Fluorescein,
4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-, disodium
salt
CAS
:
632-69-9
SYNONYMS
:
* Food Red Color No. 105, sodium salt
* Food Red No. 105, sodium salt
* Rose bengal sodium
* R105 sodium
* 9-(3',4',5',6'-Tetrachloro-o-carboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo-
3-isoxanthone 2Na
* 4,5,6,7-Tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : LM5920000
CHEMICAL NAME : Fluorescein,
4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-, disodium
salt
CAS REGISTRY NUMBER : 632-69-9
LAST UPDATED : 199701
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C20-H2-Cl4-I4-O5.2Na
MOLECULAR WEIGHT : 1017.60
COMPOUND DESCRIPTOR : Tumorigen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Food Red Color No. 105, sodium salt
* Food Red No. 105, sodium salt
* Rose bengal sodium
* R105 sodium
* 9-(3',4',5',6'-Tetrachloro-o-carboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo-
3-isoxanthone 2Na
* 4,5,6,7-Tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 707 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Endocrine - thyroid tumors
REFERENCE :
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC)
V.61-79, 1978-87. For publisher information, see JNCIEQ.
Volume(issue)/page/year: 77,277,1986
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 650 mg/kg
SEX/DURATION : female 8-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,391,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 400 mg/kg
SEX/DURATION : female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,391,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 20 gm/kg
SEX/DURATION : female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,391,1982
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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