SAFETY DATA SHEET
ACTINOMYCIN D Page 1
Issued: 28/09/2007
Revision No: 1
1. IDENTIFICATION OF THE SUBSTANCE / PREPARATION AND OF THE COMPANY / UNDERTAKING
Product name: ACTINOMYCIN D
CAS number: 50-76-0
BIA0175
Product code:
Company name: Apollo Scientific Ltd
Bredbury, Stockport, SK6 2QR, Tel 0161 406 0505
2. HAZARDS IDENTIFICATION
Main hazards: Toxic by inhalation, in contact with skin and if swallowed.
3. COMPOSITION / INFORMATION ON INGREDIENTS
Hazardous ingredients: ACTINOMYCIN D >90%
4. FIRST AID MEASURES (SYMPTOMS)
Skin contact: There may be redness or whiteness of the skin in the area of exposure. Irritation or pain may
occur at the site of contact. Absorption through the skin may be fatal.
Eye contact: There may be severe pain. The eyes may water profusely.
Ingestion: There may be soreness and redness of the mouth and throat. There may be vomiting.
Convulsions may occur. There may be loss of consciousness.
Inhalation: There may be shortness of breath with a burning sensation in the throat. Absorption through the
lungs can occur causing symptoms similar to those of ingestion. Convulsions may occur. There
may be loss of consciousness.
4. FIRST AID MEASURES (ACTION)
Skin contact: Remove all contaminated clothes and footwear immediately unless stuck to skin. Drench the
affected skin with running water for 10 minutes or longer if substance is still on skin. Transfer to
hospital if there are burns or symptoms of poisoning.
Eye contact: Bathe the eye with running water for 15 minutes. Transfer to hospital for specialist examination.
Ingestion: Wash out mouth with water. Do not induce vomiting. If conscious, give half a litre of water to
drink immediately. If unconscious, check for breathing and apply artificial respiration if
necessary. If unconscious and breathing is OK, place in the recovery position. Transfer to
hospital as soon as possible.
Inhalation: Remove casualty from exposure ensuring one's own safety whilst doing so. If conscious, ensure
the casualty sits or lies down. If unconscious and breathing is OK, place in the recovery
position. If unconscious, check for breathing and apply artificial respiration if necessary. If
breathing becomes bubbly, have the casualty sit and provide oxygen if available. Transfer to
hospital as soon as possible.
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ACTINOMYCIN D Page 2
5. FIRE-FIGHTING MEASURES
Extinguishing media: Suitable extinguishing media for the surrounding fire should be used. Carbon dioxide. Dry
chemical powder.
Exposure hazards: Toxic. In combustion emits toxic fumes.
Protection of fire-fighters: Wear self-contained breathing apparatus. Wear protective clothing to prevent contact with skin
and eyes.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions: Notify the police and fire brigade immediately. If outside do not approach from downwind. If
outside keep bystanders upwind and away from danger point. Mark out the contaminated area
with signs and prevent access to unauthorised personnel. Do not attempt to take action without
suitable protective clothing - see section 8 of SDS. Do not create dust.
Environmental precautions: Do not discharge into drains or rivers.
Clean-up procedures: Clean-up should be dealt with only by qualified personnel familiar with the specific substance.
Transfer to a closable, labelled salvage container for disposal by an appropriate method.
7. HANDLING AND STORAGE
Handling requirements: Avoid direct contact with the substance. Ensure there is exhaust ventilation of the area. Avoid
the formation or spread of dust in the air. Only use in fume hood.
Storage conditions: Keep refrigerated (store below 4*C).
Suitable packaging: Must only be kept in original packaging.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering measures: Ensure there is exhaust ventilation of the area.
Respiratory protection: Self-contained breathing apparatus must be available in case of emergency. Particle filter class
P1 (EN143).
Hand protection: Protective gloves.
Eye protection: Safety glasses with side-shields. Ensure eye bath is to hand.
Skin protection: Protective clothing.
9. PHYSICAL AND CHEMICAL PROPERTIES
State: Powder
10. STABILITY AND REACTIVITY
Stable under normal conditions.
Stability:
Conditions to avoid: Heat.
Materials to avoid: Strong oxidising agents. Strong acids.
Haz. decomp. products: In combustion emits toxic fumes.
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ACTINOMYCIN D Page 3
11. TOXICOLOGICAL INFORMATION
MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION.
Chronic toxicity:
Routes of exposure: Refer to section 4 of SDS for routes of exposure and corresponding symptoms.
12. ECOLOGICAL INFORMATION
Data not yet known
Mobility:
Persistence and degradability: No data available.
Bioaccumulative potential: No data available.
Other adverse effects: Data not known
13. DISPOSAL CONSIDERATIONS
Disposal operations: MATERIAL SHOULD BE DISPOSED OF IN ACCORDANCE WITH LOCAL, STATE AND
FEDERAL REGULATIONS
Disposal of packaging: Dispose of as special waste in compliance with local and national regulations Observe all
federal, state and local environmental regulations.
NB: The user's attention is drawn to the possible existence of regional or national regulations
regarding disposal.
14. TRANSPORT INFORMATION
ADR / RID
UN no: 2811 ADR Class: 6.1
Packing group: III Classification code: T2
Shipping name: TOXIC SOLID, ORGANIC, N.O.S.
Labelling: 6.1 Hazard ID no: 60
IMDG / IMO
UN no: 2811 Class: 6.1
Packing group: III EmS: F-A,S-A
Marine pollutant: .
Labelling: 6.1
IATA / ICAO
UN no: 2811 Class: 6.1
Packing group: III
Packing instructions: 619
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ACTINOMYCIN D Page 4
Labelling: 6.1
15. REGULATORY INFORMATION
Hazard symbols: Very toxic.
Risk phrases: R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
Safety phrases: S36/37/39: Wear suitable protective clothing, gloves and eye / face protection.
S38: In case of insufficient ventilation, wear suitable respiratory equipment.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label
where possible).
S63: In case of accident by inhalation, remove casualty to fresh air and keep at rest.
Note: The regulatory information given above only indicates the principal regulations specifically
applicable to the product described in the safety data sheet. The user's attention is drawn to
the possible existence of additional provisions which complete these regulations. Refer to all
applicable national, international and local regulations or provisions.
16. OTHER INFORMATION
Legal disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall
be used only as a guide. This company shall not be held liable for any damage resulting from
handling or from contact with the above product.
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