The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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"DuPont" "LAYBY" PRO HERBICIDE
M0000584 Revised 21-DEC-2007
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
"DuPont", "LAYBY" are trademarks of DuPont.
Tradenames and Synonyms
LAYBY PRO
B11932524
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
*LINURON 330-55-2 20.3
3-(3,4-DICHLOROPHENYL)-1-METHOXY-1-METHYLUREA
*DIURON 330-54-1 20
3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYLUREA
INERT INGREDIENTS (Including percentages of the 59.7
following):
* Ethylene Glycol 107-21-1
* Disclosure as a toxic chemical is required under Section 313 of
Title III of the Superfund Amendments and Reauthorization Act of 1986
and 40 CFR part 372.
M0000584 DuPont Page 2
Material Safety Data Sheet
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HAZARDS IDENTIFICATION
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Emergency Overview
Caution! Harmful if swallowed, inhaled, or absorbed through
the skin. Causes moderate eye irritation. Avoid breathing
spray mist. Avoid contact with eyes, skin, or clothing.
# Potential Health Effects
BASED ON THE COMPONENTS
Human Health Effects of Overexposure:
Significant skin permeation, and systemic toxicity, after
contact appears unlikely. There are no reports of human
sensitization.
Eye contact may initially include eye irritation with
discomfort, tearing, or blurring of vision.
Based on data from animal testing, ingestion of large
amounts may cause alterations in red blood cell counts
and/or anemia, and spleen and liver effects.
No epidemiologic studies are available.
ETHYLENE GLYCOL
The estimated lethal oral dose of Ethylene Glycol in humans
is 100 mL.
Immediate effects of inhalation overexposure to Ethylene
Glycol may include irritation of the nose and throat with
sneezing, sore throat or runny nose. Gross overexposure may
cause pulmonary edema (body fluid in the lungs) with cough,
wheezing, abnormal lung sounds, possibly progressing to
severe shortness of breath and bluish discoloration of the
skin; symptoms may be delayed.
Immediate effects of overexposure to Ethylene Glycol by
inhalation or ingestion may include headache and nausea.
Gross overexposure may cause central nervous system
depression with dizziness, confusion, incoordination,
drowsiness or unconsciousness; convulsions; altered kidney
function which may be accompanied by abnormal urine volume,
low back pain, discomfort or edema; kidney failure; deposits
of calcium oxalate in the brain, spinal cord and kidneys;
liver abnormalities; high blood pressure; irregular heart
beat with a strange sensation in the chest, "heart
thumping", apprehension, lightheadedness, feeling of
fainting, dizziness, weakness, sometimes progressing to loss
of consciousness and death. Other effects may include
congestive heart failure; retention of acid in the blood,
making oxygen less available in the blood stream and leading
to symptoms of increased pulse rate, nausea, vomiting,
confusion and weakness which may progress to loss of
consciousness; low blood sugar; low blood calcium with
M0000584 DuPont Page 3
Material Safety Data Sheet
(HAZARDS IDENTIFICATION - Continued)
muscle twitching; involuntary movement of the eyes; facial
paralysis; or fatality.
No increases in chromosomal changes were noted in the
circulating blood of workers exposed to Ethylene Glycol.
Increased susceptibility to the effects of Ethylene Glycol
may be observed in persons with pre-existing disease of the
kidneys.
Carcinogenicity Information
The following components are listed by IARC, NTP, OSHA or ACGIH as
carcinogens.
Material IARC NTP OSHA ACGIH
DIURON A4
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FIRST AID MEASURES
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First Aid
IF SWALLOWED: Call a poison control center or doctor
immediately for treatment advice. Have person sip a glass
of water if able to swallow. Do not induce vomiting unless
told to do so by the poison control center or doctor. Do
not give anything by mouth to an unconscious person.
IF ON SKIN OR CLOTHING: Take off contaminated clothing.
Rinse skin immediately with plenty of water for 15-20
minutes. Call a poison control center or doctor for
treatment advice.
IF IN EYES: Hold eye open and rinse slowly and gently
with water for 15-20 minutes. Remove contact lenses, if
present, after the first 5 minutes, then continue rinsing
eye. Call a poison control center or doctor for treatment
advice.
IF INHALED: Move person to fresh air. If person is not
breathing, call 911 or an ambulance, then give artificial
respiration, preferably mouth-to-mouth, if possible. Call a
poison control center or doctor for further treatment
advice.
Have product container or label with you when calling a
poison control center or doctor, or going for treatment.
You may also contact 1-800-441-3637 for emergency medical
treatment information.
M0000584 DuPont Page 4
Material Safety Data Sheet
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FIRE FIGHTING MEASURES
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Flammable Properties
Not a fire or explosion hazard.
Extinguishing Media
Dry Chemical, CO2, Water Spray, Foam.
Fire Fighting Instructions
Keep personnel removed and upwind of fire. Wear self-contained
breathing apparatus (SCBA) and full protective equipment.
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Spill Clean Up
Dike Spill. Prevent material from entering sewers,
waterways, or low areas. Cover spill with absorbent
material such as sweeping compound or clay. Sweep up and
place in suitable (fiberboard) containers for later
disposal.
For minor spills, leaks, etc., follow all precautions
indicated on the product label and clean up immediately.
Take special care to avoid contamination of equipment and
facilities during cleanup procedures and disposal of
wastes. In the event of a major spill, fire or other
emergency, call 1-800-441-3637 day or night.
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HANDLING AND STORAGE
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Handling (Personnel)
USERS SHOULD: Wash hands before eating, drinking, chewing
gum, using tobacco or using the toilet. Remove clothing/PPE
immediately if pesticide gets inside. Then wash thoroughly
and put on clean clothing. Remove PPE immediately after
handling this product. Wash the outside of gloves before
removing. As soon as possible, wash thoroughly and change
into clean clothing.
M0000584 DuPont Page 5
Material Safety Data Sheet
(HANDLING AND STORAGE - Continued)
Storage
Do not contaminate water, food or feed by storage or disposal.
Store product in original container only.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
When handlers use closed systems, enclosed cabs, or aircraft
in a manner that meets the requirements listed in the Worker
Protection Standard (WPS) for agricultural pesticides (40
CFR 170.240(d)(4-6)), the handler PPE requirements may be
reduced or modified as specified in the WPS.
Personal Protective Equipment
Mixers and loaders supporting ground application
equipment must wear:
- Coveralls over long-sleeved shirt and long pants.
- Chemical resistant footwear plus socks.
- Chemical resistant gloves made of any waterproof
material such as polyethylene or polyvinylchloride.
- A NIOSH approved particulate filtering respirator
equipped with any N, R, or P class filter media with
NIOSH approval number prefix TC-84A. It is
recommended that the respirator wearer be fit tested,
and trained in use, maintenance, and limitations of
the respirator.
- Chemical resistant apron.
Groundboom applicators must wear:
- Long-sleeved shirt and long pants.
- Shoes plus socks.
- Chemical resistant gloves made of any waterproof
material such as polyethylene or polyvinylchloride.
- Chemical resistant apron when cleaning equipment or
spills.
All other mixers, loaders, and handlers must wear:
- Long sleeved shirt and long pants.
- Shoes plus socks.
- Chemical resistant gloves made of any waterproof
material such as polyethylene or polyvinylchloride.
- A NIOSH approved particulate filtering respirator
equipped with any N, R, or P class filter media with
NIOSH approval number prefix TC-84A. It is
recommended that the respirator wearer be fit tested,
and trained in use, maintenance, and limitations of
the respirator.
- Chemical resistant apron when cleaning equipment or
spills.
M0000584 DuPont Page 6
Material Safety Data Sheet
(EXPOSURE CONTROLS/PERSONAL PROTECTION - Continued)
Discard clothing and other absorbent materials that have
been drenched or heavily contaminated with this product鈥檚
concentrate. Do not reuse them. Follow manufacturer鈥檚
instructions for cleaning/maintaining PPE. If no such
instructions for washables, use detergent and hot water.
Keep and wash PPE separately from other laundry.
PPE required for early entry to treated areas that is
permitted under the Worker Protection Standard and that
involves contact with anything that has been treated, such
as plants, soil, or water, is:
- Coveralls.
- Chemical-resistant gloves made of any waterproof material
- Shoes plus socks.
Exposure Guidelines
Applicable Exposure Limits
LINURON
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
DIURON
PEL (OSHA) : None Established
TLV (ACGIH) : 10 mg/m3, 8 Hr. TWA, A4
AEL * (DuPont) : 1 mg/m3, 8 & 12 Hr. TWA, total dust
Ethylene Glycol
PEL (OSHA) : None Established
TLV (ACGIH) : Ceiling: 39.4 ppm, 100 mg/m3, aerosol,A4
AEL * (DuPont) : 50 ppm, 8 & 12 Hr. TWA, vapor
10 mg/m3, 8 & 12 Hr. TWA, particulate
Aerosol
* AEL is DuPont鈥檚 Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Form : Liquid
Color: : Off-White
Odor: : Odorless
pH : 7.31 (1% in water)
Density : 9.92 lbs/gal
Viscosity : 917 cps @ 23.7 C
Relative Density: 1.19 g/mL @ 19.9 C
M0000584 DuPont Page 7
Material Safety Data Sheet
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STABILITY AND REACTIVITY
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Chemical Stability
Stable at normal conditions.
Incompatibility with Other Materials
None reasonably foreseeable.
Decomposition
Thermal decomposition may release toxic and/or hazardous
gases.
Polymerization
Polymerization will not occur.
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TOXICOLOGICAL INFORMATION
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# Animal Data
Data based on product components:
Oral LD50 : 1919 mg/kg (rats)
Dermal LD50 : > 2000 mg/kg (rabbits)
Inhalation 4-hour LC50 : > 1.7 mg/L (rats)
Based on data from components, this product is a moderate
eye irritant, but is not a skin irritant or skin sensitizer
in animals.
LINURON TECHNICAL
Repeated ingestion at high exposure levels caused increased
sulfhemoglobin, reduced weight gain, central nervous system
depression, growth depression, increased liver/body weight
ratio, anemia, and decreased red blood cell counts;
increased white blood cell counts, decreased weights
(absolute and relative) of liver, kidneys and adrenals in
male mice, and increased weights (absolute and relative) of
liver, lung and spleen in female mice. Long term dietary
administration of high doses of Linuron result in increased
methemoglobin and sulfhemoglobin levels, hematological
changes including mild hemolytic and bone marrow effects,
liver changes, and organ weight changes. Animals exposed
to a high dose before birth and until maturity showed weight
loss and testicular effects; a few animals also exhibited
eye lesions.
Tests in mice and rats demonstrate limited evidence for
carcinogenic activity. Animal testing indicates that this
compound does not have developmental, or reproductive
effects.
M0000584 DuPont Page 8
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
Linuron does not produce genetic damage in animals or in
bacterial or mammalian cell cultures.
DIURON
Repeated ingestion of Diuron led to increased hemolysis
(destruction) of red blood cells and and hemolytic anemia
after continued exposure to high doses. Secondary effects as
a result of excessive red blood cell hemolysis included
enlarged spleens, pigment deposits in the spleen, changes in
the bone marrow and kidney. Decreased body weights were
also related to repeated ingestion of high doses of Diuron.
In addition to the effects described above, long-term
effects observed in rodents after repeated ingestion of high
doses also included thickening of the urinary bladder and
kidney epithelium and liver toxicity. In chronic feeding
studies, an increase in urinary bladder and renal pelvic
tumors was observed in high-dose rats. A borderline
increase in mammary tumors was observed in high-dose female
mice, which is considered equivocal.
The weight of evidence indicates that Diuron does not
produce genetic damage in bacterial or mammalian cell
cultures, or in animals. Diuron is not considered a
developmental toxicant. There was no evidence of
developmental toxicity in rabbits. In rats, developmental
effects occurred at doses higher than those which produced
maternal toxicity. Testing in rats demonstrated no
reproductive toxicity.
ETHYLENE GLYCOL
Repeated ingestion exposure to Ethylene Glycol caused
histopathological changes of the kidneys and bone marrow;
kidney effects with oxalate crystal deposition; altered
hematology, and decreased body weight. Long-term exposure
caused kidney effects with oxalate crystal deposition;
histopathological changes of the kidneys, liver, blood
vessels, testes, and sperm; and decreased body weight. No
deaths occurred in animals exposed by inhalation to
saturated vapors of Ethylene Glycol.
Repeated inhalation exposure caused histopathological
changes of the liver and lungs; eye irritation; and clouding
of the eye (corneal opacity).
In animal testing Ethylene Glycol has not caused
carcinogenicity. Reproductive data on adult animals show
interference with reproduction only at levels which produce
other toxic effects in the adult animal. Tests have shown
Ethylene Glycol to cause developmental toxicity in animals.
Ethylene Glycol has not produced genetic damage in bacterial
cultures. There are reports indicating that Ethylene Glycol
does not produce genetic damage in some animal or mammalian
cell culture tests; however, there are reports in the
M0000584 DuPont Page 9
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
literature that suggest positive results.
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ECOLOGICAL INFORMATION
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# Ecotoxicological Information
AQUATIC TOXICITY:
LINURON
96 hour LC50 - Bluegill sunfish: 9.6 mg/L.
96 hour LC50 - Rainbow trout: 3.3 mg/L.
48 hour EC50 - Daphnia magna: 1.9 mg/L.
72 hour, EC50, Freshwater algae: 0.028 mg/L.
AVIAN TOXICITY:
LINURON
Acute Oral LD50 - Bobwhite Quail: 940 mg/kg.
Acute Dietary LC50 - Bobwhite Quail: 1838 ppm.
Acute Dietary LC50 - Mallard Duck: 5224 ppm
Oral LC50 - Mallard duck: 3083 ppm.
AQUATIC TOXICITY:
DIURON
96-Hour LC50 - Bluegill sunfish: 25 mg/L
96-Hour LC50 - Rainbow trout: 14.7 mg/L
48-Hour EC50 - Daphnia magna: 1.4 mg/L
EC50 - Algae - 0.018 mg/L
AVIAN TOXICITY:
DIURON
LD50 - Bobwhite Quail: 1104 mg/kg
AQUATIC TOXICITY:
ETHYLENE GLYCOL
96 hour LC50 - Fathead minnows: 49,000 mg/L.
48 hour EC50 - Daphnia magna: 46,300 mg/L
96 hour EC50 - Algae: 10,940 mg/L
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Do not contaminate water, food or feed by disposal. Wastes
resulting from the use of this product may be disposed of
on site or at an approved waste disposal facility.
ENVIRONMENTAL HAZARDS
This pesticide is toxic to fish and aquatic invertebrates.
For terrestrial uses, do not apply directly to water, to
areas where surface water is present or to intertidal areas
below the mean high water mark. Do not apply where weather
conditions favor drift from areas treated. Do not
M0000584 DuPont Page 10
Material Safety Data Sheet
(DISPOSAL CONSIDERATIONS - Continued)
contaminate water when cleaning of equipment or disposing
of equipment washwater and rinsate.
Ground Water Advisory: Linuron is known to leach through
soil into ground water under certain conditions as a result
of agricultural use. Use of this chemical in areas where
soils are permeable, particularly where the water table is
shallow, may result in ground-water contamination.
Refer to the product label for additional application
instructions relating to environmental precautions.
Container Disposal
Triple rinse (or equivalent). Then offer for recycling or
reconditioning, or puncture and dispose of in a sanitary
landfill, by incineration, or, if allowed by State and local
authorities, by burning. If burned, stay out of smoke.
Container Refilling and Disposal (For Containers up to 250
gal): Refer to the product label.
This is a refillable container. If the container is
to be refilled, do not rinse with any material or introduce
any pesticide other than this product.
Container Disposal for Bulk Containers: Refer to the
product label.
The container must only be refilled with this pesticide
product. DO NO REUSE THE CONTAINER FOR ANY OTHER PURPOSE.
Check for leaks after refilling and before transporting.
Do not transport if this container is damaged or leaking.
Disposal of this container must be in compliance with State
and local regulations.
For minor spills, leaks, etc., follow all precautions
indicated on the product label and clean up immediately.
Take special care to avoid contamination of equipment and
facilities during cleanup procedures and disposal of
wastes. In the event of a major spill, fire or other
emergency, call 1-800-441-3637 day or night.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT
Proper Shipping Name : Not Regulated by DOT (* See Note 1)
IMO/IMDG : Environmentally Hazardous Substance,
Liquid, n.o.s., (Linuron)
Hazard Class :9
M0000584 DuPont Page 11
Material Safety Data Sheet
(TRANSPORTATION INFORMATION - Continued)
UN/NA Number : UN 3082
Packaging Group : III
Marine Pollutant : Yes (add Marine Pollutant after basic
description)
Reportable Quantity : 100 Pounds (Diuron)
IATA/ICAO : Not Regulated by IATA/ICAO
(* See Note 2)
Notes:
(1) If shipped in a bulk package for domestic transport use
IMO/IMDG shipping description. And, if 100 or more
pounds Diuron in a single package add RQ, (Diuron).
(2) If a single package contains 100 or more pounds Diuron
add RQ, (Diuron) and use IMO/IMDG description without
Marine pollutant notation.
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REGULATORY INFORMATION
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U.S. Federal Regulations
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : Yes
Fire : No
Reactivity : No
In the United States this product is regulated by the US
Environmental Protection Agency under the Federal Insecticide,
Fungicide and Rodenticide Act. It is a violation of federal law
to use this product in a manner inconsistent with its labeling.
EPA Reg. No. 352-660
OSHA:
These products are considered hazardous under the OSHA
Hazardous Communication Standard (29 CFR Section 1910.1200).
TSCA:
All product components are on the TSCA Chemical Inventory.
CERCLA:
Releases of this material (Diuron: RQ = 100 pounds;
Ethylene glycol: RQ = 5000 pounds) to air, land, or water
are reportable to the National Response Center under the
Comprehensive Environmental Response, Compensation, and
Liability Act (CERCLA) or to the state and local emergency
planning committees under the Superfund Amendments and
Reauthorization Act (SARA) Title III Section 304 and
40 CFR 搂302.
RCRA:
M0000584 DuPont Page 12
Material Safety Data Sheet
(REGULATORY INFORMATION - Continued)
When a decision is made to discard this material as
supplied, it does not meet RCRA鈥檚 characteristic definition
of ignitability, corrositivity, or reactivity, and is not
listed in 40 CFR Section 261.33.
State Regulations (U.S.)
CALIFORNIA PROP 65
This material contains Diuron, a chemical known to the State
of California to cause cancer in laboratory animals.
Linuron: Listed as a developmental toxin.
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OTHER INFORMATION
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NFPA, NPCA-HMIS
HAZARDS CLASSIFICATION:
(0-minimal, 1-slight, 2-moderate, 3-serious, 4-severe)
HMIS:赂HEALTH-2 FIRE-1 REACTIVITY-0
NFPA:赂HEALTH-1 FIRE-1 REACTIVITY-0
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS: DuPont Crop Protection
Address : Wilmington, DE 19898
Telephone : 1-888-638-7668
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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