| MSDS | : | DOVONEX OINTMENT 0.005% 30 GRAM ALUMINUM TUBES | | CAS | : | 112965-21-6
8009-03-8
57-55-6
8012-95-1
9005-00-9
7732-18-5
7558-79-4
6381-92-6
59-02-9 | | NAME | : | calcipotriene
petrolatum, grease *95-1*
1,2-propanediol (propylene glycol)
mineral oil; petrolatum-liquid; white mineral oil, paraffin
stearyl alcohol w/ethylene oxide, polyoxyethylene (100)
water
sodium phosphate, dibasic, anhydrous, disodium phosphate
edta disodium dihydrate
vitamin e, tocopherol *95-1*
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===================== Product Identification =====================
MSDS NAME:DOVONEX OINTMENT 0.005% 30 GRAM ALUMINUM TUBES
NIIN:00F039702
MSDS Number: BWXLY
=== Responsible Party ===
Company:BRISTOL-MYERS SQUIBB, PHARMACEUTICAL GRP
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903-5000
Country:US
Info Phone Num:800-332-2056/908-519-3843
Emergency Phone Num:908-519-3843/609-921-4081
CAGE:BRIST
=== Contractor Identification ===
Company:BRISTOL-MYERS SQUIBB PHARMACEUTICAL GROUP
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:908-519-2385
CAGE:BRIST
Company:E R SQUIBB MEDATOPE DIV
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:609-921-4081
CAGE:4T649
============= Composition/Information on Ingredients =============
Name:CALCIPOTRIENE
CAS:112965-21-6
Fraction by Wt: 0.005%
Name:PETROLATUM, GREASE *95-1*
CAS:8009-03-8
Fraction by Wt: >1%
Name:1,2-PROPANEDIOL (PROPYLENE GLYCOL)
CAS:57-55-6
RTECS #:TY2000000
Fraction by Wt: >1%
Name:MINERAL OIL; PETROLATUM-LIQUID; WHITE MINERAL OIL, PARAFFIN
OIL
CAS:8012-95-1
RTECS #:PY8030000
Fraction by Wt: >1%
Other REC Limits:10 MG/CUM STEL
OSHA PEL:5 MG/CUM
ACGIH TLV:5 MG/CUM
Name:STEARYL ALCOHOL W/ETHYLENE OXIDE, POLYOXYETHYLENE (100)
STEARYL ETHER
CAS:9005-00-9
RTECS #:WI6300000
Fraction by Wt: >1%
Name:WATER
CAS:7732-18-5
RTECS #:ZC0110000
Fraction by Wt: >1%
Name:SODIUM PHOSPHATE, DIBASIC, ANHYDROUS, DISODIUM PHOSPHATE
CAS:7558-79-4
RTECS #:WC4500000
Fraction by Wt: <1%
EPA Rpt Qty:5000 LBS
DOT Rpt Qty:5000 LBS
Name:EDTA DISODIUM DIHYDRATE
CAS:6381-92-6
RTECS #:AH4410000
Fraction by Wt: <1%
Name:VITAMIN E, TOCOPHEROL *95-1*
CAS:59-02-9
RTECS #:DJ2900000
Fraction by Wt: <1%
===================== Hazards Identification =====================
LD50 LC50 Mixture:ORAL LD50 (RAT): 19 MG/KG
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:INGESTION: VITAMIN D TOXICITY MAY
RESULT. HYPERCALCEMIA RESULTING FROM EXCESS OF VITAMIN D ANALOGS.
SKIN: FACIAL IRRITATION WAS OBSERVED IN A SMALL PERCENTAGE OF
PATIENTS PARTICIPATING IN DOVONEX OINT MENT TRIALS. EYES:
MILD/TRANSIENT CONJUNCTIVAL IRRITATION. VITAMIN D ANALOGS
IMPAIRMENT OF RENAL FUNCTION (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:WEAKNESS, FATIGUE, HEADACHE, ANOREXIA, VERTIGO,
MUSCLE & BONE PAIN, IRRITATION, REDNESS, SWELLING, BURNING,
STINGING, TEARING, PAIN, DECREASED GROWTH IN CHILDREN, SEIZURES.
Medical Cond Aggravated by Exposure:VITAMIN D: HYPOPARATHYROIDISM,
IMPAIRED RENAL FUNCTION.
======================= First Aid Measures =======================
First Aid:INGESTION: VOMITING MAY BE INDUCED IF CONSCIOUS & NOT
EXPERIENCING ANY CONVULSIONS. NEVER GIVE ANYTHING BY MOUTH TO AN
UNCONSCIOUS PERSON. INHALATION: REMOVE TO FRESH AIR. GIVE
CPR/OXYGEN IF NEEDED. S KIN/EYES: FLUSH W/PLENTY OF WATER FOR 15
MINS. OBTAIN MEDICAL ATTENTION IN ALL CASES. NOTE TO PHYSICIANS:
THE ACTIVE INGREDIENT, CALCIPOTRIENE IS A VITAMIN D ANALOG. (SEE
SUPP)
===================== Fire Fighting Measures =====================
Extinguishing Media:USE WATER, CO2, FOAM/DRY CHEMICAL
Fire Fighting Procedures:WEAR SCBA, FLAME & CHEMICAL RESISTANT
CLOTHING, BOOTS & GLOVES. EVACUATE TO UPWIND DIRECTION, REMOVE
UNNEEDED MATERIAL & COOL CONTAINER W/WATER FROM A DISTANCE.
Unusual Fire/Explosion Hazard:ORGANIC MATERIALS SUCH AS THIS PRODUCT
MAY REACT W/OXIDIZERS RESULTING IN A FIRE HAZARD.
================== Accidental Release Measures ==================
Spill Release Procedures:ABSORB W/INERT, NON-COMBUSTIBLE ABSORBENT &
PLACE IN A CLOSED CONTAINER FOR RECLAMATION/DISPOSAL. IMPERMEABLE
GLOVES/CHEMICAL GOGGLES SHOULD BE WORN. ADDITIONAL PROTECTION MAY
BE NEEDED. VENTILATE ARE A & DECONTAMINATE AFTER MATERIAL IS PICKED
UP.
====================== Handling and Storage ======================
Handling and Storage Precautions:STORE AWAY FROM INCOMPATIBLE
SUBSTANCES. STORE AT 59-86F IN LIGHT RESISTANT CONTAINERS.
Other Precautions:AVOID SKIN & EYE CONTACT.
============= Exposure Controls/Personal Protection =============
Respiratory Protection:WEAR NIOSH APPROVED RESPIRATORY PROTECTION. SCBA
FOR EMERGENCY USE. IN A CLINICAL SETTING A RESPIRATOR SHOULDN'T BE
REQUIRED. WEAR A SCBA FOR EMERGENCIES.
Ventilation:LOCAL EXHAUST/ENCLOSURE OF PROCESSES
Protective Gloves:LATEX/NITRILE
Eye Protection:SAFETY GOGGLES, SAFETY GLASSES
Other Protective Equipment:PROTECTIVE COVERALLS.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING & BEFORE EATING/SMOKING/USING
LAVATORY
Supplemental Safety and Health
CONCURRENT USE OF THERAPEUTIC DOSES OF VITAMIN D ANALOGS W/CARDIAC
GLYCOSIDES MAY RESULT IN CARDIAC ARRHYTHMIAS. HEALTH HAZARDS
CONT'D: OSTEOPOROSIS IN ADULTS. FIRST AID CONT'D: ALTHOUGH HIGHLY
TOXIC, IT'S PRESENT AT A LOW CONCENTRATION INOINTMENT.
================== Physical/Chemical Properties ==================
Melt/Freeze Pt:M.P/F.P Text:131F
Vapor Density:>1
Solubility in Water:INSOLUBLE
Appearance and Odor:SMOOTH WHITE OINTMENT
================= Stability and Reactivity Data =================
Stability Indicator/Materials to Avoid:YES
OXIDIZERS, STRONG ACIDS, ALKALIES
Stability Condition to Avoid:LIGHT, TEMP >59-86F, HEAT
Hazardous Decomposition Products:CO, CO2
==================== Disposal Considerations ====================
Waste Disposal Methods:DISPOSE OF IAW/NATIONAL, STATE & LOCAL
REGULATIONS.
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.
*** END OF RECORD *** |
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