**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 75-56-9 |Propylene oxide | ca.100 | 200-879-2
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T F+
Risk Phrases: 12 20/21/22 36/37/38 45 46
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Extremely flammable. Harmful by inhalation, in contact with skin and
if swallowed. Irritating to eyes, respiratory system and skin. May
cause cancer. May cause heritable genetic damage.
Potential Health Effects
Eye:
Produces irritation, characterized by a burning sensation, redness,
tearing, inflammation, and possible corneal injury.
Skin:
May cause skin sensitization, an allergic reaction, which becomes
evident upon re-exposure to this material. Causes severe skin
irritation and possible burns. May lead to the formation of
blisters.
Ingestion:
Harmful if swallowed. Causes gastrointestinal irritation with
nausea, vomiting and diarrhea. May cause central nervous system
depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause
collapse, unconsciousness, coma and possible death due to respiratory
failure. Aspiration of material into the lungs may cause chemical
pneumonitis, which may be fatal.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Causes respiratory tract irritation. Aspiration may cause
respiratory swelling and pneumonitis. Vapors may cause dizziness or
suffocation.
Chronic:
Prolonged inhalation may cause respiratory tract inflammation and
lung damage. Prolonged or repeated skin contact may cause
dermatitis. May cause cancer according to animal studies. May cause
reproductive and fetal effects. Laboratory experiments have resulted
in mutagenic effects.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
soap and water for at least 15 minutes while removing contaminated
clothing and shoes. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Possible aspiration hazard. Get medical aid
immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air
immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Persons with kidney disease, chronic respiratory disease, liver
disease, or skin disease may be at increased risk from exposure to
this substance. Treat symptomatically and supportively.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
Containers can build up pressure if exposed to heat and/or fire. As
in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Extremely
flammable. Material will readily ignite at room temperature. Use
water spray to keep fire-exposed containers cool. Containers may
explode in the heat of a fire. Liquid will float and may reignite on
the surface of water. May polymerize explosively when involved in a
fire.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. For large fires, use water spray, fog, or
alcohol-resistant foam. Use water spray to cool fire-exposed
containers. Water may be ineffective. Do NOT use straight streams of
water.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation. A
vapor suppressing foam may be used to reduce vapors.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Ground and
bond containers when transferring material. Empty containers retain
product residue, (liquid and/or vapor), and can be dangerous. Avoid
contact with heat, sparks and flame. Do not get on skin or in eyes.
Do not ingest or inhale. Prevent build up of vapors to explosive
concentration. This product may be under pressure; cool before
opening. Do not pressurize, cut, weld, braze, solder, drill, grind,
or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
Flammables-area.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use adequate general or local exhaust
ventilation to keep airborne concentrations below the permissible
exposure limits.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Color: colorless
Odor: alcohol-like - ethereal odor
pH: 7
Vapor Pressure: 400 mm Hg @ 17.8 deg C
Viscosity: 0.28 cP @ 25 deg C
Boiling Point: 34 deg C
Freezing/Melting Point: -112 deg C
Autoignition Temperature: 449 deg C ( 840.20 deg F)
Flash Point: -375 deg C ( -643.00 deg F)
Explosion Limits, lower: 2.3 vol %
Explosion Limits, upper: 36.0 vol %
Decomposition Temperature: Not available.
Solubility in water: Soluble.
Specific Gravity/Density: 0.8304 @ 20/20C
Molecular Formula: C3H6O
Molecular Weight: 58.0414
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal temperatures and pressures. May polymerize.
Conditions to Avoid:
High temperatures, incompatible materials, ignition sources, excess
heat.
Incompatibilities with Other Materials:
Epoxy resin, sodium hydroxide, oxygen, ethylene oxide + polyhydric
alcohol, ammonium hydroxide, chlorosulfonic acid, hydrochloric acid,
hydrofluoric acid, nitric acid, oleum, sulfuric acid, oxidizing
agents, copper, copper alloys, anhydrous metal chloride, iron,
aluminum chloride, strong acids, caustics (e.g. ammonia, ammonium
hydroxide, calcium hydroxide, potassium hydroxide, sodium
hydroxide), peroxides, alkalis.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Hazardous Polymerization: Will occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 75-56-9: TZ2975000
LD50/LC50:
Not available.
Carcinogenicity:
Propylene oxide -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish: Goldfish: LC50 = 170 mg/L; 24 Hr; UnspecifiedFish:
Bluegill/Sunfish: TLm = 215 mg/L; 96 Hr; Static bioassay @ 24CIf
released to soil, propylene oxide is expected to be susceptible to
leaching and chemical hydrolysis in moist soils. It is expected to
evaporate relatively rapidly from dry soil surfaces; evaporation
from wet soils may also occur, but at a rate diminished by leaching.
If released to water, propylene oxide will hydrolyze. Volatilization
of propylene oxide from the aquatic environment may be an important
transport mechanism.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
**** SECTION 14 - TRANSPORT INFORMATION ****
IATA
Shipping Name: PROPYLENE OXIDE
Hazard Class: 3
UN Number: 1280
Packing Group: I
IMO
Shipping Name: PROPYLENE OXIDE
Hazard Class: 3
UN Number: 1280
Packing Group: I
RID/ADR
Shipping Name: PROPYLENE OXIDE
Hazard Class: 3
UN Number: 1280
Packing group: I
**** SECTION 15 - REGULATORY INFORMATION ****
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F+
Risk Phrases:
R 12 Extremely flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 75-56-9: 2
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 75-56-9 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 75-56-9: OEL-AUSTRALIA:TWA 20 ppm (50 mg/m3);Carcinogen
OEL-BELGIUM:TWA 20 ppm (48 mg/m3)
OEL-DENMARK:TWA 5 ppm (12 mg/m3);Skin;Carcinogen
OEL-FINLAND:TWA 5 ppm (12 mg/m3);Carcinogen
OEL-FRANCE:TWA 20 ppm (50 mg/m3)
OEL-GERMANY;Carcinogen
OEL-THE NETHERLANDS:TWA 100 ppm (240 mg/m3)
OEL-THE PHILIPPINES:TWA 100 ppm (240 mg/m3)
OEL-RUSSIA:STEL 1 mg/m3;Skin
OEL-SWEDEN:TWA 5 ppm (12 mg/m3);STEL 10 ppm (25 mg/m3)
OEL-SWITZERLAND:TWA 2.5 ppm (6 mg/m3);Carcinogen
OEL-TURKEY:TWA 100 ppm (240 mg/m3)
OEL-UNITED KINGDOM:TWA 20 ppm (50 mg/m3);STEL 100 ppm
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 75-56-9 is not listed on the TSCA inventory.
It is for research and development use only.
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 7/01/1999 Revision #5 Date: 7/23/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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