**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 127-07-1 |Hydroxyurea | 98 | 204-821-7 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: XN
Risk Phrases: 33
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Danger of cumulative effects.Mutagen.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May cause dermatitis.
Ingestion:
May cause bone marrow depression. Ingestion of large amounts may
cause nausea and vomiting, which can produce dehydration, internal
organ congestion and possibly coma. May cause microcytosis (smaller
than normal red blood cells), normocytic anemia (reduced red blood
cell count), luekopenia(reduced white blood cell count),
thrombocytopenia (decreased number of blood platelets) and other
blood abnormalities.
Inhalation:
Inhalation of dust may cause respiratory tract irritation.
Chronic:
Laboratory experiments have resulted in mutagenic effects. This
substance has caused adverse reproductive and fetal effects in
laboratory animals.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up, then place into a suitable container for
disposal. Avoid generating dusty conditions. Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Minimize dust
generation and accumulation. Avoid contact with eyes, skin, and
clothing. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible
substances. Keep containers tightly closed.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 127-07-1:
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Crystalline powder
Color: white to off-white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 144.00 - 146.00 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: freely soluble in water
Specific Gravity/Density:
Molecular Formula: CH4N2O2
Molecular Weight: 76.04
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 127-07-1: YT4900000
LD50/LC50:
CAS# 127-07-1: Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 =
5760 mg/kg.
Carcinogenicity:
Hydroxyurea -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 33 Danger of cumulative effects.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 127-07-1: 1
Canada
CAS# 127-07-1 is listed on Canada's DSL List.
CAS# 127-07-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 127-07-1 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 6/24/1998 Revision #4 Date: 2/04/2004
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
|
|
|
| ALL MSDS PAGES IN THIS GROUP
| | NAME | CAS |
|
Methyl methacrylate, 99+% (GC)
| 80-62-6 |
|
Bicine, Biograde
| 150-25-4 |
|
Methyl P-Hydroxybenzoate, 99% (Titr.)
| 99-76-3 |
|
Methyl Red, reagent ACS
| 493-52-7 |
|
Methyl Salicylate, 99+%
| 119-36-8 |
|
Triethylphenylammonium iodide, 99% (titr.)
| 1010-19-1 |
|
CAPS, BioGRADE
| 1135-40-6 |
|
1,6-Dibromohexane, 98%
| 629-03-8 |
|
tert-Butyl methyl ether, 99%
| 1634-04-4 |
|
MES monohydrate
| 4432-31-9 |
|
Aluminum sulfate
| 10043-01-3 |
|
Aluminum sulfate octadecahydrate
| 7784-31-8 |
|
Dimethoxymethane, 99.5+%
| 109-87-5 |
|
Methylamine, 40 wt. % solution in water
| 74-89-5 |
|
TAPS, Biograde
| 29915-38-6 |
|
TRICINE, BioGRADE
| 5704-04-1 |
|
Acetone, Electronic Use Grade, Residue Free
| 67-64-1 |
|
Butyl acetate Electronic use grade, residue free
| 123-86-4 |
|
1,2-Dichloroethane, electronic use grade, residue free
| 107-06-2 |
|
Dichloromethane, Stabilized, Electronic Use Grade, Residue Free
| 75-09-2 |
|
Ethyl Acetate, Electronic use Grade, Residue Free
| 141-78-6 |
|
N-Hexane, Electronic Use Grade, Residue Free
| 110-54-3 |
|
Methyl alcohol, electronic use grade, residue free
| 67-56-1 |
|
2-Butanone, Electronic Use Grade, Residue Free
| 78-93-3 |
|
4-Methyl-2-Pentanone, Electronic Use Grade, Residue Free
| 108-10-1 |
|
Isopropanol, Electronic use Grade, Residue Free
| 67-63-0 |
|
Xylenes mixed, electronic use grade, residue free
| 1330-20-7 |
|
5-Fluorocytosine, 98%
| 2022-85-7 |
|
A23187 (Free Acid)
| 52665-69-7 |
|
A23187(Mixed Calcium-Magnesium Salt)
| 52665-69-7 |
|
Aluminum (Metallic, Powder)
| 7429-90-5 |
|
A23187, 4-Bromo
| 76455-82-8 |
|
Hydroxyurea, 98%
| 127-07-1 |
|
AEBSF Hydrochloride
| 30827-99-7 |
|
Calmidazolium chloride
| 57265-65-3 |
|
Calpain Inhibitor I
| 110044-82-1 |
|
Calpain Inhibitor II
| 136632-32-1 |
|
Calpeptin
| 117591-20-5 |
|
Calphostin C
| 121263-19-2 |
|
Capsazepine
| 138977-28-3 |
|
Creatine Phosphate Disodium Salt Tetrahydrate, 99%
| 922-32-7 |
|
D-LUCIFERIN
| 2591-17-5 |
|
D-LUCIFERIN SODIUM SALT MONOHYDRATE
| 103404-75-7 |
|
4-Nitrophenyl-Beta-D-Glucuronide
| 10344-94-2 |
|
4-NITROPHENYL-ALPHA-D-MANNOPYRANOSIDE HYDRATE, 99%
| 10357-27-4 |
|
Dichloromethane, CP, Stabilized With ca 0.2% Ethanol
| 75-09-2 |
|
Tris(2-butoxyethyl)phosphate 98%
| 78-51-3 |
|
D-Ribose-5-Phosphate Disodium Salt Hydrate, 95%
| 18265-46-8 |
|
Diiodomethane, 99+%
| 75-11-6 |
|
2-Phenylethyl-Beta-D-Thiogalactoside
| 63407-54-5 |
|
|