Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
SECTION 1. PRODUCT AND COMPANY IDENTIFICATION
Product name : 0.05% Trifluoroacetic Acid in Acetonitrile.
MSDS Number : 000000011213
Product Use Description : Solvent
Company : Honeywell International Inc.
1953 South Harvey Street
Muskegon, MI 49442
For more information call : 1-800-368-0050
(Monday-Friday, 9:00am-5:00pm)
In case of emergency call : Medical: 1-800-498-5701
Transportation: 1-800-424-9300 or 703-527-3887
:
: (24 hours/day, 7 days/week)
SECTION 2. HAZARDS IDENTIFICATION
Emergency Overview
Form : liquid, clear
Color : colourless
Odor : sweet ether-like
Hazard Summary : Flammable. In use, may form flammable/explosive vapour-air
mixture. May be harmful if inhaled. May be harmful if
absorbed through skin. May be harmful if swallowed. Irritating
to eyes, respiratory system and skin. Causes headache,
drowsiness or other effects to the central nervous system.
May cause irritation of the gastrointestinal tract. Can cause
fatal cyanide poisoning. May cause convulsions. Symptoms
may be delayed. Can be absorbed through skin. Repeated
exposure may cause skin dryness or cracking. Do not
swallow. Avoid breathing vapors, mist or gas. Avoid contact
with skin, eyes and clothing.
Potential Health Effects
Skin : May be harmful if absorbed through skin.
Irritating to skin.
Can be absorbed through skin.
May cause systemic poisoning with symptoms paralleling
those of inhalation.
Prolonged or repeated skin contact with liquid may cause
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
defatting resulting in drying, redness and possible blistering.
Can cause fatal cyanide poisoning.
Symptoms may be delayed.
Eyes : Irritating to eyes.
Causes itching, burning, redness and tearing.
Ingestion : May be harmful if swallowed.
Causes headache, drowsiness or other effects to the central
nervous system.
Ingestion may cause gastrointestinal irritation, nausea,
vomiting and diarrhoea.
May cause systemic poisoning with symptoms paralleling
those of inhalation.
Can cause fatal cyanide poisoning.
Symptoms may be delayed.
Inhalation : May be harmful if inhaled.
Causes respiratory tract irritation.
Causes headache, drowsiness or other effects to the central
nervous system.
Inhalation of high vapour concentrations can cause CNS-
depression and narcosis.
Can cause fatal cyanide poisoning.
May cause convulsions.
Symptoms may be delayed.
Chronic Exposure : Can cause fatal cyanide poisoning.
Symptoms may be delayed.
Causes damage to the kidneys/liver/eyes/brain/respiratory
system/central nervous system through prolonged or repeated
exposure.
Prolonged or repeated skin contact with liquid may cause
defatting resulting in drying, redness and possible blistering.
Aggravated Medical : People suffering from pre-existing thyroid conditions may
Condition experience adverse effects.
Neurological disorders
Heart disease
Respiratory disorders
Liver disorders
Kidney disorders
Skin disorders
Eye disorders
Target Organs : Respiratory system
Cardiovascular system
Central nervous system
Liver
Kidney
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
Skin
Eyes
Heart
thyroid gland
Carcinogenicity
No component of this product present at levels greater than or equal to 0.1% is identified as a known
or anticipated carcinogen by NTP, IARC, or OSHA.
SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS
Component CAS-No. Weight %
Acetonitrile 75-05-8 >99.00
Trifluoroacetic acid 76-05-1 0.05
SECTION 4. FIRST AID MEASURES
Inhalation : Remove to fresh air. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen. Use oxygen as required,
provided a qualified operator is present. Call a physician.
Skin contact : Wash off immediately with plenty of water for at least 15
minutes. Take off contaminated clothing and shoes
immediately. Wash contaminated clothing before re-use. Call a
physician.
Eye contact : Rinse immediately with plenty of water, also under the eyelids,
for at least 15 minutes. Call a physician.
Ingestion : Do not induce vomiting without medical advice. Immediate
medical attention is required. Never give anything by mouth to
an unconscious person. Call a physician.
Notes to physician
Treatment : Treat as cyanide poisoning. Symptoms of poisoning may not
appear for several hours. Keep under medical supervision for
at least 48 hours.
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
SECTION 5. FIRE-FIGHTING MEASURES
Flash point : 6 掳C (43 掳F)
open cup
Information regarding the flash point and the explosion limits
are those of the solvents.
Ignition temperature : 524 掳C (975 掳F)
Lower explosion limit : 3 %(V)
Upper explosion limit : 16 %(V)
Suitable extinguishing : Carbon dioxide (CO2)
media Dry chemical
Alcohol-resistant foam
Extinguishing media which : Water may be ineffective.
shall not be used for safety Do not use a solid water stream as it may scatter and spread
reasons fire.
Specific hazards during fire : Flammable.
fighting Vapours may form explosive mixtures with air.
Vapours are heavier than air and may spread along floors.
Vapors may travel to areas away from work site before
igniting/flashing back to vapor source.
Cool closed containers exposed to fire with water spray.
Do not allow run-off from fire fighting to enter drains or water
courses.
In case of fire hazardous decomposition products may be
produced such as:
Hydrogen cyanide (hydrocyanic acid)
Carbon dioxide (CO2), carbon monoxide (CO), oxides of
nitrogen (NOx), dense black smoke.
Special protective : In the event of fire and/or explosion do not breathe fumes.
equipment for fire-fighters Wear self-contained breathing apparatus and protective suit.
No unprotected exposed skin areas.
SECTION 6. ACCIDENTAL RELEASE MEASURES
Personal precautions : Immediately evacuate personnel to safe areas.
Keep people away from and upwind of spill/leak.
Wear personal protective equipment. Unprotected persons
must be kept away.
Ensure adequate ventilation.
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
Remove all sources of ignition.
Vapors may travel to areas away from work site before
igniting/flashing back to vapor source.
Do not swallow.
Avoid breathing vapors, mist or gas.
Avoid contact with skin, eyes and clothing.
Environmental precautions : Prevent further leakage or spillage if safe to do so.
Discharge into the environment must be avoided.
Do not flush into surface water or sanitary sewer system.
Prevent product from entering drains.
Collect contaminated fire extinguishing water separately. This
must not be discharged into drains.
Methods for cleaning up : Ventilate the area.
No sparking tools should be used.
Use explosion-proof equipment.
Contain and collect spillage with non-combustible absorbent
materials, e.g. sand, earth, vermiculite, diatomaceous earth
and place in container for disposal according to local
regulations (see section 13).
SECTION 7. HANDLING AND STORAGE
Handling
Handling : Handle with care.
Wear personal protective equipment.
Use only in well-ventilated areas.
Keep container tightly closed.
Containers which are opened must be carefully resealed and
kept upright to prevent leakage.
Keep away from fire, sparks and heated surfaces.
Take precautionary measures against static discharges.
Ensure all equipment is electrically grounded before beginning
transfer operations.
No sparking tools should be used.
Use explosion-proof equipment.
Do not smoke.
Do not swallow.
Avoid breathing vapors, mist or gas.
Avoid contact with skin, eyes and clothing.
Advice on protection : Vapours may form explosive mixtures with air.
against fire and explosion Prevent the creation of flammable or explosive concentrations
of vapour in air and avoid vapour concentration higher than the
occupational exposure limits.
Vapours are heavier than air and may spread along floors.
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
Vapors may travel to areas away from work site before
igniting/flashing back to vapor source.
Container hazardous when empty.
Keep product and empty container away from heat and
sources of ignition.
Do not pressurize, cut, weld, braze, solder, drill, grind or
expose containers to heat or sources of ignition.
Take measures to prevent the build up of electrostatic charge.
To avoid ignition of vapours by static electricity discharge, all
metal parts of the equipment must be grounded.
Electrical equipment should be protected to the appropriate
standard.
No sparking tools should be used.
Use explosion-proof equipment.
No smoking.
Storage
Requirements for storage : Storage rooms must be properly ventilated.
areas and containers Keep containers tightly closed in a dry, cool and well-ventilated
place.
Containers which are opened must be carefully resealed and
kept upright to prevent leakage.
Keep away from heat and sources of ignition.
Keep away from direct sunlight.
Store in area designed for storage of flammable liquids.
Protect from physical damage.
Store away from incompatible substances.
SECTION 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Protective measures : Ensure that eyewash stations and safety showers are close to
the workstation location.
Do not swallow.
Avoid breathing vapors, mist or gas.
Avoid contact with skin, eyes and clothing.
Engineering measures : Use with local exhaust ventilation.
Prevent vapor buildup by providing adequate ventilation during
and after use.
Eye protection : Do not wear contact lenses.
Wear as appropriate:
Safety glasses with side-shields
If splashes are likely to occur, wear:
Goggles or face shield, giving complete protection to eyes
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
Hand protection : Solvent-resistant gloves
Gloves must be inspected prior to use.
Replace when worn.
Skin and body protection : Wear as appropriate:
Solvent-resistant apron and boots
Flame retardant antistatic protective clothing
If splashes are likely to occur, wear:
Protective suit
Respiratory protection : When workers are facing concentrations above the exposure
limit they must use appropriate certified respirators.
For rescue and maintenance work in storage tanks use self-
contained breathing apparatus.
Use NIOSH approved respiratory protection.
Hygiene measures : Handle in accordance with good industrial hygiene and safety
practice.
When using, do not eat, drink or smoke.
Wash hands before breaks and immediately after handling the
product.
Keep working clothes separately.
Remove and wash contaminated clothing before re-use.
Do not swallow.
Avoid breathing vapors, mist or gas.
Avoid contact with skin, eyes and clothing.
Exposure Guidelines
Acetonitrile 75-05-8 ACGIH TWA 20 ppm
Skin designation:
Can be absorbed through the skin.
NIOSH REL 20 ppm 34 mg/m3
US CA OEL TWA PEL 40 ppm 70 mg/m3
US CA OEL STEL 60 ppm 105 mg/m3
Skin designation:
Can be absorbed through the skin.
OSHA Z1 PEL 40 ppm 70 mg/m3
OSHA Z1A TWA 40 ppm 70 mg/m3
OSHA Z1A STEL 60 ppm 105 mg/m3
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
TX ESL ST ESL 200 ppm 340 ug/m3
TX ESL AN ESL 20 ppm 34 ug/m3
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
Form : liquid, clear
Color : colourless
Odor : sweet ether-like
pH : not applicable
Melting point/range : -46 掳C (-51 掳F)
Boiling point/boiling range : 82 掳C (180 掳F)
Vapor pressure : 97.325 hPa
at 20 掳C (68 掳F)
Relative vapour density : 1.42
(Air = 1.0)
Density : 0.7829 g/cm3
at 20 掳C (68 掳F)
Water solubility : completely soluble
SECTION 10. STABILITY AND REACTIVITY
Conditions to avoid : Heat, flames and sparks.
Keep away from direct sunlight.
Materials to avoid : Acids
Bases
Oxidizing agents
Reducing agents
Sulfites
Perchlorates
May attack many plastics, rubbers and coatings.
Hazardous decomposition : In case of fire hazardous decomposition products may be
products produced such as:
Hydrogen cyanide (hydrocyanic acid)
Carbon dioxide (CO2), carbon monoxide (CO), oxides of
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
nitrogen (NOx), dense black smoke.
Hazardous reactions : Hazardous polymerisation does not occur.
Stable under normal conditions.
SECTION 11. TOXICOLOGICAL INFORMATION
Acute oral toxicity Component: 75-05-8 Acetonitrile
(Component) LD50 rat
Dose: 2,460 mg/kg
Acute oral toxicity Component: 76-05-1 Trifluoroacetic acid
(Component) LDLo rat
Dose: 500 mg/kg
Acute dermal toxicity Component: 75-05-8 Acetonitrile
(Component) LD50 rabbit
Dose: > 2,000 mg/kg
Acute inhalation toxicity Component: 75-05-8 Acetonitrile
(Component) LC50 rat
Dose: 12.68 mg/l
Exposure time: 8 h
Acute inhalation toxicity Component: 76-05-1 Trifluoroacetic acid
(Component) LC50 mouse
Dose: 13.5 mg/l
LC50 rat
Dose: 10 mg/l
SECTION 12. ECOLOGICAL INFORMATION
Toxicity to fish : Component: 75-05-8 Acetonitrile
(Component) flow-through test LC50
Species: Pimephales promelas (fathead minnow)
Dose: 1,640 mg/l
Exposure time: 96 h
SECTION 13. DISPOSAL CONSIDERATIONS
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
Waste Information: Avoid contact of spilled material and runoff with soil and surface waterways.
Consult an environmental professional to determine if local, regional or national regulations would
classify spilled or contaminated materials as hazardous waste. Use only approved transporters,
recyclers, treatment, storage or disposal facilities. Dispose of according to all federal, state and local
applicable regulations.
Other Disposal Considerations: Observe all Federal, State, and Local Environmental regulations.
The information offered here is for the product as shipped. Use and/or alterations to the product
such as mixing with other materials may significantly change the characteristics of the material and
alter the RCRA classification and the proper disposal method.
SECTION 14. TRANSPORT INFORMATION
DOT Proper shipping name : Acetonitrile solution
UN-Number : 1648
Class : 3
Packing group : II
IATA UN Number : 1648
Description of the goods : Acetonitrile solution
Class : 3
Packaging group : II
Hazard Label : 3
Packing instruction (cargo : 307
aircraft)
Packing instruction : 305
(passenger aircraft)
Packing instruction : Y305
(passenger aircraft)
IMDG Substance No. : UN 1648
Description of the goods : Acetonitrile solution
Class : 3
Packaging group : II
Hazard Label : 3
EmS Number : F-E
Marine pollutant : no
SECTION 15. REGULATORY INFORMATION
Inventories
EU. EINECS : On or in compliance with the inventory
US. Toxic Substances : On TSCA Inventory
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
Control Act
Australia. Industrial : On or in compliance with the inventory
Chemical (Notification and
Assessment) Act
Canada. Canadian : All components of this product are on the Canadian DSL list.
Environmental Protection
Act (CEPA). Domestic
Substances List (DSL).
(Can. Gaz. Part II, Vol. 133)
Japan. Kashin-Hou Law : On or in compliance with the inventory
List
Korea. Toxic Chemical : On or in compliance with the inventory
Control Law (TCCL) List
Philippines. The Toxic : On or in compliance with the inventory
Substances and Hazardous
and Nuclear Waste Control
Act
China. Inventory of Existing : On or in compliance with the inventory
Chemical Substances
Switzerland. Consolidated : On or in compliance with the inventory
Inventory
New Zealand. Inventory of : On or in compliance with the inventory
Chemicals (NZIoC), as
published by ERMA New
Zealand
TSCA 12B : US. Toxic Substances Control Act (TSCA) Section 12(b) Export
Notification (40 CFR 707, Subpt D)
Acetonitrile 75-05-8
National regulatory information
SARA 302 Components : Acrylonitrile 107-13-1
SARA 313 Components : Acetonitrile 75-05-8
SARA 311/312 Hazards : Fire Hazard
Acute Health Hazard
Chronic Health Hazard
CERCLA Reportable : 5000 lbs
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Material Safety Data Sheet
0.05% Trifluoroacetic Acid in Acetonitrile (423)
Version 1 Revision Date 12/18/2007 Print Date 12/18/2007
Quantity
California Prop. 65 : WARNING! This product contains a chemical known in the
State of California to cause cancer.
Acrylonitrile 107-13-1
Massachusetts RTK : Acetonitrile 75-05-8
New Jersey RTK : Acetonitrile 75-05-8
Pennsylvania RTK : Acetonitrile 75-05-8
WHMIS Classification : B2
D1A
D2B
SECTION 16. OTHER INFORMATION
HMIS III NFPA
Health Hazard :- 2
Flammability :- 3
Physical Hazard :-
Instability : 0
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