Fluorescein,
2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-, disodium
salt
CAS
:
18472-87-2
SYNONYMS
:
* Acid Red 92
* Aizen Acid Phloxine PB
* C.I. 45410
* C.I. Acid Red 92
* Cyanosin
* Cyanosin (acid dye)
* Cyanosine
* D and C Red No. 28
* Eosin Blue
* Eosine Blue
* Eosine bluish
* Food Dye Red No. 104
* Food Red No. 104
* Japan Red 104
* Orient Water Pink 2
* Phloxin B
* Phloxine B
* Phloxine P
* Red 104
* 11969 Red
* Red No. 104
* 3427 Veri Pur Pink
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : LM5900000
CHEMICAL NAME : Fluorescein,
2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-, disodium
salt
CAS REGISTRY NUMBER : 18472-87-2
OTHER CAS REGISTRY NOS. : 37361-25-4
LAST UPDATED : 199701
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C20-H2-Br4-Cl4-O5.2Na
MOLECULAR WEIGHT : 829.64
WISWESSER LINE NOTATION : T C666 BO EVJ DE FE IR BG CG DG EG FVO& LE MO NE
&-NA- 2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acid Red 92
* Aizen Acid Phloxine PB
* C.I. 45410
* C.I. Acid Red 92
* Cyanosin
* Cyanosin (acid dye)
* Cyanosine
* D and C Red No. 28
* Eosin Blue
* Eosine Blue
* Eosine bluish
* Food Dye Red No. 104
* Food Red No. 104
* Japan Red 104
* Orient Water Pink 2
* Phloxin B
* Phloxine B
* Phloxine P
* Red 104
* 11969 Red
* Red No. 104
* 3427 Veri Pur Pink
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
44,225,1978
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 75600 mg/kg/90W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Endocrine - tumors
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
32,517,1994
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 63 gm/kg
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.1- 1960- Volume(issue)/page/year: 16,34,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 39600 mg/kg
SEX/DURATION : female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
22,55,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 66 gm/kg
SEX/DURATION : female 6-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
22,55,1984
** MUTATION DATA **
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Human Lung
DOSE/DURATION : 3 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 30,239,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4129
No. of Facilities: 301 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 1460 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4129
No. of Facilities: 559 (estimated)
No. of Industries: 3
No. of Occupations: 11
No. of Employees: 9866 (estimated)
No. of Female Employees: 3202 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X9003
No. of Facilities: 636 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 8722 (estimated)
No. of Female Employees: 6754 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine
reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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