Material Safety Data Sheet
HMIS
NFPA Personal Protective Equipment
Health Hazard
2
1 Fire Hazard
1
2 0
Reactivity
0 See Section 15.
Section 1. Chemical Product and Company Identification Page Number: 1
Catalog
Diclofenac sodium D1287, D1151
Common Name/
Number(s).
Trade Name
15307-79-6
CAS#
Manufacturer AG6330000
RTECS
SPECTRUM LABORATORY PRODUCTS INC.
14422 S. SAN PEDRO STREET TSCA 8(b) inventory: No
TSCA
products were found.
GARDENA, CA 90248
Not available.
Commercial Name(s) Not available.
CI#
(o-(2,6-Dichloroanilino)phenyl)acetic acid monosodium salt;
Synonym
(o-(2,6-Dichloroanilino)phenyl)acetic acid sodium salt; Benzeneacetic IN CASE OF EMERGENCY
acid, 2-((2,6-dichnlorophenyl)amino)-, monosodium salt; Dichronic; CHEMTREC (24hr) 800-424-9300
Diclophenac sodium; Huma-Difenac; Kriplex; Nerodin; Orthophen;
Ortofen; Prophpenatin; Sodium
(o-((2,6-dichlorophenyl)amino)phenyl)acetate; Sodium
(o-(2,6-dichloroanilino)phenyl)acetate; Sodium diclofenac
Acetic acid, o-(2,6-dichloroanilino)phenyl-, monosodium salt
Chemical Name
Not available. CALL (310) 516-8000
Chemical Family
C14-H10-Cl2-N-Na-O2
Chemical Formula
SPECTRUM LABORATORY PRODUCTS INC.
Supplier
14422 S. SAN PEDRO STREET
GARDENA, CA 90248
Section 2.Composition and Information on Ingredients
Exposure Limits
3
STEL (mg/m3) CEIL (mg/m3)
Name CAS # TWA (mg/m ) % by Weight
1) Diclofenac sodium 15307-79-6 100
Diclofenac sodium:
Toxicological Data
ORAL (LD50): Acute: 53 mg/kg [Rat]. 95 mg/kg [Mouse]. 157 mg/kg [Rabbit].
on Ingredients
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Diclofenac sodium
Section 3. Hazards Identification
Potential Acute Health Effects Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of
inhalation. Severe over-exposure can result in death.
CARCINOGENIC EFFECTS: Not available.
Potential Chronic Health
MUTAGENIC EFFECTS: Not available.
Effects
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance may be toxic to kidneys, liver, gastrointestinal tract.
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a
highly toxic material may produce general deterioration of health by an accumulation in one or many human
organs.
Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Cold water may be used.
Serious Skin Contact Not available.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Seek medical attention.
Ingestion If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
attention immediately.
Serious Ingestion Not available.
Section 5. Fire and Explosion Data
May be combustible at high temperature.
Flammability of the Product
Not available.
Auto-Ignition Temperature
Not available.
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds. Some
Products of Combustion
metallic oxides.
Slightly flammable to flammable in presence of heat.
Fire Hazards in Presence of
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
of Various Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
As with most organic solids, fire is possible at elevated temperatures
Special Remarks on
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
explosion hazard.
Hazards
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Diclofenac sodium
Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill Poisonous solid.
Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to
reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition
sources. Call for assistance on disposal.
Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
Precautions
ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and
show the container or the label. Keep away from incompatibles such as oxidizing agents, acids.
Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in
Storage
light-resistant containers.
Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Safety glasses. Lab coat. Dust respirator. Use a dust respirator if ventilation is inadequate and handling or
product produces visible dust clouds. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Solid crystalline powder.) Odorless.
Odor
Not available.
Taste
318.13 g/mole
Molecular Weight
White. White to yellowish. Off-white.
Color
Not available.
pH (1% soln/water)
Not available.
Boiling Point
268掳C (514.4掳F) - 278 C.
Melting Point
Not available.
Critical Temperature
Not available.
Specific Gravity
Not applicable.
Vapor Pressure
Not available.
Vapor Density
Not available.
Volatility
Not available.
Odor Threshold
The product is more soluble in oil; log(oil/water) = 13.4
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
See solubility in water, methanol.
Dispersion Properties
Easily soluble in methanol.
Solubility
Sparingly soluble in cold water.
Practically insoluble in chloroform.
Soluble in ethanol.
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Diclofenac sodium
Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Excess heat, incompatible materials, dust generation.
Conditions of Instability
Reactive with oxidizing agents, acids.
Incompatibility with various
substances
Non-corrosive in presence of glass.
Corrosivity
Sensitive to light.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
Will not occur.
Polymerization
Section 11. Toxicological Information
Routes of Entry Inhalation. Ingestion.
Toxicity to Animals Acute oral toxicity (LD50): 53 mg/kg [Rat].
Chronic Effects on Humans May cause damage to the following organs: kidneys, liver, gastrointestinal tract.
Other Toxic Effects on Hazardous in case of ingestion.
Humans Slightly hazardous in case of skin contact (irritant), of inhalation.
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on May cause adverse reproductive effects.
Chronic Effects on Humans
Special Remarks on other Acute Potential Health Effects:
Toxic Effects on Humans Skin: May cause skin irritation.
Eyes: Dust may cause eye irritation.
Inhalation: Dust may cause respiratory tract irritation.
Ingestion: May cause nausea, vomiting, hypermotility, diarrhea. May affect behavior/central nervous system
(ataxia, altered sleep time), repsiration (respiratory stimulation).
Chronic Potential Health Effects:
Ingestion: Harmful if swallowed. May cause nausea, vomiting, hypermotility, diarrhea, ulceration or bleeding from
small intestine, anorexia. May affect kidneys (acute renal failure, acute tubular necrosis, Interstitial nephritis,
Proteinuria), liver (hepatitis, jaundice, liver function tests impaired), blood (decrease in red blood cell count
(anemia) due to bone marrow depression, leukocytosis, agranulocytosis, and thrombopenia with /without purpura),
respiration. May cause dermatitis.
Medical Conditions Aggravated By Exposure: Hypersensitivity to Diclofenac; history of allergic reactions
(bronchospasm, shock, rhinitis, urticaria) following the use of Aspirin or another NSAID; Third-trimester pregancy;
Acitive stomach and/or duodenal ulceration or gastrointestinal bleeding; Inflammative intestinal disorders such as
Crohn's disease or ulcerative cholitis; severe insufficiency of the heartl; recovering from heart surgery; liver or
kidney insufficiency/disease.
Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
Products of Biodegradation
arise.
The products of degradation are as toxic as the product itself.
Toxicity of the Products
of Biodegradation
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Diclofenac sodium
Not available.
Special Remarks on the
Products of Biodegradation
Section 13. Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental
Waste Disposal
control regulations.
Section 14. Transport Information
DOT Classification CLASS 6.1: Poisonous material.
: Toxic Solid, organic, n.o.s (Diclofenac sodium) UNNA: 2811 PG: III
Identification
Not available.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
California prop. 65: This product contains the following ingredients for which the State of California has found
California
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.
239-346-4).
Canada: Listed on Canadian Domestic Substance List (DSL).
Korea: Listed on Natioinal Inventory (KECI).
CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
Other Classifications WHMIS (Canada)
DSCL (EEC) R25- Toxic if swallowed. S22- Do not breathe dust.
S36/37- Wear suitable protective clothing and
gloves.
S45- In case of accident or if you feel unwell,
seek medical advice immediately (show the
label where possible).
Health Hazard
HMIS (U.S.A.) 2 National Fire Protection Flammability
1
Association (U.S.A.)
Fire Hazard
1
0
2
Health Reactivity
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
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Diclofenac sodium
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Safety glasses.
Section 16. Other Information
D3232
MSDS Code
Not available.
References
Other Special Use: Pharmaceutical Drug. A nonsteroidal anti-inflammatory (NSAID) and prostaglandin synthetase inhibitor, and
Considerations non-selective COX inhibitor. Used for musculoskeletal complaints, especially arthritis, gout attacks, and pain
management in case of kidney stones and gallstones.
Validated by Sonia Owen on 8/11/2006. Verified by Sonia Owen.
Printed 9/12/2006.
CALL (310) 516-8000
Notice to Reader
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is
combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper
methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,
Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.
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