Material Safety Data Sheet
Revision date: 03/15/2006
Print Date: 08/29/2006
Version: 1
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING
Product name: TaqMan HCV Master Mix Set-ASR (12 x 6.5 mL)
Product number: 04828569190
Business area: Molecular Diagnostics.
Supplier: Emergency telephone number:
Roche Molecular Systems, Inc. CHEMTREC:
1080 US Highway 202 South 1-800-424-9300 (U.S. or Canada)
Branchburg, NJ 08876-3733 1-703-527-3887 (International)
Technical Support: 1-800-526-1247
2. COMPOSITION/INFORMATION ON INGREDIENTS
Description 1: All bottles
Components CAS Number Weight % OSHA PEL: OSHA STEL: ACGIH TLV: ACGIH STEL:
Glycerol 56-81-5 15-40 15 mg/m鲁 NA 10 mg/m鲁 NA
5 mg/m鲁
Dimethyl Sulfoxide (DMSO) 67-68-5 15-40 NA NA NA NA
Tricine 5704-04-1 1-5 NA NA NA NA
Potassium acetate 127-08-2 1-5 NA NA NA NA
Potassium Hydroxide 1310-58-3 <1 NA NA NA 2 mg/m鲁 Ceiling
0.29 mg/m3 Ceiling
Sodium azide 26628-22-8 <0.1 NA NA NA
0.11 ppm Ceiling
3. HAZARDS IDENTIFICATION
Emergency Overview
NFPA Ratings: Health= 1 Flammability= 1 Reactivity= 0 Special= I
Special Definitions: A=Allergen CA=Carcinogen CO=Corrosive F=Flammable H=Harmful I=Irritant Ox=Oxidizer PB=Potential Biohazard
R=Reproductive S=Sensitizer T=Toxic T+=Highly Toxic W=Water Reactive
Principle routes of exposure: Ingestion, inhalation, skin absorption, skin and/or eye contact.
Inhalation: Avoid breathing vapors or mists. May cause irritation of respiratory tract.
Ingestion: Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhea. DMSO - Repeated oral
doses may effect the liver and kidneys.
Skin contact: May cause irritation in contact with skin. May be absorbed through the skin in harmful amounts.
Eye contact: Contact with eyes may cause irritation
Sensitization or Odor threshold: The following chemical(s) may cause sensitization, be absorbed via skin, and/or has an odor threshold for
detection:
Components ACGIH - Germany (DFG) - Switzerland - AIHA - Odor Threshold
Sensitizer Designation: Skin/Sensitizers: Sensitizers: Values:
Dimethyl Sulfoxide (DMSO) danger of percutaneous
absorption
Medical conditions aggravated by Persons with pre-existing skin disorders, eye problems, impaired liver, kidney, or respiratory function may
exposure: be more susceptible to the effects of the substance.
Additional information: DMSO - Repeated skin application may cause scaling dermatitis. May affect the blood.
4. FIRST AID MEASURES
Inhalation: Consult a physician. Move to fresh air. If not breathing, give artificial respiration. If breathing is difficult,
give oxygen
Skin contact: Rinse with plenty of water. If skin irritation persists, call a physician. Remove and wash contaminated
clothing before re-use
Ingestion: Consult a physician. Do not induce vomiting without medical advice
Eye contact: In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice
Notes to physician: None determined
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media: Use dry chemical, CO2, water spray or `alcohol` foam
Unusual hazards: Combustible material.
Special protective equipment for Wear self contained breathing apparatus for fire fighting if necessary
firefighters:
6. ACCIDENTAL RELEASE MEASURES
Personal precautions: Use personal protective equipment. Evacuate personnel to safe areas
Environmental precautions: Prevent further leakage or spillage if safe to do so. Prevent product from entering drains.
Methods for cleaning up: Never return spills in original containers for re-use. Sweep up or vacuum (if powder) or soak up with inert
absorbent material (if liquid), then place into a suitable clean, dry, closed container, and label for disposal
7. HANDLING AND STORAGE
Handling: Protect from contamination. Wear personal protective equipment
Storage: No special precautions required
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering measures: Not applicable
Personal Protective Equipment
Respiratory protection: Respiratory protection is not required under normal use of this product. If respiratory protection is needed,
follow the OSHA regulation, 29CFR1910.134. Always use a NIOSH approved respirator when necessary
Hand protection: Wear appropriate protective gloves to prevent skin contact. Replace torn or punctured gloves promptly
Skin and body protection: Wear appropriate body protection to prevent skin contact
Eye protection: Wear appropriate eye protection to prevent eye contact
Hygiene measures: Avoid contact with skin, eyes and clothing
9. PHYSICAL AND CHEMICAL PROPERTIES
pH: 7.8
Physical state: Liquid.
Specific gravity: 1.077 kg/l
10. STABILITY AND REACTIVITY
Stability: Stable under recommended storage conditions
Polymerization: Not applicable
Hazardous decomposition products: Sulphur oxides. Carbon oxides.
Materials to avoid: Strong bases. Strong acids. Strong oxidising agents.
11. TOXICOLOGICAL INFORMATION
Product number: 04828569190 Page 2 of 4
Product name: TaqMan HCV Master Mix Set-ASR (12 x 6.5 mL)
11. TOXICOLOGICAL INFORMATION
Components NIOSH - NIOSH Pocket Guide -
Selected LD50s and LC50s: Target Organs:
Glycerol = 12600 mg/kg Oral LD50 Rat respiratory system, skin, eyes, kidneys
= 4090 mg/kg Oral LD50 Mouse
> 10 g/kg Dermal LD50 Rabbit
> 570 mg/m鲁 Inhalation LC50 Rat 1 h
Dimethyl Sulfoxide (DMSO) = 14500 mg/kg Oral LD50 Rat
= 7920 mg/kg Oral LD50 Mouse
Potassium acetate = 3250 mg/kg Oral LD50 Rat
Potassium Hydroxide = 273 mg/kg Oral LD50 Rat eyes, skin, respiratory system
Sodium azide = 20 mg/kg Dermal LD50 Rabbit eyes, skin, CNS, CVS, kidneys
= 27 mg/kg Oral LD50 Mouse
= 27 mg/kg Oral LD50 Rat
Inhalation: No additional data available
Skin: No additional data available
Oral: No additional data available
Mutagenic effects: No data is available on the product itself
Reproductive toxicity: No data is available on the product itself
Carcinogenic effects:
12. ECOLOGICAL INFORMATION
Bioaccumulation: No data available
Aquatic toxicity: Not applicable
Ecotoxicity effects: No data is available on the product itself
Components Ecotoxicity - Ecotoxicity - Ecotoxicity - Ecotoxicity -
Fish Species Data Microtox Data Water Flea Data Freshwater Algae Data
Glycerol = 50 mg/L LC50 rainbow
trout 96 h
> 5000 mg/L LC50 goldfish
96 h
Dimethyl Sulfoxide (DMSO) = 34.0 mg/L LC50 fathead
minnow 96 h flow-through
Potassium Hydroxide = 80.0 mg/L LC50
mosquito fish 24 h
Sodium azide = 0.7 mg/L LC50 bluegill
96 h
= 0.8 mg/L LC50 rainbow
trout 96 h
= 5.46 mg/L LC50 fathead
minnow 96 h flow-through
13. DISPOSAL CONSIDERATIONS
Waste from residues / unused products: Waste disposal must be in accordance with appropriate Federal, State, and local regulations. This product,
if unaltered by use, may be disposed of by treatment at a permitted facility or as advised by your local
hazardous waste regulatory authority. Residue from fires extinguished with this material may be
hazardous.
14. TRANSPORT INFORMATION
Is product hazardous to ship? No
DOT
Proper shipping name: None
UN Number: Not applicable Hazard class: Not applicable Subsidiary risk: Not applicable Packing group: Not applicable
ICAO/IATA
Proper shipping name: None
UN Number: Not applicable Hazard class: Not applicable Subsidiary risk: Not applicable Packing group: Not applicable
Product number: 04828569190 Page 3 of 4
Product name: TaqMan HCV Master Mix Set-ASR (12 x 6.5 mL)
15. REGULATORY INFORMATION
U.S. Regulations:
U.S. CERCLA/SARA/TSCA Regulatory Information: The following chemicals are listed under the following TSCA/SARA/CERCLA lists. Refer to
TSCA regulation if you need a definition for acronyms that may be shown in the TSCA Inventory field in the table below
Components CERCLA/SARA 302 CERCLA/SARA 304 SARA 313 TSCA Inventory
RQ and TPQ RQ Emission reporting
(40 CFR 355, App.A) (40 CFR Table 302.4)
Glycerol Present
Dimethyl Sulfoxide (DMSO) Present
Tricine Present
Potassium acetate Present
Potassium Hydroxide = 1000 lb final RQ XU
= 454 kg final RQ
= 500 lb TPQ This material
Sodium azide = 1000 lb final RQ Listed XU
is a reactive solid. The TPQ = 454 kg final RQ
does not default to 10,000
pounds for non-powder, non-
molten, non-solvent form
U.S. Clean Water Act (CWA)/ California The following chemicals are listed under the CWA and/or California Proposition 65:
Proposition 65:
Components Clean Water Act Clean Water Act California Proposition 65
Hazardous Substances Priority Pollutants
Potassium Hydroxide Present
Canadian Regulations:
Canada DSL Inventory List - This product complies with DSL
Canada NDSL Inventory List - This product does not comply with NDSL
Components Canada - WHMIS: Classifications of Substances:
Glycerol Uncontrolled product according to WHMIS classification criteria.
Dimethyl Sulfoxide (DMSO) D2B
Potassium acetate Uncontrolled product according to WHMIS classification criteria.
Potassium Hydroxide D1B; E
Sodium azide D1A
16. OTHER INFORMATION
Reason for revision: Not applicable
References: None
Additional advice: None
Prepared by: Roche Diagnostics, Health & Safety Department, MSDS Contact: 317-521-7425 or 317-521-7505
The information, data and recommendations contained herein are based upon information believed by Roche Diagnostics Corporation, after reasonable investigation and
research, to be accurate; however, Roche Diagnostics Corporation does not warrant the accuracy of this information. All materials and mixtures may present unknown
hazards and should be used with caution. When necessary or appropriate, independent opinions regarding the risk of handling or exposure should be obtained from trained
professionals. Roche Diagnostics Corporation disclaims any warranty against patent infringement and the implied warranties of merchantability and fitness for a particular
purpose. Customer's sole and exclusive remedy shall be replacement of the product or return of the product and refund of the purchase price, at Roche Diagnostics
Corporation's option. In no case shall Roche Diagnostics Corporation be liable for incidental or consequential damages, including lost profits.
End of Safety Data Sheet
Product number: 04828569190 Page 4 of 4
Product name: TaqMan HCV Master Mix Set-ASR (12 x 6.5 mL)
|