MATERIAL SAFETY DATA SHEET
I IDENTIFICATION
PRODUCT: DTT
MANUFACTURER: BioVectra dcl
16McCarville St.
West Royalty Industrial Park
Charlottetown, P.E .I.
C1E 2A6
(902)566-1396
EMERGENCY TELEPHONE NO.: CANUTEC 613-996-6666
CHEMICAL NAME: Dith iothreitol
CATALOGUE NUMBER: 1365-MBG
CHEMICAL FAMILY: Thiol
MOLECULAR FORMULA: C 4H10O2S2
MOLECULAR WEIGHT: 15 4.25 g.mol -1
WHMIS CLASSIFICATION : Class D, Division 1, Subd ivision B. Toxic Material.
TSCA STATUS : This substance is listed on the T SCA inventory.
PRODUCT U SE: Stabilizer, oxygen scavenger, pha rmacology
II HAZARDOUS INGREDIENTS
Dithiothreitol $99.0
CAS Registry No.: 3483-12-3
of our knowledge, the toxicological properties of this
III TOXICOLOGICAL PROPERTIES
product have not been thoroughly investigated.
EFFECTS OF ACUTE EXPOSURE
Routes of Entry Skin Contact [x] Eye Contact [ x]
Skin Absorption [x] In halation [x] Ingestion [x]
EYES: Causes irritation.
III TOXICOLOGICAL PROPERTIES (continued)
SKIN: Causes irritation, may be absorbed.
E V I D E N C E O F C A R C I N O G E N I C IT Y ,
TERATOGENICITY, REPRODUCTIVE TOXICITY,
INHALATION: Harmful, irritating, exposure can cause
MUTAGENICITY: DNA Inhibition observed in rat
nausea, headache and vomiting. Exposure may also result
livers 1mmol/L RTECS Reference Number :
in blood in uri ne, difficulty breathing, irregular heartbeat,
XO8576500. Additional data under RTECS Number
anaemia, weakness, drunkenness, bluish skin colour, lung
EK1610000.
congestion, kidney damage, paralysis, convulsions
unconsciousness and coma.
SYNERGISTIC P RODUCTS: Not avai lable
SENSITIZATION TO PRODUC T: Not available
INGESTION: Harmful if ingested, exposure can cause
IRRITANCY OF PRODUCT: Strong irritant
nausea, headache, vomiting, diarrhea, weakness,
drunkenness, restlessness, bluish skin colour, paralysis and
EXPOSURE LIMITS: None assigned.
coma.
LD50: Intraperitoneal, Mouse: 154, and 169 mg/Kg
LD50: Oral rat 400 mg/Kg
NOTE: Toxicological Effects Associated with Thiols:
Acute Exposure to Thiols may cause upper respiratory
IV FIRST AID MEASURES
tract irritation. Exposure to C-8 Thiols may produce
analeptic and psycho mimetic effects, other Thiols may
EYES: Flush eyes with water for at least 15 minutes and
cause Central Nerv ous System Dep ression (CNS). In
get medical attention.
addition to the symptoms described previously under
SKIN: In case of contact, immediately flush area with
Inhalation and Ingestion exposure to Thiols, especially in
plenty of water.
excess of 50 ppm, may result in c yanosis, rap id pulse,
INHALATION: If inhaled, remove victim to fresh air . If
dyspnea, fever, irreversible depression of cerebral function,
not breathing, give artificial respiration. If breathing is
respiratory paralysis, delayed pulmonary edema, renal
difficult, give oxygen and obtain medical attention.
damage, with haematuria and albuminuria, and hepatic
INGESTION: If ingested, drink plenty of fluids and obtain
damage.
medical attention.
Low molecular weight Thiols are capable of causing
V FIRE AND EXPLOSION HAZARDS
contact-type dermatitis. Sensitization and dermal
irritancy are low up to C-6, increase to C-8 and level off FLAMMABLE: No
to C-12 dim inishing r apidly fro m there. FLASH POIN T: > 230掳 F
FLAMMABLE LIMITS (% in air):
CHRONIC HEALTH HAZARDS: Unknown. To the best Lower: Not applicable
Upper: Not applicable
The information provided on this Material Safety Data
EXTINGUISHING MEDIA: Water spray, carbon diox ide,
Sheet is provided in the interest of promoting safe
dry chemical, alcohol or polymer foam.
handling of the material. While this inf ormation is
AUTOIGNITION T EMPERATU RE: Not available
believed to be correct, DCL makes no warranty in respect
HAZARDOUS COMBUSTION PRODUCTS: Toxic f umes
to any of the information disclosed. Observe all federal,
of carbon monoxide, carbon dioxide, oxides of sulphur
provincial, state and local laws concerning health and
EXPLOSION DATA: Sensitivity to mechanical impact,
pollution.
not available; Sensitivity to static discharge, not a vailable.
msds1365mbg-3
VI REACTIVITY
STABILITY : Stable
INCOMPATIBILITY: Strong oxidizing agents
HAZARDOUS DECOMPOS ITION PRODUCTS: Thermal
decomposition may produce toxic fumes of ca rbon
monoxide, carbon dioxide, and oxides of sulphur.
HAZARDOUS POLYMERIZATION: Will not occur.
VII PHYSICAL DATA
PHYSICAL STATE: Solid
APPEARANCE AND ODOUR: White crystals, Thiol
odour
ODOUR THRE SHOLD: Not available
MELTING P OINT: > 42+ /- 2掳 C
SPECIFIC GRAVITY: 1.0 (H2O = 1)
VAPOUR PRE SSURE: Not available
VAPOUR DENSITY: 5.3 (AIR = 1)
WATER SO LUBILITY: Solu ble (10-50 g/100 mL)
EVAPORATION RATE: Not available
pH: 4.3 (5% solution)
COEFFICIENT OF O IL/WATER: Not available
VIII PREVENTIVE MEASURES
PERSONAL PROTECTIVE EQUIPMENT: Lab coat,
safety goggles, and rubber gloves.
VENTILATION: Local exhaust required.
RESPIRATORY PROTECTION: Standard chemical dust
protection, ie. appropriate OSHA/MSHA appr oved
respirator.
LEAK AND SPILL PROCEDURES: Ventilate the area.
Wear appropriate personal protective equipment. Avoid
raising dust. Sweep up and collect in bag for disposal. Wash
spill site af ter material p ick up is com plete.
WASTE DISPOSAL: Burn in chemical incinerator.
Observe all federal, provincial, state and local regulations.
OTHER PRECAUTIONS: Avoid contact. Do not get in
eyes, on skin, or clothing. Wash thor oughly after handling.
Wash contam inated cloth ing before r euse.
STORAGE REQUIRE MENTS: 2 -8掳C under Nitrogen
SPECIAL SHIPPING INFORMATION: Not regulated.
LABEL PRECAUTIONARY STATE MENTS: Harmf ul,
possible risk of ir reversible eff ects, irrit ating to ski n, eyes
and respiratory system. Avoid eye and skin contact.
Avoid inhalation and ingesti on. Unpleasa nt odour. T arget
Organ(s): Central Nervous System.
IX PREPARATION OF MSDS
PREPARED BY: Jeremy Stiles
DATE: 26 September 2001
Phone Number: 902-566-1396
*n.av. not available n.ap. not applicable
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