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MSDS Material Safety Data Sheet
CAS

115-69-5

File Name: mylabonline_com---44552.asp
                                        Material Safety Data Sheet
Authorization date: 11/17/2000
Revision date: 06/14/2002
Print Date: 11/12/2004
Version: 0


1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING

Product name: Alkaline Phosphatase
Product number: 44552
Business area: Point of Care.
Product line: Mira.
Instrument type: Not applicable.

Supplier: Emergency telephone number:
Roche Diagnostics Corporation CHEMTREC:
9115 Hague Road 1-800-424-9300 (U.S. or Canada)
Indianapolis, IN 46250 1-703-527-3887 (International)
Site Phone Number: 1-800-428-5074


2. COMPOSITION/INFORMATION ON INGREDIENTS

Component 1: Bottle 1
Components CAS Number Weight % OSHA PEL: OSHA STEL: ACGIH TLV: ACGIH STEL:
2-Amino-2-methyl-1,3-propanediol 115-69-5 1-5 NA NA NA NA



3. HAZARDS IDENTIFICATION

Emergency Overview

NFPA Ratings: Health= 1. Flammability= 0 Reactivity= 0 Special= I.
Special Definitions: A=Allergen CA=Carcinogen CO=Corrosive F=Flammable H=Harmful I=Irritant Ox=Oxidizer PB=Potential Biohazard
R=Reproductive S=Sensitizer T=Toxic T+=Highly Toxic W=Water Reactive

Principle routes of exposure: Ingestion, skin and/or eye contact.

Inhalation: None.

Ingestion: Ingestion may cause gastrointestinal irritation, nausea, vomiting and
diarrhea.

Skin contact: Substance may cause slight skin irritation.

Eye contact: May cause slight irritation.

Sensitization: None.

Medical conditions aggravated by exposure: None known

Additional information: None

Target organ effects: The following chemical(s) have target organ effects:


4. FIRST AID MEASURES

Inhalation: Consult a physician. Move to fresh air. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen.

Skin contact: Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists, call a
physician.

Ingestion: Call a physician immediately. Do not induce vomiting without medical advice.

Eye contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.

Notes to physician: None determined
5. FIRE-FIGHTING MEASURES

Suitable extinguishing media: Use dry chemical, CO2, water spray or "alcohol" foam.

Unusual hazards: None known.

Special protective equipment for firefighters: In the event of fire, wear self-contained breathing apparatus.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions: Use personal protective equipment. Evacuate personnel to safe areas. Remove all sources of ignition.
Environmental precautions: Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. Do not flush
into surface water or sanitary sewer system. Do not let product enter drains.
Methods for cleaning up: Never return spills in original containers for re-use. Soak up with oil absorbent material. Sweep up or
vacuum (if powder) or soak up with inert absorbent material (if liquid), then place into a suitable clean,
dry, closed container, and label for disposal.

7. HANDLING AND STORAGE

Handling: Protect from contamination. Wear personal protective equipment.
Storage: No special precaustions required.

8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering measures: Not applicable.

Personal Protective Equipment

Respiratory protection: Respiratory protection is not required under normal use of this product. If respiratory protection is
needed, follow the OSHA regulation, 29CFR1910.134. Always use a NIOSH approved respirator when
necessary.

Hand protection: Wear appropriate protective gloves to prevent skin contact. Replace torn or punctured gloves
promptly.

Skin and body protection: Wear appropriate body protection to prevent skin contact.

Eye protection: Wear appropriate eye protection to prevent eye contact.

Hygiene measures: When using, do not eat, drink or smoke. Keep away from food and drink. Wash hands before breaks
and at the end of workday.

Exposure limit(s)


9. PHYSICAL AND CHEMICAL PROPERTIES

Boiling point/range: No information available
Melting point/range: Not determined
pH: 10.4
Physical state: Not determined.
Flash point: No information available.
LEL (%): Not determined
UEL (%): Not determined

10. STABILITY AND REACTIVITY

Stability: Stable under recommended storage conditions.
Polymerization: None under normal processing.
Hazardous decomposition products: No data available.
Materials to avoid: Incompatible with strong acids and bases. Oxidising agents (strong).

11. TOXICOLOGICAL INFORMATION




Product number: 44552 Page 2 of 4
Product name: Alkaline Phosphatase
Components EPA-IRIS Oral Reference Dose EPA-IRIS Inhalation Reference NIOSH -
(RfD) Information: Concentration (RfC) Information: Selected LD50s and LC50s:
2-Amino-2-methyl-1,3-propanediol = 17 g/kg Oral LD50 Rat


Inhalation: No data available
Skin: No data available
Oral: No data available
Mutagenic effects: No data is available on the product itself
Reproductive toxicity: No data is available on the product itself
Carcinogenic effects:


12. ECOLOGICAL INFORMATION

Bioaccumulation: Not determined

Aquatic toxicity: Not applicable

Ecotoxicity effects:


13. DISPOSAL CONSIDERATIONS

Waste from residues / unused products: Waste disposal must be in accordance with appropriate Federal, State, and local regulations. This
product, if unaltered by use, may be disposed of by treatment at a permitted facility or as advised by your local hazardous waste regulatory
authority. Residue from fires extinguished with this material may be hazardous.

14. TRANSPORT INFORMATION

Is product hazardous to ship? No

DOT

Proper shipping name: None
UN Number: Not applicable Hazard class: Not applicable Subsidiary risk: Not applicable Packing group: Not applicable

ICAO/IATA

Proper shipping name: None
UN Number: Not applicable Hazard class: Not applicable Subsidiary risk: Not applicable Packing group: Not applicable


15. REGULATORY INFORMATION

U.S. Regulations:

U.S. TSCA/SARA/CERCLA Regulatory Information: The following chemicals are listed under the following TSCA/SARA/CERCLA lists


Components CERCLA/SARA 302 CERCLA/SARA 304 SARA 313 TSCA Inventory
RQ and TPQ RQ Emission reporting
(40 CFR 355, App.A) (40 CFR Table 302.4)
2-Amino-2-methyl-1,3-propanediol Present


U.S. Clean Air Act (CAA): The following chemicals are listed under the following CAA lists

U.S. Clean Water Act (CWA): The following chemicals are listed under the following CWA lists

California Safe Drinking Water and Toxic Enforcement Act (Prop 65): The following chemicals are listed under the California Prop 65 list

Canadian Regulations:

Canada DSL Inventory List - This product complies with DSL
Canada NDSL Inventory List - This product does not comply with NDSL

Components Canada - WHMIS: Classifications of Substances:
2-Amino-2-methyl-1,3-propanediol E



Product number: 44552 Page 3 of 4
Product name: Alkaline Phosphatase
16. OTHER INFORMATION

Reason for revision: Not applicable
References: None.
Additional advice: None
Prepared by: Roche Diagnostics Corporation, Safety and Environmental Department, MSDS Contact: 317-521-7425

The information, data and recommendations contained herein are based upon information believed by Roche Diagnostics Corporation ("RDC"), after reasonable
investigation and research, to be accurate; however, RDC does not warrant the accuracy of this information. All materials and mixtures may present unknown hazards
and should be used with caution. When necessary or appropriate, independent opinions regarding the risk of handling or exposure should be obtained from trained
professionals. RDC disclaims any warranty against patent infringement and the implied warranties of merchantability and fitness for a particular purpose. Customer's
sole and exclusive remedy shall be replacement of the product or return of the product and refund of the purchase price, at RDC's option. In no case shall RDC be
liable for incidental or consequential damages, including lost profits.

End of Safety Data Sheet




Product number: 44552 Page 4 of 4
Product name: Alkaline Phosphatase

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