MATERIAL SAFETY DATA SHEET
SECTION 1 - CHEMICAL PRODUCT & COMPANY IDENTIFICATION
Pfizer Consumer Healthcare (973) 385-2000
Emergency telephone
Pfizer Inc 24 hours
Hours of operation
201 Tabor Road
Morris Plains, New Jersey 07950
Trade names LISTERINE 庐
Product name Listerine 庐 Antiseptic-Coolmint
Prevention of plaque, gingivitis and bad breath
Therapeutic use
Blue Liquid
Description
SECTION 2 - COMPOSITION/INFORMATION ON INGREDIENTS
Ingredient CAS Number Amount
Thymol* 89-83-8 0.064%
Eucalyptol 470-82-6 0.092%
Methyl salicylate 119-36-8 0.060%
Menthol* 89-78-1 0.042%
Deionized water 7732-18-5 >50%
Ethanol* 64-17-5 21.6%
Sorbitol solution 50-70-4 Proprietary
Flavor Not assigned Proprietary
Poloxamer 407 9003-11-6 Proprietary
Benzoic Acid* 65-85-0 Proprietary
Sodium saccharin USP* 128-44-9 Proprietary
Sodium benzoate 532-32-1 Proprietary
FD&C Green No. 3* 2353-45-9 Proprietary
*Hazardous
Note: Ingredient(s) indicated as hazardous have been assessed under US OSHA
Hazard Communication Standard for workplace safety (29 CFR
1910.1200).
SECTION 3 - HAZARDS IDENTIFICATION
Signal word CAUTION!
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SECTION 3 - HAZARDS IDENTIFICATION ... continued
Statements of hazard FLAMMABLE!
MAY CAUSE EYE AND RESPIRATORY TRACT IRRITATION.
THIS PRODUCT CONTAINS ETHANOL WHICH CAN CAUSE
LIVER CHANGES, CENTRAL NERVOUS SYSTEM EFFECTS,
AND BIRTH DEFECTS IN THE DEVELOPING FETUS.
May cause eye irritation.
Eye effects
Not a skin irritant.
Skin effects
Inhalation effects May cause respiratory tract irritation. Exposure to high concentrations
may cause irritation, headache, drowsiness and symptoms of drunkenness.
An Occupational Exposure Limit has been established for one or more of
the ingredients (see Section 8).
Ingestion of large quantities may cause may cause headache, dizziness,
Ingestion effects
nausea, vomiting, diarrhea, dehydration, and symptoms of drunkenness.
See 'Statements of hazard' and/or 'Other potential health effects' in this
section.
Chronic ingestion of ethanol has been associated with an increased
Other potential health
incidence of cancer, liver cirrhosis, and congenital malformations.
effects
For a more detailed discussion of potential health hazards and toxicity see
Additional data
Section 11.
This document has been prepared in accordance with the US OSHA
NOTE:
Hazard Communication Standard, which requires the inclusion of all
known hazards of the product or its ingredients regardless of the potential
risk. The precautionary statements and warnings included may not apply in
all cases. Your needs may vary depending upon the potential for exposure
in your workplace. If your workplace is regulated by OSHA, this
document must be used as a part of a complete hazard-training program.
SECTION 4 - FIRST AID MEASURES
Eyes Immediately flush eyes with water for at least 15 minutes. If irritation
occurs or persists, get medical attention.
Skin Remove clothing and wash affected skin with soap and water. If irritation
occurs or persists, get medical attention.
Inhalation Remove to fresh air. If discomfort persists, get medical attention.
Ingestion Do not induce vomiting unless directed by medical personnel. Never give
anything by mouth to an unconscious person. Seek medical assistance if
symptoms occur or persist.
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SECTION 5 - FIRE FIGHTING MEASURES
General hazard Flammable Vapors are heavier than air and can travel to a source of
ignition and flash back. Vapors may form explosive mixture with air.
Wear approved positive pressure, self-contained breathing apparatus and
Fire fighting instructions
full protective turn out gear.
Extinguishing media Use carbon dioxide, sand, extinguishing powder.Do not use water.
Flash point 33掳C (<100掳F)
Emits fumes of carbon dioxide, nitrogen oxides, and hydrogen cyanide.
Hazardous combustion
products
SECTION 6 - ACCIDENTAL RELEASE MEASURES
Review Sections 3, 8 and 12 before proceeding with clean up.
General
Use non-combustible absorbent material to wipe up spill and place in a
Small spill
sealed container for disposal. Clean spill area thoroughly.
Large spill Contain the source of the spill or leak if it is safe to do so. Collect spill
with a non-combustible absorbent material and transfer to labeled
container for disposal. Close container and move it to a secure holding area.
SECTION 7 - HANDLING AND STORAGE
General handling Keep away from heat. Use with adequate ventilation. Avoid contact with
eyes, skin and clothing. Avoid contact with skin and clothing. Avoid
breathing vapor or mist.
Storage conditions Keep container tightly closed when not in use. Store in a cool, dry area.
Keep away from heat, sparks, flame, and other sources of ignition.
Store as directed by product packaging.
Temperature range
for storage
SECTION 8 - EXPOSURE CONTROLS/PERSONAL PROTECTION
Exposure limits
Compound Issuer Type OEL
Ethanol ACGIH TWA-8 Hr 1000 ppm
OSHA TWA-8 Hr 1000 ppm
Keep airborne contamination levels below the exposure limits listed above
Ventilation
in this section. Engineering controls should be used as the primary means
to control exposures.
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SECTION 8 - EXPOSURE CONTROLS/PERSONAL PROTECTION ... continued
Eye protection Not required for the normal use of this product. Wear safety glasses or
goggles if eye contact is possible.
Skin protection Not required for the normal use of this product. Use protective clothing
(lab coats, disposable coveralls, etc.) in both production and laboratory
areas.
Hand protection Not required for the normal use of this product. Wear protective gloves
when working with large quantities.
Respiratory protection Not required for the normal use of this product. If the applicable
Occupational Exposure Limit (OEL) is exceeded, wear an appropriate
respirator with a protection factor sufficient to control exposures to below
the OEL.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Liquid
Physical form
Blue
Color
Mixture
Molecular weight
Mixture
Molecular formula
4.2 at 20掳C
pH
Not applicable
Melting point
Soluble
Water solubility
Soluble in alcohol
Solvent solubility
SECTION 10 - STABILITY AND REACTIVITY
Stable
Reactivity
Avoid direct sunlight, conditions that might generate heat, and sources of
Conditions to avoid
ignition.
None known.
Incompatibilities
None known
Hazardous
decomposition
products
Not expected to occur
Hazardous
polymerization
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SECTION 11 - TOXICOLOGY INFORMATION
The information included in this section describes the potential hazards of
Toxicology summary
the individual ingredients.
Acute toxicity
Compound Type Route Species Dosage
Ethanol LD50 Oral Rat 7,060 mg/kg
LC50 10h Inhalation Rat 20,000 ppm
Benzoic Acid LD50 Oral Rat 2350 mg/kg
Sodium benzoate LD50 Oral Rat 4,070 mg/kg
LD50 Oral Mouse 1,600 mg/kg
Eye Not determined for this product. May cause moderate eye irritation based
on components.
Not expected to cause skin irritation
Skin
Not determined for this product. However, moderate irritation may occur
Inhalation
based on effects of individual components.
Ingestion Not determined for this product. See Acute toxicity table.
Not determined for this product.
Mutagenicity
Not determined for this product.
Subchronic effects
Chronic ingestion of ethanol has been reported to be associated with an
Chronic toxicity
increased incidence of cancer, liver cirrhosis, and congenital
malformations. However, occupational handling of this product is not
expected to result in relevant exposures.
IARC (International Agency for Research on Cancer) has classified
Chronic effects/
Alcoholic Beverages as Group 1 (carcinogenic to humans). However,
carcinogenicity
occupational handling of this product is not expected to result in relevant
exposures.
Carcinogenicity of the mixture has not been determined. Alcohol is listed
Carcinogen status
as a carcinogen by IARC. The IARC monograph examines the
carcinogenic potential of ethanol only as an alcoholic beverage. No other
components are listed as carcinogens by IARC, US OSHA or NTP.
Not determined for this product.
Reproductive effects
Teratogenicity Not determined for this product. Developmental effects have been reported
in humans and experimental animals given large doses of ethanol.
However, occupational handling of this product is not expected to result in
relevant exposures.
Liver, Central nervous system
Target organs
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SECTION 12 - ECOLOGICAL INFORMATION
The environmental characteristics of this material have not been fully
Environmental overview
evaluated. Releases to the environment should be avoided.
SECTION 13 - DISPOSAL INFORMATION
Waste materials may be classified as hazardous due to the low flash point.
Disposal procedure
Treatment, storage, transportation and disposal must be in accordance with
applicable national and local regulations.
SECTION 14 - TRANSPORTATION INFORMATION
Aqueous products containing ethanol at 24 percent or less are not subject
General shipping
to the requirements of the EU ADR, IATA, or IMDG. They are similarly
instructions
exempt from US DOT requirements provided that they contain no less
than 50 percent water.
SECTION 15 - REGULATORY INFORMATION
Irritant
EU Classification
EU Labelling Xi
R10 - Flammable.
Risk phrases
R36 - Irritating to eyes.
S26 - In case of contact with eyes, rinse immediately with plenty of water
Safety phrases
and seek medical advice.
S36 - Wear suitable protective clothing.
Class B, Division 2 (flammable liquid)
Canadian WHMIS
Class D, Division 2, Subdivision B
EU Label Pictogram(s)
SECTION 16 - OTHER
Disclaimer The information contained in this Material Safety Data Sheet is
believed to be accurate, and while it is provided in good faith, it is
without a warranty of any kind, express or implied.
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