Forane (R) 404A
Material Safety Data Sheet
Arkema Inc.
1 PRODUCT AND COMPANY IDENTIFICATION
EMERGENCY PHONE NUMBERS:
DFO
Chemtrec: (800) 424-9300 (24hrs) or (703) 527-3887
2000 Market Street
Medical: Rocky Mountain Poison Control Center
(866) 767-5089 (24Hrs)
Philadelphia, PA 19103
Information Telephone Numbers Phone Number Available Hrs
Product Information 800-245-5858 8:00 am - 5:30 pm (Eastern)
Product Name Forane (R) 404A
Product Synonym(s) R-404A, HFC/ HFC/ HFC-404A, FORANE FX 70
Chemical Family Hydrofluorocarbon Blend
Chemical Formula CF3CH2F/CF3CHF2/CF3CH3
Chemical Name 1,1,1,2-tetrafluoroethane / Pentafluoroethane / 1,1,1-trifluoroethane
EPA Reg Num
Product Use Refrigerant
2 COMPOSITION / INFORMATION ON INGREDIENTS
Ingredient Name CAS RegistryNumber Typical Wt. % OSHA
1,1,1-trifluoroethane (HFC-143a) 420-46-2 52% Y
pentafluoroethane (HFC-125) 354-33-6 44% Y
1,1,1,2-tetrafluoroethane (HFC-134a) 811-97-2 4% Y
The substance(s) marked with a "Y" in the OSHA column, are identified as hazardous chemicals according to the
criteria of the OSHA Hazard Communication Standard (29 CFR 1910.1200)
This material is classified as hazardous under Federal OSHA regulation.
The components of this product are all on the TSCA Inventory list.
3 HAZARDS IDENTIFICATION
Emergency Overview
Colorless liquified gas with faint ether odor.
WARNING!
LIQUID AND GAS UNDER PRESSURE, OVERHEATING AND OVERPRESSURIZING MAY CAUSE GAS RELEASE
OR VIOLENT CYLINDER BURSTING. MAY DECOMPOSE ON CONTACT WITH FLAMES OR EXTREMELY HOT
METAL SURFACES TO PRODUCE TOXIC AND CORROSIVE PRODUCTS. VAPOR REDUCES OXYGEN
AVAILABLE FOR BREATHING AND IS HEAVIER THAN AIR. HARMFUL IF INHALED AND MAY CAUSE HEART
IRREGULARITIES, UNCONSCIOUSNESS OR DEATH. LIQUID CONTACT WITH EYES OR SKIN MAY CAUSE
FROSTBITE.
Potential Health Effects
Skin contact and inhalation are expected to be the primary routes of occupational exposure to this material. As with
most liquefied gases, contact with the rapidly volatilizing liquid can cause frostbite to any tissue. High vapor
concentrations are irritating to the eyes and respiratory tract and may result in central nervous system (CNS) effects
such as headache, dizziness, drowsiness and, in severe exposure, loss of consciousness and death. The dense vapor
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Forane (R) 404A
Material Safety Data Sheet
Arkema Inc.
of this material may reduce the available oxygen for breathing. Prolonged exposure to an oxygen-deficient atmosphere
may be fatal. Inhalation may cause an increase in the sensitivity of the heart to adrenaline, which could result in
irregular or rapid heartbeats. Medical conditions aggravated by exposure to this material include heart disease or
compromised heart function.
4 FIRST AID MEASURES
IF IN EYES, immediately flush with plenty of water. Get medical attention if irritation persists.
IF ON SKIN, Flush exposed skin with lukewarm water (not hot), or use other means to warm skin slowly. Get
medical attention if frostbitten by liquid or if irritation occures.
IF SWALLOWED, Not applicable - product is a gas at ambient temperatures.
IF INHALED, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical attention. Do not give adrenaline, epinephrin or similar drugs following exposure to this
product.
5 FIRE FIGHTING MEASURES
Fire and Explosive Properties
Auto-Ignition Temperature NE
Flash Point NA - GAS Flash Point Method
Flammable Limits- Upper NONE
NONE
Lower
Extinguishing Media
Use extinguishing media appropriate to surrounding fire conditions.
Fire Fighting Instructions
Stop the flow of gas if possible. Use water spray on person making shut-off. Fire fighters and others who may
be exposed to products of combustion should wear full fire fighting turn out gear (full Bunker Gear) and self-
contained breathing apparatus (pressure demand NIOSH approved or equivalent). Fire fighting equipment
should be thoroughly decontaminated after use.
Fire and Explosion Hazards
May decompose on contact with flames or extremely hot metal surfaces to produce toxic and corrosive
products. Liquid and gas under pressure, overheating or overpressurizing may cause gas release and/or violent
cylinder bursting. Container may explode if heated due to resulting pressure rise. Some mixtures of HCFCs
and/or HFCs, and air or oxygen may be combustible if pressurized and exposed to extreme heat or flame.
6 ACCIDENTAL RELEASE MEASURES
In Case of Spill or Leak
Use Halogen leak detector or other suitable means to locate leaks or check atmosphere. Keep upwind.
Evacuate enclosed spaces and disperse gas with floor-level forced-air ventilation. Exhaust vapors outdoors.
Do not smoke or operate internal combustion engines. Remove flames and heating elements.
7 HANDLING AND STORAGE
Handling
Avoid breathing gas. Avoid contact with eyes, skin and clothing. Keep container closed. Use only with
adequate ventilation. Do not enter confined spaces unless adequately ventilated.
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Forane (R) 404A
Material Safety Data Sheet
Arkema Inc.
7 HANDLING AND STORAGE
Storage
Do not apply direct flame to cylinder. Do not store cylinder in direct sun or expose it to heat above 120 F.
Do not drop or refill this cylinder. Keep away from heat, sparks and flames.
8 EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Controls
Investigate engineering techniques to reduce exposures below airborne exposure limits. Provide ventilation
if necessary to control exposure levels below airborne exposure limits (see below). If practical, use local
mechanical exhaust ventilation at sources of air contamination such as open process equipment.
Eye / Face Protection
Where there is potential for eye contact, wear chemical goggles and have eye flushing equipment available.
Skin Protection
Wear appropriate chemical resistant protective clothing and chemical resistant gloves to prevent skin
contact. Consult glove manufacturer to determine appropriate type glove material for given application.
Rinse contaminated skin promptly. Wash contaminated clothing and clean protective equipment before
reuse. Wash skin thoroughly after handling.
Respiratory Protection
Avoid breathing gas. When airborne exposure limits are exceeded (see below), use NIOSH approved
respiratory protection equipment appropriate to the material and/or its components (full facepiece
recommended). Consult respirator manufacturer to determine appropriate type equipment for a given
application. Observe respirator use limitations specified by NIOSH or the manufacturer. For emergency and
other conditions where exposure limit may be significantly exceeded, use an approved full face positive-
pressure, self-contained breathing apparatus or positive-pressure airline with auxiliary self-contained air
supply. Respiratory protection programs must comply with 29 CFR 搂 1910.134.
Airborne Exposure Guidelines for Ingredients
Exposure Limit Value
1,1,1,2-tetrafluoroethane (HFC-134a)
WEEL TWA - 1000 ppm 4240 mg/m3
pentafluoroethane (HFC-125)
WEEL TWA - 4900 mg/m3 1000 ppm
1,1,1-trifluoroethane (HFC-143a)
WEEL TWA - 3400 mg/m3 1000 ppm
-Only those components with exposure limits are printed in this section.
-Skin contact limits designated with a "Y" above have skin contact effect. Air sampling alone is insufficient to accurately quantitate
exposure. Measures to prevent significant cutaneous absorption may be required.
-ACGIH Sensitizer designator with a value of "Y" above means that exposure to this material may cause allergic reactions.
-WEEL-AIHA Sensitizer designator with a value of "Y" above means that exposure to this material may cause allergic skin reactions.
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Forane (R) 404A
Material Safety Data Sheet
Arkema Inc.
9 PHYSICAL AND CHEMICAL PROPERTIES
Colorless liquified gas with faint ether odor.
Appearance/Odor
pH NA
Specific Gravity 1.05 @ 25 C
Vapor Pressure (BUBBLE) 163.3 psia @ 21.1 C (70 F)
Vapor Density (AIR = 1) 3.39
Melting Point NE
Freezing Point NE
Boiling Point -47.8 C/ -54 F
Solubility In Water Negligible
Percent Volatile 100
Molecular Weight 97.60
10 STABILITY AND REACTIVITY
Stability
This material is chemically stable under specified conditions or storage, shipment and/or use. See
HANDLING AND STORAGE section of this MSDS for specified conditions.
Incompatibility
Avoid contact with strong alkali or alkaline earth metals, finely powdered metals such as aluminum, magnesium
or zinc and strong oxidizers, since they may react or accelerate decomposition.
Hazardous Decomposition Products
Thermal decomposition products could include Halogen acid (HF), Halogens, Carbon monoxide, Carbon dioxide,
and Carbonyl halides.
11 TOXICOLOGICAL INFORMATION
Toxicological Information
1,1,1,2-Tetrafluoroethane (HFC-134a)
No skin allergy was observed in guinea pigs following repeated exposure. Acute inhalation exposure produced
anesthetic effects in mice, dogs, cats and monkeys. Repeated inhalation exposure produced no adverse
effects in rats. Inhalation, followed by intravenous injection of epinephrine to simulate stress reactions, resulted
in cardiac sensitization in dogs. Following long-term inhalation studies in rats, an increased incidence of benign
tumors (at high concentrations) in the testes was observed. No birth defects were noted in the offspring of rats
exposed by inhalation during pregnancy, even at dosages that produced significant adverse effects in the
mother. No genetic changes were observed in tests using bacteria, animal cells or animals. Single exposure
(acute) studies indicate:
Inhalation - Practically Non-toxic to Rats (4-hr LC50 >500,000 ppm; 30-min LC50 ~750,000 ppm)
Eye Irritation - Slightly Irritating to Rabbits
Skin Irritation - Slightly Irritating to Rabbits (24-hr exposure)
Ethane, 1,1,1-trifluoro-
Inhalation of high concentrations of this material, followed by intravenous injection of epinephrine to simulate
stress reactions, resulted in cardiac sensitization in dogs. Following repeated inhalation exposure, lung irritant
effects including mild bronchitis and pneumonia were observed in rats and guinea pigs. No adverse effects
were observed in long-term oral studies with rats. No birth defects were noted in the offspring of rats or rabbits
exposed by inhalation during pregnancy. No genetic changes were observed in tests using animal cells or
animals. Both positive and negative results have been reported in tests using bacteria. Single exposure (acute)
studies indicate:
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Forane (R) 404A
Material Safety Data Sheet
Arkema Inc.
11 TOXICOLOGICAL INFORMATION
Inhalation - Practically Non-toxic to Rats (4-hr LC50 >540,000 ppm)
Ethane, pentafluoro-
Inhalation followed by intravenous injection of epinephrine to simulate stress reactions resulted in cardiac
sensitization in dogs. Following repeated inhalation exposure, no adverse effects were observed in rats. No
birth defects were noted in the offspring of rats or rabbits exposed by inhalation during pregnancy. No genetic
changes were observed in tests using bacteria, animal cells or animals. Single exposure (acute) studies
indicate:
Inhalation - Practically Non-toxic to Rats (4-hr LC50 >800,000 ppm)
12 ECOLOGICAL INFORMATION
Ecotoxicological Information
Ethane, 1,1,1-trifluoro-
This material is practically non-toxic to Daphnia magna (48-hr LC50 300 mg/l) and no more than slightly toxic to
rainbow trout (96-hr LC50 >40 mg/l).
1,1,1,2-Tetrafluoroethane (HFC-134a)
This material is practically non-toxic to Daphnia magna (48-hr EC50 930 mg/l), rainbow trout (96-hr LC50 450
mg/l) and bacteria (16-hr EC10 >730 mg/l).
Chemical Fate Information
1,1,1,2-Tetrafluoroethane (HFC-134a)
This material is not readily biodegradable (3% after 28-days). Its degradation half-life in the atmosphere is 9.6-
16.7 years. The ozone depletion potential (ODP) is 0 and the halocarbon global warming potential (HGWP) is
0.3. It is practically not bioaccumulable (log Pow 1.06).
Ethane, pentafluoro-
When released into the environment, this material is expected to partition almost exclusively into the
atmosphere. Based on its low n-octanol/water partition coefficient (log Pow 1.48), bioaccumulation is
considered unlikely. In a 28-day ready biodegradability closed bottle test, it appeared to be stable (about 10%
degraded). This material does not dissociate in water.
13 DISPOSAL CONSIDERATIONS
Waste Disposal
Recover, reclaim or recycle when practical. Dispose of in accordance with federal, state and local regulations.
Note: Chemical additions to, processing of, or otherwise altering this material may make this waste
management information incomplete, inaccurate, or otherwise inappropriate. Furthermore, state and local
waste disposal requirements may be more restrictive or otherwise different from federal laws and regulations.
14 TRANSPORT INFORMATION
DOT Name Refrigerant Gas R 404A
DOT Technical Name
DOT Hazard Class 2.2
UN Number UN 3337
DOT Packing Group PG NA
RQ
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Revision: 10 Issued: 11 OCT 2004 of 6
Forane (R) 404A
Material Safety Data Sheet
Arkema Inc.
15 REGULATORY INFORMATION
Hazard Categories Under Criteria of SARA Title III Rules (40 CFR Part 370)
Immediate (Acute) Health Y Fire N
Reactive
Delayed (Chronic) Health N N
Sudden Release of Pressure Y
The components of this product are all on the TSCA Inventory list.
Ingredient Related Regulatory Information:
CERCLA RQ SARA TPQ
SARA Reportable Quantities
1,1,1,2-tetrafluoroethane (HFC-134a) NE
New Jersey Right to Know
This product does contain the following chemical(s), as indicated below, currently on the New Jersey Right-to-Know Substances List.
1,1,1-trifluoroethane (HFC-143a)
16 OTHER INFORMATION
Revision Information
Revision Number 10
11 OCT 2004
Revision Date
Supercedes Revision Dated 30-SEP-2004
Revision Summary
ATOFINA Chemicals, Inc. has changed its name to Arkema Inc..
Key
NE= Not Established NA= Not Applicable (R) = Registered Trademark
Arkema Inc. believes that the information and recommendations contained herein (including data and
statements) are accurate as of the date hereof. NO WARRANTY OF FITNESS FOR ANY PARTICULAR
PURPOSE, WARRANTY OF MERCHANTABILITY, OR ANY OTHER WARRANTY, EXPRESSED OR
IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED HEREIN. The information provided
herein relates only to the specific product designated and may not be valid where such product is used in
combination with any other materials or in any process. Further, since the conditions and methods of use are
beyond the control of Arkema Inc., Arkema Inc. expressly disclaims any and all liability as to any results
obtained or arising from any use of the product or reliance on such information.
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