**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 302-79-4 |All-trans retinoic acid | 97.0 | 206-129-0 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: XI
Risk Phrases: 36/37/38
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.Light sensitive.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause irritation of the digestive tract. May cause
gastrointestinal irritation with nausea, vomiting and diarrhea. May
be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary
edema.
Chronic:
Effects may be delayed.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse. Remove contaminated clothing and shoes.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical
aid immediately. Do NOT induce vomiting. If conscious and alert,
rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out
with water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up or absorb material, then place into a
suitable clean, dry, closed container for disposal. Provide
ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Avoid contact with eyes, skin, and clothing. Keep
container tightly closed. Avoid ingestion and inhalation. Use with
adequate ventilation. Store protected from light. Wash clothing
before reuse.
Storage:
Keep container closed when not in use. Store in a tightly closed
container. Store in a cool, dry, well-ventilated area away from
incompatible substances. Keep refrigerated. (Store below 4C/39F.)
Store protected from light.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
CAS# 302-79-4:
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Powder
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 180.00 - 181.00 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C20H28O2
Molecular Weight: 300.44
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions. May decompose when exposed to light.
Conditions to Avoid:
Incompatible materials, light, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 302-79-4: VH6475000
LD50/LC50:
CAS# 302-79-4: Oral, mouse: LD50 = 1100 mg/kg; Oral, rat: LD50 = 2
gm/kg.
Carcinogenicity:
All-trans retinoic acid -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 302-79-4: No information available.
Canada
CAS# 302-79-4 is listed on Canada's DSL List.
CAS# 302-79-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 302-79-4 is listed on the TSCA inventory.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 6/30/1999 Revision #3 Date: 3/18/2003
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
|
|
|
| ALL MSDS PAGES IN THIS GROUP
| | NAME | CAS |
|
Ethyl delta-bromo-beta,beta-dimethyl levulinate, 96%
| 197234-17-6 |
|
1-Cyclohexyl-3-(2-Morpholinoethyl)Carbodiimide
| 2491-17-0 |
|
3-Chloroanisole, 99%
| 2845-89-8 |
|
2-Acetamidoacrylic acid, 99+ %
| 5429-56-1 |
|
Bianthrone
| 434-85-5 |
|
1-(4-Chlorophenyl)-1-cyclopentanecarbonyl chloride, 97%
| 71501-44-5 |
|
Acetic acid-d, 98 atom % d
| 758-12-3 |
|
n-Phenyl-1-naphthylamine, 98%
| 90-30-2 |
|
5-Methyl-2-Nitrobenzyl Chloride
| 66424-91-7 |
|
2-Hydroxy-4-Methoxybenzophenone, 98%
| 131-57-7 |
|
Myristyltrimethylammonium bromide, 99% (ti tr.)
| 1119-97-7 |
|
Cyclododecanone, 99+%
| 830-13-7 |
|
4,4'-Biphenol, 97%
| 92-88-6 |
|
Diphenylacetylene (Tolan), 99%
| 501-65-5 |
|
Dicyclohexyl Phenyl Phosphine
| 6476-37-5 |
|
(+/-)-2-azabicyclo2.2.1hept-5-en-3-one 98% (hplc)
| 49805-30-3 |
|
Iron (III) Sulfate Tetrahydrate, Reagent (Powder), 97% (Titr.)
| 15244-10-7 |
|
Phenyl Isocyanate (Pract), 98% (gc)
| 103-71-9 |
|
3,5-Dichlorosalicylaldehyde
| 90-60-8 |
|
1,5-Dicyanopentane, 98%
| 646-20-8 |
|
2-Pyridinecarboxaldehyde, 99%
| 1121-60-4 |
|
Lithium Iodide, Anhydrous, 99%
| 10377-51-2 |
|
Alginic Acid, Sodium Salt
| 9005-38-3 |
|
(2R,3R)-1-Carboxy-4,5-dichloro-2,3-dihydroxycyclohexa-4,6-diene
| 205587-32-2 |
|
4-Chloro-3-Nitrobenzoic Acid, 99.5%
| 96-99-1 |
|
Barium Titanate(iv), 99%
| 12047-27-7 |
|
2,3-Dichloro-5,6 Dicyano-1,4-Benzoquinone, 98%
| 84-58-2 |
|
Triethanolamine hydrochloride
| 637-39-8 |
|
2,6-Diisopropylaniline, 95%
| 24544-04-5 |
|
3-Quinuclidinol, 99%
| 1619-34-7 |
|
n,n-Dimethylformamide diethyl acetal, 98%
| 1188-33-6 |
|
(R)-4-Benzyl-2-oxazolidinone, 99%, (>99% e.e.)
| 102029-44-7 |
|
2-Ethylimidazole, 98%
| 1072-62-4 |
|
All-Trans-Retinoic Acid 97%
| 302-79-4 |
|
Bis(2-Ethylhexyl) Terephthalate, 98.5% (GC)
| 6422-86-2 |
|
D(+)-10-camphorsulfonic acid 99%
| 3144-16-9 |
|
1,6-Hexanedithiol, 97%
| 1191-43-1 |
|
Ferric benzoylacetonate
| 14323-17-2 |
|
3-Chlorophenyl isothiocyanate
| 2392-68-9 |
|
1-Bromodecane, 98%
| 112-29-8 |
|
Didodecyldimethylammonium bromide, 99%
| 3282-73-3 |
|
1,4-Cyclohexadiene, 97%
| 628-41-1 |
|
Dl-3-(alpha-acetonyl-4'-chlorobenzyl)- 4-hydroxycoumarin, 98%
| 81-82-3 |
|
3-Nitrophenol, 99%
| 554-84-7 |
|
O,O-Dimethyl-1-Hydroxy-2,2,2-Trichloroethylphosphonate, 98%
| 52-68-6 |
|
Allyl Chloride
| 107-05-1 |
|
1,2,3,4-Tetrahydroacridine-9-Carboxylic Acid Dihydrate
| 38186-54-8 |
|
1-Bromododecane, 98%
| 143-15-7 |
|
Ethyl 2,4-dioxovalerate, 98%
| 615-79-2 |
|
Arsenazo I, Indicator Grade
| 520-10-5 |
|
|