SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 09/18/2006
Date Updated: 02/06/2006
Version 1.3
Section 1 - Product and Company Information
Product Name PARA-TOLUENESULFONYL FLUORIDE, 98%
Product Number 117455
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
P-TOLUENESULFONYL FLUORIDE 455-16-3 No
Formula C7H7FO2S
Synonyms Benzenesulfonyl fluoride, 4-methyl- (9CI) *
p-Methylbenzenesulfonyl fluoride *
4-Methylbenzenesulfonyl fluoride *
p-Methylphenylsulfonyl fluoride *
Toluene-4-sulfonyl fluoride * Toluene-p-sulphonyl
fluoride * Tosyl fluoride
RTECS Number: XT8050000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Corrosive.
Causes burns. Harmful by inhalation, in contact with skin and if
swallowed.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
EYE EXPOSURE
Assure adequate flushing of the eyes by separating the eyelids
with fingers.
Section 5 - Fire Fighting Measures
CONDITIONS OF FLAMMABILITY
Water hydrolyzes material liberating acidic gas which in contact
with metal surfaces can generate flammable and/or explosive
hydrogen gas.
FLASH POINT
222 藲F 106 藲C Method: closed cup
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Do not use water.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
EXPOSURE HAZARD(S)
Material: Corrosive. Harmful solid.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Avoid raising dust.
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Store in a cool dry place.
SPECIAL REQUIREMENTS
Moisture sensitive.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Other: Wear appropriate government approved respirator,
chemical-resistant gloves, safety goggles, other protective
clothing.
GENERAL HYGIENE MEASURES
ALDRICH - 117455 www.sigma-aldrich.com Page 2
Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Molecular Weight 174.19 AMU
pH N/A
BP/BP Range 112 藲C 16 mmHg
MP/MP Range 41.0 - 42.0 藲C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point 222 藲F 106 藲C Method: closed cup
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Sulfur oxides, Hydrogen fluoride.
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Multiple Routes: Causes burns. Harmful if swallowed, inhaled, or
absorbed through skin.
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Inhalation may result in spasm, inflammation and edema
of the larynxand bronchi, chemical pneumonitis, and pulmonary
edema. Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
TOXICITY DATA
Intraperitoneal
ALDRICH - 117455 www.sigma-aldrich.com Page 3
Rat
200 MG/KG
LD50
Section 12 - Ecological Information
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Corrosive solid, acidic,
organic, n.o.s.
UN#: 3261
Class: 8
Packing Group: Packing Group II
Hazard Label: Corrosive
PIH: Not PIH
IATA
Proper Shipping Name: Corrosive solid, acidic,
organic, n.o.s.
IATA UN Number: 3261
Hazard Class: 8
Packing Group: II
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: C
Indication of Danger: Corrosive.
R: 20/21/22-34
Risk Statements: Harmful by inhalation, in contact with skin and
if swallowed. Causes burns.
S: 22-26-27-36/37/39-45
Safety Statements: Do not breathe dust. In case of contact with
eyes, rinse immediately with plenty of water and seek medical
advice. Take off immediately all contaminated clothing. Wear
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Corrosive.
Risk Statements: Causes burns. Harmful by inhalation, in contact
with skin and if swallowed.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Take
off immediately all contaminated clothing. Wear suitable
protective clothing, gloves, and eye/face protection. Do not
breathe dust.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
TSCA INVENTORY ITEM: Yes
ALDRICH - 117455 www.sigma-aldrich.com Page 4
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: Yes
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2006 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
ALDRICH - 117455 www.sigma-aldrich.com Page 5
|