File No. MPCR-191 Rev.1.0 Page 1 of 10
EFFECTIVE: JUL-03
SUPERSEDES: JAN-03
MATERIAL SAFETY DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
PART I What is the material and what do I need to know in an emergency?
1. PRODUCT IDENTIFICATION
TRADE NAME (AS LABELED): COBAS TaqMan鈩? HBV TEST KIT (HPS)
PRODUCT USE: For in vitro use
ORDER NUMBER: 03500748190 (RUO), 03604322190 (IUO),
03500756190 (EXPT-IVD), 03577163190 (US-IVD)
SUPPLIER/MANUFACTURER'S NAME: ROCHE MOLECULAR SYSTEMS, INC.
ADDRESS: Branchburg Township, 1080 US Highway 202
Somerville, NJ 08876-3771
EMERGENCY PHONE: 1-800-451-8346
ROCHE RESPONSE CENTER 1-800-526-1247 (For Technical Assistance)
2. COMPOSITION and INFORMATION ON INGREDIENTS
This Material Safety Data sheet describes the COBAS TaqMan鈩? HBV TEST KIT (HPS) which is used in conjunction with the HIGH PURE
SYSTEM VIRAL NUCEIC ACID KIT, sample preparation kit. This product consists of six reagents. This Material Safety Data Sheet provides
complete information on all the components described in the following tables. Unless otherwise specified, the information in each of the
following sections (Sections 3鈥?16) of this document is pertinent to each solution.
CHEMICAL NAME CAS # %w/w EXPOSURE LIMITS IN AIR
ACGIH-TLV OSHA-PEL NIOSH OTHER
TWA STEL TWA STEL IDLH
mg/m3 mg/m3 mg/m3 mg/m3 mg/m3 mg/m3
COMPONENT 1: COBAS TaqMan HBV MASTER MIX; Code 00058004660 (RUO), 03604373001 (IUO),
0352261001 (IVD), 00058004221 (Bulk)
Potassium Acetate 127-08-2 1鈥?5 NE NE NE NE NE NE
5704-04-1 1鈥?5 NE NE NE NE NE NE
N-Tris(hydroxymethyl)-
methylglycine (Tricine)
Glycerin 56-81-5 1鈥?10 10 NE 15 (Total dust); 5 NE NE NE
(Respirable fraction)
(exposure limits are for
10 (Total dust); 5
glycerin mist)
(Respirable fraction)
[vacated 1989 PEL]
Water and other constituents. Each of the Balance None of the other constituents in this mixture contribute significantly to the hazards
other constituents are present in less than associated with this component. All hazard information pertinent to this product has
1 percent concentration (0.1% been provided in this Material Safety Data Sheet, per the requirements of the U.S.
concentration for potential carcinogens, Federal Occupational Safety and Health Administration Standard (29 CFR
reproductive toxins, respiratory tract 1910.1200), U.S. State equivalent standards, and Canadian Workplace Hazardous
sensitizers, and mutagens). Materials Identification System Standards (CPR 4).
COMPONENT 2: COBAS TaqMan HBV QUANTITATION STANDARD; Code 00058004686 (RUO), 03604365001 (IUO),
03522695001 (IVD), 00058004195 (Bulk)
Water and other constituents. Each of the Balance None of the other constituents in this mixture contribute significantly to the hazards
other constituents are present in less than associated with this component. All hazard information pertinent to this product has
1 percent concentration (0.1% been provided in this Material Safety Data Sheet, per the requirements of the U.S.
concentration for potential carcinogens, Federal Occupational Safety and Health Administration Standard (29 CFR
reproductive toxins, respiratory tract 1910.1200), U.S. State equivalent standards, and Canadian Workplace Hazardous
sensitizers, and mutagens). Materials Identification System Standards (CPR 4).
NE = Not Established. See Section 16 for Definitions of Terms Used.
NOTE: ALL WHMIS required information is included in appropriate sections based on the ANSI Z400.1-1998 format. This product has been
classified in accordance with the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.
File No. MPCR-191 Rev. 1.0 Page 2 of 10
COBAS TaqMan鈩? HBV TEST KIT
2. COMPOSITION and INFORMATION ON INGREDIENTS (Continued)
CHEMICAL NAME CAS # %w/w EXPOSURE LIMITS IN AIR
ACGIH-TLV OSHA-PEL NIOSH OTHER
TWA STEL TWA STEL IDLH
mg/m3 mg/m3 mg/m3 mg/m3 mg/m3 mg/m3
COMPONENT 3: COBAS TaqMan MANGANESE ACETATE; Code 00058004958 (RUO), 03605094001 (IUO),
0058005038 (IVD), 00058004133 (Bulk)
Manganese (II) Acetate, 6156-78-1 1鈥?5 NE NE NE NE NE NE
Tetrahydrate
Water and other constituents. Each of Balance None of the other constituents in this mixture contribute significantly to the hazards
the other constituents are present in less associated with this component. All hazard information pertinent to this product has
than 1 percent concentration (0.1% been provided in this Material Safety Data Sheet, per the requirements of the U.S.
concentration for potential carcinogens, Federal Occupational Safety and Health Administration Standard (29 CFR 1910.1200),
reproductive toxins, respiratory tract U.S. State equivalent standards, and Canadian Workplace Hazardous Materials
sensitizers, and mutagens). Identification System Standards (CPR 4).
COMPONENT 4: COBAS TaqMan HBV LOW POSITIVE CONTROL; Code 00058004689 (RUO), 03604347001 (IUO),
00058004281 (IVD), 00058004281 (Bulk)
Human Plasma and other constituents. > 99 None of the constituents in this mixture have an established exposure limit or
Each of the other constituents are contribute significantly to the hazards associated with the product. The Human
present in less than 0.1 percent Plasma has been tested by US FDA licensed tests and is not reactive for antibody to
concentration. HCV, antibody to HIV-1/HIV-2, HIV p24 antigen, HbsAg, and antibody to HbcAg.
Negative for HIV-1 RNA, HCV RNA, and HBV DNA by COBAS AmpliScreen Tests.
However, no known test method can offer complete assurance that products derived
from human blood will not transmit infectious agents. It is prudent practice to regard
this component as a potentially infectious material and to handle it in accordance with
Universal Precautions and the OSHA Bloodborne Pathogen Standard (29 CFR
1910.1030).
COMPONENT 5: COBAS TaqMan HBV HIGH POSITIVE CONTROL; Code 00058004690 (RUO), 03604349001 (IUO),
03522580001 (IVD), 00058004280 (Bulk)
Human Plasma and other constituents. > 99 None of the constituents in this mixture have an established exposure limit or
Each of the other constituents are contribute significantly to the hazards associated with the product. The Human
present in less than 0.1 percent Plasma has been tested by US FDA licensed tests and is not reactive for antibody to
concentration. HCV, antibody to HIV-1/HIV-2, HIV p24 antigen, HbsAg, and antibody to HbcAg.
Negative for HIV-1 RNA, HCV RNA, and HBV DNA by COBAS AmpliScreen Tests.
However, no known test method can offer complete assurance that products derived
from human blood will not transmit infectious agents. It is prudent practice to regard
this component as a potentially infectious material and to handle it in accordance with
Universal Precautions and the OSHA Bloodborne Pathogen Standard (29 CFR
1910.1030).
COMPONENT 6: COBAS TaqMan NEGATIVE CONTROL; Code 00058004136 (RUO), 03605132001 (IUO),
03561119001 (IVD) , 00058004486 (Bulk)
Human Plasma and other constituents. > 99 None of the constituents in this mixture have an established exposure limit or
Each of the other constituents are contribute significantly to the hazards associated with the product. The Human
present in less than 0.1 percent Plasma has been tested by US FDA licensed tests and is not reactive for antibody to
concentration. HCV, antibody to HIV-1/HIV-2, HIV p24 antigen, HbsAg, and antibody to HbcAg.
Negative for HIV-1 RNA, HCV RNA, and HBV DNA by COBAS AmpliScreen Tests.
However, no known test method can offer complete assurance that products derived
from human blood will not transmit infectious agents. It is prudent practice to regard
this component as a potentially infectious material and to handle it in accordance with
Universal Precautions and the OSHA Bloodborne Pathogen Standard (29 CFR
1910.1030).
NE = Not Established. See Section 16 for Definitions of Terms Used.
NOTE (1): ALL WHMIS required information is included in appropriate sections based on the ANSI Z400.1-1998 format. This product has been
classified in accordance with the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.
NOTE (2): Unless otherwise indicated, the hazard assessments in the following sections are pertinent to all component reagents.
3. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: The QUANTITATION STANDARD is a clear, red, odorless liquid. The LOW POSITIVE
CONTROL, HIGH POSITIVE CONTROL, and NEGATIVE CONTROL are colorless to yellow, clear to hazy, odorless liquids.
The Human Plasma has been tested by US FDA licensed tests and is not reactive for antibody to HCV, antibody to HIV-
1/HIV-2, HIV p24 antigen, HbsAg, and antibody to HbcAg. Negative for HIV-1 RNA, HCV RNA, and HBV DNA by COBAS
AmpliScreen Tests. However, no known test method can offer complete assurance that products derived from human blood
will not transmit infectious agents. It is prudent practice to regard these components as potentially infectious materials and to
handle them in accordance with Universal Precautions and the OSHA Bloodborne Pathogen Standard (29 CFR 1910.1030).
(section continued on next page)
File No. MPCR-191 Rev. 1.0 Page 3 of 10
COBAS TaqMan鈩? HBV TEST KIT
3. HAZARD IDENTIFICATION (Continued)
EMERGENCY OVERVIEW (continued): ALL OTHER COMPONENTS are clear, colorless, odorless liquids. The components
of this product present no significant contact, fire or reactivity hazards; the chief hazard to emergency responders is the
potential for irritation of contaminated skin or eyes. In the event of a fire, this product will not contribute significant additional
hazards. Emergency responders must wear personal protective equipment suitable for the situation to which they are
responding.
SYMPTOMS OF OVEREXPOSURE BY ROUTE OF EXPOSURE:
HAZARDOUS MATERIAL IDENTIFICATION SYSTEM
No adverse health effects should occur from routine, occupational
use of this product鈥檚 components in the manner specified by the
manufacturer's instructions. The potential health effects of this
(BLUE) 1
HEALTH HAZARD
product鈥檚 components are as follows:
INHALATION: Inhalation of vapors, mists, or sprays of these
components may slightly irritate the nose, throat, and lungs.
Symptoms are generally alleviated upon breathing fresh air.
FLAMMABILITY HAZARD (RED) 0
CONTACT WITH SKIN or EYES: Contact with the skin or eyes may
cause mild irritation, which is alleviated upon rinsing.
SKIN ABSORPTION: Skin absorption is not known to be a potential
route of exposure for any constituents in these components. PHYSICAL HAZARD (YELLOW) 0
INGESTION: Ingestion is not anticipated to be a significant route of
exposure for the product鈥檚 solutions. Symptoms of such
overexposure are described below. If these components are B
PROTECTIVE EQUIPMENT
swallowed they may cause gastric distress. Large doses may
cause nausea, vomiting, and diarrhea.
EYES HANDS BODY
RESPIRATORY
INJECTION:
LOW POSITIVE CONTROL, HIGH POSITIVE CONTROL, and
SEE SECTION 8
NEGATIVE CONTROL: Though not anticipated to be a significant SEE SECTION 8
route of exposure, injection of these products can cause reddening
and local swelling. The Human Plasma has been tested by US FDA For Routine Use and Handling Applications
licensed tests and is not reactive for antibody to HCV, antibody to
HIV-1/HIV-2, HIV p24 antigen, HbsAg, and antibody to HbcAg. See Section 16 for Definition of Ratings
Negative for HIV-1 RNA, HCV RNA, and HBV DNA by COBAS
AmpliScreen Tests. However, no known test method can offer complete assurance that products derived from
human blood will not transmit infectious agents. It is prudent practice to regard these components as a potentially
infectious materials and to handle them in accordance with Universal Precautions and the OSHA Bloodborne
Pathogen Standard (29 CFR 1910.1030).
ALL OTHER COMPONENTS: Accidental injection of these components, via laceration or puncture by a
contaminated object, may cause local reddening, tissue swelling, and discomfort in addition to the wound.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms.
ACUTE: Beyond mild irritation of the skin or eyes, contact with these components does not usually cause acute
health effects.
CHRONIC: These components are not known to cause any significant chronic health effects.
TARGET ORGANS: ACUTE: Eyes, gastrointestinal tract. CHRONIC: None known.
PART II What should I do if a hazardous situation occurs?
4. FIRST-AID MEASURES
Victims of chemical exposure must be taken for medical attention. Rescuers should be taken for medical attention, if
necessary. Take a copy of label and MSDS to physician or health professional with victim.
SKIN EXPOSURE: Basic hygiene should prevent any problems. If contact with this product causes reddening,
inflammation, or irritation, flush the exposed area with running water. Remove any contaminated clothing, taking care
not to contaminate eyes. The contaminated individual must seek medical attention if any adverse effect develops
after the area is flushed.
EYE EXPOSURE: If liquid or vapors of this product enter the eyes, open victim's eyes while under gently running
water. Use sufficient force to open eyelids. Have victim "roll" eyes. Minimum flushing is for 15 minutes. The
contaminated individual must seek immediate medical attention after flushing if any adverse effect occurs.
File No. MPCR-191 Rev. 1.0 Page 4 of 10
COBAS TaqMan鈩? HBV TEST KIT
4. FIRST-AID MEASURES (Continued)
INHALATION: If vapors, mists, or sprays of this product are inhaled, causing irritation, remove victim to fresh air. If
necessary, use artificial respiration to support vital functions. Seek medical attention if adverse effect continues after
removal to fresh air.
INGESTION: If this product is swallowed, CALL PHYSICIAN OR POISON CONTROL CENTER FOR MOST
CURRENT INFORMATION. DO NOT INDUCE VOMITING, unless directed by medical personnel. If conscious,
have victim rinse mouth with water. Never induce vomiting or give diluents (milk or water) to someone who is
unconscious, having convulsions, or unable to swallow.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Pre-existing dermatitis, other skin conditions, respiratory
conditions, conditions impacting the central nervous system, and kidney and liver disorders may be aggravated by
overexposure to components of this product.
RECOMMENDATIONS TO PHYSICIANS: Treat symptoms and eliminate overexposure.
5. FIRE-FIGHTING MEASURES
FLASH POINT: Not applicable.
AUTOIGNITION TEMPERATURE: Not applicable.
NFPA RATING
FLAMMABLE LIMITS (in air by volume, %):
FLAMMABILITY
Lower (LEL): Not applicable.
Upper (UEL): Not applicable.
FIRE EXTINGUISHING MATERIALS: In the event of a fire, use 0
suppression methods for surrounding materials.
Water Spray: YES Carbon Dioxide: YES 1 0
HEALTH REACTIVITY
Dry Chemical: YES Halon: NO
Foam: YES Other: Any "ABC" Class.
UNUSUAL FIRE AND EXPLOSION HAZARDS: When involved in a
fire, this product鈥檚 components may decompose and produce
irritating fumes and toxic gases (including carbon monoxide, carbon OTHER
dioxide, and oxides of potassium and manganese).
See Section 16 for
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Definition of Ratings
Explosion Sensitivity to Static Discharge: Not sensitive.
SPECIAL FIRE-FIGHTING PROCEDURES: Move containers from fire area if it can be done without risk to
personnel. Incipient fire responders should wear eye protection. Structural firefighters must wear Self-Contained
Breathing Apparatus and full protective equipment. Chemical resistant clothing may be necessary. If possible,
prevent runoff water from entering storm drains, bodies of water, or other environmentally sensitive areas.
6. ACCIDENTAL RELEASE MEASURES
SPILL AND LEAK RESPONSE: For small releases, take basic hygiene precautions. Lightweight gloves, a lab coat,
and eye protection should be worn. Absorb spilled liquid with paper towels. Wash contaminated area with soap and
water, absorb with paper towels, and rinse with water. Trained personnel using pre-planned procedures should
respond to large releases that are not immediately controlled. Proper protective equipment should be used. In case
of a non-incidental spill, clear the affected area and protect people. Minimum Personal Protective Equipment should
be Level D: lab-gloves, chemical resistant apron, boots, and splash goggles. Respiratory protection should
not be necessary. Absorb spilled liquid with polypads or other suitable absorbent materials. If LOW POSITIVE
CONTROL, HIGH POSITIVE CONTROL, or NEGATIVE CONTROL are released, disinfect area with 0.5%
hypochlorite solution (a freshly prepared 1:10 dilution of Chlorox). Decontaminate the area thoroughly. Place all spill
residue in a suitable container and seal. Dispose of in accordance with U.S. Federal, State, and local hazardous
waste disposal regulations and those of Canada and it鈥檚 Provinces (see Section 13, Disposal Considerations).
PART III How can I prevent hazardous situations from occurring?
7. HANDLING and STORAGE
WORK PRACTICES AND HYGIENE PRACTICES: As with all chemicals, avoid getting this product ON YOU or IN
YOU. Wash thoroughly after handling this product. Avoid splashing or spraying this product. Do not eat or drink
while handling this product. It is prudent practice to regard LOW POSITIVE CONTROL, HIGH POSITIVE
CONTROL, and NEGATIVE CONTROL as potentially infectious materials and to handle them in accordance with
Universal Precautions and the OSHA Bloodborne Pathogen Standard (29 CFR 1910.1030).
File No. MPCR-191 Rev. 1.0 Page 5 of 10
COBAS TaqMan鈩? HBV TEST KIT
7. HANDLING and STORAGE (Continued)
STORAGE AND HANDLING PRACTICES: All employees who handle this material should be trained to handle it
safely. Avoid breathing vapors or mists generated by this product. Ensure containers of this product are properly
labeled. Open containers slowly on a stable surface. Store vials as directed in the product insert. Keep vials tightly
closed when not in use. Store away from incompatible materials. Inspect vials containing this product for leaks or
damage. Read instructions provided with the product prior to use.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices
indicated in Section 6 (Accidental Release Measures). Make certain that application equipment is locked and tagged-
out safely, as applicable. Collect all rinsates and dispose of according to applicable Federal, State, or local
procedures.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Use with adequate ventilation to ensure exposure levels are
maintained below the limits provided in Section 2 (Composition and Information on Ingredients), if applicable. Ensure
eyewash/safety shower stations are available near areas where this product is used.
RESPIRATORY PROTECTION: Respiratory protection is not generally needed when using this product. Maintain
airborne contaminant concentrations below limits listed in Section 2 (Composition and Information on Ingredients). If
respiratory protection is needed, use only protection authorized in the U.S. Federal OSHA Standard (29 CFR
1910.134), applicable U.S. State regulations, or the Canadian CSA Standard Z94.4-93 and applicable standards of
Canadian Provinces. Oxygen levels below 19.5% are considered IDLH by OSHA. In such atmospheres, use of a
full-facepiece pressure/demand SCBA or a full facepiece, supplied air respirator with auxiliary self-contained air
supply is required under OSHA鈥檚 Respiratory Protection Standard (1910.134-1998).
EYE PROTECTION: Splash goggles or safety glasses. If necessary, refer to U.S. OSHA 29 CFR 1910.133, or
Canadian Standards.
HAND PROTECTION: Wear butyl rubber gloves for routine industrial use. If necessary, refer to U.S. OSHA 29 CFR
1910.138 or appropriate Standards of Canada.
BODY PROTECTION: Use body protection appropriate for task, such as a lab coat. If a hazard of injury to the feet
exists due to falling objects, rolling objects, where objects may pierce the soles of the feet or where employee鈥檚 feet
may be exposed to electrical hazards, use foot protection, as described in U.S. OSHA 29 CFR.
9. PHYSICAL and CHEMICAL PROPERTIES
FOR ALL COMPONENTS UNLESS OTHERWISE INDICATED:
RELATIVE VAPOR DENSITY (air = 1): Not established. EVAPORATION RATE (nBuAc = 1): Similar to water.
SPECIFIC GRAVITY (water = 1): 1.001鈥?1.172 FREEZING/MELTING POINT: Not established.
SOLUBILITY IN WATER: Completely soluble. BOILING POINT: Not established.
FOR QUANTITATION STANDARD:
VAPOR PRESSURE, mm Hg @ 20掳C: Not established. pH: 8.0
ODOR THRESHOLD: Not available.
LOG WATER/OIL DISTRIBUTION COEFFICIENT: Not available.
APPEARANCE AND COLOR: Clear, red liquid.
HOW TO DETECT THIS SUBSTANCE: The appearance may act as a warning property associated with this
component.
FOR LOW POSITIVE CONTROL, HIGH POSITIVE CONTROL, and NEGATIVE CONTROL:
VAPOR PRESSURE, mm Hg @ 20掳C: Not established. pH: Not applicable.
ODOR THRESHOLD: Not established.
LOG WATER/OIL DISTRIBUTION COEFFICIENT: Not established.
APPEARANCE AND COLOR: These components are clear, to hazy, colorless to yellow liquids.
HOW TO DETECT THIS SUBSTANCE: The appearance may act as a warning property associated with these
components.
FOR ALL OTHER COMPONENTS:
VAPOR PRESSURE, mm Hg @ 20掳C: Not established. pH: 5.0鈥?7.5
ODOR THRESHOLD: Not available.
LOG WATER/OIL DISTRIBUTION COEFFICIENT: Not available.
APPEARANCE AND COLOR: Clear, colorless liquids.
HOW TO DETECT THIS SUBSTANCE: There are no unusual warning properties associated with these
components.
File No. MPCR-191 Rev. 1.0 Page 6 of 10
COBAS TaqMan鈩? HBV TEST KIT
10. STABILITY and REACTIVITY
STABILITY: Stable.
DECOMPOSITION PRODUCTS: Thermal decomposition of this product鈥檚 components may produce carbon
monoxide, carbon dioxide, and oxides of potassium and manganese.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: Strong oxidizers, strong acids, some metals,
substances that are incompatible with water.
HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS TO AVOID: Any conditions that are incompatible with water, mixing this product with incompatible
chemicals.
PART IV Is there any other useful information about this material?
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: The specific toxicology data available for constituents greater than 1% in concentration are as
follows:
GLYCERIN: GLYCERIN (continued): GLYCERIN (continued):
Skin Irritancy (rabbit) = 500 mg/24 hours; mild TDLo (intratesticular, rat) = 280 mg/kg/male 2 LD50 (intraperitoneal, rat) = 4420 mg/kg; toxic
Eye Irritancy (rabbit) = 126 mg; mild days pre-mating; Reproductive: Paternal psychosis; Cardiac; other changes;
Eye Irritancy (rabbit) = 500 mg/24 hours; mild Effects: spermatogenesis, testes, Kidney, Urethra, Bladder: other changes
DNA Inhibition (human, lymphocyte) = 200 epididymis, sperm duct LD50 (subcutaneous, rat) = 100 mg/kg
mmol/L TDLo (intratesticular, rat) = 1600 mg/kg/male 1 LD50 (intravenous, rat) = 5566 mg/kg
Cytogenetic Analysis (oral, rat) = 1 g/kg day pre-mating; Reproductive: Fertility: LD50 (oral, mouse) = 4090 mg/kg
TDLo (oral, rat) = 16800 mg/kg/28 male fertility index LD50 (intraperitoneal, mouse) = 8700 mg/kg
days/continuous; Endocrine: changes in TDLo (intratesticular, rat) = 862 mg/kg/male 1 LD50 (subcutaneous, mouse) = 91 mg/kg
adrenal weight day pre-mating; Reproductive: Paternal LD50 (intravenous, mouse) = 4250 mg/kg
TDLo (oral, rat) = 96 g/kg/30 days/intermittent; Effects: spermatogenesis LD50 (oral, rabbit) = 27 g/kg
Blood: changes in leukocyte (WBC) count, LD50 (skin, rabbit) > 10 g/kg
TDLo (intratesticular, monkey) = 119
changes in serum composition (e.g. TP, LD50 (intravenous, rabbit) = 53 g/kg
mg/kg/male 1 day pre-mating;
bilirubin, cholesterol); Biochemical: LD50 (oral, guinea pig) = 7750 mg/kg
Reproductive: Paternal Effects:
Enzyme inhibition, induction, or change in spermatogenesis, testes, epididymis, MANGANESE ACETATE TETRAHYDRATE:
blood or tissue levels: true cholinesterase sperm duct LD50 (oral, rat) = 3730 mg/kg
TDLo (oral, rat) = 100 mg/kg/male 1 day pre- TDLo (oral, mouse) = 560 g/kg/8
POTASSIUM ACETATE:
mating; Reproductive: Fertility: post- weeks/continuous; Lungs, Thorax, or
Currently, there are no toxicological data
implantation mortality Respiration: structural or functional change
available for this constituent.
in trachea or bronchi
N-TRIS(HYDROXYMETHYL)-
LD50 (oral, rat) = 12600 mg/kg; general
METHYLGLYCINE (TRICINE):
anesthetic, muscle weakness, Liver: other
Currently, there are no toxicological data
changes
LC50 (inhalation, rat) > 570 mg/m3/1 hour available for this constituent.
SUSPECTED CANCER AGENT: The constituents in this product鈥檚 components are not found on the following
lists: NTP, IARC, FEDERAL OSHA Z-List, and CAL-OSHA and therefore are neither considered to be nor
suspected to be cancer causing agents by these agencies.
IRRITANCY OF PRODUCT: Contact with the skin or eyes may cause mild irritation, which is alleviated upon
rinsing.
SENSITIZATION TO THE PRODUCT: The components of this product are not known to cause sensitization with
prolonged or repeated exposure.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of this product and
its constituents on the human reproductive system.
Mutagenicity: This product is not reported to produce mutagenic effects in humans. Human mutation data are
available for the Glycerin component of this product; these data were obtained during clinical studies on specific
human tissues exposed to high doses of this compound.
Embryotoxicity: This product is not reported to cause human embryotoxic effects.
Teratogenicity: This product is not reported to cause teratogenic effects in humans.
Reproductive Toxicity: This product is not reported to cause adverse reproductive effects in humans. Clinical
studies on test animals exposed to relatively high doses of the Glycerin component of this product indicate
adverse reproductive effects.
A mutagen is a chemical that causes permanent changes to genetic material (DNA) such that the changes will
propagate through generational lines. An embryotoxin is a chemical that causes damage to a developing embryo (i.e.
within the first eight weeks of pregnancy in humans), but the damage does not propagate across generational lines.
A teratogen is a chemical that causes damage to a developing fetus, but the damage does not propagate across
generational lines. A reproductive toxin is any substance that interferes in any way with the reproductive process.
BIOLOGICAL EXPOSURE INDICES: Currently, there are no Biological Exposure Indices (BEIs) determined for the
constituents in this product鈥檚 components.
File No. MPCR-191 Rev. 1.0 Page 7 of 10
COBAS TaqMan鈩? HBV TEST KIT
12. ECOLOGICAL INFORMATION
ALL WORK PRACTICES MUST BE AIMED AT ELIMINATING ENVIRONMENTAL CONTAMINATION.
ENVIRONMENTAL STABILITY: The constituents of this product will degrade in the environment into organic and
inorganic constituents. Additional environmental data for constituents are available as follows:
GLYCERIN:
Water Solubility = Miscible. Log Kow = -1.76.
5-Day Biological Oxygen Demand = 0.54 p/p; 10 day BOD = 0.98 p/p; 20 Day BOD = 1.0 p/p:
Terrestrial Fate: If released to soil, glycerin is expected to undergo rapid biodegradation under aerobic conditions. Biodegradation is also
expected under anaerobic condition. Based on its Log Kow of -1.76 and its water solubility, the soil absorption coefficients for glycerin can be
estimated at 3 and 2, respectively, using regression-derived equations. These values indicated that glycerin will be highly mobile in soil.
Glycerin is not expected to significantly volatilize from most or dry soil to the atmosphere.
Aquatic Fate: If released to an aquatic environment, glycerin is expected to rapidly degrade under aerobic conditions. Degradation is also likely
in seawater and under anaerobic conditions. Based on water solubility and its Log Kow, the bioconcentration factors for glycerin can be
estimated at 3 and 0.2, respectively. These values indicate that bioconcentration is not significant in aquatic organisms.
Atmospheric Fate: If released to the atmosphere, glycerin may undergo a gas-phase oxidization with photochemically produced hydroxyl
radicals. An estimated reaction rate indicates that the atmospheric half-life of glycerin in the atmosphere to be 33 hours. The water solubility
of glycerin indicates that is may also undergo atmospheric removal by wet deposition processes.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: Due to the small product size and dilute concentration of the
constituents, no unusual effects on plants or animals are expected if this product is released into the environment.
EFFECT OF CHEMICAL ON AQUATIC LIFE: Due to the small product size and dilute concentration of the
constituents, this product is not anticipated to cause adverse effects on aquatic life. Additional aquatic toxicity data for
constituents are available as follows:
GLYCERIN: GLYCERIN (continued): GLYCERIN (continued):
EC0 (Pseudomonas putida bacteria) 16 hours EC0 (Scenedesmus quadricauda green EC0 (Uronema parduczi Chatton-Lwoff
= >10,000 mg/L algae) 7 days = > 10,000 mg/L protozoa) = > 10,000 mg/L
LC50 (goldfish) 24 hours = > 5,000 mg/
EC0 (Microcystis aeruginosa algae) 8 days = EC0 (Entosiphon sulcatum protozoa) 72 hours
2,900 mg/L = 3,200 mg/L
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with appropriate Federal, State,
and local regulations. This product鈥檚 components, if unaltered by use, may be disposed of by treatment at a
permitted facility or as advised by your local hazardous waste regulatory authority.
EPA WASTE NUMBER: Not applicable.
14. TRANSPORTATION INFORMATION
THIS PRODUCT IS NOT HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF
TRANSPORTATION
PROPER SHIPPING NAME: Not Regulated
HAZARD CLASS NUMBER and DESCRIPTION: Not Applicable
UN IDENTIFICATION NUMBER: Not Applicable
PACKING GROUP: Not Applicable
DOT LABEL(S) REQUIRED: Not Applicable
EMERGENCY RESPONSE GUIDEBOOK NUMBER (2000): Not Applicable
MARINE POLLUTANT: Not applicable (49 CFR 172.101, Appendix B).
TRANSPORT CANADA, TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: This product is not
considered as dangerous goods, per regulations of Transport Canada.
15. REGULATORY INFORMATION
ADDITIONAL U.S. REGULATIONS:
U.S. SARA REPORTING REQUIREMENTS: The constituents in components of this product are not subject to
Sections 302, 304, and 313 reporting requirements under the Superfund Amendment and Reauthorization Act:
U.S. SARA THRESHOLD PLANNING QUANTITY: Not applicable.
U.S. CERCLA REPORTABLE QUANTITY (RQ): Not applicable.
U.S. TSCA INVENTORY STATUS: This product is regulated by the Food and Drug Administration; it is exempt from
the requirements of TSCA.
OTHER U.S. FEDERAL REGULATIONS: The requirements of the OSHA Bloodborne Pathogen Standard (29 CFR
1910.1030) may be applicable, based on the use of these products.
File No. MPCR-191 Rev. 1.0 Page 8 of 10
COBAS TaqMan鈩? HBV TEST KIT
15. REGULATORY INFORMATION (Continued)
ADDITIONAL U.S. REGULATIONS (continued):
U.S. STATE REGULATORY INFORMATION: Constituents of this product that are listed in Section 2 (Composition
and Information on Ingredients) are covered under specific State regulations, as denoted below:
Alaska - Designated Toxic and Hazardous Minnesota - List of Hazardous Pennsylvania - Hazardous Substance List:
Glycerin.
Substances: Glycerin. Substances: Glycerin.
Rhode Island - Hazardous Substance List:
California - Permissible Exposure Limits Missouri - Employer Information/Toxic
Glycerin.
for Chemical Contaminants: Glycerol. Substance List: Glycerin.
Texas - Hazardous Substance List: No.
Florida - Substance List: No. New Jersey - Right to Know Hazardous
West Virginia - Hazardous Substance List:
Illinois - Toxic Substance List: Glycerin. Substance List: No.
No.
Kansas - Section 302/313 List: No. North Dakota - List of Hazardous
Wisconsin - Toxic and Hazardous
Massachusetts - Substance List: Glycerin. Chemicals, Reportable Quantities:
Substances: No.
Glycerin.
Michigan - Critical Materials Register: No.
CALIFORNIA SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT (PROPOSITION 65): No constituent of
this product鈥檚 components is on the California Proposition 65 lists.
ANSI LABELING (Z129.1; Provided to Summarize Occupational Hazard Information): CAUTION! MAY CAUSE SKIN
AND EYE IRRITATION. MAY CAUSE DISCOMFORT IF SWALLOWED OR INHALED. Do not taste or swallow. Do
not get on skin, in eyes, or on clothes. Avoid prolonged or repeated skin contact. Avoid breathing mists or sprays.
Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. Wear gloves and
goggles. FIRST-AID: In case of contact, immediately flush skin or eyes with plenty of water. If inhaled, remove to
fresh air. If ingested, do not induce vomiting. Get medical attention if necessary. IN CASE OF FIRE: Use water fog,
dry chemical, CO2, or 鈥渁lcohol鈥? foam. IN CASE OF SPILL: Absorb spill with polypads and place in suitable container.
Consult Material Safety Data Sheet for additional information.
CANADIAN REGULATIONS:
CANADIAN DSL/NDSL INVENTORY STATUS: The constituents in this product鈥檚 components are listed on the DSL
Inventory.
OTHER CANADIAN REGULATIONS: Not applicable.
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA) PRIORITY SUBSTANCES LISTS: The components of
this product are not on the CEPA Priority Substances Lists.
CANADIAN WHMIS SYMBOLS: Not applicable.
16. OTHER INFORMATION
PREPARED BY: CHEMICAL SAFETY ASSOCIATES, Inc.
PO Box 3519, La Mesa, CA 91944-3519
(619) 670-0609
DEFINITIONS OF TERMS
A large number of abbreviations and acronyms appear on a MSDS. Some of these, which are commonly used, include the following:
CAS #: This is the Chemical Abstract Service Number that uniquely EXPOSURE LIMITS IN AIR (continued):
identifies each component. PEL-Permissible Exposure Limit: OSHA鈥檚 Permissible Exposure
EXPOSURE LIMITS IN AIR: Limits. This exposure value means exactly the same as a TLV, except
that it is enforceable by OSHA. The OSHA Permissible Exposure
CEILING LEVEL: The concentration that shall not be exceeded during
Limits are based in the 1989 PELs and the June, 1993 Air
any part of the working exposure.
Contaminants Rule (Federal Register: 58: 35338-35351 and 58:
IDLH-Immediately Dangerous to Life and Health: This level
40191). Both the current PELs and the vacated PELs are indicated.
represents a concentration from which one can escape within 30-
The phrase, 鈥淰acated 1989 PEL,鈥? is placed next to the PEL that was
minutes without suffering escape-preventing or permanent injury.
vacated by Court Order.
LOQ: Limit of Quantitation.
SKIN: Used when a there is a danger of cutaneous absorption.
MAK: Federal Republic of Germany Maximum Concentration Values
STEL-Short Term Exposure Limit: Short Term Exposure Limit,
in the workplace.
usually a 15-minute time-weighted average (TWA) exposure that
NE: Not Established. When no exposure guidelines are established,
should not be exceeded at any time during a workday, even if the 8-hr
an entry of NE is made for reference.
TWA is within the TLV-TWA, PEL-TWA or REL-TWA.
NIC: Notice of Intended Change.
TLV-Threshold Limit Value: An airborne concentration of a
NIOSH CEILING: The exposure that shall not be exceeded during any
substance that represents conditions under which it is generally
part of the workday. If instantaneous monitoring is not feasible, the
believed that nearly all workers may be repeatedly exposed without
ceiling shall be assumed as a 15-minute TWA exposure (unless
adverse effect. The duration must be considered, including the 8-hour.
otherwise specified) that shall not be exceeded at any time during a
TWA-Time Weighted Average: Time Weighted Average exposure
workday.
concentration for a conventional 8-hr (TLV, PEL) or up to a 10-hr (REL)
NIOSH RELs: NIOSH鈥檚 Recommended Exposure Limits.
workday and a 40-hr workweek.
File No. MPCR-191 Rev. 1.0 Page 9 of 10
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DEFINITIONS OF TERMS (Continued)
HAZARDOUS MATERIALS IDENTIFICATION SYSTEM HAZARDOUS MATERIALS IDENTIFICATION SYSTEM
HAZARD RATINGS: This rating system was developed by the HAZARD RATINGS (continued):
National Paint and Coating Association and has been adopted by FLAMMABILITY HAZARD (continued):
industry to identify the degree of chemical hazards. 3 (continued): Liquids having a flash point below 22.8掳C [73掳F] and
HEALTH HAZARD: having a boiling point at or above 38掳C [100掳F] and below 37.8掳C
0 (Minimal Hazard: No significant health risk, irritation of skin or eyes [100掳F] [e.g. OSHA Class IB and IC]; Materials that on account of
not anticipated. Skin Irritation: Essentially non-irritating. PII or Draize their physical form or environmental conditions can form explosive
= 鈥?0鈥?. Eye Irritation: Essentially non-irritating, or minimal effects which mixtures with air and are readily dispersed in air [e.g., dusts of
clear in < 24 hours [e.g. mechanical irritation]. Draize = 鈥?0鈥?. Oral combustible solids, mists or droplets of flammable liquids]; Materials
Toxicity LD50 Rat: < 5000 mg/kg. Dermal Toxicity LD50Rat or Rabbit: < that burn extremely rapidly, usually by reason of self-contained
2000 mg/kg. Inhalation Toxicity 4-hrs LC50 Rat: < 20 mg/L.); 1 (Slight oxygen [e.g. dry nitrocellulose and many organic peroxides]); 4
Hazard: Minor reversible Injury may occur; slightly or mildly irritating. (Severe Hazard-Materials that will rapidly or completely vaporize at
Skin Irritation: Slightly or mildly irritating. Eye Irritation: Slightly or atmospheric pressure and normal ambient temperature or that are
readily dispersed in air, and which will burn readily, including:
mildly irritating. Oral Toxicity LD50 Rat: > 500-5000 mg/kg. Dermal
Flammable gases; Flammable cryogenic materials; Any liquid or
Toxicity LD50Rat or Rabbit: > 1000-2000 mg/kg. Inhalation Toxicity
gaseous material that is liquid while under pressure and has a flash
LC50 4-hrs Rat: > 2-20 mg/L); 2 (Moderate Hazard: Temporary or
point below 22.8掳C [73掳F] and a boiling point below 37.8掳C [100掳F]
transitory injury may occur. Skin Irritation: Moderately irritating;
[e.g. OSHA Class IA; Material that ignite spontaneously when
primary irritant; sensitizer. PII or Draize > 0, < 5. Eye Irritation:
Moderately to severely irritating and/or corrosive; reversible corneal exposed to air at a temperature of 54.4掳C [130掳F] or below [e.g.
opacity; corneal involvement or irritation clearing in 8-21 days. Draize pyrophoric]).
> 0, < 25. Oral Toxicity LD50 Rat: > 50-500 mg/kg. Dermal Toxicity PHYSICAL HAZARD:
LD50Rat or Rabbit: > 200-1000 mg/kg. Inhalation Toxicity LC50 4-hrs 0 (Water Reactivity: Materials that do not react with water. Organic
Rat: > 0.5-2 mg/L.); 3 (Serious Hazard: Major injury likely unless Peroxides: Materials that are normally stable, even under fire
prompt action is taken and medical treatment is given; high level of conditions and will not react with water. Explosives: Substances
toxicity; corrosive. Skin Irritation: Severely irritating and/or corrosive; that are Non-Explosive. Unstable Compressed Gases: No Rating.
may destroy dermal tissue, cause skin burns, dermal necrosis. PII or Pyrophorics: No Rating. Oxidizers: No 鈥?0鈥? rating allowed. Unstable
Draize > 5-8 with destruction of tissue. Eye Irritation: Corrosive, Reactives: Substances that will not polymerize, decompose,
irreversible destruction of ocular tissue; corneal involvement or irritation condense or self-react.); 1 Water Reactivity: Materials that change
persisting for more than 21 days. Draize > 80 with effects irreversible or decompose upon exposure to moisture. Organic Peroxides:
in 21 days. Oral Toxicity LD50 Rat: > 1-50 mg/kg. Dermal Toxicity Materials that are normally stable, but can become unstable at high
LD50Rat or Rabbit: > 20-200 mg/kg. Inhalation Toxicity LC50 4-hrs temperatures and pressures. These materials may react with water,
Rat: > 0.05-0.5 mg/L.); 4 (Severe Hazard: Life-threatening; major or but will not release energy. Explosives: Division 1.5 & 1.6
permanent damage may result from single or repeated exposure. Skin substances that are very insensitive explosives or that do not have a
Irritation: Not appropriate. Do not rate as a 鈥?4鈥?, based on skin irritation mass explosion hazard. Compressed Gases: Pressure below
alone. Eye Irritation: Not appropriate. Do not rate as a 鈥?4鈥?, based on OSHA definition. Pyrophorics: No Rating. (Oxidizers: Packaging
eye irritation alone. Oral Toxicity LD50 Rat: < 1 mg/kg. Dermal Group III; Solids: any material that in either concentration tested,
Toxicity LD50Rat or Rabbit: < 20 mg/kg. Inhalation Toxicity LC50 4-hrs exhibits a mean burning time less than or equal to the mean burning
Rat: < 0.05 mg/L). time of a 3:7 potassium bromate/cellulose mixture and the criteria for
FLAMMABILITY HAZARD: Packing Group I and II are not met. Liquids: any material that
exhibits a mean pressure rise time less than or equal to the pressure
0 (Minimal Hazard-Materials that will not burn in air when exposure
rise time of a 1:1 nitric acid (65%)/cellulose mixture and the criteria
to a temperature of 815.5掳C [1500掳F] for a period of 5 minutes.); 1
for Packing Group I and II are not met. Unstable Reactives:
(Slight Hazard-Materials that must be pre-heated before ignition can
Substances that may decompose, condense or self-react, but only
occur. Material require considerable pre-heating, under all ambient
under conditions of high temperature and/or pressure and have little
temperature conditions before ignition and combustion can occur,
or no potential to cause significant heat generation or explosive
Including: Materials that will burn in air when exposed to a
hazard. Substances that readily undergo hazardous polymerization
temperature of 815.5掳C (1500掳F) for a period of 5 minutes or less;
in the absence of inhibitors.); 2 (Water Reactivity: Materials that may
Liquids, solids and semisolids having a flash point at or above
react violently with water. Organic Peroxides: Materials that, in
93.3掳C [200掳F] (e.g. OSHA Class IIIB, or; Most ordinary combustible
themselves, are normally unstable and will readily undergo violent
materials [e.g. wood, paper, etc.]; 2 (Moderate Hazard-Materials that
chemical change, but will not detonate. These materials may also
must be moderately heated or exposed to relatively high ambient
react violently with water. Explosives: Division 1.4 鈥? Explosive
temperatures before ignition can occur. Materials in this degree
substances where the explosive effect are largely confined to the
would not, under normal conditions, form hazardous atmospheres in
package and no projection of fragments of appreciable size or range
air, but under high ambient temperatures or moderate heating may
are expected. An external fire must not cause virtually instantaneous
release vapor in sufficient quantities to produce hazardous
explosion of almost the entire contents of the package. Compressed
atmospheres in air, Including: Liquids having a flash-point at or
Gases: Pressurized and meet OSHA definition but < 514.7 psi
above 37.8掳C [100掳F]; Solid materials in the form of course dusts
absolute at 21.1掳C (70掳F) [500 psig]. Pyrophorics: No Rating.
that may burn rapidly but that generally do not form explosive
Oxidizers: Packing Group II Solids: any material that, either in
atmospheres; Solid materials in a fibrous or shredded form that may
concentration tested, exhibits a mean burning time of less than or
burn rapidly and create flash fire hazards (e.g. cotton, sisal, hemp;
equal to the mean burning time of a 2:3 potassium bromate/cellulose
Solids and semisolids that readily give off flammable vapors.); 3
mixture and the criteria for Packing Group I are not met. Liquids: any
(Serious Hazard- Liquids and solids that can be ignited under almost
material that exhibits a mean pressure rise time less than or equal to
all ambient temperature conditions. Materials in this degree produce
the pressure rise of a 1:1 aqueous sodium chlorate solution
hazardous atmospheres with air under almost all ambient
(40%)/cellulose mixture and the criteria for Packing Group I are not
temperatures, or, unaffected by ambient temperature, are readily
met. Unstable Reactives: Substances that may polymerize,
ignited under almost all conditions, including:
decompose, condense, or self-react at ambient temperature and/or
pressure, but have a low potential for significant heat generation or
explosion. Substances that readily form peroxides upon exposure to
air or oxygen at room temperature);
File No. MPCR-191 Rev. 1.0 Page 10 of 10
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DEFINITIONS OF TERMS (Continued)
HAZARDOUS MATERIALS IDENTIFICATION SYSTEM TOXICOLOGICAL INFORMATION:
Human and Animal Toxicology: Possible health hazards as derived
HAZARD RATINGS (continued):
from human data, animal studies, or from the results of studies with
PHYSICAL HAZARD (continued):
similar compounds are presented. Definitions of some terms used in
3 (continued): 3 (Water Reactivity: Materials that may form explosive
this section are: LD50 - Lethal Dose (solids & liquids) which kills 50% of
reactions with water. Organic Peroxides: Materials that are capable of
the exposed animals; LC50 - Lethal Concentration (gases) which kills
detonation or explosive reaction, but require a strong initiating source,
50% of the exposed animals; ppm concentration expressed in parts of
or must be heated under confinement before initiation; or materials that
material per million parts of air or water; mg/m3 concentration
react explosively with water. Explosives: Division 1.2 鈥? Explosive
expressed in weight of substance per volume of air; mg/kg quantity of
substances that have a fire hazard and either a minor blast hazard or a
material, by weight, administered to a test subject, based on their body
minor projection hazard or both, but do not have a mass explosion
weight in kg. Other measures of toxicity include TDLo, the lowest
hazard. Compressed Gases: Pressure > 514.7 psi absolute at 21.1掳C
dose to cause a symptom and TCLo the lowest concentration to cause
(70掳F) [500 psig]. Pyrophorics: No Rating. Oxidizers: Packing Group
a symptom; TDo, LDLo, and LDo, or TC, TCo, LCLo, and LCo, the
I Solids: any material that, in either concentration tested, exhibits a
lowest dose (or concentration) to cause lethal or toxic effects. Cancer
mean burning time less than the mean burning time of a 3.:2
potassium bromate/cellulose mixture. Liquids: Any material that Information: The sources are: IARC - the International Agency for
spontaneously ignites when mixed with cellulose in a 1:1 ratio, or which Research on Cancer; NTP - the National Toxicology Program, RTECS
exhibits a mean pressure rise time less than the pressure rise time of a - the Registry of Toxic Effects of Chemical Substances, OSHA and
1:1 perchloric acid (50%)/cellulose mixture. Unstable Reactives: CAL/OSHA. IARC and NTP rate chemicals on a scale of decreasing
Substances that may polymerize, decompose, condense or self-react potential to cause human cancer with rankings from 1 to 4.
at ambient temperature and/or pressure and have a moderate potential Subrankings (2A, 2B, etc.) are also used. Other Information: BEI -
to cause significant heat generation or explosion.); 4 (Water Reactivity: ACGIH Biological Exposure Indices, represent the levels of
Materials that react explosively with water without requiring heat or determinants which are most likely to be observed in specimens
confinement. Organic Peroxides: Materials that are readily capable of collected from a healthy worker who has been exposed to chemicals to
detonation or explosive decomposition at normal temperature and the same extent as a worker with inhalation exposure to the TLV.
pressures. Explosives: Division 1.1 & 1.2-explosive substances that REGULATORY INFORMATION:
have a mass explosion hazard or have a projection hazard. A mass U.S. and CANADA:
explosion is one that affects almost the entire load instantaneously.
ACGIH: American Conference of Governmental Industrial Hygienists,
Compressed Gases: No Rating. Pyrophorics: Add to the definition of
a professional association which establishes exposure limits.
Flammability 鈥?4鈥?. Oxidizers: No 鈥?4鈥? rating. Unstable Reactives:
This section explains the impact of various laws and regulations on
Substances that may polymerize, decompose, condense or self-react
the material. EPA is the U.S. Environmental Protection Agency.
at ambient temperature and/or pressure and have a high potential to
NIOSH is the National Institute of Occupational Safety and Health,
cause significant heat generation or explosion.). PPE Rating B: Hand
which is the research arm of the U.S. Occupational Safety and
and eye protection is required for routine chemical use. PPE Rating C:
Health Administration (OSHA). WHMIS is the Canadian Workplace
Hand, eye, and body protection may be required for routine chemical
Hazardous Materials Information System. DOT and TC are the U.S.
use.
Department of Transportation and the Transport Canada,
NATIONAL FIRE PROTECTION ASSOCIATION HAZARD
respectively.
RATINGS: REGULATORY INFORMATION (continued):
HEALTH HAZARD: 0 (material that on exposure under fire conditions
U.S. and CANADA (continued):
would offer no hazard beyond that of ordinary combustible materials); 1
Superfund Amendments and Reauthorization Act (SARA); the
(materials that on exposure under fire conditions could cause irritation
Canadian Domestic/Non-Domestic Substances List (DSL/NDSL);
or minor residual injury); 2 (materials that on intense or continued
the U.S. Toxic Substance Control Act (TSCA); Marine Pollutant
exposure under fire conditions could cause temporary incapacitation or
status according to the DOT; the Comprehensive Environmental
possible residual injury); 3 (materials that can on short exposure could
Response, Compensation, and Liability Act (CERCLA or
cause serious temporary or residual injury); 4 (materials that under
Superfund); and various state regulations. This section also
very short exposure could cause death or major residual injury).
includes information on the precautionary warnings which appear on
FLAMMABILITY LIMITS IN AIR: the material鈥檚 package label. OSHA - U.S. Occupational Safety and
Much of the information related to fire and explosion is derived from the Health Administration.
National Fire Protection Association (NFPA). Flash Point - Minimum
temperature at which a liquid gives off sufficient vapors to form an
ignitable mixture with air. Autoignition Temperature: The minimum
temperature required to initiate combustion in air with no other source
of ignition. LEL - the lowest percent of vapor in air, by volume, that will
explode or ignite in the presence of an ignition source. UEL - the
highest percent of vapor in air, by volume, that will explode or ignite in
the presence of an ignition source.
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