Material Safety Data Sheet
HMIS
NFPA Personal Protective Equipment
Health Hazard
2
1 Fire Hazard
1
2 0
Reactivity
0 See Section 15.
Section 1. Chemical Product and Company Identification Page Number: 1
Catalog
Hydroxyurea H1181
Common Name/
Number(s).
Trade Name
127-07-1
CAS#
Manufacturer YT4900000
RTECS
SPECTRUM LABORATORY PRODUCTS INC.
14422 S. SAN PEDRO STREET TSCA 8(b) inventory: No
TSCA
products were found.
GARDENA, CA 90248
Not available.
Commercial Name(s) Not available.
CI#
Not available.
Synonym
IN CASE OF EMERGENCY
Hydroxyurea
Chemical Name CHEMTREC (24hr) 800-424-9300
Not available. CALL (310) 516-8000
Chemical Family
C-H4-N2-O2
Chemical Formula
SPECTRUM LABORATORY PRODUCTS INC.
Supplier
14422 S. SAN PEDRO STREET
GARDENA, CA 90248
Section 2.Composition and Information on Ingredients
Exposure Limits
3
STEL (mg/m3) CEIL (mg/m3)
Name CAS # TWA (mg/m ) % by Weight
1) Hydroxyurea 127-07-1 100
Hydroxyurea:
Toxicological Data
ORAL (LD50): Acute: 5760 mg/kg [Rat]. 7330 mg/kg [Mouse].
on Ingredients
Section 3. Hazards Identification
Potential Acute Health Effects Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC.
Potential Chronic Health
MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
Effects
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
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Hydroxyurea
Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. Get medical attention.
Skin Contact In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove
contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes
before reuse. Get medical attention.
Serious Skin Contact Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical
attention.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation Not available.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if
symptoms appear.
Serious Ingestion Not available.
Section 5. Fire and Explosion Data
May be combustible at high temperature.
Flammability of the Product
Not available.
Auto-Ignition Temperature
Not available.
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Products of Combustion
Slightly flammable to flammable in presence of heat.
Fire Hazards in Presence of
Non-flammable in presence of shocks.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
of Various Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
Not available.
Special Remarks on
Fire Hazards
Special Remarks on Explosion Not available.
Hazards
Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Continued on Next Page
Page Number: 3
Hydroxyurea
Section 7. Handling and Storage
Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,
Precautions
evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not
breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory
equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with
skin and eyes. Keep away from incompatibles such as oxidizing agents.
Sensitive to moisture. Hygroscopic. Keep container tightly closed. Keep container in a cool, well-ventilated area.
Storage
Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (crystalline powder.) Not available.
Odor
Tasteless.
Taste
76.06 g/mole
Molecular Weight
White.
Color
Not available.
pH (1% soln/water)
Decomposes.
Boiling Point
141掳C (285.8掳F)
Melting Point
Not available.
Critical Temperature
Not available.
Specific Gravity
Not applicable.
Vapor Pressure
Not available.
Vapor Density
Not available.
Volatility
Not available.
Odor Threshold
The product is more soluble in water; log(oil/water) = -1.8
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
See solubility in water.
Dispersion Properties
Easily soluble in cold water, hot water.
Solubility
Slightly soluble in alcohol.
Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Excessive heat, moisture.
Conditions of Instability
Reactive with oxidizing agents.
Incompatibility with various
substances
Continued on Next Page
Page Number: 4
Hydroxyurea
Not available.
Corrosivity
Sensitive to moisture. Hygroscopic.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
Will not occur.
Polymerization
Section 11. Toxicological Information
Routes of Entry Inhalation. Ingestion.
Toxicity to Animals Acute oral toxicity (LD50): 5760 mg/kg [Rat].
Chronic Effects on Humans CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC.
MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
Other Toxic Effects on Hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on May cause adverse reproductive effects(post-implantation mortality and fetotoxicity) and birth defects based on
Chronic Effects on Humans animal data.
May affect genetic material.
May cause cancer based on animal data. Human data found.
Special Remarks on other Acute Potential Health Effects:
Toxic Effects on Humans Skin: May cause skin irritation. High exposure may cause hair loss and skin rash.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation with coughing and dyspnea.
Ingestion: Ingestion of large amounts may cause digestive tract irritation with sore mouth, stomach pain, nausea,
vomiting, hypermotility, and diarrhea. May cause bone marrow depression and reduce the marrow's ability to
make white blood cells (reduced resistance to infection), blood platelets(increased bleeding tendency), and red
blood cells (anemia, weakness). High exposure can also affect the metabolism, liver, kidneys, and damage the
nervous system/affect behavior(drowsiness, somnolence, disorientation, hallucinations, convulsions).
Chronic Potential Health Effects:
Skin: Prolonged or repeated skin contact may cause dermatitis (skin rash), and hair loss.
Ingestion: Prolonged or repeated ingestion may have similiar symptoms as acute ingestion.
Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
Products of Biodegradation
arise.
The product itself and its products of degradation are not toxic.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation
Continued on Next Page
Page Number: 5
Hydroxyurea
Section 13. Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental
Waste Disposal
control regulations.
Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
California prop. 65: This product contains the following ingredients for which the State of California has found to
Federal and State
cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:
Regulations
Hydroxyurea
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: Hydroxyurea
New Jersey: Hydroxyurea
California
California prop. 65: This product contains the following ingredients for which the State of California has found
Proposition 65
to cause birth defects which would require a warning under the statute: Hydroxyurea
Warnings
Other Regulations EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Not controlled under WHMIS (Canada).
Other Classifications WHMIS (Canada)
DSCL (EEC) R33- Danger of cumulative effects. S2- Keep out of the reach of children.
R36/38- Irritating to eyes and skin. S24/25- Avoid contact with skin and eyes.
R40- Possible risks of irreversible S36/37- Wear suitable protective clothing and
effects. gloves.
S46- If swallowed, seek medical advice
immediately and show this container or label.
Health Hazard
HMIS (U.S.A.) 2 National Fire Protection Flammability
1
Association (U.S.A.)
Fire Hazard
1
0
2
Health Reactivity
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
Continued on Next Page
Page Number: 6
Hydroxyurea
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
Splash goggles.
Section 16. Other Information
H3406
MSDS Code
Hazardous Substance Data Bank, Merck Index, Registery of Toxic Effects of Chemical Substances, New Jersey
References
Hazardous Substance Fact Sheet.
Other Special Not available.
Considerations
Validated by Sonia Owen on 8/11/2006. Verified by Sonia Owen.
Printed 9/12/2006.
CALL (310) 516-8000
Notice to Reader
All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is
combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper
methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,
Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.
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