SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 02/24/2004
Date Updated: 04/23/2003
Version 1.3
Section 1 - Product and Company Information
Product Name PREDNISONE
Product Number 81550
Brand FLUKA
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
PREDNISONE 53-03-2 No
Formula C21H26O5
Synonyms Ancortone * Bicortone * Colisone * Cortan *
delta-Cortelan * Cortidelt * delta-Cortisone *
delta-1-Cortisone * delta(sup 1)-Cortisone *
delta-Cortone * Dacortin * Decortancyl * Decortin
* Decortisyl * delta-1-Dehydrocortisone *
1-Dehydrocortisone * 1,2-Dehydrocortisone *
Dekortin * Delta-dome * Delta E * Deltasone *
Deltison * Deltisone * Deltra * Di-adreson *
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione *
Encorton * Encortone * Enkorton * Hostacortin *
IN-Sone * Juvason * Lisacort * Metacortandracin *
Meticorten * NCI-C04897 * NSC 10023 * Orasone *
Paracort * Precort * Prednicen-M * Prednilonga *
Prednison * Prednisone * Prednizon *
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione *
Rectodelt * Servisone * SK-Prednisone *
Supercortil * U 6020 * Ultracorten * Ultracortene
* Wojtab * Zenadrid * Zenadrid (veterinary)
RTECS Number: TU4154100
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful.
Possible risk of harm to the unborn child.
Target organ(s): Adrenal cortex. Eyes.
HMIS RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Noncombustible. Use extinguishing media appropriate to
surrounding fire conditions.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
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HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Store in a cool dry place.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Powder
Property Value At Temperature or Pressure
Molecular Weight 358.44 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 230 掳C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation Degree of Rotation: 5 g/l Solvent: EtOH/H2O
+210 - +171 (+/-4) 1:1
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
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STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Adrenal cortex. Eyes. Bones. Immune system.
TOXICITY DATA
Oral
Man
0.4 mg/kg
LDLO
Remarks: Skin and Appendages:Skin: After systemic exposure:
Dermatitis, other
Intraperitoneal
Mouse
135 MG/KG
LD50
Subcutaneous
Mouse
101 MG/KG
LD50
Intramuscular
Mouse
600 MG/KG
LD50
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Species: Rat
Route of Application: Intraperitoneal
Dose: 860 MG/KG
Exposure Time: 26W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Endocrine:Tumors. Skin and Appendages: Other: Tumors.
IARC CARCINOGEN LIST
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Rating: Group 3
NTP CARCINOGEN LIST
Rating: Equivocal evidence.
Species: Rat
Route: Intraperitoneal
CHRONIC EXPOSURE - TERATOGEN
Result: Possible risk of congenital malformation in the fetus.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 24 MG/KG
Route of Application: Subcutaneous
Exposure Time: (13-18D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Behavioral.
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 63
Risk Statements: Possible risk of harm to the unborn child.
S: 45 36/37/39
Safety Statements: In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
Wear suitable protective clothing, gloves, and eye/face
protection.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Harmful.
Risk Statements: Possible risk of harm to the unborn child.
Safety Statements: In case of accident or if you feel unwell,
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seek medical advice immediately (show the label where possible).
Wear suitable protective clothing, gloves, and eye/face
protection.
US Statements: Target organ(s): Adrenal cortex. Eyes.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: Yes
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide.
Sigma-Aldrich Inc., shall not be held liable for any damage
resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms
and conditions of sale. Copyright 2004 Sigma-Aldrich Co. License
granted to make unlimited paper copies for internal use only.
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