NFPA RATING
FLAMMABILITY
4
MATERIAL SAFETY DATA SHEET 0
3
HEALTH REACTIVITY
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
OTHER
PART I What is the material and what do I need to know in an emergency?
1. PRODUCT IDENTIFICATION
DIMETHYLAMINE - (CH3)2NH
CHEMICAL NAME; CLASS:
Document Number: 001020
PRODUCT USE: For general analytical/synthetic chemical uses.
SUPPLIER/MANUFACTURER'S NAME: AIRGAS INC.
ADDRESS: 259 N. Radnor-Chester Road
Suite 100
Radnor, PA 19087-5283
BUSINESS PHONE: 1-610-687-5253
EMERGENCY PHONE: CHEMTREC: 1-800-424-9300
International: 703-527-3887 (Call Collect)
DATE OF PREPARATION: May 20, 1996
SECOND REVISION: January 30, 1998
2. COMPOSITION and INFORMATION ON INGREDIENTS
CHEMICAL NAME CAS # mole % EXPOSURE LIMITS IN AIR
ACGIH OSHA
TLV STEL PEL STEL IDLH OTHER
ppm ppm ppm ppm ppm
Dimethylamine 124-40-3 > 99.0% 5 15 10 NE 500 NIOSH REL: 10 ppm
A4 (Not
Classifiable DFG MAK: 2 ppm
as a Human
Carcinogen)
< 1.0% None of the trace impurities in this mixture contribute significantly to the hazards associated
Maximum Impurities
with the product. All hazard information pertinent to this product has been provided in this
Material Safety Data Sheet, per the requirements of the OSHA Hazard Communication
Standard (29 CFR 1910.1200) and State equivalent standards.
NE = Not Established C = Ceiling Limit See Section 16 for Definitions of Terms Used
NOTE: All WHMIS required information is included. It is located in appropriate sections based on the ANSI Z400.1-1993 format.
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 1 OF 11
3. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: Dimethylamine is a colorless, corrosive, flammable gas with a strong 鈥渇ishy鈥? odor (at
concentrations below about 100 ppm) or an ammonia-like odor (at higher concentrations). This gas is shipped as a
liquefied gas under its own vapor pressure. This gas is a strong lachrymator, and irritant to the skin, eyes, and mucous
membranes. Flame or high temperature impinging on a localized area of the cylinder of Dimethylamine can cause the
cylinder to rupture without activating the cylinder鈥檚 relief devices. Dimethylamine can undergo a violent chemical reaction
at elevated temperatures. Provide adequate fire protection during emergency response situations. Vapor clouds of the
gas may be controlled using a water fog. Persons who respond to releases of Dimethylamine must protect themselves
from inhalation of Dimethylamine gases and mists, especially in areas which are downwind of the release. Extreme
caution must be used when responding to releases.
SYMPTOMS OF OVEREXPOSURE BY ROUTE OF EXPOSURE: The
most significant route of overexposure for this gas is by inhalation. Skin HAZARDOUS MATERIAL INFORMATION
or eye contact may cause serious injury. The following paragraphs SYSTEM
describe symptoms of exposure by route of exposure.
HEALTH
INHALATION: Inhalation of Dimethylamine vapors or gases may lead to 3
(BLUE)
irritation of the nose and throat. Exposures to high concentrations of
Dimethylamine gas can lead to symptoms such as coughing, labored
breathing, sore throat, and in some instances, chemical pneumonitis and
pulmonary edema. Pulmonary edema may be delayed. High
FLAMMABILITY 4
(RED)
concentrations of Dimethylamine gas may cause an oxygen-deficient
atmosphere. Repeated exposure to high concentrations of
Dimethylamine can cause liver damage. Exposure to high
concentrations may cause unconsciousness, and under some
REACTIVITY
circumstances, death. Exposure to the eyes may cause temporary (YELLOW) 0
blindness, leading to permanent vision impairment.
CONTACT WITH SKIN or EYES: Contact of the liquid (or gaseous
product or the mist produced by Dimethylamine), with the skin can lead
PROTECTIVE EQUIPMENT H
to severe burns or dermatitis (red, cracked, irritated skin), depending
upon concentration and duration of exposure. Exposure to low
concentrations may cause blurred vision commonly referred to as 鈥渂lue EYES HANDS BODY
RESPIRATORY
haze鈥? or 鈥渉alo vision鈥?. This is caused by the swelling of the surface of
the eye caused by the amine. After about 1 - 3 hours of overexposure,
SEE SECTION 8
vision may become foggy or blurred, objects can appear blurred, bluish,
and with a halo around them. Persons suffering this symptom may not
experience pain or discomfort. The effect normally clears up within 1 - 2 For routine industrial applications
days, with no permanent effect. Contact with the liquid or rapidly See Section 16 for Definition of Ratings
expanding gas poses a severe frostbite hazard.
OTHER POTENTIAL HEALTH EFFECTS: While ingestion is highly unlikely, ingestion of Dimethylamine can damage the
tissues of the mouth, throat, esophagus, and other tissues of the digestive system. Ingestion of Dimethylamine can be
fatal. Additionally, aspiration by inhalation is possible, causing chemical pneumonia or death.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms. Overexposure to Dimethylamine may
cause the following health effects:
ACUTE: This gas is extremely corrosive, and can burn and damage eyes, skin, mucous membranes, and any other
exposed tissue. If inhaled, irritation of the respiratory system may occur, with coughing, and breathing difficulty. Severe
eye damage may occur as a result of overexposure. Overexposure to this gas may be fatal. Though unlikely to occur
during occupational use, ingestion of large quantities may be fatal.
CHRONIC: Persistent irritation may result from repeated exposures to this gas. Repeated, high inhalation exposures can
result in bronchitis or liver damage. See Section 11 (Toxicological Information) for additional information.
TARGET ORGANS: ACUTE: Respiratory system, skin, eyes. CHRONIC: Lungs, liver.
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 2 OF 11
PART II What should I do if a hazardous situation occurs?
4. FIRST-AID MEASURES
RESCUERS SHOULD NOT ATTEMPT TO RETRIEVE VICTIMS OF EXPOSURE TO DIMETHYLAMINE
WITHOUT ADEQUATE PERSONAL PROTECTIVE EQUIPMENT. At a minimum, Self-Contained
Breathing Apparatus Personal Protective equipment should be worn.
Remove victim(s) to fresh air, as quickly as possible. Trained personnel should administer supplemental oxygen and/or
cardio-pulmonary resuscitation, if necessary. Only trained personnel should administer supplemental oxygen.
In case of frostbite, place the frostbitten part in warm water. DO NOT USE HOT WATER. If warm water is not available, or
is impractical to use, wrap the affected parts gently in blankets. Alternatively, if the fingers or hands are frostbitten, place the
affected area of the body in the armpit. Encourage victim to gently exercise the affected part while being warmed. Seek
immediate medical attention.
SKIN EXPOSURE: If Dimethylamine contaminates the skin, immediately begin decontamination with running water.
Minimum flushing is for 15 minutes. Remove exposed or contaminated clothing, taking care not to contaminate eyes.
Victim must seek immediate medical attention.
EYE EXPOSURE: If liquid is splashed into eyes, or if irritation of the eye develops after exposure to liquid or gas, open
victim's eyes while under gentle running water. Use sufficient force to open eyelids. Have victim "roll" eyes. Minimum
flushing is for 15 minutes.
SKIN or EYES CONTAMINATED WITH AMINE REQUIRE SPECIAL MEDICAL ATTENTION. Victim(s) must be taken for
medical attention. Rescuers should be taken for medical attention, if necessary. Take copy of label and MSDS to
physician or other health professional with victim(s). Medical care-providers should refer to Section 11 of this MSDS for
special Instructions to Physicians.
5. FIRE-FIGHTING MEASURES
FLASH POINT: Not applicable. Dimethylamine is extremely flammable.
NFPA RATING
AUTOIGNITION TEMPERATURE: 400掳C (736掳F) FLAMMABILITY
FLAMMABLE LIMITS (in air by volume, %):
Lower (LEL): 2.8% 4
Upper (UEL): 14.4% 0
3
HEALTH REACTIVITY
FIRE EXTINGUISHING MATERIALS:
Water Spray: YES Carbon Dioxide: YES
Halon: YES Other: Any "ABC鈥? Class.
Foam: YES Dry Chemical: YES OTHER
See Section 16 for Definition of Ratings
UNUSUAL FIRE AND EXPLOSION HAZARDS: Dimethylamine is a
flammable gas and presents significant health hazards to firefighters.
This gas may ignite, if released near an ignition source. Dimethylamine is heavier than air and may travel a considerable
distance to an ignition source and flashback. If involved in a fire, carbon monoxide, carbon dioxides, and oxides of nitrogen
will be released.
DANGER! Fires impinging (direct flame) on the outside surface of unprotected pressure storage vessels of Dimethylamine
can be very dangerous. Direct flame exposure on the cylinder wall can cause an explosion either by BLEVE (Boiling Liquid
Expanding Vapor Explosion) , or by exothermic decomposition. The resulting fire and cylinder rupture can result in severe
equipment damage and personnel injury or death over a large area around the vessel. For massive fires in large areas,
use unmanned hose holder or monitor nozzles; if this is not possible, withdraw from area and allow fire to burn.
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Explosion Sensitivity to Static Discharge: This is a flammable gas and is sensitive to static discharge.
SPECIAL FIRE-FIGHTING PROCEDURES: Incipient fire responders should wear eye protection. Structural firefighters
must wear Self-Contained Breathing Apparatus and full protective equipment. In the event of fire, cool cylinders of
Dimethylamine with water to prevent failure. Use a water spray or fog to reduce or direct vapors. Do not direct a water
spray at the source of a release. If Dimethylamine is involved in a fire, fire runoff water should be contained to prevent
possible environmental damage. If the gas is burning, extinguish the fire by stopping the release at the source. Do not
extinguish the fire if the source cannot be stopped. Allowing the fire to continue to burn until all of the gas is consumed may
be the best choice. Because of the potential for a BLEVE, evacuation of non-emergency personnel is essential. If water is
not available for cooling or protection of vessel exposures, evacuate the area. Refer to the North American Emergency
Response Guidebook (Guide #118) for additional information.
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 3 OF 11
6. ACCIDENTAL RELEASE MEASURES
SPILL AND LEAK RESPONSE: Uncontrolled releases should be responded to by trained personnel using pre-planned
procedures. Proper protective equipment should be used. In case of a large release, clear the affected area, protect
people, and respond with trained personnel. Call CHEMTREC (1-800-424-9300) for emergency assistance. Eliminate
sources of ignition. Supply maximum possible ventilation with explosion-proof equipment. Stop the release at the source.
Minimum Personal Protective Equipment should be Level A: triple-gloves (neoprene rubber gloves and nitrile gloves,
over latex or N-Dex餂? gloves), fully-encapsulating chemical resistant suit and boots, hard-hat, and Self Contained
Breathing Apparatus. Large releases of Dimethylamine will be evident by the cloud of dimethylammonium hydroxide
mist which is formed. Small releases of Dimethylamine can be detected by means of an atomizer or squeeze bottle
filled with concentrated hydrochloric acid. A white cloud will show the location of the leak. Monitor the surrounding area
for Dimethylamine gas, combustible gas, and oxygen levels. Colorimetric indicating tubes are commercially available
for Dimethylamine. The Dimethylamine level must be below levels indicated in Section 2 (Composition and Information
on Ingredients), combustible gas concentration must be below 10% of the LEL (LEL = 2.8%), AND the atmosphere must
have at least 19.5 percent oxygen before personnel can be allowed in the area without Self-Contained Breathing
Apparatus. Attempt to close the main source valve prior to entering the area. If this does not stop the release (or it is
not possible to reach the valve), allow the gas to release in place or remove it to a safe area and allow the gas to be
released there. If possible, stop the gas flow at the source. A water fog or mist can be used to control the vapor cloud
resulting from the release.
THIS IS A FLAMMABLE, CORROSIVE GAS. Protection of all personnel and the area must be maintained. All
responders must be adequately protected from exposure.
PART III How can I prevent hazardous situations from occurring?
7. HANDLING and STORAGE
WORK PRACTICES AND HYGIENE PRACTICES: As with all chemicals, avoid getting Dimethylamine ON YOU or IN
YOU. Wash hands after handling chemicals. Do not eat or drink while handling this solution. All work practices should
minimize the release of Dimethylamine. Be aware of any signs of effects of exposure indicated in Section 3 (Hazard
Identification); exposures to fatal concentrations of Dimethylamine could occur rapidly.
STORAGE AND HANDLING PRACTICES: All employees who handle this material should be trained to handle it safely.
Avoid breathing the gas or sprays or mists generated by Dimethylamine. Store containers in a cool, dry location, away
from direct sunlight, sources of intense heat, or where freezing is possible. Use only compatible materials for cylinders,
process lines, and other Dimethylamine-handling equipment. Lines should be purged with dry nitrogen both before and
after maintenance activity. Copper, tin, zinc and their alloys are not suitable materials for cylinders for Dimethylamine.
Keep container tightly-closed when not in use. Keep cylinders away from incompatible material. Wash thoroughly after
using this material. Workers must be thoroughly trained to handle Dimethylamine without causing overexposure. Periodic
inspections of process equipment by knowledgeable persons should be made to ensure that the equipment is used
appropriately and the system is kept in suitable operating condition. Dimethylamine emergency equipment should be
available near the point of use.
鈥? Workers who handle Dimethylamine should wear protective clothing, as listed in Section 8 (Exposure Controls -
Personal Protection).
鈥? Instant-acting showers should be available in the event of an emergency.
鈥? Special eye-wash fountains or similar equipment should be available for eye irrigation.
鈥? Proper respiratory protection equipment must be provided and workers using such equipment must be carefully trained
in its
operation and limitations.
鈥? Precautions must always be taken to prevent suck-back of foreign materials into the cylinder by using a check-valve,
vacuum break, or trap, since suck-back may cause dangerous pressure changes within the cylinder.
鈥? The cylinder valve should be closed after each use.
鈥? Determine cylinder contents by weight. The tare weight of the cylinder is stamped on the cylinder.
SPECIAL PRECAUTIONS FOR HANDLING GAS CYLINDERS: Protect cylinders against physical damage. Store in cool,
dry, well-ventilated area, away from sources of heat, ignition and direct sunlight. Do not allow area where cylinders are
stored to exceed 52掳C (125掳F). Isolate from incompatible materials (see Section 10, Stability and Reactivity) for more
information). Use a check valve or trap in the discharge line to prevent hazardous backflow. Never tamper with pressure
relief devices in valves and cylinders. Electrical equipment should be non-sparking or explosion proof. The following rules
are applicable to work situations in which cylinders are being used:
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 4 OF 11
7. HANDLING and STORAGE (Continued)
Before Use: Move cylinders with suitable hand-truck. Secure cylinders firmly. Leave the valve protection cap in place
(where provided) until cylinder is ready for use.
During Use: Use designated regulators, CGA fittings, and other support equipment. Do not use adapters. Do not use oil
or grease on gas handling fittings or equipment. All equipment must be properly grounded and bonded.
Dimethylamine cylinders should never be directly connected to a vessel containing a liquid since suck-back may occur
causing a violent reaction within the cylinder. To prevent suck-back, a trap, check valve or vacuum break should be
inserted into the line. The trap should be of adequate size to take the total liquid volume sucked-back.
The rate of gas flow can be increased by improving air circulation about the container or by increasing the temperature of
the room if it is below normal. Never apply heat directly to the cylinder for any reason. Do not manifold cylinders to
increase output unless check valves have been inserted at the cylinder outputs to prevent exchange of material from one
cylinder to another, causing a cylinder to become over-full.
Hoisting of cylinders is not recommended. If hoisting cannot be avoided, always use a lifting clamp, cradle, or carrier --
never use a lifting magnet, rope, or chain spring. Do not store Dimethylamine cylinders near cylinders of hydrogen,
acetylene, fuel gases, ether, turpentine, hydrocarbons, organic matter, or finely-divided metals. Never mix Dimethylamine
with other gases in the cylinder. Do not store Dimethylamine cylinders near elevators or gangways or in locations where
heavy objects may fall and strike them.
Open cylinder valves slowly. The use of large wrenches or pipe wrenches will damage the valve. One complete turn of the
valve stem in a counter-clockwise direction opens the valve sufficiently to permit maximum discharge. 鈥淓mpty鈥? containers
still contain Dimethylamine gas, and should be handled with all precautions described in this MSDS.
If leaks develop in Dimethylamine lines, they must be given prompt attention because they will become progressively
worse. Refer to Section 6 (Accidental Release Measures) for release response protocol.
After Use: Close main cylinder valve. Replace valve protection cap (where provided). Mark empty cylinders 鈥淓MPTY鈥?.
NOTE: Use only DOT or ASME code containers. Earth-ground and bond all lines and equipment associated with
Dimethylamine. Close valve after each use and when empty. Cylinders must not be recharged except by or with the
consent of owner. For additional information refer to the Compressed Gas Association Pamphlet P-1, Safe Handling of
Compressed Gases in Containers.
TANK CAR SHIPMENTS: Tank cars carrying Dimethylamine should be loaded and unloaded in strict accordance with tank-
car manufacturer鈥檚 recommendations and all established on-site safety procedures. Appropriate personal protective
equipment must be used during tank car operations (see Section 8, Exposure Controls and Personal Protection). All loading
and unloading equipment must be inspected, prior to each use. Loading and unloading operations must be attended, at all
times. Tank cars must be level and wheels must be locked or blocked prior to loading or unloading. Tank car (for loading) or
storage tank (for unloading) must be verified to be correct for receiving Dimethylamine and be properly prepared, prior to
starting the transfer operations. Hoses must be verified to be clean and free of incompatible chemicals, prior to connection to
the tank car or vessel. Valves and hoses must be verified to be in the correct positions, before starting transfer operations. A
sample (if required) must be taken and verified (if required) prior to starting transfer operations. All lines must be blown-down
and purged before disconnecting them from the tank car or vessel.
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices indicated in
Section 6 (Accidental Release Measures). Make certain application equipment is locked and tagged-out safely. Purge gas
handling equipment with inert gas (e.g., nitrogen) before attempting repairs.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Use with adequate ventilation. A hood with forced ventilation is
preferable. Because of the high hazard associated with Dimethylamine, stringent control measures such as a gas cabinet
enclosure or isolation may be necessary. Ductwork should be constructed of non-metallic material, or should be lined to
resist corrosion.
RESPIRATORY PROTECTION: Maintain airborne contaminant concentrations below exposure limits listed in Section 2
(Composition and Information on Ingredients). If respiratory protection is needed, use only protection authorized in 29 CFR
1910.134 or applicable State regulations. Use supplied-air respiration protection during emergency response procedures
to releases and if oxygen levels are below 19.5% or are unknown. The following NIOSH respiratory protection
recommendations for Dimethylamine are provided for additional information.
CONCENTRATION RESPIRATORY EQUIPMENT
Up to 250 ppm: Chemical cartridge respirator or Supplied Air Respirator (SAR).
Up to 500 ppm: SAR in the continuous flow mode, or a Powered Air-Purifying Respirator (PAPR) with
Dimethylamine cartridges, or a gas mask with a Dimethylamine canister, or a SCBA.
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 5 OF 11
8. EXPOSURE CONTROLS - PERSONAL PROTECTION (Continued)
CONCENTRATION RESPIRATORY EQUIPMENT (continued)
Emergency or Planned Entry into Unknown Concentration or IDLH Conditions: SCBA or positive pressure, full-faced SAR
with an auxiliary SCBA.
Escape: Gas mask or mouth-piece respirator with Dimethylamine cartridges or SCBA should be used.
The IDLH concentration for Dimethylamine is 500 ppm.
EYE PROTECTION: Splash goggles or safety glasses and face shield.
HAND PROTECTION: Wear Neoprene Rubber gloves for industrial use. Use triple gloves for spill response (see Section
6, Accidental Release Measures).
BODY PROTECTION: Use body protection appropriate for task. An apron, or other impermeable body protection is
suggested. Full-body chemical protective clothing is recommended for emergency response procedures.
PROTECTION FOR TANK CAR OPERATIONS: Splash-suit, gloves, goggles, face-shield, boots and hard-hat should be
worn during operations involving tank-cars or trucks containing Dimethylamine.
HAND PROTECTION: Wear mechanical resistant gloves when handling cylinders of Dimethylamine.
BODY PROTECTION: Use body protection appropriate for task. Transfer of large quantities under pressure may require
protective equipment appropriate to protect employees from splashes of liquefied Dimethylamine, as well provide sufficient
insulation from extreme cold.
9. PHYSICAL and CHEMICAL PROPERTIES
VAPOR DENSITY: 1.844 kg/m (0.115 lb/ft3)
3
EVAPORATION RATE (nBuAc = 1): Not applicable.
SPECIFIC GRAVITY (air = 1): 1.557 FREEZING POINT: -92掳C (-134掳F)
SOLUBILITY IN WATER: 23.7% BOILING POINT @ 1 atm: 6.9掳C (44.4掳F)
VAPOR PRESSURE (psia): 26 pH: Not applicable. (A 1% solution in water will have a pH > 13).
SPECIFIC VOLUME (ft3/lb): 8.6
EXPANSION RATIO: Not applicable.
COEFFICIENT WATER/OIL DISTRIBUTION: Not applicable.
ODOR THRESHOLD: 6 ppm (100 % recognition)
APPEARANCE AND COLOR: Dimethylamine is a pungent-smelling, toxic, corrosive gas having a fishy odor (at
concentrations less than 100 ppm) and an ammonia-like odor (at concentrations greater than 100 ppm). This gas is
heavier than air and fumes in moist air, producing a cloud of dimethylammonium hydroxide mist.
HOW TO DETECT THIS SUBSTANCE (warning properties): The odor and dense appearance of this gas are distinctive
warning properties associated with Dimethylamine. An atomizer of concentrated hydrochloric acid, or wet pH paper can be
used to detect amines.
10. STABILITY and REACTIVITY
STABILITY: Stable.
CONDITIONS TO AVOID: Dimethylamine does not burn, but reacts with water to form dimethylammonium hydroxide.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: Dimethylamine is not compatible with most metals, acids,
or oxidizers. Dimethylamine can form explosive compounds with mercury. Dimethylamine reacts violently with
acrylaldehyde, acids, acid halides, and acid anhydrides. Sodium nitrite reacts with amines to form carcinogenic
nitrosoamines. Maleic anhydride reacts with amines with the release of significant amounts of heat.
HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS TO AVOID: Extreme heat, fire, or contact with incompatible chemicals.
PART IV Is there any other useful information about this material?
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: The following information is for Dimethylamine (gas):
Irritant test (eye, rabbit) = 50 mg/5 minutes LC50 (rat): 1250-2000 ppm (2-hr exposure)
LC50 (inhalation, rat) = 4540 ppm/5 hours LC50 (mouse): 7650 ppm (2-hr exposure)
LC50 mg/kg (inhalation, mouse) = 7650 mg/kg LD50 (oral, rat): 698 mg/kg body weight
LD50 (intravenous, rabbit) = 4000 mg/kg LD50 (oral, mouse): 316 mg/kg body weight
3
LC50 (inhalation, mammal) = 3700 mg/m LD50 (oral, guinea pig): 240 mg/kg body weight
LC50 (rat): 4700 ppm (4-hr exposure) LD50 (oral, rabbit): 240 mg/kg body weight
* Solution of 33% dimethylamine (DMA) in water
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 6 OF 11
11. TOXICOLOGICAL INFORMATION (Continued)
TOXICITY DATA (continued):
RESPIRATORY IRRITATION: Dimethylamine concentrations of 573 ppm and 511 ppm were found to cause a 50% reduction in the
respiratory rate (RD50) of rats and mice respectively. In another study with mice, the RD50 value was found to be 70 ppm.
SHORT-TERM INHALATION: Animals exposed to concentrated vapors showed signs of mucous membrane and respiratory tract irritation.
Single and repeated exposures at sub-lethal concentrations may result in inflammation of the trachea, bronchitis, pneumonitis and
pulmonary edema. Rats exposed to single concentrations of Dimethylamine from 600-6000 ppm showed concentration-related changes
ranging from ulceration and tissue death to inflammation of the mucous membrane of the nose and trachea and emphysema. Exposures
of mice at concentrations above 5420 ppm caused cyanosis, convulsions and death.
EYE IRRITATION: Guinea pigs and rabbits exposed to 183 or 97 ppm Dimethylamine gas for 7 hours/day, 5 days/week had corneal damage
after 9 days. Rats exposed to 1000-6000 ppm Dimethylamine gas for 6 hours developed swelling of the cornea. Inflammation and
ulceration of the cornea, and swelling were present at 2500-6000 ppm. At 4000 or 6000 ppm, tissue death (necrosis) in the iris and severe
cataract-like lens degeneration in many rats. Mice exposed at concentrations from 813 to 1626 ppm showed eye and respiratory irritation.
SKIN IRRITATION: No information on Dimethylamine gas. A 6% solution of Dimethylamine in water caused ulceration when applied to rabbit
skin. Repeated (5 times) exposure to a 3% solution gave the same effects. Mouse tails dipped into a 20% solution for 5 minutes showed
massive bleeding. Skin returned to normal in 2 weeks.
LONG-TERM INHALATION: Repeated exposure of rats and mice to Dimethylamine gas caused moderate to severe damage to the tissues
lining the nasal passages. Sometimes, there was damage to nerves responsible for the sense of smell. Damage was seen in animals
exposed to concentrations ranging from 50 to 511 ppm for periods of 1 week to 2 years. The nasal lesions in rats exposed to 175 ppm
Dimethylamine for 2 years were very similar to those found in rats exposed for 6 hours , 6 months or 12 months. Decreased body weights
were observed at some of these exposures. No deaths, no signs of toxicity and normal blood values were observed in a number of animal
species (rats, guinea pigs, rabbits, dogs and monkeys) exposed continuously to 5 ppm Dimethylamine for 90 days. Mild inflammatory
changes in the lungs of all species and dilated bronchi in rabbits and monkeys were noted on autopsy. No harmful effects were seen in
rats exposed to 10, 30 or 100 ppm Dimethylamine for 6 hours/day, 5 days/week for 13 weeks.
LIVER DAMAGE: One study reported permanent liver damage (degeneration and necrosis) in rats, mice, guinea pigs and rabbits exposed to
97 or 183 ppm Dimethylamine (7 hours/day, 5 days/week, 18-20 weeks). Another study reported liver lesions in rats exposed to 2500-
6000 ppm Dimethylamine for 6 hours. Lesions were not found at lower exposure levels.
SUSPECTED CANCER AGENT: Dimethylamine is listed by ACGIH as a TLV-A4 (Not Classifiable as a Human
Carcinogen). Dimethylamine is not found on the following lists: FEDERAL OSHA Z LIST, NTP, CAL/OSHA or IARC and
there fore is not considered to be, nor suspected to be a cancer-causing agent by these agencies. Amines can react with
chemicals such as sodium nitrite to form carcinogenic nitrosoamines. Additional information is available as follows:
Groups of mice and rats were exposed for 6 hours/day, 5 days/week for 2 years at 10, 50 or 175 ppm Dimethylamine. No increase in tumor or
incidence was found in animals at 6, 12, 18 and 24 months. No evidence of a carcinogenic response was found in these animals.
Dimethylamine can react with nitrosating agents such as nitrogen dioxide or nitrites to produce the carcinogen N-nitrosodimethylamine.
IRRITANCY OF PRODUCT: Dimethylamine is severely irritating to contaminated tissue.
SENSITIZATION OF PRODUCT: Dimethylamine is not known to be a human sensitizer upon repeated or prolonged
exposure.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of Dimethylamine on the
human reproductive system.
Mutagenicity: Dimethylamine has not been reported to cause mutagenic effects in humans. Additional animal information
is available as follows:
Inconclusive results. Mutations were reported in rats that breathed 50 ug/m3 Dimethylamine. Details are lacking. Dimethylamine was weakly
mutagenic in one strain of Salmonella typhimurium with mouse liver activation. It gave negative results in this strain without activation, in
several other strains, in host-mediated assays with mice and rats and in some cultured mammalian cells. Dimethylamine has been
reported to be mutagenic in the Chinese hamster ovary cell assay, but only at high concentrations (specific values not available). A
mixture of Dimethylamine and sodium nitrite caused mutations (Ames test).
Teratogenicity: Dimethylamine has been not been reported to cause teratogenic effects.
Embryotoxicity: Dimethylamine has not been reported to cause embryotoxic effects
Reproductive Toxicity: Dimethylamine is not reported to cause adverse reproductive effects in humans. Additional
information is available as follows:
Testicular damage was seen in a monkey (exposed at 97 ppm) and a rabbit (exposed at 183 ppm).
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the changes will propagate
through generation lines. An embryotoxin is a chemical which causes damage to a developing embryo (i.e. within the first
eight weeks of pregnancy in humans), but the damage does not propagate across generational lines. A teratogen is a
chemical which causes damage to a developing fetus, but the damage does not propagate across generational lines. A
reproductive toxin is any substance which interferes in any way with the reproductive process.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Conditions relating to the target organs may be aggravated by
overexposures to Dimethylamine. See Section 3 (Hazard Identification) for information on these conditions.
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 7 OF 11
11. TOXICOLOGICAL INFORMATION (Continued)
RECOMMENDATIONS TO PHYSICIANS: Treat symptoms and reduce overexposure. If necessary, administer lung
function tests, liver function tests, chest x-rays. Delayed pulmonary edema may occur, following overexposure by
inhalation. Special Care for Chemical Burns from Amines: Use no ointments on the skin or mucous membranes during the
first 24-hour period after the injury. Do not cover the injured area with clothing or a dry dressing. During the first 24-hours,
the area may be covered with a dressing kept moist with sterile, Normal Saline. Special Care for Chemical Injury to the
Eyes by Amines: The eyes must be thoroughly flushed with running water for at least fifteen minutes. Use a topical
anesthetic in the affected eye(s) and then use fluorescein to determine if injury to the eye has occurred. If injury has
occurred, repeat the water-rinsing, at least twice more. If fluorescein reveals injury to the eye, an eye specialist should
examine the victim. Do not apply eye pads or pressure, as gluing of the lids to the eye will occur.
BIOLOGICAL EXPOSURE INDICES (BEIs): Currently, Biological Exposure Indices (BEIs) are not applicable for
Dimethylamine.
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL STABILITY: Dimethylamine can cause harm to the environment. All work practices should be aimed
at eliminating environmental contamination. Additional environmental data are available as follows:
DIMETHYLAMINE: Log KOW = -0.38. Water solubility: Very soluble. BCF 鈮? 0.30. Dimethylamine is not expected to bioconcentrate in aquatic
organisms. Amines degrade at moderate rate. Tests indicate that dimethylamine should be readily degraded in biological treatment plants.
Dimethylamine forms alkaline solution from probable dissociation of amine group to release ammonium ion.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: Due to the corrosive nature of Dimethylamine, animals exposed to
Dimethylamine will experience tissue damage, burns, and may be killed. Oxygen displacement can also be a factor in the
toxicity of Dimethylamine. Plants contaminated with Dimethylamine may be adversely affected or destroyed.
EFFECT OF CHEMICAL ON AQUATIC LIFE: Dimethylamine is very soluble in water, and even low concentrations of
Dimethylamine in water is detrimental to aquatic life. A release of Dimethylamine that occurs near a river or other body of
water, the release has the potential to kill fish and other aquatic life.
LC50 (rainbow trout) = 120 mg/L
Lethal (chub) = 50 ppm, 24 hours, fresh water
LC50 (shrimp) = > 100 ppm, 48 hours, salt water
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with appropriate Federal, State, and local
regulations. Return cylinders with any residual product to Airgas Inc. Do not dispose of locally.
14. TRANSPORTATION INFORMATION
THIS MATERIAL IS HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF
TRANSPORTATION.
PROPER SHIPPING NAME: Dimethylamine, anhydrous
HAZARD CLASS NUMBER and DESCRIPTION: 2.1 (Flammable Gas)
UN IDENTIFICATION NUMBER: UN 1032
PACKING GROUP: Not Applicable
DOT LABEL(S) REQUIRED: Flammable Gas
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (1996): 118
FOR BULK SHIPMENTS: Follow the requirements of 49 CFR 172.314 and 315.
MARINE POLLUTANT: Dimethylamine is not designated by the Department of Transportation to be a Marine Pollutant (49
CFR 172.101, Appendix B).
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: THIS MATERIAL IS
CONSIDERED AS DANGEROUS GOODS. Refer to the following information for Canadian Shipments. Additional
information for Canadian shipments is as follows: Hazard Class: 2.1 (Flammable Gas), 8 (Corrosive Substance); Label
required: Flammable Gas, Corrosive
CANADIAN SPECIAL PROVISION: 102 Emergency Response Assistance Planning requirements must be met for
shipments in excess of 3,000 kg or liters.
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 8 OF 11
15. REGULATORY INFORMATION
U.S. SARA REPORTING REQUIREMENTS: Dimethylamine is subject to the reporting requirements of Sections 302, 304,
and 313 of Title III of the Superfund Amendments and Reauthorization Act, as follows:
CHEMICAL NAME SARA 302 SARA 304 SARA 313
(40 CFR 355, Appendix A) (40 CFR Table 302.4) (40 CFR 372.65)
Dimethylamine NO YES NO
U.S. SARA THRESHOLD PLANNING QUANTITY: Not regulated.
U.S. CERCLA REPORTABLE QUANTITIES (RQ): 1,000 lb.
CANADIAN DSL/NDSL INVENTORY STATUS: Dimethylamine is on the DSL Inventory.
U.S. TSCA INVENTORY STATUS: Dimethylamine is listed on the TSCA Inventory.
OTHER U.S. FEDERAL REGULATIONS: Dimethylamine is subject to the reporting requirements of Section 112(r) of the
Clean Air Act. The Threshold Quantity of Dimethylamine is 10,000 lbs. Compliance with the OSHA Process Safety
Standard, 29 CFR 1910.119 may be applicable to operations involving the use of Dimethylamine. Under this regulation
Dimethylamine is listed in Appendix A with a Threshold Quantity of 2500 lb.
CALIFORNIA SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT (PROPOSITION 65): Dimethylamine is not
on the California Proposition 65 lists.
U.S. STATE REGULATORY INFORMATION: Dimethylamine is covered under the following specific State regulations:
Alaska - Designated Toxic and Massachusetts - Substance List: North Dakota - List of Hazardous
Hazardous Substances: Dimethylamine Chemicals, Reportable Quantities:
Dimethylamine. Dimethylamine.
Michigan Critical Register List: No.
California - Permissible Exposure Pennsylvania - Hazardous Substance
Minnesota - List of Hazardous
Limits for Chemical Contaminants: List: Dimethylamine.
Substances: Dimethylamine.
Dimethylamine. Rhode Island - Hazardous Substance
Missouri - Employer Information/Toxic
Florida - Substance List: List: Dimethylamine.
Substance List: Dimethylamine.
Dimethylamine. Texas - Hazardous Substance List:
New Jersey - Right to Know Hazardous
Illinois - Toxic Substance List: Dimethylamine.
Substance List: Dimethylamine.
Dimethylamine. West Virginia - Hazardous Substance
Kansas - Section 302/313 List: List: Dimethylamine.
Dimethylamine. Wisconsin - Toxic and Hazardous
Substances: Dimethylamine.
LABELING:
DANGER: FLAMMABLE, CORROSIVE LIQUID AND GAS UNDER PRESSURE.
CAN CAUSE EYE, SKIN, AND RESPIRATORY TRACT BURNS.
MAY CAUSE LIVER AND KIDNEY DAMAGE.
Avoid breathing gas.
Store and use with adequate ventilation.
Keep away from heat, flame, and sparks.
Do not get in eyes, on skin or clothing.
Use only with equipment of compatible material and construction.
Cylinder temperature should not exceed 52掳C (125掳F)
Close valve after each use and when empty.
Use in accordance with the Material Safety Data Sheet.
NOTE: Suck-back into cylinder may cause rupture.
Always use a back flow preventative device in piping.
FIRST-AID: IF INHALED, remove to fresh air. If not breathing, give artificial respiration. (Rescuer may
receive chemical burns as a result of giving mouth to mouth). If breathing, give oxygen. Call a
physician.
IN CASE OF CONTACT, immediately flush eyes or skin with water for at least 15 minutes
while removing contaminated clothing and shoes. Call a physician. Wash clothing before
reuse. (Discard contaminated shoes).
DO NOT REMOVE THIS PRODUCT LABEL.
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 9 OF 11
15. REGULATORY INFORMATION (Continued)
CANADIAN WHMIS SYMBOLS: Class A: Compressed Gas
Class B1: Flammable Gas
Class D1A: Toxic Material/Immediate and Serious Effects
Class D2B: Other Toxic Effects
Class E: Corrosive Material
16. OTHER INFORMATION
PREPARED BY: CHEMICAL SAFETY ASSOCIATES, Inc.
9163 Chesapeake Drive, San Diego, CA 92123-1002
619/565-0302
The information contained herein is based on data considered accurate. However, no warranty is expressed or implied regarding the
accuracy of these data or the results to be obtained from the use thereof. AIRGAS, Inc. assumes no responsibility for injury to the vendee or
third persons proximately caused by the material if reasonable safety procedures are not adhered to as stipulated in the data sheet.
Additionally, AIRGAS, Inc. assumes no responsibility for injury to vendee or third persons proximately caused by abnormal use of the material
even if reasonable safety procedures are followed. Furthermore, vendee assumes the risk in his use of the material.
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 10 OF 11
DEFINITIONS OF TERMS
A large number of abbreviations and acronyms appear on a MSDS. Some of these which are commonly used include the following:
CAS #: This is the Chemical Abstract Service Number which uniquely identifies each constituent. It is used for computer-related searching.
EXPOSURE LIMITS IN AIR: FLAMMABILITY LIMITS IN AIR:
Much of the information related to fire and explosion is derived from the
ACGIH - American Conference of Governmental Industrial Hygienists, a
National Fire Protection Association (NFPA). Flash Point - Minimum
professional association which establishes exposure limits.
temperature at which a liquid gives off sufficient vapors to form an
TLV - Threshold Limit Value - an airborne concentration of a substance
ignitable mixture with air. Autoignition Temperature: The minimum
which represents conditions under which it is generally believed that
temperature required to initiate combustion in air with no other source of
nearly all workers may be repeatedly exposed without adverse effect.
ignition. LEL - the lowest percent of vapor in air, by volume, that will
The duration must be considered, including the 8-hour Time Weighted
explode or ignite in the presence of an ignition source. UEL - the highest
Average (TWA), the 15-minute Short Term Exposure Limit, and the
percent of vapor in air, by volume, that will explode or ignite in the
instantaneous Ceiling Level (C). Skin absorption effects must also be
presence of an ignition source.
considered.
OSHA - U.S. Occupational Safety and Health Administration.
TOXICOLOGICAL INFORMATION:
PEL - Permissible Exposure Limit - This exposure value means exactly
Possible health hazards as derived from human data, animal studies, or
the same as a TLV, except that it is enforceable by OSHA. The OSHA
from the results of studies with similar compounds are presented.
Permissible Exposure Limits are based in the 1989 PELs and the June,
Definitions of some terms used in this section are: LD50 - Lethal Dose
1993 Air Contaminants Rule (Federal Register: 58: 35338-35351 and
(solids & liquids) which kills 50% of the exposed animals; LC50 - Lethal
58: 40191). Both the current PELs and the vacated PELs are indicated.
Concentration (gases) which kills 50% of the exposed animals; ppm
The phrase, 鈥淰acated 1989 PEL,鈥? is placed next to the PEL which was
concentration expressed in parts of material per million parts of air or
vacated by Court Order.
water; mg/m3 concentration expressed in weight of substance per
IDLH - Immediately Dangerous to Life and Health - This level represents
volume of air; mg/kg quantity of material, by weight, administered to a
a concentration from which one can escape within 30-minutes without
test subject, based on their body weight in kg. Data from several
suffering escape-preventing or permanent injury. The DFG - MAK is the
sources are used to evaluate the cancer-causing potential of the
Republic of Germany鈥檚 Maximum Exposure Level, similar to the U.S.
material. The sources are: IARC - the International Agency for
PEL. NIOSH is the National Institute of Occupational Safety and Health,
Research on Cancer; NTP - the National Toxicology Program, RTECS -
which is the research arm of the U.S. Occupational Safety and Health
the Registry of Toxic Effects of Chemical Substances, OSHA and
Administration (OSHA). NIOSH issues exposure guidelines called
CAL/OSHA. IARC and NTP rate chemicals on a scale of decreasing
Recommended Exposure Levels (RELs). When no exposure guidelines
potential to cause human cancer with rankings from 1 to 4. Subrankings
are established, an entry of NE is made for reference.
(2A, 2B, etc.) are also used. Other measures of toxicity include TDLo,
the lowest dose to cause a symptom and TCLo the lowest concentration
HAZARD RATINGS:
to cause a symptom; TDo, LDLo, and LDo, or TC, TCo, LCLo, and
HAZARDOUS MATERIALS IDENTIFICATION SYSTEM: Health
LCo, the lowest dose (or concentration) to cause lethal or toxic effects.
Hazard: 0 (minimal acute or chronic exposure hazard); 1 (slight acute or
BEI - Biological Exposure Indices, represent the levels of determinants
chronic exposure hazard); 2 (moderate acute or significant chronic
which are most likely to be observed in specimens collected from a
exposure hazard); 3 (severe acute exposure hazard; onetime
healthy worker who has been exposed to chemicals to the same extent
overexposure can result in permanent injury and may be fatal); 4
as a worker with inhalation exposure to the TLV. Ecological Information:
(extreme acute exposure hazard; onetime overexposure can be fatal).
EC is the effect concentration in water.
Flammability Hazard: 0 (minimal hazard); 1 (materials that require
substantial pre-heating before burning); 2 (combustible liquid or solids;
REGULATORY INFORMATION:
liquids with a flash point of 38-93掳C [100-200掳F]); 3 (Class IB and IC
This section explains the impact of various laws and regulations on the
flammable liquids with flash points below 38掳C [100掳F]); 4 (Class IA
material. EPA is the U.S. Environmental Protection Agency. WHMIS is
flammable liquids with flash points below 23掳C [73掳F] and boiling points the Canadian Workplace Hazardous Materials Information System.
below 38掳C [100掳F]. Reactivity Hazard: 0 (normally stable); 1 (material DOT and TC are the U.S. Department of Transportation and the
that can become unstable at elevated temperatures or which can react Transport Canada, respectively. Superfund Amendments and
slightly with water); 2 (materials that are unstable but do not detonate or Reauthorization Act (SARA); the Canadian Domestic/Non-Domestic
which can react violently with water); 3 (materials that can detonate Substances List (DSL/NDSL); the U.S. Toxic Substance Control Act
when initiated or which can react explosively with water); 4 (materials (TSCA); Marine Pollutant status according to the DOT; the
that can detonate at normal temperatures or pressures). Comprehensive Environmental Response, Compensation, and Liability
NATIONAL FIRE PROTECTION ASSOCIATION: Health Hazard: 0 Act (CERCLA or Superfund); and various state regulations.
(material that on exposure under fire conditions would offer no hazard
beyond that of ordinary combustible materials); 1 (materials that on
exposure under fire conditions could cause irritation or minor residual
injury); 2 (materials that on intense or continued exposure under fire
conditions could cause temporary incapacitation or possible residual
injury); 3 (materials that can on short exposure could cause serious
temporary or residual injury); 4 (materials that under very short
exposure could cause death or major residual injury). Flammability
Hazard and Reactivity Hazard: Refer to definitions for 鈥淗azardous
Materials Identification System鈥?.
DIMETHYLAMINE - (CH3)2NH MSDS (Document # 001020) PAGE 11 OF 11
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