429.2 Taste: Not Available
Boiling Point: Not Available Melting Point: >320掳C
Solubility: Water l Vapor Density: Not Available
Specific Gravity: Not Available Vapor Pressure: Not Available
Volatility: Not Available
Section 8 : Stability and Reactivity Data
Stability: This material is stable if stored as directed
Conditions to Avoid: None known
Incompatibles: None known
Section 9 : Toxicity Data
RTECS#: Not Available
I.V. LD50: Mouse : 620mg/kg
Section 10 : Ecological Data
Ecotoxicological Information: None Available
The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of
safe use of this material rests entirely with the user.
Emergency Contact:
BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting, PA 19462 USA
(610) 941-0430
Last Revised : 10/14/03
庐
Biomolecules for research MATERIAL SAFETY DATA SHEET
Section 1 : Substance Identification
Nicotinamide
Name: CAS Number: 98-92-0
Component Number: KI-283 Chemical Formula: C 6 H6 N2 O
Chemical Name: 3-Pyridinecarboxamide
Chemical Class: Pyridine derivative
Company Identification: BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting PA 19462-1202 USA
(610) 941-0430 (9am-5pm ET)
Section 2 : Health Hazard Data
Acute Health Effects: May be harmful if ingested, inhaled, or absorbed through the skin. May cause
irritation of the eyes, skin, or respiratory system. Other symptoms of exposure may include anorexia,
excessive salivation, constriction of the pupils, bronchoconstriction, respiratory failure, tightness of the
chest, coma, pulmonary, ureter, and bladder effects. Compound may also be mutagenic. To the best of
our knowledge, the toxicological properties of this compound have not been fully investigated. All
uncharacterized chemicals should be treated as suspected toxins.
Chronic Health Effects: unknown
Target Organs: Eyes, Kidneys, Liver
Section 3 : First Aid Measures
Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15
minutes separating eyelids. Seek medical attention immediately.
Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes.
Seek medical attention immediately.
Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops,
administer artificial respiration. Seek medical attention immediately. Provide chemical label
and MSDS if possible.
Ingestion: Remove dentures and clear mouth. Do NOT induce vomiting. If person is conscious, have
him/her rinse mouth with water. Call physician or poison control immediately. Provide
chemical label and MSDS information if possible.
Section 4 : Fire and Explosion Data
Flammability: Not Available
Flash Point: Not Available
Combustion Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides
Extinguishing Media: Carbon Dioxide, Dry chemical powder, polymer foam, water spray
Special Firefighting Procedures: Use self-contained breathing apparatus and protective clothing to
prevent contact with skin and eyes.
Unusual Fire/Explosion Hazards: None known
Section 5 : Spill or Leak Procedures
Cleanup Procedures: Wearing appropriate protective gear as outlined under 鈥淧rotective equipment鈥?
wipe up spill and place in sealed container and hold for disposal. Ventilate the area and wash spill
site after material has been removed.
Waste Disposal Method: Observe all Federal, State and Local regulations concerning the disposal of
this product.
Section 6 : Storage and Handling Precautions
Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber
gloves, rubber boots, and chemical safety goggles.
Storage and Handling: This product should be stored at 鈥?20掳C or colder. It should be kept in a tightly
closed container. This product should be handled only by qualified experienced professionals.
Wash thoroughly after handling this material.
Section 7 : Physical Data
Appearance: Clear Solution Odor: Not Available
Molecular Weight: 122.1 Taste: Not Available
Boiling Point: Not Applicable Melting Point: Not applicable
Solubility: Supplied dissolved in Assay Buffer Vapor Density: Not Available
Specific Gravity: Not Available Vapor Pressure: Not Available
Volatility: Not Available
Section 8 : Stability and Reactivity Data
Stability: This material is stable if stored as directed
Conditions to Avoid: None known
Incompatibles: Strong oxidizing agents
Section 9 : Toxicity Data
RTECS#: QS3675000
Oral LD50: Mouse : 2500 mg/kg Rat : 3500 mg/kg
S.C. LD50: Mouse : 2 g/kg Rat : 1680 mg/kg
I.P. LD50: Mouse : 2050 mg/kg
Section 10 : Ecological Data
Ecotoxicological Information: None Available
The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of
safe use of this material rests entirely with the user.
Emergency Contact:
BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting, PA 19462 USA
(610) 941-0430
Last Revised : 10/14/03
庐
Biomolecules for research MATERIAL SAFETY DATA SHEET
Section 1 : Substance Identification
NAD+
Name: CAS Number: 53-84-9
Component Number: KI-282 Chemical Formula: C21H27N7O14P2
Chemical Name: 脽-Nicotinamide adenine dinucleotide
Chemical Class: Nucleotide
Company Identification: BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting PA 19462-1202 USA
(610) 941-0430 (9am-5pm ET)
Section 2 : Health Hazard Data
Acute Health Effects: May be harmful if ingested, inhaled, or absorbed through the skin. May cause
irritation of the eyes, skin, or respiratory system. To the best of our knowledge, the toxicological
properties of this compound have not been fully investigated. All uncharacterized chemicals
should be treated as suspected toxins.
Chronic Health Effects: unknown
Section 3 : First Aid Measures
Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15
minutes separating eyelids. Seek medical attention immediately.
Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes.
Seek medical attention immediately.
Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops,
administer artificial respiration. Seek medical attention immediately. Provide chemical label
and MSDS if possible.
Ingestion: Remove dentures and clear mouth. Do NOT induce vomiting. If person is conscious, have
him/her rinse mouth with water and drink several glasses of water. Call physician or poison
control immediately. Provide chemical label and MSDS information if possible.
Section 4 : Fire and Explosion Data
Flammability: Not Available
Flash Point: Not Available
Combustion Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides
Extinguishing Media: Carbon Dioxide, Dry chemical powder, polymer foam, water spray
Special Firefighting Procedures: Use self-contained breathing apparatus and protective clothing to
prevent contact with skin and eyes.
Unusual Fire/Explosion Hazards: None known
Section 5 : Spill or Leak Procedures
Cleanup Procedures: Wearing appropriate protective gear as outlined under 鈥淧rotective equipment鈥?
wipe up spill and place in sealed container and hold for disposal. Ventilate the area and wash spill
site after material has been removed.
Waste Disposal Method: Observe all Federal, State and Local regulations concerning the disposal of
this product.
Section 6 : Storage and Handling Precautions
Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber
gloves, rubber boots, and chemical safety goggles.
Storage and Handling: This product should be stored at 鈥?20掳C or colder. It should be kept in a tightly
closed container. This product should be handled only by qualified experienced professionals.
Wash thoroughly after handling this material.
Section 7 : Physical Data
Appearance: Solution Odor: Not Available
Molecular Weight: 663.4 Taste: Not Available
Boiling Point: Not Applicable Melting Point: Not Applicable
Solubility: Supplied dissolved in Assay Buffer Vapor Density: Not Available
Specific Gravity: Not Available Vapor Pressure: Not Available
Volatility: Not Available
Section 8 : Stability and Reactivity Data
Stability: This material is stable if stored as directed
Conditions to Avoid: None known
Incompatibles: Strong oxidizing agents
Section 9 : Toxicity Data
RTECS#: UU3450000
I.P. LD50: Mouse : 4333 mg/kg
Section 10 : Ecological Data
Ecotoxicological Information: None Available
The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of
safe use of this material rests entirely with the user.
Emergency Contact:
BIOMOL International L.P.
5120 Butler Pike
Plymouth Meeting, PA 19462 USA
(610) 941-0430
Last Revised : 10/14/03
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