MATERIAL SAFETY DATA SHEET
In Case of Emergency, Call
Syngenta Crop Protection, Inc.
1-800-888-8372
Post Office Box 18300
Greensboro, NC 27419
1. PRODUCT IDENTIFICATION
Product Name: Product No.: A10976D
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EPA Signal Word: Caution
Active Ingredient(%): Brodifacoum Technical (0.005%) CAS No.: 56073-10-0
Chemical Name: 3-[3-(4鈥?-bromo[1,1鈥?-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-
one
Chemical Class: A coumarin-type anticoagulant rodenticide
EPA Registration Number(s): 100-1050, 100-1051, 100-1052, 100-1057 Section(s) Revised: 2
2. COMPOSITION/INFORMATION ON INGREDIENTS
ACGIH
OSHA NTP/IARC/OSHA
Other
TLV
PEL Carcinogen
Material
Crystalline Silica, Quartz 10 mg/m鲁/(%SiO2+2) 0.05 mg/m鲁 (respirable 0.05 mg/m鲁 IARC Group 2A
(respirable dust) silica) (respirable dust)**
Kaolin Clay 15 mg/m鲁 TWA (total); 5 2 mg/m鲁 TWA 10 mg/m鲁 TWA No
mg/m鲁 TWA (respirable) (respirable) (total); 5 mg/m鲁
TWA (respirable)**
Cereal Ingredients Not Established Not Established Not Established No
Green Pigment Not Established Not Established Not Established No
Brodifacoum Technical (0.005%) Not Established Not Established 0.002 mg/m鲁 TWA*** No
** recommended by NIOSH
*** Syngenta Occupational Exposure Limit (OEL)
Ingredients not precisely identified are proprietary or non-hazardous. Values are not product specifications.
Syngenta Hazard Category: A
3. HAZARDS IDENTIFICATION
Symptoms of Acute Exposure
Slightly irritating to the eyes. The active ingredient is designed to cause bleeding after repeated ingestion.
Hazardous Decomposition Products
Can decompose at high temperatures forming toxic gases.
Physical Properties
Appearance: Green pellets
Odor: Faint grain-like
Unusual Fire, Explosion and Reactivity Hazards
During a fire, irritating and possibly toxic gases may be generated by thermal decomposition or combustion.
4. FIRST AID MEASURES
Have the product container, label or Material Safety Data Sheet with you when calling Syngenta (800-888-8372), a poison
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contol center or doctor, or going for treatment.
If swallowed: Call Syngenta (800-888-8372), a poison control center or doctor immediately for treatment
Ingestion:
advice. Have the person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so
after calling 800-888-8372 or by a poison control center or doctor. Do not give anything by mouth to an
unconscious person.
If in eyes: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if
Eye Contact:
present, after 5 minutes, then continue rinsing eye. Call Syngenta (800-888-8372), a poison control center or
doctor for treatment advice.
Skin Contact: If on skin or clothing: Take off contaminated clothing. Wash skin with soap and water.
Not applicable.
Inhalation:
Notes to Physician
This product contains anticoagulants with an effect similar to warfarin in that they act by interfering with the synthesis of
prothrombin. The specific measure of effect is the prothrombin time. Note this may not become prolonged until 12-18
hours after ingestion. The specific antidote is Vitamin K1 (Phytomenandione BP).
Antidote must be administered under medical supervision. Initially, antidote should be given by injection (10-20 mg, or
0.25 mg/kg for children, by slow intravenous infusion at a rate not exceeding 1 mg/minute. In severe cases the use of fresh
frozen plasma may be required). Maintenance treatment is given orally (40 mg/day in divided doses for adults; up to 20
mg/day in divided doses for children). The prothrombin time and the hemoglobin should be monitored. Patients should be
kept under medical supervision until the prothrombin time has been normal for 3 consecutive days. Oral treatment may
need to be continued for several months (20 mg/day in divided doses for adults, and up to 20 mg/day in divided doses for
children). (For animal cases the dose is 2-5 mg/kg).
Further information is available from the Syngenta emergency number provided in this document.
Medical Condition Likely to be Aggravated by Exposure
As stated above this product contains anticoagulants with an effect similar to that of warfarin. The anticoagulant interferes
with the synthesis of prothrombin. Significant exposure (e.g. ingestion) can cause anticoagulation effects and could
aggravate existing blood clotting disorders.
5. FIRE FIGHTING MEASURES
Fire and Explosion
Flash Point (Test Method): > 375掳F (paraffin wax) Method: PMCC
Flammable Limits (% in Air): Lower: % Not Applicable Upper: % Not Applicable
Autoignition Temperature: Not Available
Flammability: Not Flammable
Unusual Fire, Explosion and Reactivity Hazards
During a fire, irritating and possibly toxic gases may be generated by thermal decomposition or combustion.
In Case of Fire
Use dry chemical, foam or CO2 extinguishing media. Wear full protective clothing and self-contained breathing apparatus.
Evacuate nonessential personnel from the area to prevent human exposure to fire, smoke, fumes or products of combustion.
Prevent use of contaminated buildings, area, and equipment until decontaminated.
6. ACCIDENTAL RELEASE MEASURES
In Case of Spill or Leak
Control the spill at its source. Clean up spills immediately, observing precautions outlined in Section 8. Sweep up material
and place in a compatible disposal container. Once all material is collected, seal container and arrange for disposition.
7. HANDLING AND STORAGE
Store the material in a well-ventilated, secure area out of reach of children and domestic animals. Do not store food, beverages
or tobacco products in the storage area. Prevent eating, drinking, tobacco use, and cosmetic application in areas where there is a
potential for exposure to the material. Wash thoroughly with soap and water after handling.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
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THE FOLLOWING RECOMMENDATIONS FOR EXPOSURE CONTROLS/PERSONAL PROTECTION ARE INTENDED FOR
THE MANUFACTURE, FORMULATION, PACKAGING AND USE OF THIS PRODUCT.
FOR COMMERCIAL APPLICATIONS AND/OR ON-FARM APPLICATIONS CONSULT THE PRODUCT LABEL.
Prevent eating, drinking, tobacco usage and cosmetic application in areas where there is a potential for
Ingestion:
exposure to the material. Wash thoroughly with soap and water after handling.
Eye Contact: Eye protection is not required for normal handling. Where eye contact is likely, wear tight-fitting chemical
goggles.
Skin Contact: Gloves are not required for normal handling. Where heavy contact is likely, wear chemical resistant (such as
nitrile or butyl) gloves.
Inhalation: Respiratory protection is not required for normal handling. In the event of an unusual dust exposure, use
engineering controls or a NIOSH-certified particulate respirator (N, P, R or HE filter) to keep exposure
below the Occupational Exposure Limit.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Green pellets
Odor: Faint grain-like
Melting Point: Not Available
Boiling Point: 442 - 446掳F (Brodifacoum)
Specific Gravity/Density: 40.00 lbs./cu.ft.
Not Available
pH:
Solubility in H2O
Brodifacoum Technical: Insoluble
Vapor Pressure
Brodifacoum Technical: 6 x 10(-6) mmHg @ 68掳F (20掳C)
10. STABILITY AND REACTIVITY
Stability: Stable under normal use and storage conditions.
Hazardous Polymerization: Will not occur.
Conditions to Avoid: None known.
Materials to Avoid: None known.
Hazardous Decomposition Products: Can decompose at high temperatures forming toxic gases.
11. TOXICOLOGICAL INFORMATION
Acute Toxicity/Irritation Studies (Finished Product)
Ingestion: Practically Non-Toxic
Oral (LD50 Rat) : > 5,000 mg/kg body weight
Dermal: Slightly Toxic
Dermal (LD50 Rat) : > 2,000 mg/kg body weight (calculated from
technical material)
Inhalation: Not Available
Inhalation (LC50 Rat) : See "Other Toxicity Information", Sec. 11
Eye Contact: See "Other Toxicity Information", Sec. 11
Skin Contact: See "Other Toxicity Information", Sec. 11
Skin Sensitization: Not Available
Reproductive/Developmental Effects
Brodifacoum Not teratogenic, embryotoxic or fetotoxic in rats or rabbits at doses up to 0.02 mg/kg/day - the dose
Technical: causing excessive maternal toxicity.
Non-genotoxic in a range of assays.
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Chronic/Subchronic Toxicity Studies
The biological half-life for brodifacoum in body tissue in rats is > 100 days. Adverse clinical
Brodifacoum
effects can develop from body accumulation. Prolonged prothrombin time, depression, pallor,
Technical:
subcutaneous hemorrhage, bleeding of nose or gums, gastrointestinal hemorrhage, cerebral
hemorrhage, shock and death can develop following exposures.
No neurotox studies have been conducted.
Carcinogenicity
Brodifacoum Unlikely to be carcinogenic.
Technical:
Other Toxicity Information
Effects of overexposure are those of anticoagulant overdose, i.e., reduced blood clotting ability with spontaneous bleeding in
various organs. Body accumulation can result from repeated exposures since the half-life of brodifacoum is > 100 days.
Individuals with blood clotting disorders may be more susceptible to overexposure effects.
Systemically toxic concentrations of this product will probably not be absorbed through human skin.
No toxic effects are known to be associated with inhalation of dust from this material.
No irritation is likely to develop following contact with human eyes.
Irritation will probably not develop following contact with human skin.
Toxicity of Other Components
Cereal Ingredients
Not applicable
Crystalline Silica, Quartz
Chronic inhalation exposure to crystalline silica is known to cause silicosis and pulmonary fibrosis in humans.
Experimental animals exposed to crystalline silica developed respiratory tract cancers.
Green Pigment
Not applicable
Kaolin Clay
The toxicological properties of this material have not been fully investigated. May cause eye and skin irritation.
May cause respiratory and digestive tract irritation. This is expected to be a low hazard for usual industrial handling.
Long term exposure to high concentrations of this dust may produce x-ray evidence of dust in the lungs. Continued
long term overexposure may affect respiratory function in some individuals.
Target Organs
Active Ingredients
Brodifacoum Technical: Blood
Inert Ingredients
Cereal Ingredients: Not applicable
Crystalline Silica, Quartz: Respiratory tract
Green Pigment: Not applicable
Kaolin Clay: Eye, skin, lung, digestive tract
12. ECOLOGICAL INFORMATION
Summary of Effects
Brodifacoum Technical:
The risk of this formulation to most non-target organisms is low. However, if this product is misused or stored
improperly, birds and non-target animals may be at higher risk.
Eco-Acute Toxicity
Brodifacoum Brodifacoum Technical:
Technical: Fish (Trout) 96-hr LC50 0.04 ppm
Invertebrates (Daphnia) 48-hr EC50 0.06 ppm
Birds (8-day dietary - Bobwhite Quail) 40-day LC50 0.8 ppm
Birds (8-day dietary - Mallard Duck) 40-day LC50 2.7 ppm
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.
Formulation (predicted):
Fish (Trout) 96-hr LC50 800 ppm
Invertebrates (Daphnia) 48-hr EC50 1,200 ppm
Birds (8-day dietary - Bobwhite Quail) LC50 16,000 ppm
Birds (8-day dietary - Mallard Duck) LC50 54,000 ppm
Eco-Chronic Toxicity
Brodifacoum No applicable studies available.
Technical:
Environmental Fate
Brodifacoum Technical:
The information presented here is for the active ingredient, brodifacoum.
Not persistent in soil. Stable in water. Immobile in soil. Sinks in water (after 24 h).
13. DISPOSAL CONSIDERATIONS
Disposal
Do not reuse empty container except for holding additional product.
Characteristic Waste: Not Applicable
Listed Waste: Not Applicable
14. TRANSPORT INFORMATION
DOT Classification
Ground Transport - NAFTA
Not regulated.
B/L Freight Classification
Exterminator, Vermin, O/T Poison
Comments
Water Transport - International
Proper Shipping Name: Environmentally Hazardous Substance, Solid, N.O.S. (Brodifacoum), Marine Pollutant
Hazard Class or Division: Class 9
Identification Number: UN 3077
Packing Group: PG III
15. REGULATORY INFORMATION
EPCRA SARA Title III Classification
Acute Health Hazard
Section 311/312 Hazard Classes:
Chronic Health Hazard
Section 313 Toxic Chemicals: Not Applicable
California Proposition 65
Not Applicable
CERCLA/SARA 302 Reportable Quantity (RQ)
None
RCRA Hazardous Waste Classification (40 CFR 261)
Not Applicable
TSCA Status
Exempt from TSCA, subject to FIFRA
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16. OTHER INFORMATION
HMIS Hazard Ratings 0 Minimal
NFPA Hazard Ratings
1 Slight
Health: 1
Health: 1
2 Moderate
Flammability: 1
Flammability: 1
3 Serious
Reactivity: 0
Instability: 0
4 Extreme
For non-emergency questions about this product call:
1-800-334-9481
Original Issued Date: 09/20/2000
Revision Date: Replaces: 07/01/2005
04/10/2006
The information and recommendations contained herein are based upon data believed to be correct.
However, no guarantee or warranty of any kind, expressed or implied, is made with respect to the
information contained herein.
RSVP# : Not Applicable
End of MSDS
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