Material Safety Data Sheet
Revision date:
Print Date: 08/29/2006
Version: 0
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING
Product name: TaqMan HBV Analyte Specific Reagents "ASR" SET C-TAQ HBV 48 TEST ASR
Product number: 03350924190
Business area: Molecular Diagnostics.
Supplier: Emergency telephone number:
Roche Molecular Systems, Inc. CHEMTREC:
1080 US Highway 202 South 1-800-424-9300 (U.S. or Canada)
Branchburg, NJ 08876-3733 1-703-527-3887 (International)
Technical Support: 1-800-526-1247
2. COMPOSITION/INFORMATION ON INGREDIENTS
Description 1: Master Mix
Components CAS Number Weight % OSHA PEL: OSHA STEL: ACGIH TLV: ACGIH STEL:
Potassium acetate 127-08-2 1-5 NA NA NA NA
Glycerol 56-81-5 1-10 15 mg/m鲁 NA 10 mg/m鲁 NA
5 mg/m鲁
Tricine 5704-04-1 1-5 NA NA NA NA
Description 2: Quantitation Standard
Components CAS Number Weight % OSHA PEL: OSHA STEL: ACGIH TLV: ACGIH STEL:
No hazardous components >1%, NONE N/A NA NA NA NA
>0.1% carcinogen
3. HAZARDS IDENTIFICATION
Emergency Overview
NFPA Ratings: Health= 1 Flammability= 0 Reactivity= 0 Special= I
Special Definitions: A=Allergen CA=Carcinogen CO=Corrosive F=Flammable H=Harmful I=Irritant Ox=Oxidizer PB=Potential Biohazard
R=Reproductive S=Sensitizer T=Toxic T+=Highly Toxic W=Water Reactive
Principle routes of exposure: Ingestion, inhalation, skin absorption, skin and/or eye contact.
Inhalation: Avoid breathing vapors or mists. May cause irritation of respiratory tract.
Ingestion: Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhea
Skin contact: Prolonged skin contact may cause irritation.
Eye contact: Contact with eyes may cause irritation
Sensitization or Odor threshold: The following chemical(s) may cause sensitization, be absorbed via skin, and/or has an odor threshold for
detection:
Medical conditions aggravated by Persons with pre-existing skin disorders or impaired liver, kidney, and pulmonary function may be more
exposure: susceptible to the effects of this material.
Additional information: None
4. FIRST AID MEASURES
Inhalation: Consult a physician. Move to fresh air. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen
Skin contact: Rinse with plenty of water. If skin irritation persists, call a physician. Remove and wash contaminated
clothing before re-use
Ingestion: Consult a physician. Do not induce vomiting without medical advice
Eye contact: In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice
Notes to physician: None determined
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media: Use dry chemical, CO2, water spray or `alcohol` foam
Unusual hazards: None known
Special protective equipment for Wear self contained breathing apparatus for fire fighting if necessary
firefighters:
6. ACCIDENTAL RELEASE MEASURES
Personal precautions: Use personal protective equipment. Evacuate personnel to safe areas
Environmental precautions: Prevent further leakage or spillage if safe to do so. Prevent product from entering drains.
Methods for cleaning up: Never return spills in original containers for re-use. Sweep up or vacuum (if powder) or soak up with inert
absorbent material (if liquid), then place into a suitable clean, dry, closed container, and label for disposal
7. HANDLING AND STORAGE
Handling: Protect from contamination. Wear personal protective equipment
Storage: No special precautions required
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering measures: Ensure adequate ventilation. Where reasonably practicable this should be achieved by the use of local
exhaust ventilation and good general extraction.
Personal Protective Equipment
Respiratory protection: Respiratory protection is not required under normal use of this product. If respiratory protection is needed,
follow the OSHA regulation, 29CFR1910.134. Always use a NIOSH approved respirator when necessary
Hand protection: Wear appropriate protective gloves to prevent skin contact. Replace torn or punctured gloves promptly
Skin and body protection: Wear appropriate body protection to prevent skin contact
Eye protection: Wear appropriate eye protection to prevent eye contact
Hygiene measures: Avoid contact with skin, eyes and clothing
9. PHYSICAL AND CHEMICAL PROPERTIES
Color: Quantitation standard = red to pink. Master Mix = blue to purple.
Odor: None.
pH: ~8
Physical state: Liquid.
Solubility in water: Soluble.
10. STABILITY AND REACTIVITY
Stability: Stable under recommended storage conditions
Polymerization: Not applicable
Hazardous decomposition products: Carbon oxides
Materials to avoid: Strong acids and strong bases. Strong oxidising agents
11. TOXICOLOGICAL INFORMATION
Components NIOSH - NIOSH Pocket Guide -
Selected LD50s and LC50s: Target Organs:
Potassium acetate = 3250 mg/kg Oral LD50 Rat
Glycerol = 12600 mg/kg Oral LD50 Rat respiratory system, skin, eyes, kidneys
= 4090 mg/kg Oral LD50 Mouse
> 10 g/kg Dermal LD50 Rabbit
> 570 mg/m鲁 Inhalation LC50 Rat 1 h
Product number: 03350924190 Page 2 of 4
Product name: TaqMan HBV Analyte Specific Reagents "ASR" SET C-TAQ HBV 48 TEST ASR
Inhalation: No additional data available
Skin: No additional data available
Oral: No additional data available
Mutagenic effects: No data is available on the product itself
Reproductive toxicity: No data is available on the product itself
Carcinogenic effects:
12. ECOLOGICAL INFORMATION
Bioaccumulation: Components of this product will degrade in the environment to smaller organic and inorganic constituents.
Aquatic toxicity: Because of the small volume of solutions in this product, no unusual effects on aquatic plants or animals
are expected if this product is released into the environment.
Ecotoxicity effects: No data is available on the product itself
Components Ecotoxicity - Ecotoxicity - Ecotoxicity - Ecotoxicity -
Fish Species Data Microtox Data Water Flea Data Freshwater Algae Data
Glycerol = 50 mg/L LC50 rainbow
trout 96 h
> 5000 mg/L LC50 goldfish
96 h
13. DISPOSAL CONSIDERATIONS
Waste from residues / unused products: Waste disposal must be in accordance with appropriate Federal, State, and local regulations. This product,
if unaltered by use, may be disposed of by treatment at a permitted facility or as advised by your local
hazardous waste regulatory authority. Residue from fires extinguished with this material may be
hazardous.
14. TRANSPORT INFORMATION
Is product hazardous to ship? No
DOT
Proper shipping name: None
UN Number: Not applicable Hazard class: Not applicable Subsidiary risk: Not applicable Packing group: Not applicable
ICAO/IATA
Proper shipping name: None
UN Number: Not applicable Hazard class: Not applicable Subsidiary risk: Not applicable Packing group: Not applicable
15. REGULATORY INFORMATION
U.S. Regulations:
U.S. CERCLA/SARA/TSCA Regulatory Information: The following chemicals are listed under the following TSCA/SARA/CERCLA lists. Refer to
TSCA regulation if you need a definition for acronyms that may be shown in the TSCA Inventory field in the table below
Components CERCLA/SARA 302 CERCLA/SARA 304 SARA 313 TSCA Inventory
RQ and TPQ RQ Emission reporting
(40 CFR 355, App.A) (40 CFR Table 302.4)
Potassium acetate Present
Glycerol Present
Tricine Present
U.S. Clean Water Act (CWA)/ California The following chemicals are listed under the CWA and/or California Proposition 65:
Proposition 65:
Canadian Regulations:
Canada DSL Inventory List - This product complies with DSL
Canada NDSL Inventory List - This product does not comply with NDSL
Product number: 03350924190 Page 3 of 4
Product name: TaqMan HBV Analyte Specific Reagents "ASR" SET C-TAQ HBV 48 TEST ASR
Components Canada - WHMIS: Classifications of Substances:
Potassium acetate Uncontrolled product according to WHMIS classification criteria.
Glycerol Uncontrolled product according to WHMIS classification criteria.
16. OTHER INFORMATION
Reason for revision: Not applicable
References: None
Additional advice: None
Prepared by: Roche Diagnostics, Health & Safety Department, MSDS Contact: 317-521-7425 or 317-521-7505
The information, data and recommendations contained herein are based upon information believed by Roche Diagnostics Corporation, after reasonable investigation and
research, to be accurate; however, Roche Diagnostics Corporation does not warrant the accuracy of this information. All materials and mixtures may present unknown
hazards and should be used with caution. When necessary or appropriate, independent opinions regarding the risk of handling or exposure should be obtained from trained
professionals. Roche Diagnostics Corporation disclaims any warranty against patent infringement and the implied warranties of merchantability and fitness for a particular
purpose. Customer's sole and exclusive remedy shall be replacement of the product or return of the product and refund of the purchase price, at Roche Diagnostics
Corporation's option. In no case shall Roche Diagnostics Corporation be liable for incidental or consequential damages, including lost profits.
End of Safety Data Sheet
Product number: 03350924190 Page 4 of 4
Product name: TaqMan HBV Analyte Specific Reagents "ASR" SET C-TAQ HBV 48 TEST ASR
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