RTECS NUMBER : LP4200000
CHEMICAL NAME : Fluvomycin
CAS REGISTRY NUMBER : 1391-62-4
LAST UPDATED : 199501
DATA ITEMS CITED : 5
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Efsiomycin
* Riomycin
* Vivicil
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 240 mg/kg/60D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations
Behavioral - muscle contraction or spasticity
REFERENCE :
JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428
E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/page/year:
13,365,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 16 mg/kg/8D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 342,304,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 3,765,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 3,765,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 3,765,1953
*** END OF RECORD ***
ALL Chemical Property And Toxicity Analysis PAGES IN THIS GROUP