RTECS NUMBER : LM5250000
CHEMICAL NAME : Fluorescein, 2',7'-dibromo-4'-(hydroxymercurio)-,
disodium salt
CAS REGISTRY NUMBER : 129-16-8
LAST UPDATED : 199710
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C20-H8-Br2-Hg-O6.2Na
MOLECULAR WEIGHT : 750.67
WISWESSER LINE NOTATION : T C666 BO EVJ D-HG-Q FE IR BVQ& LE MQ &-NA- 2
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Asceptichrome
* Aseptichrome
* Chromargyre
* 2,7-Dibromo-4-hydroxymercurifluoresceine disodium salt
* Disodium 2,7-dibrom-4-hydroxy-mercuri-fluorescein
* Disodium 2',7'-dibromo-4'-(hydroxymercury)fluorescein
* DOMF
* Flavurol
* Fluorochrome
* Gallochrome
* Gynochrome
* Merbromin
* Mercuranine
* Mercurochrome
* Mercurochrome-220 soluble
* Mercurocol
* Mercurome
* Mercurophage
* Planochrome
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 43,71,1931
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MOLAAF Monatsschrift fuer Ohrenheilkunde und Laryngo-Rhinologie. (Vienna,
Austria) V.1-108, 1867-1974. For publisher information, see LROTDW.
Volume(issue)/page/year: 73,751,1939
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 43,645,1931
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 35,343,1929
** MUTATION DATA **
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 10 mg/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 31,97,1979
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 50 mg/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 31,97,1979
*** REVIEWS ***
TOXICOLOGY REVIEW
SDGTB3 Seminars in Drug Treatment. (New York, NY) V.1-3, 1971-74.
Discontinued. Volume(issue)/page/year: 1,177,1971
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 44650
No. of Facilities: 586 (estimated)
No. of Industries: 5
No. of Occupations: 10
No. of Employees: 7896 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 44650
No. of Facilities: 372 (estimated)
No. of Industries: 3
No. of Occupations: 6
No. of Employees: 5294 (estimated)
No. of Female Employees: 3955 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S
cerevisiae-aneuploidy
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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