ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 1 of 14
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
ZINC OXIDE
SYNONYMS
"O-Zn ZnO", "O-Zn ZnO", "C.I. Pigment White 14 C.I. 77947", "Amolox Azo-33 Azo-55 Azo-66
Azo-77 Azodox-55 Azodox-55TT Azo-55TT Azo-66TT", Azo-77TT, "Calamine Chinese White",
"Emanay zinc oxide", Emar, "Felling zinc oxide", "Flowers of zinc green", "Seal-8 white
seal 7", "Snow white", "Hubbuck's White", "Kadox-25 k-zinc ozide", Zincite, "Ozlo Zincoid
Pasco Zinc white", "Permanent white", "Philosopher's wool", "Protox type 166 167 168 267
268", XX503R, XX601R, Cerox-506, ZC-X013
PROPER SHIPPING NAME
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
(contains zinc oxide)
PRODUCT USE
As a pigment in white paints and enamels; printing inks, in cosmetics, quick setting
cements; rubber mixes, white glue, porcelain glazes. In medicine as component of ointments
(zinc cream), cosmetics, lotions, dusting powders, bandages. Zinc oxide is a bacteriostat
not a bactericide. Manufacture of opaque glass and certain transparent glasses;
electrostatic copying paper; as flame retardant; in electronics as semiconductor. Used in
some animal food additives and fertilizers.
SUPPLIER
Company: Quantum Chemicals Pty Ltd
Address:
70 Quantum Close
Dandenong South
Victoria 3175
Telephone: 03 8795 8000
Emergency Tel: 1300 131 001
Fax: 03 8795 8099
HAZARD RATINGS
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 2 of 14
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Flammability
Toxicity
Body Contact
Reactivity
Chronic
SCALE: Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the Criteria of NOHSC,
and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
Very toxic to aquatic organisms may cause long- Do not breathe dust.
term adverse effects in the aquatic environment.
Inhalation may produce health damage*. Wear eye/ face protection.
Cumulative effects may result following Use only in well ventilated areas.
exposure*.
May produce discomfort of the eyes respiratory Keep container in a well ventilated place.
tract and skin*.
* (limited evidence). To clean the floor and all objects contaminated
by this material use water and detergent.
This material and its container must be disposed
of in a safe way.
Take off immediately all contaminated clothing.
In case of contact with eyes rinse with plenty
of water and contact Doctor or Poisons
Information Centre.
Use appropriate container to avoid environment
contamination.
Avoid release to the environment. Refer to
special instructions/ safety data sheets.
This material and its container must be disposed
of as hazardous waste.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
zinc oxide 1314-13-2 > 99
commercial product may contain varying amounts of
lead monoxide 1317-36-8
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 3 of 14
Section 4 - FIRST AID MEASURES
SWALLOWED
路 Immediately give a glass of water.
路 First aid is not generally required. If in doubt, contact a Poisons Information Centre
or a doctor.
EYE
If this product comes in contact with the eyes:
路 Wash out immediately with fresh running water.
路 Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and
moving the eyelids by occasionally lifting the upper and lower lids.
路 If pain persists or recurs seek medical attention.
路 Removal of contact lenses after an eye injury should only be undertaken by skilled
personnel.
SKIN
If skin contact occurs:
路 Immediately remove all contaminated clothing, including footwear.
路 Flush skin and hair with running water (and soap if available).
路 Seek medical attention in event of irritation.
INHALED
路 If fumes or combustion products are inhaled remove from contaminated area.
路 Lay patient down. Keep warm and rested.
路 Prostheses such as false teeth, which may block airway, should be removed, where
possible, prior to initiating first aid procedures.
路 Apply artificial respiration if not breathing, preferably with a demand valve
resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary.
路 Transport to hospital, or doctor.
NOTES TO PHYSICIAN
路 Absorption of zinc compounds occurs in the small intestine.
路 The metal is heavily protein bound.
路 Elimination results primarily from faecal excretion.
路 The usual measures for decontamination (Ipecac Syrup, lavage, charcoal or cathartics)
may be administered, although patients usually have sufficient vomiting not to require
them.
路 CaNa2EDTA has been used successfully to normalise zinc levels and is the agent of
choice.
[Ellenhorn and Barceloux: Medical Toxicology].
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
路 Water spray or fog.
路 Foam.
路 Dry chemical powder.
路 BCF (where regulations permit).
路 Carbon dioxide.
FIRE FIGHTING
路 Alert Fire Brigade and tell them location and nature of hazard.
路 Wear breathing apparatus plus protective gloves for fire only.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Use fire fighting procedures suitable for surrounding area.
路 DO NOT approach containers suspected to be hot.
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 4 of 14
Section 5 - FIRE FIGHTING MEASURES
路 Cool fire exposed containers with water spray from a protected location.
路 If safe to do so, remove containers from path of fire.
路 Equipment should be thoroughly decontaminated after use.
FIRE/EXPLOSION HAZARD
路 Solid which exhibits difficult combustion or is difficult to ignite.
路 Avoid generating dust, particularly clouds of dust in a confined or unventilated space
as dusts may form an explosive mixture with air, and any source of ignition, i.e.
flame or spark, will cause fire or explosion. Dust clouds generated by the fine
grinding of the solid are a particular hazard; accumulations of fine dust may burn
rapidly and fiercely if ignited.
路 Dry dust can also be charged electrostatically by turbulence, pneumatic transport,
pouring, in exhaust ducts and during transport.
路 Build-up of electrostatic charge may be prevented by bonding and grounding.
路 Powder handling equipment such as dust collectors, dryers and mills may require
additional protection measures such as explosion venting.
路 All movable parts coming in contact with this material should have a speed of less than
1-metre/sec.
Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), metal oxides,
other pyrolysis products typical of burning organic material.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine
bleaches, pool chlorine etc. as ignition may result.
HAZCHEM: 2X
Personal Protective Equipment
Gas tight chemical resistant suit.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
Environmental hazard - contain spillage.
路 Remove all ignition sources.
路 Clean up all spills immediately.
路 Avoid contact with skin and eyes.
路 Control personal contact by using protective equipment.
路 Use dry clean up procedures and avoid generating dust.
路 Place in a suitable labelled container for waste disposal.
MAJOR SPILLS
Environmental hazard - contain spillage.
Moderate hazard.
路 CAUTION: Advise personnel in area.
路 Alert Emergency Services and tell them location and nature of hazard.
路 Control personal contact by wearing protective clothing.
路 Prevent, by any means available, spillage from entering drains or water courses.
路 Recover product wherever possible.
路 IF DRY: Use dry clean up procedures and avoid generating dust. Collect residues and
place in sealed plastic bags or other containers for disposal. IF WET: Vacuum/shovel up
and place in labelled containers for disposal.
路 ALWAYS: Wash area down with large amounts of water and prevent runoff into drains.
路 If contamination of drains or waterways occurs, advise Emergency Services.
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 5 of 14
Section 6 - ACCIDENTAL RELEASE MEASURES
PROTECTIVE ACTIONS FOR SPILL
WARNING
PROTECTIVE ACTION ZONE
half
evacuation
downwind
direction
distance
down wind distance
wind isolation
distance
direction
half
evacuation downwind
INITIAL direction distance
ISOLATION
ZONE
From IERG (Canada/Australia)
Isolation Distance -
Downwind Protection Distance 10 metres
IERG Number 47
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone
assumes that random changes in wind direction confines the vapour plume to an area within 30 degrees on
either side of the predominant wind direction, resulting in a crosswind protective action distance equal
to the downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spill
and working away from the site in the downwind direction. Within the protective action zone a level of
vapour concentration may exist resulting in nearly all unprotected persons becoming incapacitated and
unable to take protective action and/or incurring serious or irreversible health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high
probability of localised wind reversal may expose nearly all persons without appropriate protection to
life-threatening concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less, such as a drum (jerrican or
box with inner containers). Larger packages leaking less than 200 litres and compressed gas leaking from
a small cylinder are also considered "small spills".
LARGE SPILLS involve many small leaking packages or a leaking package of greater than 200 litres, such as
a cargo tank, portable tank or a "one-tonne" compressed gas cylinder.
5 Guide 171 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
zinc oxide 500 mg/m鲁
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
zinc oxide 15 mg/m鲁
other than mild, transient adverse effects without perceiving a clearly defined odour is:
zinc oxide 15 mg/m鲁
The threshold concentration below which most people will experience no appreciable risk of health effects:
zinc oxide 15 mg/m鲁
American Industrial Hygiene Association (AIHA)
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 6 of 14
Section 6 - ACCIDENTAL RELEASE MEASURES
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
路 Avoid all personal contact, including inhalation.
路 Wear protective clothing when risk of exposure occurs.
路 Use in a well-ventilated area.
路 Prevent concentration in hollows and sumps.
路 DO NOT enter confined spaces until atmosphere has been checked.
路 DO NOT allow material to contact humans, exposed food or food utensils.
路 Avoid contact with incompatible materials.
路 When handling, DO NOT eat, drink or smoke.
路 Keep containers securely sealed when not in use.
路 Avoid physical damage to containers.
路 Always wash hands with soap and water after handling.
路 Work clothes should be laundered separately. Launder contaminated clothing before re
-use.
路 Use good occupational work practice.
路 Observe manufacturer's storing and handling recommendations.
路 Atmosphere should be regularly checked against established exposure standards to ensure
safe working conditions are maintained.
SUITABLE CONTAINER
Multi-ply paper bag with sealed plastic liner or heavy gauge plastic bag.
NOTE: Bags should be stacked, blocked, interlocked, and limited in height so that they
are stable and secure against sliding or collapse. Check that all containers are clearly
labelled and free from leaks. Packing as recommended by manufacturer.
路 Polyethylene or polypropylene container.
路 Check all containers are clearly labelled and free from leaks.
STORAGE INCOMPATIBILITY
Avoid reaction with oxidising agents.
Avoid strong acids, bases.
Segregate from magnesium, chlorinated rubber and alkali hydroxides.
Slowly absorbs carbon dioxide from the air.
STORAGE REQUIREMENTS
Observe manufacturer's storing and handling recommendations.
_____________________________________________________
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ + + + + +
_____________________________________________________
+: May be stored together
O: May be stored together with specific preventions
X: Must not be stored together
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 7 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA mg/m鲁 STEL mg/m鲁
_________ _________ _____ _____
Australia Exposure zinc oxide (Zinc oxide 10
Standards (dust) (a))
Australia Exposure zinc oxide (Zinc oxide 5 10
Standards (fume))
Australia Exposure lead monoxide (Lead, 0.15
Standards inorganic dusts &
fumes (as Pb))
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
zinc oxide 500
lead monoxide 100
MATERIAL DATA
It is the goal of the ACGIH (and other Agencies) to recommend TLVs (or their equivalent)
for all substances for which there is evidence of health effects at airborne
concentrations encountered in the workplace.
At this time no TLV has been established, even though this material may produce adverse
health effects (as evidenced in animal experiments or clinical experience). Airborne
concentrations must be maintained as low as is practically possible and occupational
exposure must be kept to a minimum.
NOTE: The ACGIH occupational exposure standard for Particles Not Otherwise Specified
(P.N.O.S) does NOT apply.
Sensory irritants are chemicals that produce temporary and undesirable side-effects on
the eyes, nose or throat. Historically occupational exposure standards for these
irritants have been based on observation of workers' responses to various airborne
concentrations. Present day expectations require that nearly every individual should be
protected against even minor sensory irritation and exposure standards are established
using uncertainty factors or safety factors of 5 to 10 or more. On occasion animal no
-observable-effect-levels (NOEL) are used to determine these limits where human results
are unavailable. An additional approach, typically used by the TLV committee (USA) in
determining respiratory standards for this group of chemicals, has been to assign ceiling
values (TLV C) to rapidly acting irritants and to assign short-term exposure limits (TLV
STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints
combine to warrant such a limit. In contrast the MAK Commission (Germany) uses a five
-category system based on intensive odour, local irritation, and elimination half-life.
However this system is being replaced to be consistent with the European Union (EU)
Scientific Committee for Occupational Exposure Limits (SCOEL); this is more closely
allied to that of the USA.
OSHA (USA) concluded that exposure to sensory irritants can:
路 cause inflammation
路 cause increased susceptibility to other irritants and infectious agents
路 lead to permanent injury or dysfunction
路 permit greater absorption of hazardous substances and
路 acclimate the worker to the irritant warning properties of these substances thus
increasing the risk of overexposure.
The concentration of respirable dust for application of this limit is to be determined
from the fraction that penetrates a separator whose size collection efficiency is
described by a cumulative lognormal function with a median aerodynamic diameter of 4.0 碌m
(+-) 0.3 碌m and with a geometric standard deviation of 1.5 碌m (+-) 0.1 碌m, i.e..generally
less than 5 碌m.
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 8 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
INGREDIENT DATA
LEAD MONOXIDE:
The lead concentration in air is to be maintained so that the lead concentration in
workers' blood remains below 0.060 mg/100 g of whole blood. The recommended TLV-TWA has
been derived following a review of reports of adverse effects on reproduction, blood
-pressure and other end-points of toxicity. A particular focus was an assessment of pre
-natal blood lead (PbB) levels and post-natal cognitive levels. The fact that lead is a
cumulative toxicant which can produce subtle, persistent and apparently permanent effects
in the off-spring of lead exposed women is of particular concern. A current view holds
that the identification of the PbB levels, that are protective during a working lifetime,
is a necessary prerequisite in the recommendation of the TLV because PbB values, rather
than workplace air lead concentrations, are more clearly related to adverse health
effects.
(see Biological Exposure Index - BEI - in "Advice to Doctor".).
PERSONAL PROTECTION
EYE
路 Safety glasses with side shields.
路 Chemical goggles.
路 Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
Suitability and durability of glove type is dependent on usage. Factors such as:
路 frequency and duration of contact,
路 chemical resistance of glove material,
路 glove thickness and
路 dexterity,
are important in the selection of gloves.
Wear chemical protective gloves, eg. PVC.
Wear safety footwear or safety gumboots, eg. Rubber.
OTHER
路 Overalls.
路 P.V.C. apron.
路 Barrier cream.
路 Skin cleansing cream.
路 Eye wash unit.
RESPIRATOR
Protection Factor Half- Face Respirator Full- Face Respirator Powered Air Respirator
10 x ES P1 Air- line* -- PAPR- P1 -
50 x ES Air- line** P2 PAPR- P2
100 x ES - P3 -
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 9 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
Air- line* -
100+ x ES - Air- line** PAPR- P3
* - Negative pressure demand ** - Continuous flow.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required.
For further information consult site specific
CHEMWATCH data (if available), or your
Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
Local exhaust ventilation usually required. If risk of overexposure exists, wear approved
respirator. Correct fit is essential to obtain adequate protection. Supplied-air type
respirator may be required in special circumstances. Correct fit is essential to ensure
adequate protection.
An approved self contained breathing apparatus (SCBA) may be required in some situations.
Provide adequate ventilation in warehouse or closed storage area. Air contaminants
generated in the workplace possess varying "escape" velocities which, in turn, determine
the "capture velocities" of fresh circulating air required to effectively remove the
contaminant.
Type of Contaminant: Air Speed:
solvent, vapours, degreasing etc., evaporating 0.25- 0.5 m/s (50- 100 f/min.)
from tank (in still air).
aerosols, fumes from pouring operations, 0.5- 1 m/s (100- 200 f/min.)
intermittent container filling, low speed
conveyer transfers, welding, spray drift,
plating acid fumes, pickling (released at low
velocity into zone of active generation)
direct spray, spray painting in shallow booths, 1- 2.5 m/s (200- 500 f/min.)
drum filling, conveyer loading, crusher dusts,
gas discharge (active generation into zone of
rapid air motion)
grinding, abrasive blasting, tumbling, high 2.5- 10 m/s (500- 2000 f/min.)
speed wheel generated dusts (released at high
initial velocity into zone of very high rapid
air motion).
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to 1: Disturbing room air currents
capture
2: Contaminants of low toxicity or of nuisance 2: Contaminants of high toxicity
value only.
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood- local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening
of a simple extraction pipe. Velocity generally decreases with the square of distance
from the extraction point (in simple cases). Therefore the air speed at the extraction
point should be adjusted, accordingly, after reference to distance from the contaminating
source. The air velocity at the extraction fan, for example, should be a minimum of 1-2
m/s (200-400 f/min) for extraction of solvents generated in a tank 2 meters distant from
the extraction point. Other mechanical considerations, producing performance deficits
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 10 of 14
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
within the extraction apparatus, make it essential that theoretical air velocities are
multiplied by factors of 10 or more when extraction systems are installed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
White or yellowish white powder. Practically insoluble in water. Odourless. Soluble in
acids, alkalis and ammonium carbonate. Insoluble in alcohol. Solubility in water @ 29
deg.C: 0.00016 g/100cc Available in a range of grades; Technical, Pigment, Rubber and BP
grades. Whiteness of pigment grades described as White Seal, Blue Seal, Red Seal.
PHYSICAL PROPERTIES
Solid.
Does not mix with water.
Sinks in water.
Molecular Weight: 81.38 Boiling Range (掳C): Sublimes.
Melting Range (掳C): 1975 (sublimes) Specific Gravity (water=1): 5.67
Solubility in water (g/L): Immiscible pH (as supplied): Not applicable
pH (1% solution): Not applicable. Vapour Pressure (kPa): 1.6 @ 1500C
Volatile Component (%vol): Not applicable. Evaporation Rate: Not applicable
Relative Vapour Density (air=1): Not applicable. Flash Point (掳C): Not applicable.
Lower Explosive Limit (%): Not applicable Upper Explosive Limit (%): Not applicable
Autoignition Temp (掳C): Not applicable. Decomposition Temp (掳C): Not available.
State: Divided solid Viscosity: Not Applicable
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
路 Presence of incompatible materials.
路 Product is considered stable.
路 Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Although ingestion is not thought to produce harmful effects (as classified under EC
Directives), the material may still be damaging to the health of the individual,
following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is
evident. Present definitions of harmful or toxic substances are generally based on doses
producing mortality rather than those producing morbidity (disease, ill-health).
Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational
setting however, ingestion of insignificant quantities is not thought to be cause for
concern.
Soluble zinc salts produce irritation and corrosion of the alimentary tract with pain,
and vomiting. Death can occur due to insufficiency of food intake due to severe narrowing
of the oesophagus and pylorus.
EYE
There is some evidence to suggest that this material can cause eye irritation and damage
in some persons.
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
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CD 2007/3 Page 11 of 14
Section 11 - TOXICOLOGICAL INFORMATION
SKIN
There is some evidence to suggest that the material may cause mild but significant
inflammation of the skin either following direct contact or after a delay of some time.
Repeated exposure can cause contact dermatitis which is characterised by redness,
swelling and blistering.
Skin contact is not thought to have harmful health effects (as classified under EC
Directives); the material may still produce health damage following entry through wounds,
lesions or abrasions.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may
produce systemic injury with harmful effects. Examine the skin prior to the use of the
material and ensure that any external damage is suitably protected.
Repeated or excessive handling, coupled with poor personal hygiene, may result in acne
-like eruptions known as "zinc oxide pox".
INHALED
Inhalation of vapours or aerosols (mists, fumes), generated by the material during the
course of normal handling, may be damaging to the health of the individual.
There is some evidence to suggest that the material can cause respiratory irritation in
some persons. The body's response to such irritation can cause further lung damage.
Persons with impaired respiratory function, airway diseases and conditions such as
emphysema or chronic bronchitis, may incur further disability if excessive concentrations
of particulate are inhaled.
Inhalation of freshly formed zinc oxide particles sized below 1.5 microns and generally
between 0.02 to 0.05 microns may result in "metal fume fever", with symptoms resembling
influenza. Symptoms may be delayed for up to 12 hours and begin with the sudden onset of
thirst, and a sweet, metallic or foul taste in the mouth. Other symptoms include upper
respiratory tract irritation accompanied by coughing and a dryness of the mucous
membranes, lassitude and a generalised feeling of malaise. Mild to severe headache,
nausea, occasional vomiting, fever or chills, exaggerated mental activity, profuse
sweating, diarrhoea, excessive urination and prostration may also occur. Tolerance to the
fumes develops rapidly, but is quickly lost. All symptoms usually subside within 24-36
hours following removal from exposure. Leucocytosis, a transient increase in white blood
cell counts, is reported as a common finding in metal fume fever but is not known to be
common amongst welders. Severe over-exposure to zinc oxide, following inhalation of fumes
or finely divided dusts may result in bronchitis or pneumonia; a bluish skin tint may be
present.
CHRONIC HEALTH EFFECTS
Repeated exposures, in an occupational setting, to high levels of fine- divided dusts may
produce a condition known as pneumoconiosis which is the lodgement of any inhaled dusts
in the lung irrespective of the effect. This is particularly true when a significant
number of particles less than 0.5 microns (1/50,000 inch), are present. Lung shadows are
seen in the X-ray. Symptoms of pneumoconiosis may include a progressive dry cough,
shortness of breath on exertion, increased chest expansion, weakness and weight loss. As
the disease progresses the cough produces a stringy mucous, vital capacity decreases
further and shortness of breath becomes more severe. Pneumoconiosis is the accumulation
of dusts in the lungs and the tissue reaction in its presence. It is further classified
as being of noncollagenous or collagenous types. Noncollagenous pneumoconiosis, the
benign form, is identified by minimal stromal reaction, consists mainly of reticulin
fibres, an intact alveolar architecture and is potentially reversible.
Substance accumulation, in the human body, may occur and may cause some concern following
repeated or long-term occupational exposure.
Welding or flame cutting of metals with zinc or zinc dust coatings may result in
inhalation of zinc oxide fume; high concentrations of zinc oxide fume may result in
"metal fume fever"; also known as "brass chills", an industrial disease of short
duration. [I.L.O] Symptoms include malaise, fever, weakness, nausea and may appear
quickly if operations occur in enclosed or poorly ventilated areas.
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 12 of 14
Section 11 - TOXICOLOGICAL INFORMATION
TOXICITY AND IRRITATION
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (human) LDLo: 500 mg/kg Skin : Mild
Inhalation (human) TCLo: 600 mg/m鲁 Eye : Mild
Oral (mouse) LD50: 7950 mg/kg
Oral (Rat) LD50: >8437 mg/kg
The material may cause skin irritation after prolonged or repeated exposure and may
produce on contact skin redness, swelling, the production of vesicles, scaling and
thickening of the skin.
LEAD MONOXIDE:
TOXICITY IRRITATION
Nil Reported Skin (rabbit): 100mg/24h - Mild
MATERIAL CARCINOGEN REPROTOXIN SENSITISER SKIN
_______________ ____________ __________ __________ __________
lead monoxide IARC:2A NTPB
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: lead monoxide
Category: 2A
CARCINOGEN
NTPB: US National Toxicology Program (NTP) 11th Report Part B. Reasonably Anticipated
to be a Human Carcinogen: lead monoxide Category:
Section 12 - ECOLOGICAL INFORMATION
Marine Pollutant:Not Determined
Do NOT allow product to come in contact with surface waters or to intertidal areas below
the mean high water mark. Do not contaminate water when cleaning equipment or disposing
of equipment wash-waters.
Wastes resulting from use of the product must be disposed of on site or at approved waste
sites.
DO NOT discharge into sewer or waterways.
Refer to data for ingredients, which follows:
LEAD MONOXIDE:
Lead is primarily an atmospheric pollutant that enters soil and water as fallout, a
process determined by physical form and particle size. Lead in the form of alkyls has
been introduced to the environment primarily from leaded petrol. These are converted to
water-soluble lead compounds of high toxicity and availability to plants. Such compounds
easily leach from soil to contaminate water sources close to highways. Lead that has
entered the aquatic system from run-off or as fallout of insoluble precipitates is found
in sediments. The biological methylation of inorganic lead by lake sediment micro
-organisms has been demonstrated although its significance is not entirely clear. Other
forms of soluble or insoluble lead may also enter the environment and undergo
bioaccumulation through a series of biological incidents.
Section 13 - DISPOSAL CONSIDERATIONS
路 Recycle wherever possible.
路 Consult manufacturer for recycling options or consult local or regional waste
management authority for disposal if no suitable treatment or disposal facility can be
identified.
路 Dispose of by: Burial in a licenced land-fill or Incineration in a licenced apparatus
(after admixture with suitable combustible material)
路 Decontaminate empty containers. Observe all label safeguards until containers are
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 13 of 14
Section 13 - DISPOSAL CONSIDERATIONS
cleaned and destroyed.
Section 14 - TRANSPORTATION INFORMATION
Labels Required: MISCELLANEOUS
HAZCHEM: 2X
UNDG:
Dangerous Goods Class: 9 Subrisk: None
UN Number: 3077 Packing Group: III
Shipping Name:ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
(contains zinc oxide)
Air Transport IATA:
ICAO/IATA Class: 9 ICAO/IATA Subrisk: None
UN/ID Number: 3077 Packing Group: III
Special provisions: A97
Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID
N.O.S.
Maritime Transport IMDG:
IMDG Class: 9 IMDG Subrisk: None
UN Number: 3077 Packing Group: III
EMS Number: F- A, S- F Special provisions: 274 909 944
Marine Pollutant: Not Determined
Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID,
N.O.S.
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: None
REGULATIONS
zinc oxide (CAS: 1314-13-2) is found on the following regulatory lists;
Australia Exposure Standards
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
Australia National Pollutant Inventory
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 4
Australia Therapeutic Goods Administration (TGA) Substances that may be used as active ingredients in Listed medicines
Australia Therapeutic Goods Administration (TGA) Sunscreening agents permitted as active ingredients in listed products
CODEX General Standard for Food Additives (GSFA) - Additives Permitted for Use in Food in General, Unless Otherwise Specified, in Accordance with GMP
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
MSDS SECTION CHANGES
The following table displays the version number of and date on which each section was last changed.
Section Name Version Date Section Name Version Date Section Name Version Date
Advice to Doctor 6 30- Mar- 2007 Storage (storage 6 30- Mar- 2007 Acute Health 6 30- Mar- 2007
incompatibility) (skin)
First Aid 6 30- Mar- 2007 Storage (suitable 6 30- Mar- 2007 Acute Health 6 30- Mar- 2007
ZINC OXIDE
Chemwatch Material Safety Data Sheet (REVIEW)
Issue Date: 30-Mar-2007 CHEMWATCH 22544
NC317TCP Version No:2.0
CD 2007/3 Page 14 of 14
Section 16 - OTHER INFORMATION
(inhaled) container) (swallowed)
Fire Fighter 6 30- Mar- 2007 Engineering 6 30- Mar- 2007 Chronic Health 6 30- Mar- 2007
(extinguishing Control
media)
Fire Fighter (fire 6 30- Mar- 2007 Exposure Standard 6 30- Mar- 2007 Toxicity and 6 30- Mar- 2007
incompatibility) Irritation (Other)
Fire Fighter 6 30- Mar- 2007 Personal 6 30- Mar- 2007 Environmental 6 30- Mar- 2007
(fire/explosion Protection (eye)
hazard)
Spills (major) 6 30- Mar- 2007 Personal 6 30- Mar- 2007 Disposal 6 30- Mar- 2007
Protection
(hands/feet)
Spills (minor) 6 30- Mar- 2007 Appearance 6 30- Mar- 2007 Transport 6 30- Mar- 2007
Handling Procedure 6 30- Mar- 2007
Classification of the preparation and its individual components has drawn on official and
authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 30-Mar-2007
Print Date: 18-Jan-2008
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