METHYLENE BISPHENYL ISOCYANATE 0298
March 1999
CAS No: 101-68-8 Diphenylmethane-4.4'-diisocyanate
RTECS No: NQ9350000 bis(1,4-Isocyanatophenyl)methane
EC No: 615-005-00-9 MDI
4,4'-Methylenediphenyldiisocyanate
C15H10N2O2 / OCNC6H4CH2C6H4NCO
Molecular mass: 250.3
TYPES OF
ACUTE HAZARDS/SYMPTOMS PREVENTION FIRST AID/FIRE FIGHTING
HAZARD/
EXPOSURE
FIRE Combustible. Gives off irritating or toxic NO open flames. Powder, carbon dioxide.
fumes (or gases) in a fire.
EXPLOSION
EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
Inhalation Headache. Nausea. Shortness of breath. Local exhaust or breathing protection. Fresh air, rest. Artificial respiration may
Sore throat. be needed. Refer for medical attention.
Skin Redness. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse
skin with plenty of water or shower. Refer
for medical attention.
Eyes Pain. Safety goggles or face shield. First rinse with plenty of water for several
minutes (remove contact lenses if easily
possible), then take to a doctor.
Ingestion Do not eat, drink, or smoke during work. Rinse mouth. Do NOT induce vomiting.
Refer for medical attention.
SPILLAGE DISPOSAL PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Chemical EU classification Unbreakable packaging; put breakable
protection suit including self-contained breathing apparatus. Xn Symbol packaging into closed unbreakable
Sweep spilled substance into sealable containers. Carefully R: 20-36/37/38-42/43 container. Do not transport with food and
collect remainder, then remove to safe place. S: (1/2-)23-3 feedstuffs.
Note: C6/37-45
EMERGENCY RESPONSE SAFE STORAGE
Separated from food and feedstuffs, incompatible materials. See Chemical Dangers.
Cool. Dry. Keep in the dark.
Prepared in the context of cooperation between the International
IPCS Programme on Chemical Safety and the European Commission 漏
IPCS 2006
International
Programme on
SEE IMPORTANT INFORMATION ON THE BACK.
Chemical Safety
0298 METHYLENE BISPHENYL ISOCYANATE
IMPORTANT DATA
Physical State; Appearance Routes of exposure
WHITE TO PALE YELLOW CRYSTALS OR FLAKES. The substance can be absorbed into the body by inhalation.
Chemical dangers Inhalation risk
The substance may polymerize under the influence of temperatures above Evaporation at 20/C is negligible; a harmful concentration of airborne
204/C. On combustion, forms toxic and corrosive fumes including nitrogen particles can, however, be reached quickly when dispersed.
oxides and hydrogen cyanide (see ICSC 0492). Reacts readily with water
to form insoluble polyureas. Reacts violently with acids, alcohols, amines, Effects of short-term exposure
bases and oxidants causing fire and explosion hazard. Tear drawing. The substance irritates the eyes, the skin and the
respiratory tract. The substance may cause effects on the lungs, resulting
Occupational exposure limits in impaired functions.
TLV: 0.005 ppm as TWA; (skin); (ACGIH 2004).
MAK: (Inhalable fraction) 0.05 mg/m3; Peak limitation category: I(1); Effects of long-term or repeated exposure
sensitization of respiratory tract and skin (Sah); Carcinogen category: 3B; Repeated or prolonged contact may cause skin sensitization. Repeated
Pregnancy risk group: D; (DFG 2006). or prolonged inhalation exposure may cause asthma (see Notes).
PHYSICAL PROPERTIES
Boiling point at 100 kPa: 314/C Vapour pressure, Pa at 20/C: negligible
Melting point: 37/C Relative vapour density (air = 1): 8.6
Relative density (water = 1): 1.2 Flash point: 196/C c.c.
Solubility in water: reaction Auto-ignition temperature: 240/C
ENVIRONMENTAL DATA
NOTES
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical
observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.
MDI may sensitize workers so that they react to other isocyanates (asthma).
Do NOT take working clothes home.
Caradate 30, Desmodur 44, Hylene M 150, Isonate, Nacconate 300, NCI-C50668, Rubinate 44 are trade names.
Card has been partially updated in July 2007: see Occupational Exposure Limits.
ADDITIONAL INFORMATION
Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible
LEGAL NOTICE for the use which might be made of this information
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