**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 110-86-1 |Pyridine | 65.0 | 203-809-9 |
|----------------|--------------------------------------|----------|-----------|
| 7732-18-5 |Water | Balance | 231-791-2 |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: XN F
Risk Phrases: 11 20/21/22
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Highly flammable. Harmful by inhalation, in contact with skin and if
swallowed.Stench.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye
burns.
Skin:
May cause skin irritation. May be harmful if absorbed through the
skin. Effects may be delayed. May cause smarting of the skin and
first-degree burns on short exposure. Substance is readily absorbed
through the skin. Pyridine was determined not to be a skin sensitizer
in guinea pigs.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause liver and kidney damage. May cause central
nervous system depression, characterized by excitement, followed by
headache, dizziness, drowsiness, and nausea. Advanced stages may
cause collapse, unconsciousness, coma and possible death due to
respiratory failure. May cause effects similar to those for
inhalation exposure. Effects may be delayed.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. May cause respiratory tract irritation. Prolonged exposure
may result in dizziness and general weakness. Other symptoms
reported with acute exposure to pyridine include nervousness,
insomnia, and loss of appetite.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic
inhalation and ingestion may cause effects similar to those of acute
inhalation and ingestion. May cause liver and kidney damage.
Exposures to doses of pyridine that are too low to produce overt
clinical symptoms can cause liver damage and repeated low-level
exposures can cause cirrhosis. Feeding studies in rats produced
blood effects like changes in clotting factors.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water.
Remove contaminated clothing and shoes. Get medical aid. Wash
clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a
fire, irritating and highly toxic gases may be generated by thermal
decomposition or combustion. Water may be ineffective. Material is
lighter than water and a fire may be spread by the use of water.
Containers may explode in the heat of a fire. Flammable liquid and
vapor. Vapors may be heavier than air. They can spread along the
ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. For large fires, use water spray, fog, or
alcohol-resistant foam. Do NOT use straight streams of water. Cool
containers with flooding quantities of water until well after fire is
out. Solid streams of water may be ineffective and spread material.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation. A
vapor suppressing foam may be used to reduce vapors. Prevent
spreading of vapors through sewers, ventilation systems and confined
areas. Evacuate unnecessary personnel. Approach spill from upwind.
U.S. regulations require reporting spills and releases to soil,
water and air in excess of reportable quantities.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Do not get in eyes, on skin, or on clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Keep container tightly closed. Keep away from heat, sparks
and flame. Do not pressurize, cut, weld, braze, solder, drill, grind,
or expose empty containers to heat, sparks or open flames. Do not
breathe vapor. Use only with adequate ventilation.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
Flammables-area. Isolate from oxidizing materials and acids.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Facilities storing or utilizing this material should
be equipped with an eyewash facility and a safety shower. Ventilation
fans and other electrical service must be non-sparking and have an
explosion-proof design.
Exposure Limits
CAS# 110-86-1:
United Kingdom, WEL - TWA: 5 ppm TWA; 16 mg/m3 TWA
United Kingdom, WEL - STEL: 10 ppm STEL; 33 mg/m3 STEL
United States OSHA: 5 ppm TWA; 15 mg/m3 TWA
Belgium - TWA: 5 ppm VLE; 16 mg/m3 VLE
France - VME: 5 ppm VME; 15 mg/m3 VME
France - VLE: 10 ppm VLE; 30 mg/m3 VLE
Germany: 5 ppm TWA; 16 mg/m3 TWA
Germany: Skin absorber
Malaysia: 5 ppm TWA; 16 mg/m3 TWA
Netherlands: 0.3 ppm MAC; 0.9 mg/m3 MAC
Russia: 5 mg/m3 TWA
Spain: 5 ppm VLA-ED; 15 mg/m3 VLA-ED
CAS# 7732-18-5:
Personal Protective Equipment
Eyes:
Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: clear, colorless - colorless to light yellow
Odor: pyridine-like - strong odor - fish-like
pH: 8.5 (0.2 M aq soln)
Vapor Pressure: 18 mm Hg @ 20 deg C
Viscosity: 0.95 mPa s 20 deg C
Boiling Point: 115 deg C
Freezing/Melting Point: -42 deg C
Autoignition Temperature: 900 deg F ( 482.22 deg C)
Flash Point: 68 deg F ( 20.00 deg C)
Explosion Limits, lower: 1.8%
Explosion Limits, upper: 12.4%
Decomposition Temperature: Not available.
Solubility in water: Miscible in water. Volatile in steam.
Specific Gravity/Density: .9780
Molecular Formula: C5H5N
Molecular Weight: 79.10
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, electrical sparks, exposure to flame.
Incompatibilities with Other Materials:
Acids; acid chlorides; oxidizing agents; chloroformates; bromine
trifluoride; mixtures with formamide, iodine, and sulfur trioxide,
chlorosulfonic acid, chromic acid, maleic anhydride, sulfuric acid,
perchromates, and dinitrogen tetroxide
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, cyanide fumes.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 110-86-1: UR8400000
CAS# 7732-18-5: ZC0110000
LD50/LC50:
CAS# 110-86-1: Dermal, guinea pig: LD50 = 1 gm/kg; Draize test,
rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 28500
mg/m3/1H; Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 891
mg/kg; Skin, rabbit: LD50 = 1121 mg/kg.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
Inhalation, rat: LC50 = 28500 mg/m3/1H
gm/kg.
Carcinogenicity:
Pyridine -
ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to
California: carcinogen, initial date 5/17/02
Water -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Fathead Minnow: 106mg/L; 96H; Flow-through
Other
For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND
EXPOSURE DATA."
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Products which are considered hazardous for supply are classified as Special
Waste and the disposal of such chemicals is covered by regulations which may
vary according to location. Contact a specialist disposal company or the local
waste regulator for advice. Empty containers must be decontaminated before
returning for recycling.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: PYRIDINE SOLUTION
Hazard Class: 3
UN Number: 1282
Packing Group: II
IMO
Shipping Name: PYRIDINE SOLUTION
Hazard Class: 3
UN Number: 1282
Packing Group: II
RID/ADR
Shipping Name: PYRIDINE SOLUTION
Hazard Class: 3
UN Number: 1282
Packing group:
USA RQ: CAS# 110-86-1: 1000 lb final RQ; 454 kg final RQ
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN F
Risk Phrases:
R 11 Highly flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28 After contact with skin, wash immediately
with...
WGK (Water Danger/Protection)
CAS# 110-86-1: 2
CAS# 7732-18-5: No information available.
Canada
CAS# 110-86-1 is listed on Canada's DSL List.
CAS# 7732-18-5 is listed on Canada's DSL List.
CAS# 110-86-1 is listed on Canada's Ingredient Disclosure List.
CAS# 7732-18-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 110-86-1 is listed on the TSCA inventory.
CAS# 7732-18-5 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
Text for R-phrases from Section 2
MSDS Creation Date: 1/06/2000 Revision #5 Date: 3/18/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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