SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/JUL/2005
Date Updated: 17/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DIMETHYLCARBAMYL CHLORIDE, 98%
Product Number D152803
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DIMETHYLCARBAMOYL CHLORIDE 79-44-7 201-208-6 006-041-00-0
Formula C3H6ClNO
Molecular Weight 107.54 AMU
Synonyms Carbamic acid, dimethyl- (9CI) * Carbamyl
chloride, N,N-dimethyl- * Chlorid kyseliny
dimethylkarbaminove (Czech) * Chloroformic acid
dimethylamide * Dimethylamid kyseliny
chlormravenci (Czech) * (Dimethylamino)carbonyl
chloride * N,N-Dimethylaminocarbonyl chloride *
Dimethylcarbamic acid chloride *
N,N-Dimethylcarbamic acid chloride *
Dimethylcarbamic chloride * Dimethylcarbamidoyl
chloride * N,N-Dimethylcarbamidoyl chloride *
Dimethylcarbamoyl chloride *
N,N-Dimethylcarbamoyl chloride * Dimethyl
carbamoyl chloride (ACGIH) * Dimethylcarbamyl
chloride * N,N-Dimethylcarbamyl chloride *
Dimethylchloroformamide *
Dimethylkarbamoylchlorid (Czech) * RCRA waste
number U097 * TL 389
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. Also harmful if swallowed. Also toxic by
inhalation. Irritating to eyes, respiratory system and skin.
Carc. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame.
SPECIAL REQUIREMENTS: Moisture sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
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GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
Remarks: K
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 167 - 168 掳C 775 mmHg
MP/MP Range -33 掳C
Flash Point 82 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 1.172 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to moist air
or water.
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
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RTECS NUMBER: FD4200000
ACUTE TOXICITY
LD50
Oral
Rat
1000 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
LC50
Inhalation
Rat
180 ppm
6H
LD50
Intraperitoneal
Mouse
300 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
Inhalation: Toxic if inhaled. Material is extremely destructive
to the tissue of the mucous membranes and upper respiratory
tract.
Ingestion: Harmful if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Inhalation
Exposure Time: 6H/6W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Mouse
Route of Application: Skin
Exposure Time: 72W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and
Appendages: Other: Tumors. Tumorigenic:Tumors at site or
application.
Mouse
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Route of Application: Intraperitoneal
Exposure Time: 64W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Tumorigenic:Tumors at site or application.
Mouse
Route of Application: Subcutaneous
Exposure Time: 52W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Skin and
Appendages: Other: Tumors. Tumorigenic:Tumors at site or
application.
Hamster
Route of Application: Inhalation
Exposure Time: 6H/89W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Nutritional and Gross Metabolic:Weight loss or decreased weight
gain.
Mouse
Route of Application: Skin
Exposure Time: 55W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Skin and Appendages: Other: Tumors.
Mouse
Route of Application: Subcutaneous
Exposure Time: 40W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Tumorigenic:Tumors at site or application.
Rat
Route of Application: Inhalation
Exposure Time: 6H/6W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Rat
Route of Application: Inhalation
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Tumors.
Mouse
Route of Application: Subcutaneous
Exposure Time: 26W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
or Respiration:Tumors. Tumorigenic:Tumors at site or application.
Mouse
Route of Application: Skin
Exposure Time: 55W
Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and
Appendages: Other: Tumors. Tumorigenic:Tumors at site or
application.
Hamster
Route of Application: Inhalation
Exposure Time: 6H/2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
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Taste):Olfaction:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2A
CHRONIC EXPOSURE - MUTAGEN
Human
32 UG/L
Cell Type: fibroblast
Unscheduled DNA synthesis
Mouse
1400 UG/KG
Intraperitoneal
Micronucleus test
Mouse
187 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
1200 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Mouse
1 GM/KG
Cell Type: S. typhimurium
Host-mediated assay
Hamster
80 UG/L
Cell Type: kidney
Morphological transformation.
Hamster
100 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
33 UL/L
Cell Type: ovary
Cytogenetic analysis
Hamster
100 UMOL/L
Cell Type: ovary
Sister chromatid exchange
Hamster
100 UMOL/L
Cell Type: lung
Sister chromatid exchange
12 - Ecological Information
No data available.
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2262
Class: 8
PG: II
Proper Shipping Name: Dimethylcarbamoyl chloride
IMDG
UN#: 2262
Class: 8
PG: II
Proper Shipping Name: N,N-DIMETHYLCARBAMOYL CHLORIDE
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2262
Class: 8
PG: II
Proper Shipping Name: Dimethylcarbamoyl chloride
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 006-041-00-0
NOTA: E
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 45 22 23 36/37/38
May cause cancer. Also harmful if swallowed. Also toxic by
inhalation. Irritating to eyes, respiratory system and skin.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
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or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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