Amino Allyl MessageAmp鈩I
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
DNA Polymerase
Material Safety Data Sheet
Section 1-Identification of Product
2025G3
WHMIS Classification Health: 1 Fire: 1 Stability: 0
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Glycerol 50% 56-81-5 Oral-Rat Inhalation, rat:
LD50: 12,600 >570 mg/m3/1H
mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes skin irritation
Skin Absorption Causes skin irritation
Eye Contact Causes eye irritation
Inhalation Causes respiratory irritation
Ingestion Causes gastrointestinal irritation
[Emergency Overview]
Caution! May cause eye and skin irritation. May cause respiratory and digestive tract irritation. This is
expected to be a low hazard for usual industrial handling.
WHMIS Symbols
N.A.
[Potential Health Effects]
Poison by subcutaneous route. Mildly toxic by ingestion. Human systemic effects by ingestion: headache and nausea
or vomiting. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. In the form of
mist it is a nuisance particulate and inhalation irritant. Combustible liquid when exposed to heat, flame, or powerful
oxidizers. Mixtures with hydrogen peroxide are highly explosive. Ignites on contact with potassium permanganate,
calcium hypochlorite. Mixture with nitric acid + sulfuric acid forms the explosive glyceryl nitrate. Mixture with
perchloric acid + lead oxide forms explosive perchlorate esters. Confined mixture with chlorine explodes if heated to
70鈥?80潞. Can react violently with acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, CrO3, Cr2O3, F2 + PbO,
phosphorus triiodide, ethylene oxide + heat, KMnO4, K2O2, AgClO4, Na2O2, NaH. Energetic reaction with sodium
hydride. Mixture with nitric acid + hydrofluoric acid is a storage hazard due to gas evolution. To fight fire, use
alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.
Section 4-First Aid Measures
Skin Contact Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. If irritation develops, get medical aid.
Inhalation Remove from exposure and move to fresh air immediately. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms
appear.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable Slightly flammable
Means of Extinction Use water spray to cool fire-exposed containers. Use agent
most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Version 1 Page 1 of 3 Printed: 10/28/2004
Created:082604 QC Form:1722
Revision Date: NA
Amino Allyl MessageAmp鈩I
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
DNA Polymerase
Material Safety Data Sheet
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Carbon monoxide, irritating and toxic fumes and gases,
carbon dioxide.
NFPA Health: 1 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with
Equipment adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep
container tightly closed. Avoid ingestion and inhalation. Wash
clothing before reuse
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV 10 mg/m3 TWA
OSHA PEL 15 mg/m3 TWA (total dust); 5 mg/m3 TWA (respirable fraction)
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic Gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not Available
Specific Gravity Not Available
Vapor Density (Air=1) Not Available
Vapor Pressure (mmHg) Not Available
Evaporation Rate Not Available
Boiling Point (oC) Not Available
Version 1 Page 2 of 3 Printed: 10/28/2004
Created:082604 QC Form:1722
Revision Date: NA
Amino Allyl MessageAmp鈩I
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
DNA Polymerase
Material Safety Data Sheet
Freezing Point (oC) Not Available
pH Not Available
Coefficient of Water/Oil Distribution Not Available
[Solubility in Water] Not Available
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Acetic anhydride, potassium permanganate, strong acids, caustics
(e.g. ammonia, ammonium hydroxide, calcium hydroxide,
potassium hydroxide, sodium hydroxide), isocyanates, oxidizing
agents, aliphatic amines
Reactivity Not Available
Hazardous Decomposition Products Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Not Tested
Irritancy of Product Not Tested
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity Not Listed
Teratogenicity Not Listed
Embryotoxicity Not Listed
Mutagenicity Not Listed
Name of Synergistic Not Listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity LC50 (96 Hr.) rainbow trout = 50-67 mg/L; 12 degrees CLC50 (96 Hr.) goldfish
= >5000 mg/L
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not Listed
TDG Not Listed
[DOT] Not Listed
[IMO] Not Listed
[ICAO] Not Listed
Section 15-Regulatory Information
[WHMIS Classification] Not Listed
[OSHA] Not Listed
[SARA] CAS # 56-81-5: chronic
[TSCA] Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 10/28/2004
Created:082604 QC Form:1722
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
ArrayScript鈩?
Material Safety Data Sheet
Section 1-Identification of Product
2048G1
WHMIS Classification Health: 1 Fire: 1 Stability: 0
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Glycerol 50% 56-81-5 Oral-Rat Inhalation, rat:
LD50: 12,600 >570 mg/m3/1H
mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes skin irritation
Skin Absorption Causes skin irritation
Eye Contact Causes eye irritation
Inhalation Causes respiratory irritation
Ingestion Causes gastrointestinal irritation
[Emergency Overview]
Caution! May cause eye and skin irritation. May cause respiratory and digestive tract irritation. This is expected to be
a low hazard for usual industrial handling.
WHMIS Symbols
N.A.
[Potential Health Effects]
Poison by subcutaneous route. Mildly toxic by ingestion. Human systemic effects by ingestion: headache and nausea
or vomiting. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. In the form of
mist it is a nuisance particulate and inhalation irritant. Combustible liquid when exposed to heat, flame, or powerful
oxidizers. Mixtures with hydrogen peroxide are highly explosive. Ignites on contact with potassium permanganate,
calcium hypochlorite. Mixture with nitric acid + sulfuric acid forms the explosive glyceryl nitrate. Mixture with
perchloric acid + lead oxide forms explosive perchlorate esters. Confined mixture with chlorine explodes if heated to
70鈥?80潞. Can react violently with acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, CrO3, Cr2O3, F2 + PbO,
phosphorus triiodide, ethylene oxide + heat, KMnO4, K2O2, AgClO4, Na2O2, NaH. Energetic reaction with sodium
hydride. Mixture with nitric acid + hydrofluoric acid is a storage hazard due to gas evolution. To fight fire, use
alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.
Section 4-First Aid Measures
Skin Contact Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. If irritation develops, get medical aid.
Inhalation Remove from exposure and move to fresh air immediately. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms
appear.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable NA
Means of Extinction Use water spray to cool fire-exposed containers. Use agent
most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
Flashpoint (oC) and Method NA
Upper Flammable Limit (% by volume) NA
Version 1 Page 1 of 3 Printed: 10/28/2004
Created:082604 QC Form:1716
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
ArrayScript鈩?
Material Safety Data Sheet
Lower Flammable Limit (% by volume) NA
Autoignition Temperature (oC) NA
Explosion Data 鈥? Sensitivity to Impact NA
Explosion Data 鈥? Sensitivity to Static Discharge NA
Hazardous Combustion Products Carbon monoxide, irritating and toxic fumes and gases,
carbon dioxide.
NFPA Health: 1 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with
Equipment adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep
container tightly closed. Avoid ingestion and inhalation. Wash
clothing before reuse
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV 10 mg/m3 TWA
OSHA PEL 15 mg/m3 TWA (total dust); 5 mg/m3 TWA (respirable fraction)
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic Gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not Available
Specific Gravity Not Available
Vapor Density (Air=1) Not Available
Vapor Pressure (mmHg) Not Available
Evaporation Rate Not Available
Boiling Point (oC) Not Available
Version 1 Page 2 of 3 Printed: 10/28/2004
Created:082604 QC Form:1716
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
ArrayScript鈩?
Material Safety Data Sheet
Freezing Point (oC) Not Available
pH Not Available
Coefficient of Water/Oil Distribution Not Available
[Solubility in Water] Not Available
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Acetic anhydride, potassium permanganate, strong acids, caustics
(e.g. ammonia, ammonium hydroxide, calcium hydroxide,
potassium hydroxide, sodium hydroxide), isocyanates, oxidizing
agents, aliphatic amines
Reactivity Not Available
Hazardous Decomposition Products Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Not Tested
Irritancy of Product Not Tested
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity No information available
Teratogenicity No information available
Embryotoxicity No information available
Mutagenicity No information available
Name of Synergistic No information available
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity LC50 (96 Hr.) rainbow trout = 50-67 mg/L; 12 degrees CLC50 (96 Hr.) goldfish
= >5000 mg/L
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN No information available
TDG No information available
[DOT] No information available
[IMO] No information available
[ICAO] No information available
Section 15-Regulatory Information
[WHMIS Classification] Not Available
[OSHA] Not Available
[SARA] CAS # 56-81-5: chronic
[TSCA] Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 10/28/2004
Created:082604 QC Form:1716
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
RNase H
Material Safety Data Sheet
Section 1-Identification of Product
2300G1
WHMIS Classification Health: 1 Fire: 1 Stability: 0
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Glycerol 50% 56-81-5 Oral-Rat Inhalation, rat:
LD50: 12,600 >570 mg/m3/1H
mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes skin irritation
Skin Absorption Causes skin irritation
Eye Contact Causes eye irritation
Inhalation Causes respiratory irritation
Ingestion Causes gastrointestinal irritation
[Emergency Overview]
Caution! May cause eye and skin irritation. May cause respiratory and digestive tract irritation. This is
expected to be a low hazard for usual industrial handling.
WHMIS Symbols
N.A.
[Potential Health Effects]
Poison by subcutaneous route. Mildly toxic by ingestion. Human systemic effects by ingestion: headache and nausea
or vomiting. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. In the form of
mist it is a nuisance particulate and inhalation irritant. Combustible liquid when exposed to heat, flame, or powerful
oxidizers. Mixtures with hydrogen peroxide are highly explosive. Ignites on contact with potassium permanganate,
calcium hypochlorite. Mixture with nitric acid + sulfuric acid forms the explosive glyceryl nitrate. Mixture with
perchloric acid + lead oxide forms explosive perchlorate esters. Confined mixture with chlorine explodes if heated to
70鈥?80潞. Can react violently with acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, CrO3, Cr2O3, F2 + PbO,
phosphorus triiodide, ethylene oxide + heat, KMnO4, K2O2, AgClO4, Na2O2, NaH. Energetic reaction with sodium
hydride. Mixture with nitric acid + hydrofluoric acid is a storage hazard due to gas evolution. To fight fire, use
alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.
Section 4-First Aid Measures
Skin Contact Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. If irritation develops, get medical aid.
Inhalation Remove from exposure and move to fresh air immediately. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms
appear.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable Slightly flammable
Means of Extinction Use water spray to cool fire-exposed containers. Use agent
most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Version 1 Page 1 of 3 Printed: 10/28/2004
Created:082604 QC Form:1720
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
RNase H
Material Safety Data Sheet
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Carbon monoxide, irritating and toxic fumes and gases,
carbon dioxide.
NFPA Health: 1 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with
Equipment adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep
container tightly closed. Avoid ingestion and inhalation. Wash
clothing before reuse
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV 10 mg/m3 TWA
OSHA PEL 15 mg/m3 TWA (total dust); 5 mg/m3 TWA (respirable fraction)
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic Gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not Available
Specific Gravity Not Available
Vapor Density (Air=1) Not Available
Vapor Pressure (mmHg) Not Available
Evaporation Rate Not Available
Boiling Point (oC) Not Available
Version 1 Page 2 of 3 Printed: 10/28/2004
Created:082604 QC Form:1720
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
RNase H
Material Safety Data Sheet
Freezing Point (oC) Not Available
pH Not Available
Coefficient of Water/Oil Distribution Not Available
[Solubility in Water] Not Available
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Acetic anhydride, potassium permanganate, strong acids, caustics
(e.g. ammonia, ammonium hydroxide, calcium hydroxide,
potassium hydroxide, sodium hydroxide), isocyanates, oxidizing
agents, aliphatic amines
Reactivity Not Available
Hazardous Decomposition Products Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Not Tested
Irritancy of Product Not Tested
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity No information available
Teratogenicity No information available
Embryotoxicity No information available
Mutagenicity No information available
Name of Synergistic No information available
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity LC50 (96 Hr.) rainbow trout = 50-67 mg/L; 12 degrees CLC50 (96 Hr.) goldfish
= >5000 mg/L
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN No information available
TDG No information available
[DOT] No information available
[IMO] No information available
[ICAO] No information available
Section 15-Regulatory Information
[WHMIS Classification] Not Available
[OSHA] Not Available
[SARA] CAS # 56-81-5: chronic
[TSCA] Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 10/28/2004
Created:082604 QC Form:1720
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
RNase Inhibitor
Material Safety Data Sheet
Section 1-Identification of Product
2687G13
WHMIS Classification Health: 1 Fire: 1 Stability: 0
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Glycerol 50% 56-81-5 Oral-Rat Inhalation, rat:
LD50: 12,600 >570 mg/m3/1H
mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes skin irritation
Skin Absorption Causes skin irritation
Eye Contact Causes eye irritation
Inhalation Causes respiratory irritation
Ingestion Causes gastrointestinal irritation
[Emergency Overview]
Caution! May cause eye and skin irritation. May cause respiratory and digestive tract irritation. This is
expected to be a low hazard for usual industrial handling.
WHMIS Symbols
N.A.
[Potential Health Effects]
Poison by subcutaneous route. Mildly toxic by ingestion. Human systemic effects by ingestion: headache and nausea
or vomiting. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. In the form of
mist it is a nuisance particulate and inhalation irritant. Combustible liquid when exposed to heat, flame, or powerful
oxidizers. Mixtures with hydrogen peroxide are highly explosive. Ignites on contact with potassium permanganate,
calcium hypochlorite. Mixture with nitric acid + sulfuric acid forms the explosive glyceryl nitrate. Mixture with
perchloric acid + lead oxide forms explosive perchlorate esters. Confined mixture with chlorine explodes if heated to
70鈥?80潞. Can react violently with acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, CrO3, Cr2O3, F2 + PbO,
phosphorus triiodide, ethylene oxide + heat, KMnO4, K2O2, AgClO4, Na2O2, NaH. Energetic reaction with sodium
hydride. Mixture with nitric acid + hydrofluoric acid is a storage hazard due to gas evolution. To fight fire, use
alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.
Section 4-First Aid Measures
Skin Contact Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. If irritation develops, get medical aid.
Inhalation Remove from exposure and move to fresh air immediately. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms
appear.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable Slightly flammable
Means of Extinction Use water spray to cool fire-exposed containers. Use agent
most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Version 1 Page 1 of 3 Printed: 10/28/2004
Created:082604 QC Form:1719
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
RNase Inhibitor
Material Safety Data Sheet
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Carbon monoxide, irritating and toxic fumes and gases,
carbon dioxide.
NFPA Health: 1 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with
Equipment adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep
container tightly closed. Avoid ingestion and inhalation. Wash
clothing before reuse
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV 10 mg/m3 TWA
OSHA PEL 15 mg/m3 TWA (total dust); 5 mg/m3 TWA (respirable fraction)
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic Gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not Available
Specific Gravity Not Available
Vapor Density (Air=1) Not Available
Vapor Pressure (mmHg) Not Available
Evaporation Rate Not Available
Boiling Point (oC) Not Available
Version 1 Page 2 of 3 Printed: 10/28/2004
Created:082604 QC Form:1719
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
RNase Inhibitor
Material Safety Data Sheet
Freezing Point (oC) Not Available
pH Not Available
Coefficient of Water/Oil Distribution Not Available
[Solubility in Water] Not Available
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Acetic anhydride, potassium permanganate, strong acids, caustics
(e.g. ammonia, ammonium hydroxide, calcium hydroxide,
potassium hydroxide, sodium hydroxide), isocyanates, oxidizing
agents, aliphatic amines
Reactivity Not Available
Hazardous Decomposition Products Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Not Tested
Irritancy of Product Not Tested
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity No information available
Teratogenicity No information available
Embryotoxicity No information available
Mutagenicity No information available
Name of Synergistic No information available
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity LC50 (96 Hr.) rainbow trout = 50-67 mg/L; 12 degrees CLC50 (96 Hr.) goldfish
= >5000 mg/L
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN No information available
TDG No information available
[DOT] No information available
[IMO] No information available
[ICAO] No information available
Section 15-Regulatory Information
[WHMIS Classification] Not Available
[OSHA] Not Available
[SARA] CAS # 56-81-5: chronic
[TSCA] Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 10/28/2004
Created:082604 QC Form:1719
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
T7 Enzyme Mix
Material Safety Data Sheet
Section 1-Identification of Product
2724G5
WHMIS Classification Health: 1 Fire: 1 Stability: 0
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Glycerol 50% 56-81-5 Oral-Rat Inhalation, rat:
LD50: 12,600 >570 mg/m3/1H
mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes skin irritation
Skin Absorption Causes skin irritation
Eye Contact Causes eye irritation
Inhalation Causes respiratory irritation
Ingestion Causes gastrointestinal irritation
[Emergency Overview]
Caution! May cause eye and skin irritation. May cause respiratory and digestive tract irritation. This is
expected to be a low hazard for usual industrial handling.
WHMIS Symbols
N.A.
[Potential Health Effects]
Poison by subcutaneous route. Mildly toxic by ingestion. Human systemic effects by ingestion: headache and nausea
or vomiting. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. In the form of
mist it is a nuisance particulate and inhalation irritant. Combustible liquid when exposed to heat, flame, or powerful
oxidizers. Mixtures with hydrogen peroxide are highly explosive. Ignites on contact with potassium permanganate,
calcium hypochlorite. Mixture with nitric acid + sulfuric acid forms the explosive glyceryl nitrate. Mixture with
perchloric acid + lead oxide forms explosive perchlorate esters. Confined mixture with chlorine explodes if heated to
70鈥?80潞. Can react violently with acetic anhydride, aniline + nitrobenzene, Ca(OCl)2, CrO3, Cr2O3, F2 + PbO,
phosphorus triiodide, ethylene oxide + heat, KMnO4, K2O2, AgClO4, Na2O2, NaH. Energetic reaction with sodium
hydride. Mixture with nitric acid + hydrofluoric acid is a storage hazard due to gas evolution. To fight fire, use
alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.
Section 4-First Aid Measures
Skin Contact Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. If irritation develops, get medical aid.
Inhalation Remove from exposure and move to fresh air immediately. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms
appear.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable Slightly Flammable
Means of Extinction Use water spray to cool fire-exposed containers. Use agent
most appropriate to extinguish fire. Use water spray, dry
chemical, carbon dioxide, or appropriate foam.
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Version 1 Page 1 of 3 Printed: 10/28/2004
Created:082604 QC Form:1723
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
T7 Enzyme Mix
Material Safety Data Sheet
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Carbon monoxide, irritating and toxic fumes and gases,
carbon dioxide.
NFPA Health: 1 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with
Equipment adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep
container tightly closed. Avoid ingestion and inhalation. Wash
clothing before reuse
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV 10 mg/m3 TWA
OSHA PEL 15 mg/m3 TWA (total dust); 5 mg/m3 TWA (respirable fraction)
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic Gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not Available
Specific Gravity Not Available
Vapor Density (Air=1) Not Available
Vapor Pressure (mmHg) Not Available
Evaporation Rate Not Available
Boiling Point (oC) Not Available
Version 1 Page 2 of 3 Printed: 10/28/2004
Created:082604 QC Form:1723
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
T7 Enzyme Mix
Material Safety Data Sheet
Freezing Point (oC) Not Available
pH Not Available
Coefficient of Water/Oil Distribution Not Available
[Solubility in Water] Not Available
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Acetic anhydride, potassium permanganate, strong acids, caustics
(e.g. ammonia, ammonium hydroxide, calcium hydroxide,
potassium hydroxide, sodium hydroxide), isocyanates, oxidizing
agents, aliphatic amines
Reactivity Not Available
Hazardous Decomposition Products Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Not Tested
Irritancy of Product Not Tested
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity No information available
Teratogenicity No information available
Embryotoxicity No information available
Mutagenicity No information available
Name of Synergistic No information available
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity LC50 (96 Hr.) rainbow trout = 50-67 mg/L; 12 degrees CLC50 (96 Hr.) goldfish
= >5000 mg/L
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN No information available
TDG No information available
[DOT] No information available
[IMO] No information available
[ICAO] No information available
Section 15-Regulatory Information
[WHMIS Classification] Not Available
[OSHA] Not Available
[SARA] CAS # 56-81-5: chronic
[TSCA] Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 10/28/2004
Created:082604 QC Form:1723
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #1753
T7 10X Reaction Buffer
Material Safety Data Sheet
Section 1-Identification of Product
8158G5
WHMIS Classification Health: 1 Fire: 1 Stability: 0
Product Use
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Trade secret 5-35 Trade secret Oral rat: NA
5900 mg/kg.
Trade secret 1-30 Trade secret Oral rat: NA
400 mg/kg.
Trade secret 1-30 Trade secret Oral rat: NA
8100mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes irritation to skin. Symptoms include redness, itching, and pain
Skin Absorption Causes irritation to skin. Symptoms include redness, itching, and pain
Eye Contact Causes irritation, redness, and pain.
Inhalation Causes irritation to the respiratory tract. Symptoms may include
coughing, shortness of breath. Can cause nausea, headache and
vomiting. Exposure may result in blood in urine, difficulty breathing,
irregular heartbeat, anemia, weakness, drunkenness, bluish skin color,
lung congestion, kidney damage, paralysis, convulsions
unconsciousness and coma.
Ingestion Exposure can cause nausea, headache, vomiting, diarrhea, weakness,
drunkenness, restlessness, bluish skin color, paralysis and coma.
[Emergency Overview]
WARNING! HARMFUL IF SWALLOWED OR INHALED. CAUSES IRRITATION TO SKIN, EYES AND
RESPIRATORY TRACT.
WHMIS Symbols
N.A.
[Potential Health Effects]
Trade secret - Moderately toxic by ingestion and intravenous routes. When heated to decomposition it emits toxic
fumes of NOx
Trade secret - A human poison by ingestion. Poison experimentally by ingestion, intravenous, and intraperitoneal
routes. Human systemic effects by ingestion: nausea, blood clotting changes, cardiac arrhythmias. An eye irritant.
Mutation data reported. Explosive reaction with BrF3; sulfuric acid + potassium permanganate. When heated to
decomposition it emits toxic fumes of K2O and Cl炉
Trade secret - Poison by subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. When heated
to decomposition it emits toxic fumes of SOx.
Skin Contact Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove
contaminated clothing and shoes. Get medical attention. Wash clothing before reuse.
Thoroughly clean shoes before reuse.
Eye Contact Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower
eyelids occasionally. Get medical attention.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical attention.
Ingestion Induce vomiting immediately as directed by medical personnel. Never give anything by mouth
to an unconscious person. Get medical attention.
Version: 1
Created: 082604 Page 1 of 3 Printed: 10/28/2004
Revision Date: N.A. QC Form:1724
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #1753
T7 10X Reaction Buffer
Material Safety Data Sheet
Section 5-Fire Fighting Measures
Flammable Slightly flammable
Means of Extinction Water spray, dry chemical, alcohol foam, or carbon
dioxide.
Flashpoint (oC) and Method Not Tested
Upper Flammable Limit (% by volume) Not Tested
Lower Flammable Limit (% by volume) Not Tested
Autoignition Temperature (oC) Not Tested
Explosion Data 鈥? Sensitivity to Impact Not Tested
Explosion Data 鈥? Sensitivity to Static Discharge Not Tested
Hazardous Combustion Products Not considered to be an explosion hazard. At room
temperature the addition of magnesium chloride to furan-2-
peroxycarboxylic acid, will cause the acid to explode.
NFPA Health: 1 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Remove all sources of ignition. Ventilate area of leak or spill. Pick up and place in a suitable container for
reclamation or disposal, using a method that does not generate dust.
Section 7-Handling and Storage
Handling Procedures and Containers of this material may be hazardous when empty since they retain
Equipment product residues (dust, solids); observe all warnings and precautions listed for
the product.
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from any source of heat or ignition. Isolate from
oxidizing materials.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not Listed
OSHA PEL Not Listed
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area.
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not Tested
Specific Gravity Not Tested
Vapor Density (Air=1) Not Tested
Version: 1
Created: 082604 Page 2 of 3 Printed: 10/28/2004
Revision Date: N.A. QC Form:1724
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #1753
T7 10X Reaction Buffer
Material Safety Data Sheet
Vapor Pressure (mmHg) Not Tested
Evaporation Rate Not Tested
Boiling Point (oC) Not Tested
Freezing Point (oC) Not Tested
pH Not Tested
Coefficient of Water/Oil Distribution Not Tested
[Solubility in Water] Not Tested
Section 10-Stability and Reactivity
Chemical Stability Stable.
Incompatible with other substances Copper, brass, aluminum, and oxidizing agents
Reactivity Strong oxidizing agents may release chlorine.
Hazardous Decomposition Products Burning may produce carbon monoxide, carbon dioxide, nitrogen
oxides. When heated to temperatures above 300C (572F) it emits
toxic fumes of chlorine gas.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Not Tested
Irritancy of Product Not Tested
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity Not Listed
Teratogenicity Not Listed
Embryotoxicity Not Listed
Mutagenicity Not Listed
Name of Synergistic Not Listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not Tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not Listed
TDG Not Listed
[DOT] Not Listed
[IMO] Not Listed
[ICAO] Not Listed
Section 15-Regulatory Information
[WHMIS Classification] Not Listed
[OSHA] Not Listed
[SERA] 311/312: Acute
[TSCA] Not Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version: 1
Created: 082604 Page 3 of 3 Printed: 10/28/2004
Revision Date: N.A. QC Form:1724
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
cDNA Binding Buffer
Material Safety Data Sheet
Section 1-Identification of Product
8537G5
WHMIS Classification Health: 2 Fire: 0 Stability: 0
Product Use
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Trade secret 40-90% Trade secret Intraperitoneal- NA
Mouse
LD50:300
mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes skin irritation. May cause skin sensitization, an allergic
reaction which becomes evident upon re-exposure to this material.
Skin Absorption In the presence of moisture this material may be absorbed through the
skin. May cause symptoms similar to indigestion.
Eye Contact Causes eye irritation. May cause conjunctivitis, ulceration and
turbidity of the cornea.
Inhalation May cause similar effects as indigestion. Exposure causes central
nervous system depression. Causes irritation of the mucous
membranes. High concentrations of thiocyanates can lead to fatal
pulmonary edema.
Ingestion May cause irritation to the digestive tract. May cause liver and
kidney damage. Ingestion of thiocyanates may cause disorientation,
weakness, low blood pressure, confusion, psychotic behavior,
muscular spasms, convulsions and death.
[Emergency Overview]
WARNING! HARMFUL IF SWALLOWED OR INHALED. CAUSES IRRITATION TO SKIN
WHMIS Symbols
NA
[Potential Health Effects]
Chronic effects: May cause liver and kidney damage. Effects may be delayed. May cause lung damage. Repeated
or prolonged exposure may result in allergic reactions in some people. Inhalation of product may aggravate existing
chronic respiratory problems such as asthma, emphysema or bronchitis.
Section 4-First Aid Measures
Skin Contact Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes
while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy
contaminated shoes.
Eye Contact Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the
upper and lower eyelids. Get medical aid immediately. Do not allow victim to rub or keep eyes
closed.
Inhalation Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth resuscitation.
Ingestion Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Section 5-Fire Fighting Measures
Flammable Nonflammable
Means of Extinction Use water spray, dry chemical, carbon dioxide, or
appropriate foam.
Version: 1
Created: 082604 Page 1 of 4 Printed: 10/28/2004
Revision Date: NA QC Form:1734
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
cDNA Binding Buffer
Material Safety Data Sheet
Flashpoint (oC) and Method Not Tested
Upper Flammable Limit (% by volume) Not Tested
Lower Flammable Limit (% by volume) Not Tested
Autoignition Temperature (oC) Not Tested
Explosion Data 鈥? Sensitivity to Impact Not Tested
Explosion Data 鈥? Sensitivity to Static Discharge Not Tested
Hazardous Combustion Products Irritating and highly toxic gases may be generated by
thermal decomposition or combustion.
NFPA Not Tested
Section 6-Accidental Release Measures
Leak and Spill Procedures
Wash area with soap and water. Clean up spills immediately, observing precautions in the protective equipment
section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide
ventilation.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Use with adequate3 ventilation. Minimize dst
Equipment generation and accumulation. Avoid contact with eyes, skin, and clothing.
Avoid ingestion and inhalation. Store protected from light. Discard
contaminated shoes.
Storage Requirements Do not store in direct sunlight. Keep container closed when not in use. Store in
a cool, dry, well-ventilated area away from incompatible substances. Store
protected from light.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not Listed
OSHA PEL Not Listed
Other (specify) Not Listed
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details.
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance None/White
Odor Threshold (ppm) Not Tested
Specific Gravity Not Tested
Vapor Density (Air=1) Not Tested
Vapor Pressure (mmHg) Not Tested
Version: 1
Created: 082604 Page 2 of 4 Printed: 10/28/2004
Revision Date: NA QC Form:1734
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
cDNA Binding Buffer
Material Safety Data Sheet
Evaporation Rate Not Tested
Boiling Point (oC) Not Tested
Freezing Point (oC) Not Tested
pH Not Tested
Coefficient of Water/Oil Distribution Not Tested
[Solubility in Water] Not Tested
Section 10-Stability and Reactivity
Chemical Stability Stable under normal temperatures and pressures.
Incompatible with other substances Strong bases, strong oxidizing agents, water, and acids.
Reactivity No information available
Hazardous Decomposition Products Hydrogen cyanide, nitrogen oxides, carbon monoxide, oxides of
nitrogen, oxides of sulfur, carbon dioxide, cyanide fumes,
hydrocarbons.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects May cause liver and kidney damage. Effects may be delayed. May cause lung
damage. Repeated or prolonged exposure may result in allergic reactions in
some people. Inhalation of product may aggravate existing chronic respiratory
problems such as asthma, emphysema or bronchitis.
Irritancy of Product Not Tested
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity Not Listed
Teratogenicity Not Listed
Embryotoxicity Not Listed
Mutagenicity Not Listed
Name of Synergistic Not Listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not Tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not Listed
TDG Not Listed
[DOT] Not Listed
[IMO] Not Listed
[ICAO] Not Listed
Section 15-Regulatory Information
[WHMIS Classification] Not Listed
[OSHA] Not Listed
[SERA] Not Listed
[TSCA] CAS #Trade secret is listed on the TSCA Inventory.
Version: 1
Created: 082604 Page 3 of 4 Printed: 10/28/2004
Revision Date: NA QC Form:1734
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
cDNA Binding Buffer
Material Safety Data Sheet
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version: 1
Created: 082604 Page 4 of 4 Printed: 10/28/2004
Revision Date: NA QC Form:1734
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
aRNA Binding Buffer
Material Safety Data Sheet
Section 1-Identification of Product
8540G23
WHMIS Classification Health: 2 Fire: 0 Stability: 0
Product Use
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Trade secret 20-70% Trade secret Intraperitoneal- Not Tested
Mouse
LD50:300
mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes skin irritation. May cause skin sensitization, an allergic
reaction, which becomes evident upon re-exposure to this material.
Skin Absorption In the presence of moisture this material may be absorbed through the
skin. May cause symptoms similar to indigestion.
Eye Contact Causes eye irritation. May cause conjunctivitis, ulceration and
turbidity of the cornea.
Inhalation May cause similar effects as indigestion. Exposure causes central
nervous system depression. Causes irritation of the mucous
membranes. High concentrations of thiocyanates can lead to fatal
pulmonary edema.
Ingestion May cause irritation to the digestive tract. May cause liver and kidney
damage. Ingestion of thiocyanates may cause disorientation,
weakness, low blood pressure, confusion, psychotic behavior,
muscular spasms, convulsions and death.
[Emergency Overview]
WARNING! HARMFUL IF SWALLOWED OR INHALED. CAUSES IRRITATION TO SKIN
WHMIS Symbols
NA
[Potential Health Effects]
Chronic effects: May cause liver and kidney damage. Effects may be delayed. May cause lung damage. Repeated
or prolonged exposure may result in allergic reactions in some people. Inhalation of product may aggravate existing
chronic respiratory problems such as asthma, emphysema or bronchitis.
Section 4-First Aid Measures
Skin Contact Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes
while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy
contaminated shoes.
Eye Contact Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the
upper and lower eyelids. Get medical aid immediately. Do not allow victim to rub or keep eyes
closed.
Inhalation Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth resuscitation.
Ingestion Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Section 5-Fire Fighting Measures
Flammable Nonflammable
Means of Extinction Use water spray, dry chemical, carbon dioxide, or
appropriate foam.
Version: 1
Created: 082604 Page 1 of 4 Printed: 10/28/2004
Revision Date: NA QC Form: 1736
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
aRNA Binding Buffer
Material Safety Data Sheet
Flashpoint (oC) and Method Not Tested
Upper Flammable Limit (% by volume) Not Tested
Lower Flammable Limit (% by volume) Not Tested
Autoignition Temperature (oC) Not Tested
Explosion Data 鈥? Sensitivity to Impact Not Tested
Explosion Data 鈥? Sensitivity to Static Discharge Not Tested
Hazardous Combustion Products Irritating and highly toxic gases may be generated by
thermal decomposition or combustion.
NFPA Not Tested
Section 6-Accidental Release Measures
Leak and Spill Procedures
Wash area with soap and water. Clean up spills immediately, observing precautions in the protective equipment
section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide
ventilation.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Use with adequate3 ventilation. Minimize dust
Equipment generation and accumulation. Avoid contact with eyes, skin, and clothing.
Avoid ingestion and inhalation. Store protected from light. Discard
contaminated shoes.
Storage Requirements Do not store in direct sunlight. Keep container closed when not in use. Store in
a cool, dry, well-ventilated area away from incompatible substances. Store
protected from light.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not Listed
OSHA PEL Not Listed
Other (specify) Not Listed
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details.
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance None/White
Odor Threshold (ppm) Not Tested
Specific Gravity Not Tested
Vapor Density (Air=1) Not Tested
Vapor Pressure (mmHg) Not Tested
Version: 1
Created: 082604 Page 2 of 4 Printed: 10/28/2004
Revision Date: NA QC Form: 1736
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
aRNA Binding Buffer
Material Safety Data Sheet
Evaporation Rate Not Tested
Boiling Point (oC) Not Tested
Freezing Point (oC) Not Tested
pH Not Tested
Coefficient of Water/Oil Distribution Not Tested
[Solubility in Water] Not Tested
Section 10-Stability and Reactivity
Chemical Stability Stable under normal temperatures and pressures.
Incompatible with other substances Strong bases, strong oxidizing agents, water, and acids.
Reactivity NA
Hazardous Decomposition Products Hydrogen cyanide, nitrogen oxides, carbon monoxide, oxides of
nitrogen, oxides of sulfur, carbon dioxide, cyanide fumes,
hydrocarbons.
Section 11-Toxicological Information
Acute Effects Not Listed
Chronic Effects May cause liver and kidney damage. Effects may be delayed. May cause lung
damage. Repeated or prolonged exposure may result in allergic reactions in
some people. Inhalation of product may aggravate existing chronic respiratory
problems such as asthma, emphysema or bronchitis.
Irritancy of Product Not Listed
Skin Sensitization Not Listed
Respiratory Sensitization Not Listed
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity Not Listed
Teratogenicity Not Listed
Embryotoxicity Not Listed
Mutagenicity Not Listed
Name of Synergistic Not Listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not Tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not Listed
TDG Not Listed
[DOT] Not Listed
[IMO] Not Listed
[ICAO] Not Listed
Section 15-Regulatory Information
[WHMIS Classification] Not Listed
[OSHA] Not Listed
[SERA] Not Listed
[TSCA] CAS #Trade secret is listed on the TSCA Inventory.
Version: 1
Created: 082604 Page 3 of 4 Printed: 10/28/2004
Revision Date: NA QC Form: 1736
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
aRNA Binding Buffer
Material Safety Data Sheet
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version: 1
Created: 082604 Page 4 of 4 Printed: 10/28/2004
Revision Date: NA QC Form: 1736
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
10X Second Strand Buffer
Material Safety Data Sheet
Section 1-Identification of Product
8720G3
WHMIS Classification Health: 1 Fire: 1 Stability: 0
Product Use
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Trade secret 1-30 Trade secret Oral rat: NA
5900 mg/kg
Trade secret 1-30 Trade secret Oral rat: NA
8100 mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes irritation to skin. Symptoms include redness, itching, and
pain.
Skin Absorption Causes irritation to skin. Symptoms include redness, itching, and
pain.
Eye Contact Causes irritation, redness, and pain.
Inhalation Causes irritation to the respiratory tract. Symptoms may include
coughing, shortness of breath.
Ingestion Mild alkali. Causes irritation and reddening to the mucous
membranes of the mouth, esophagus, and gastrointestinal tract.
Symptoms may include nausea, vomiting and diarrhea. Large oral
doses may cause weakness, collapse, blood clotting and coma.
Estimated lethal dose: 50 grams.
[Emergency Overview]
WARNING! HARMFUL IF SWALLOWED OR INHALED. CAUSES IRRITATION TO SKIN, EYES AND
RESPIRATORY TRACT
WHMIS Symbols
NA
[Potential Health Effects]
Trade secret - Moderately toxic by ingestion and intravenous routes. When heated to decomposition it emits toxic
fumes of NOx
Trade secret - A human poison by ingestion. Poison experimentally by ingestion, intravenous, and intraperitoneal
routes. Human systemic effects by ingestion: nausea, blood clotting changes, cardiac arrhythmias. An eye irritant.
Mutation data reported. Explosive reaction with BrF3; sulfuric acid + potassium permanganate. When heated to
decomposition it emits toxic fumes of K2O and Cl炉
Section 4-First Aid Measures
Skin Contact Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove
contaminated clothing and shoes. Get medical attention. Wash clothing before reuse.
Thoroughly clean shoes before reuse.
Eye Contact Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower
eyelids occasionally. Get medical attention.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical attention.
Ingestion Induce vomiting immediately as directed by medical personnel. Never give anything by mouth
to an unconscious person. Get medical attention.
Section 5-Fire Fighting Measures
Flammable Slightly flammable
Version: 1
Created: 082604 Page 1 of 3 Printed: 10/28/2004
Revision Date: NA QC Form:1721
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
10X Second Strand Buffer
Material Safety Data Sheet
Means of Extinction Water spray, dry chemical, alcohol foam, or carbon
dioxide.
Flashpoint (oC) and Method Not Tested
Upper Flammable Limit (% by volume) Not Tested
Lower Flammable Limit (% by volume) Not Tested
Autoignition Temperature (oC) Not Tested
Explosion Data 鈥? Sensitivity to Impact Not Tested
Explosion Data 鈥? Sensitivity to Static Discharge Not Tested
Hazardous Combustion Products Burning may produce carbon monoxide, carbon dioxide,
nitrogen oxides.
NFPA Health: 1 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as
specified in Section 8. Spills: Pick up and place in a suitable container for reclamation or disposal, using a method
that does not generate dust
Section 7-Handling and Storage
Handling Procedures and Containers of this material may be hazardous when empty since they
Equipment retain product residues (dust, solids); observe all warnings and
precautions listed for the product.
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from any source of heat or ignition. Isolate from
oxidizing materials.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not Listed
OSHA PEL Not Listed
Other (specify) Not Listed
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area.
Other NA
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not Tested
Specific Gravity Not Tested
Vapor Density (Air=1) Not Tested
Vapor Pressure (mmHg) Not Tested
Version: 1
Created: 082604 Page 2 of 3 Printed: 10/28/2004
Revision Date: NA QC Form:1721
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
10X Second Strand Buffer
Material Safety Data Sheet
Evaporation Rate Not Tested
Boiling Point (oC) Not Tested
Freezing Point (oC) Not Tested
pH Not Tested
Coefficient of Water/Oil Distribution Not Tested
[Solubility in Water] Not Tested
Section 10-Stability and Reactivity
Chemical Stability Stable under ordinary conditions of use and storage.
Incompatible with other substances Copper, brass, aluminum, and oxidizing agents.
Reactivity Strong oxidizing agents may release chlorine
Hazardous Decomposition Products Burning may produce carbon monoxide, carbon dioxide, nitrogen
oxides.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Chronic dermatitis may follow skin contact.
Irritancy of Product Not Tested
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity Not Listed
Teratogenicity Not Listed
Embryotoxicity Not Listed
Mutagenicity Not Listed
Name of Synergistic Not Listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not Tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not Listed
TDG Not Listed
[DOT] Not Listed
[IMO] Not Listed
[ICAO] Not Listed
Section 15-Regulatory Information
[WHMIS Classification] Not Listed
[OSHA] Not Listed
[SERA] 311/312: Acute
[TSCA] Not Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version: 1
Created: 082604 Page 3 of 3 Printed: 10/28/2004
Revision Date: NA QC Form:1721
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
10X First Strand Buffer
Material Safety Data Sheet
Section 1-Identification of Product
8727G1
WHMIS Classification Health: 2 Fire: 1 Stability: 0
Product Use
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Trade secret 5-35 Trade secret Oral rat: NA
5900 mg/kg
Trade secret 5-35 Trade secret Oral rat: NA
8100 mg/kg
Trade secret 1-30 Trade secret Intravenous- N.A.
Mouse
94mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes irritation to skin. Symptoms include redness, itching, and
pain.
Skin Absorption Causes irritation to skin. Symptoms include redness, itching, and pain
Eye Contact Causes irritation, redness, and pain.
Inhalation Causes irritation to the respiratory tract. Symptoms may include
coughing, shortness of breath.
Ingestion Mild alkali. Causes irritation and reddening to the mucous
membranes of the mouth, esophagus, and gastrointestinal tract.
Symptoms may include nausea, vomiting and diarrhea. Large oral
doses may cause weakness, collapse, blood clotting and coma.
Estimated lethal dose: 50 grams.
[Emergency Overview]
WARNING! HARMFUL IF SWALLOWED OR INHALED. CAUSES IRRITATION TO SKIN, EYES AND
RESPIRATORY TRACT
WHMIS Symbols
NA
[Potential Health Effects]
Trade secret - Moderately toxic by ingestion and intravenous routes. When heated to decomposition it emits toxic
fumes of NOx
Trade secret- A human poison by ingestion. Poison experimentally by ingestion, intravenous, and intraperitoneal
routes. Human systemic effects by ingestion: nausea, blood clotting changes, cardiac arrhythmias. An eye irritant.
Mutation data reported. Explosive reaction with BrF3; sulfuric acid + potassium permanganate. When heated to
decomposition it emits toxic fumes of K2O and Cl炉
Trade secret- Poison by subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. When heated
to decomposition it emits toxic fumes of SOx
Section 4-First Aid Measures
Skin Contact Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove
contaminated clothing and shoes. Get medical attention. Wash clothing before reuse.
Thoroughly clean shoes before reuse.
Eye Contact Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower
eyelids occasionally. Get medical attention.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical attention.
Ingestion Induce vomiting immediately as directed by medical personnel. Never give anything by mouth
to an unconscious person. Get medical attention.
Version: 1
Created:072104 Page 1 of 3 Printed: 10/28/2004
Revision Date: NA QC Form:1532
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
10X First Strand Buffer
Material Safety Data Sheet
Section 5-Fire Fighting Measures
Flammable Slightly flammable
Means of Extinction Water spray, dry chemical, alcohol foam, or carbon
dioxide.
Flashpoint (oC) and Method Not Tested
Upper Flammable Limit (% by volume) Not Tested
Lower Flammable Limit (% by volume) Not Tested
Autoignition Temperature (oC) Not Tested
Explosion Data 鈥? Sensitivity to Impact Not Tested
Explosion Data 鈥? Sensitivity to Static Discharge Not Tested
Hazardous Combustion Products Burning may produce carbon monoxide, carbon dioxide,
nitrogen oxides.
NFPA Health: 2 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as
specified in Section 8. Spills: Pick up and place in a suitable container for reclamation or disposal, using a method
that does not generate dust
Section 7-Handling and Storage
Handling Procedures and Containers of this material may be hazardous when empty since they
Equipment retain product residues (dust, solids); observe all warnings and
precautions listed for the product.
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from any source of heat or ignition. Isolate from
oxidizing materials.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not Listed
OSHA PEL Not Listed
Other (specify) Not Listed
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area.
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not Tested
Specific Gravity Not Tested
Vapor Density (Air=1) Not Tested
Version: 1
Created:072104 Page 2 of 3 Printed: 10/28/2004
Revision Date: NA QC Form:1532
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
10X First Strand Buffer
Material Safety Data Sheet
Vapor Pressure (mmHg) Not Tested
Evaporation Rate Not Tested
Boiling Point (oC) Not Tested
Freezing Point (oC) Not Tested
pH 8.3
Coefficient of Water/Oil Distribution Not Tested
[Solubility in Water] Not Tested
Section 10-Stability and Reactivity
Chemical Stability Stable under ordinary conditions of use and storage.
Incompatible with other substances Copper, brass, aluminum, and oxidizing agents.
Reactivity Strong oxidizing agents may release chlorine
Hazardous Decomposition Products Burning may produce carbon monoxide, carbon dioxide, nitrogen
oxides.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Chronic dermatitis may follow skin contact.
Irritancy of Product Not Listed
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity Not Listed
Teratogenicity Not Listed
Embryotoxicity Not Listed
Mutagenicity Not Listed
Name of Synergistic Not Listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not Tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not Listed
TDG Not Listed
[DOT] Not Listed
[IMO] Not Listed
[ICAO] Not Listed
Section 15-Regulatory Information
[WHMIS Classification] Not Listed
[OSHA] Not Listed
[SERA] 311/312: Acute
[TSCA] Not Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version: 1
Created:072104 Page 3 of 3 Printed: 10/28/2004
Revision Date: NA QC Form:1532
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
DMSO
Material Safety Data Sheet
Section 1-Identification of Product
9190G2
WHMIS Classification Health: 1 Fire: 1 Stability: 0
Product Use
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Methyl Sulfoxide 100 67-68-5 Oral rat: NA
14,500 mg/Kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Causes irritation to skin. Symptoms include redness, itching, and
pain. May cause scaling, Readily absorbed through the skin. Garlic-
like taste and odor may develop on the breath and skin. Transient
disturbances of color vision, photophobia, headache, diarrhea, and
dermatitis may result from skin applications. A good solvent; may
result in the increased skin absorption of other more toxic materials.
Skin Absorption Causes irritation to skin. Symptoms include redness, itching, and
pain. May cause scaling, Readily absorbed through the skin. Garlic-
like taste and odor may develop on the breath and skin. Transient
disturbances of color vision, photophobia, headache, diarrhea, and
dermatitis may result from skin applications. A good solvent; may
result in the increased skin absorption of other more toxic materials.
Eye Contact Causes irritation, redness, and pain. May cause blurred vision.
Inhalation Causes irritation to the respiratory tract. Symptoms may include
coughing, shortness of breath. May cause allergic reaction in sensitive
individuals.
Ingestion Causes irritation to the gastrointestinal tract. Symptoms may include
nausea, vomiting and diarrhea. May cause abdominal pain,
drowsiness, chills and chest pains.
[Emergency Overview]
WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES
IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. COMBUSTIBLE LIQUID AND VAPOR.
WHMIS Symbols
NA
[Potential Health Effects]
Slightly toxic by ingestion. Moderately toxic by intravenous and intraperitoneal routes. Human systemic effects by
intravenous route: nausea or vomiting and jaundice. Experimental teratogenic and reproductive effects. A skin and
eye irritant. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. Can cause
an anaphylactic reaction. Corneal opacity reported only in rabbits, dogs, and pigs. It freely penetrates the skin and
may carry dissolved chemicals with it into the body. Combustible when exposed to heat or flame; can react with
oxidizing materials. To fight fire, use water, foam, alcohol foam, CO2, dry chemical. Violent or explosive reaction
with many acyl, aryl, and nonmetal halides (e.g., acetyl chloride, benzenesulfonyl chloride, bromobenzoyl acetanilide,
cyanuric chloride, iodine pentafluoride, Mg(ClO4)2, CH3Br, NIO4, oxalyl chloride, P2O3, phosphorus trichloride,
phosphoryl chloride, silver fluoride, silver difluoride, sodium hydride, sulfur dichloride, disulfur dichloride, sulfuryl
chloride, tetrachlorosilane, thionyl chloride). Violent or explosive reaction with boron compounds (e.g., borane,
nonahydrononaborate(2-) ion), 4(4'-bromobenzoyl)acetanilide, carbonyl diisothiocyanate, dinitrogen tetraoxide,
hexachlorocyclotriphosphazine, copper + trichloroacetic acid, metal alkoxides (e.g., potassium tert-butoxide, sodium
isopropoxide), trifluoroacetic acid anhydride. Incompatible with magnesium perchlorate, metal oxosalts, perchloric
acid, periodic acid, sulfur trioxide. Forms powerfully explosive mixtures with metal salts of oxoacids (e.g., aluminum
perchlorate, sodium perchlorate, iron(III) nitrate). When heated to decomposition it emits toxic fumes of SOx
Version 1 Page 1 of 4 Printed: 10/28/2004
Created: 082604 QC Form:1731
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
DMSO
Material Safety Data Sheet
Section 4-First Aid Measures
Skin Contact Immediately flush skin with plenty of soap and water for at least 15 minutes while removing
contaminated clothing and shoes. Get medical attention. Wash clothing before reuse.
Thoroughly clean shoes before reuse.
Eye Contact Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper
eyelids occasionally. Get medical attention immediately.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical attention.
Ingestion Induce vomiting immediately as directed by medical personnel. Never give anything by mouth
to an unconscious person. Get medical attention.
Section 5-Fire Fighting Measures
Flammable Slightly flammable
Means of Extinction Dry chemical, foam or carbon dioxide.
Flashpoint (oC) and Method 89C
Upper Flammable Limit (% by volume) 42- 63
Lower Flammable Limit (% by volume) 2.6
Autoignition Temperature (oC) 215C
Explosion Data 鈥? Sensitivity to Impact Above flash point, vapor-air mixtures are explosive within
flammable limits noted above. Sealed containers may
rupture when heated.
Explosion Data 鈥? Sensitivity to Static Discharge Sensitive to static discharge.
Hazardous Combustion Products Upon heating above 100C (212F), sulfur dioxide is
evolved from this substance. Hazardous thermo-oxidative
degradation products from DMSO include formaldehyde,
methyl mercaptan and sulfur dioxide.
NFPA Health: 1 Fire: 1 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as
specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and
recover liquid when possible. Use non-sparking tools and equipment. Collect liquid in an appropriate container or
absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use
combustible materials, such as sawdust. Do not flush to sewer!
Section 7-Handling and Storage
Handling Procedures and Containers of this material may be hazardous when empty since they
Equipment retain product residues (vapors, liquid); observe all warnings and
precautions listed for the product.
Storage Requirements Keep in a tightly closed container. Store in a cool, dry, ventilated area away from
sources of heat or ignition. Protect against physical damage. Store separately
from reactive or combustible materials, and out of direct sunlight.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not Listed
OSHA PEL Not Listed
Other (specify) Not Listed
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust Local exhaust ventilation is generally preferred because it can control the
emissions of the contaminant at its source, preventing dispersion of it into the
general work area.
Other N.A.
Personal Protective Equipment (specific)
Gloves Wear impervious gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Version 1 Page 2 of 4 Printed: 10/28/2004
Created: 082604 QC Form:1731
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
DMSO
Material Safety Data Sheet
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Wear impervious boots
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Colorless liquid/Garlic-like odor.
Odor Threshold (ppm) Not Tested
Specific Gravity 1.10
Vapor Density (Air=1) 2.7
Vapor Pressure (mmHg) 0.42 @ 20C (68F)
Evaporation Rate 4.3 (CCl4 = 1)
Boiling Point (oC) 189C (372F)
Freezing Point (oC) 18.5C (64F)
pH Not Tested
Coefficient of Water/Oil Distribution Not Tested
[Solubility in Water] Miscible in water.
Section 10-Stability and Reactivity
Chemical Stability Stable under ordinary conditions of use and storage. Hygroscopic.
Incompatible with other substances Strong oxidants, acylhalides, arylhalides, bromobenzoyl
acetanilide, magnesium perchlorate, perchloric acid and sodium
hydroxide.
Reactivity Not tested
Hazardous Decomposition Products Upon heating above 100C (212F), sulfur dioxide is evolved from
this substance. Hazardous thermo-oxidative degradation products
from DMSO include formaldehyde, methyl mercaptan and sulfur
dioxide.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects Absorption may affect the blood, Repeated skin application may cause scaling
dermatitis. Repeated oral doses may effect the liver and kidneys.
Irritancy of Product Not Tested
Skin Sensitization Not Tested
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not listed
ACGIH (A1, A2, or A3) Not listed
Reproductive Toxicity Not listed
Teratogenicity Not listed
Embryotoxicity Not listed
Mutagenicity Not listed
Name of Synergistic Not listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity When released into water, this material may evaporate to a moderate extent. This
material is not expected to significantly bioaccumulate.
Soil Toxicity When released into the soil, this material is not expected to biodegrade. When
released into the soil, this material may leach into groundwater. When released
into the soil, this material may evaporate to a moderate extent.
Version 1 Page 3 of 4 Printed: 10/28/2004
Created: 082604 QC Form:1731
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
DMSO
Material Safety Data Sheet
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not listed
TDG Not listed
[DOT] Not listed
[IMO] Not listed
[ICAO] Not listed
Section 15-Regulatory Information
[WHMIS Classification] Not listed
[OSHA] Not listed
[SARA] 311/312: Acute, Chronic, Fire
[TSCA] Not listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 4 of 4 Printed: 10/28/2004
Created: 082604 QC Form:1731
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
Hydroxylamine
Material Safety Data Sheet
Section 1-Identification of Product
9425G6
WHMIS Classification Health: 3 Fire: 1 Stability: 1
Product Use
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Hydroxylamine ~13% 5470-11-1 oral mouse: NA
408 mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact Irritant and possible sensitizer. May cause burns.
Skin Absorption Irritant and possible sensitizer. May cause burns
Eye Contact Corrosive to the eyes. May cause severe irritation and corneal
damage.
Inhalation Corrosive. Extremely destructive to tissues of the mucous membranes
and upper respiratory tract. Symptoms may include burning
sensation, coughing, wheezing, laryngitis, shortness of breath,
headache, nausea and vomiting. Inhalation may be fatal as a result of
spasm inflammation and edema of the larynx and bronchi, chemical
pneumonitis and pulmonary edema.
Ingestion May convert hemoglobin to methemoglobin, producing cyanosis.
May also cause nausea, vomiting, fall in blood pressure, headache,
vertigo, ringing in the ears, shortness of breath, severe blood oxygen
deficiency and convulsions. High concentrations cause coma and
death from circulatory collapse.
[Emergency Overview]
DANGER! CORROSIVE. CAUSES BURNS TO ANY AREA OF CONTACT. HARMFUL IF SWALLOWED
OR INHALED. AFFECTS THE BLOOD. MAY CAUSE METHEMOGLOBINEMIA.
WHMIS Symbols
NA
[Potential Health Effects]
A poison by intraperitoneal and subcutaneous routes. A corrosive irritant to the eyes, skin, and mucous membranes.
Locally it is irritating, and systemically it can cause methemoglobinemia. Human mutation data reported. Dangerous
fire hazard when exposed to heat, flame, and oxidizers. May ignite spontaneously in air if a large surface area is
exposed (e.g., precipitate on paper). Explodes in air when heated above 70潞C. Explosive reaction with potassium
dichromate, chromium trioxide, powdered zinc + heat. Forms the heat-sensitive explosive bis(hydroxylamide) in
reaction with zinc or calcium. Ignites on contact with copper(II) sulfate, metals (e.g., sodium), oxidants (e.g., barium
peroxide, barium oxide, lead dioxide, potassium permanganate, chlorine), phosphorus chlorides (e.g., phosphorus
trichloride, phosphorus pentachloride). Incompatible with carbonyls, pyridine. Vigorous reaction with hypochlorites.
When heated to decomposition it emits toxic fumes of NOx
Section 4-First Aid Measures
Skin Contact Immediately flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes. Get medical attention immediately. Wash clothing before
reuse. Thoroughly clean shoes before reuse.
Eye Contact Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper
eyelids occasionally. Get medical attention immediately.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical attention immediately.
Ingestion If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give
anything by mouth to an unconscious person. Get medical attention immediately.
Version 1 Page 1 of 4 Printed: 10/28/2004
Created: 082604 QC Form: 1733
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
Hydroxylamine
Material Safety Data Sheet
Section 5-Fire Fighting Measures
Flammable Not considered to be a fire hazard. As with most organic
solids, fire is possible at elevated temperatures or by
contact with an ignition source.
Means of Extinction Water in large amounts, alcohol-resistant foam, powder.
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Emits toxic fumes of nitrogen oxides and hydrogen
chloride when heated to decomposition.
NFPA Health: 3 Fire: 1 Stability: 1
Section 6-Accidental Release Measures
Leak and Spill Procedures
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as
specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking
tools and equipment. Pick up spill for recovery or disposal and place in a closed container.
Section 7-Handling and Storage
Handling Procedures and Employ grounding, venting and explosion relief provisions in accord
Equipment with accepted engineering practices in any process capable of
generating dust and/or static electricity. Empty only into inert or non-
flammable atmosphere. Emptying contents into a non-inert atmosphere
where flammable vapors may be present could cause a flash fire or
explosion due to electrostatic discharge.
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from any source of heat or ignition. Isolate from
oxidizing materials. Avoid dust formation and control ignition sources.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not Listed
OSHA PEL Not Listed
Other (specify) Not Listed
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details.
Other N.A.
Personal Protective Equipment (specific)
Gloves Wear impervious protective gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Wear impervious protective boots
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A
Version 1 Page 2 of 4 Printed: 10/28/2004
Created: 082604 QC Form: 1733
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
Hydroxylamine
Material Safety Data Sheet
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not Tested
Specific Gravity Not Tested
Vapor Density (Air=1) Not Tested
Vapor Pressure (mmHg) Not Tested
Evaporation Rate Not Tested
Boiling Point (oC) Not Tested
Freezing Point (oC) Not Tested
pH Not Tested
Coefficient of Water/Oil Distribution Not Tested
[Solubility in Water] Soluble
Section 10-Stability and Reactivity
Chemical Stability Stable under ordinary conditions of use and storage. Slowly
decomposes when moist.
Incompatible with other substances Strong oxidizing agents, heat plus sodium acetate or ether,
carbonyl compounds, copper sulfate, zinc and phosphorus
chlorides.
Reactivity Heat, flame, moisture, dusting, sources of ignition and
shock, and incompatibles.
Hazardous Decomposition Products Emits toxic fumes of nitrogen oxides and hydrogen chloride when
heated to decomposition.
Section 11-Toxicological Information
Acute Effects Not Tested
Chronic Effects This substance is a blood toxin, causing hemoglobin to convert to
methemoglobin, resulting in cyanosis. Lengthy or repeated exposures may
result in decreased appetite, anemia, weight loss, nervous system affects, and
kidney, liver and bone marrow damage.
Irritancy of Product Not Tested
Skin Sensitization Listed as sensitizer
Respiratory Sensitization Not Tested
Carcinogenicity
IARC (1,2A, or 2B) Not Listed
ACGIH (A1, A2, or A3) Not Listed
Reproductive Toxicity Not Listed
Teratogenicity Not Listed
Embryotoxicity Not Listed
Mutagenicity Investigated as a mutagen
Name of Synergistic Not Listed
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not Tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not Listed
TDG Not Listed
Version 1 Page 3 of 4 Printed: 10/28/2004
Created: 082604 QC Form: 1733
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
Hydroxylamine
Material Safety Data Sheet
[DOT] Proper Shipping Name: CORROSIVE LIQUID,TOXIC, N.O.S.
(HYDROXYLAMINE HYDROCHLORIDE)
Hazard Class: 8, 6.1
UN/NA: UN2922
Packing Group: III
Information reported for product/size: 90uL
[IMO] Proper Shipping Name: CORROSIVE LIQUID,TOXIC, N.O.S.
(HYDROXYLAMINE HYDROCHLORIDE)
Hazard Class: 8, 6.1
UN/NA: UN2922
Packing Group: III
Information reported for product/size: 90uL
Section 15-Regulatory Information
[WHMIS Classification] Not Listed
[OSHA] Not Listed
[SARA] 311/312: Acute, Chronic
[TSCA] Not Listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 4 of 4 Printed: 10/28/2004
Created: 082604 QC Form: 1733
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
Coupling Buffer
Material Safety Data Sheet
Section 1-Identification of Product
9741G2
WHMIS Classification Health: 1 Fire: 0 Stability: 0
Product Use
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Trade secret 1-30% Trade secret Oral rat: NA
4220 mg/kg
Section 3-Hazard Identification
Routes of Entry
Skin Contact No adverse effects expected.
Skin Absorption No adverse effects expected.
Eye Contact Contact may cause mild irritation, redness, and pain.
Inhalation Product not expected to vaporize.
Ingestion Extremely large oral doses may cause gastrointestinal disturbances.
[Emergency Overview]
As part of good industrial and personal hygiene and safety procedure, avoid all unnecessary exposure to the
chemical substance and ensure prompt removal from skin, eyes and clothing.
WHMIS Symbols
NA
[Potential Health Effects]
Low toxicity by ingestion. An experimental teratogen. A nuisance dust. Human systemic effects: changes in
potassium levels, increased urine volume, metabolic acidosis, nausea or vomiting, respiratory changes, sodium level
changes
Section 4-First Aid Measures
Skin Contact Not expected to require first aid measures.
Eye Contact Wash thoroughly with running water. Get medical advice if irritation develops.
Inhalation Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion Give several glasses of water to drink to dilute. If large amounts were swallowed, get medical
advice.
Section 5-Fire Fighting Measures
Flammable Nonflammable
Means of Extinction Not tested
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Gaseous carbon dioxide.
NFPA Health: 1 Fire: 0 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills:
Sweep up and containerize for reclamation or disposal. Vacuuming or wet sweeping may be used to avoid dust
dispersal. Small amounts of residue may be flushed to sewer with plenty of water.
Version 1 Page 1 of 3 Printed: 10/28/2004
Created: 071304 QC Form:1732
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
Coupling Buffer
Material Safety Data Sheet
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with
Equipment adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep
container tightly closed. Avoid ingestion and inhalation. Wash
clothing before reuse.
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not listed
OSHA PEL Not listed
Other (specify) Not listed
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details.
Other N.A
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Liquid
Odor and Appearance Clear
Odor Threshold (ppm) Not tested
Specific Gravity Not tested
Vapor Density (Air=1) Not tested
Vapor Pressure (mmHg) Not tested
Evaporation Rate Not tested
Boiling Point (oC) Not tested
Freezing Point (oC) Not tested
pH 9.0
Coefficient of Water/Oil Distribution Not tested
[Solubility in Water] Not tested
Section 10-Stability and Reactivity
Chemical Stability Stable under ordinary conditions of use and storage.
Incompatible with other substances Reacts with acids to form carbon dioxide. Dangerous reaction with
monoammonium phosphate or a sodium-potassium alloy
Hazardous Decomposition Products Gaseous carbon dioxide.
Section 11-Toxicological Information
Acute Effects Not tested
Version 1 Page 2 of 3 Printed: 10/28/2004
Created: 071304 QC Form:1732
Revision Date: NA
Amino Allyl MessageAmp鈩? II
AMBION, INC.
aRNA Amplification Kit
Catalog #:1753
Coupling Buffer
Material Safety Data Sheet
Chronic Effects Not tested
Irritancy of Product Not tested
Skin Sensitization Not tested
Respiratory Sensitization Not tested
Carcinogenicity
IARC (1,2A, or 2B) Not tested
ACGIH (A1, A2, or A3) Not tested
Reproductive Toxicity Not tested
Teratogenicity Not tested
Embryotoxicity Not tested
Mutagenicity Not tested
Name of Synergistic Not tested
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not listed
TDG Not listed
[DOT] Not listed
[IMO] Not listed
[ICAO] Not listed
Section 15-Regulatory Information
[WHMIS Classification] Not listed
[OSHA] Not listed
[SARA] Not listed
[TSCA] Not listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 10/28/2004
Created: 071304 QC Form:1732
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?3
AMBION, INC.
Catalog #:1795
Cy3鈩? foil pack
Material Safety Data Sheet
Section 1-Identification of Product
5830G
WHMIS Classification Health: 1 Fire: 0 Stability: 0
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Cy3 100 N.A. N.A. N.A.
Section 3-Hazard Identification
Routes of Entry
Skin Contact May cause skin sensitization
Skin Absorption May cause skin sensitization
Eye Contact None known
Inhalation Toxic by inhalation May cause respiratory sensitization
Ingestion Harmful if swallowed
[Emergency Overview]
Warning! May be harmful if swallowed, may cause sensitization to skin and respiratory tract. May cause
allergic respiratory and skin reaction.
WHMIS Symbols
[Potential Health Effects]
Skin and respiratory sensitization
Section 4-First Aid Measures
Skin Contact Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid immediately.
Inhalation Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable Nonflammable
Means of Extinction Any
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Not tested
NFPA Health: 1 Fire: 0 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with adequate
Equipment ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly
closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Version 1 Page 1 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1952
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?3
AMBION, INC.
Catalog #:1795
Cy3鈩? foil pack
Material Safety Data Sheet
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not tested
OSHA PEL Not tested
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details.
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Solid
Odor and Appearance Odorless / Red
Odor Threshold (ppm) N.A.
Specific Gravity N.A.
Vapor Density (Air=1) N.A.
Vapor Pressure (mmHg) N.A.
Evaporation Rate N.A.
Boiling Point (oC) N.A.
Freezing Point (oC) N.A.
pH N.A.
Coefficient of Water/Oil Distribution N.A.
[Solubility in Water] Soluble in hot water, cold water
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Not tested
Reactivity Not tested
Hazardous Decomposition Products Not tested
Section 11-Toxicological Information
Acute Effects Not tested
Chronic Effects Not tested
Irritancy of Product Not tested
Skin Sensitization Yes
Respiratory Sensitization Yes
Carcinogenicity
IARC (1,2A, or 2B) Not tested
ACGIH (A1, A2, or A3) Not tested
Version 1 Page 2 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1952
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?3
AMBION, INC.
Catalog #:1795
Cy3鈩? foil pack
Material Safety Data Sheet
Reproductive Toxicity Not tested
Teratogenicity Not tested
Embryotoxicity Not tested
Mutagenicity Not tested
Name of Synergistic Not tested
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not listed
TDG Not listed
[DOT] Not listed
[IMO] Not listed
[ICAO] Not listed
Section 15-Regulatory Information
[WHMIS Classification]
[OSHA] Not listed
[SARA] Not listed
[TSCA] Not listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1952
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?5
AMBION, INC.
Catalog #:1796
Cy5鈩? foil pack
Material Safety Data Sheet
Section 1-Identification of Product
5831G
WHMIS Classification Health: 1 Fire: 0 Stability: 0
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Cy5 100 N.A. N.A. N.A.
Section 3-Hazard Identification
Routes of Entry
Skin Contact May cause skin sensitization
Skin Absorption May cause skin sensitization
Eye Contact None known
Inhalation Toxic by inhalation May cause respiratory sensitization
Ingestion Harmful if swallowed
[Emergency Overview]
Warning! May be harmful if swallowed, may cause sensitization to skin and respiratory tract. May cause
allergic respiratory and skin reaction.
WHMIS Symbols
[Potential Health Effects]
Skin and respiratory sensitization
Section 4-First Aid Measures
Skin Contact Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid immediately.
Inhalation Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable Nonflammable
Means of Extinction Any
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Not tested
NFPA Health: 1 Fire: 0 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with adequate
Equipment ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly
closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Version 1 Page 1 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1953
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?5
AMBION, INC.
Catalog #:1796
Cy5鈩? foil pack
Material Safety Data Sheet
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not tested
OSHA PEL Not tested
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details.
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Solid
Odor and Appearance Odorless / Purple
Odor Threshold (ppm) N.A.
Specific Gravity N.A.
Vapor Density (Air=1) N.A.
Vapor Pressure (mmHg) N.A.
Evaporation Rate N.A.
Boiling Point (oC) N.A.
Freezing Point (oC) N.A.
pH N.A.
Coefficient of Water/Oil Distribution N.A.
[Solubility in Water] Soluble in hot water, cold water
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Not tested
Reactivity Not tested
Hazardous Decomposition Products Not tested
Section 11-Toxicological Information
Acute Effects Not tested
Chronic Effects Not tested
Irritancy of Product Not tested
Skin Sensitization Yes
Respiratory Sensitization Yes
Carcinogenicity
IARC (1,2A, or 2B) Not tested
ACGIH (A1, A2, or A3) Not tested
Version 1 Page 2 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1953
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?5
AMBION, INC.
Catalog #:1796
Cy5鈩? foil pack
Material Safety Data Sheet
Reproductive Toxicity Not tested
Teratogenicity Not tested
Embryotoxicity Not tested
Mutagenicity Not tested
Name of Synergistic Not tested
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not listed
TDG Not listed
[DOT] Not listed
[IMO] Not listed
[ICAO] Not listed
Section 15-Regulatory Information
[WHMIS Classification]
[OSHA] Not listed
[SARA] Not listed
[TSCA] Not listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1953
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?3/Cy鈩?5
AMBION, INC.
Catalog #:1797
Cy3鈩? foil pack
Material Safety Data Sheet
Section 1-Identification of Product
5830G
WHMIS Classification Health: 1 Fire: 0 Stability: 0
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Cy3 100 N.A. N.A. N.A.
Section 3-Hazard Identification
Routes of Entry
Skin Contact May cause skin sensitization
Skin Absorption May cause skin sensitization
Eye Contact None known
Inhalation Toxic by inhalation May cause respiratory sensitization
Ingestion Harmful if swallowed
[Emergency Overview]
Warning! May be harmful if swallowed, may cause sensitization to skin and respiratory tract. May cause
allergic respiratory and skin reaction.
WHMIS Symbols
[Potential Health Effects]
Skin and respiratory sensitization
Section 4-First Aid Measures
Skin Contact Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid immediately.
Inhalation Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable Nonflammable
Means of Extinction Any
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Not tested
NFPA Health: 1 Fire: 0 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with adequate
Equipment ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly
closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Version 1 Page 1 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1952
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?3/Cy鈩?5
AMBION, INC.
Catalog #:1797
Cy3鈩? foil pack
Material Safety Data Sheet
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not tested
OSHA PEL Not tested
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details.
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Solid
Odor and Appearance Odorless / Red
Odor Threshold (ppm) N.A.
Specific Gravity N.A.
Vapor Density (Air=1) N.A.
Vapor Pressure (mmHg) N.A.
Evaporation Rate N.A.
Boiling Point (oC) N.A.
Freezing Point (oC) N.A.
pH N.A.
Coefficient of Water/Oil Distribution N.A.
[Solubility in Water] Soluble in hot water, cold water
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Not tested
Reactivity Not tested
Hazardous Decomposition Products Not tested
Section 11-Toxicological Information
Acute Effects Not tested
Chronic Effects Not tested
Irritancy of Product Not tested
Skin Sensitization Yes
Respiratory Sensitization Yes
Carcinogenicity
IARC (1,2A, or 2B) Not tested
ACGIH (A1, A2, or A3) Not tested
Version 1 Page 2 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1952
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?3/Cy鈩?5
AMBION, INC.
Catalog #:1797
Cy3鈩? foil pack
Material Safety Data Sheet
Reproductive Toxicity Not tested
Teratogenicity Not tested
Embryotoxicity Not tested
Mutagenicity Not tested
Name of Synergistic Not tested
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not listed
TDG Not listed
[DOT] Not listed
[IMO] Not listed
[ICAO] Not listed
Section 15-Regulatory Information
[WHMIS Classification]
[OSHA] Not listed
[SARA] Not listed
[TSCA] Not listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1952
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?3/Cy鈩?5
AMBION, INC.
Catalog #:1797
Cy5鈩? foil pack
Material Safety Data Sheet
Section 1-Identification of Product
5831G
WHMIS Classification Health: 1 Fire: 0 Stability: 0
Contact Information
Ambion, Inc 2130 Woodward St. Austin, TX 78744-1832 Tel: +1 512 651 0200 US Toll-free Tel: 800 888 8804 E-
mail: techserv@ambion.com Web address www.ambion.com
Ambion (Europe) LTD Huntingdon, Cambidgeshire UK PE29 6XY Tel:+44 (0)1480 373 020 Fax: +44 (0)1480 373
010 E-mail: eurotech@ambion.com Web address: www.ambion.com
Emergency Contact: In Europe, call 112. In USA, call 911
Section 2-Composition/Information
Hazardous Ingredients (Specific) % CAS # LD50 LC50
Cy5 100 N.A. N.A. N.A.
Section 3-Hazard Identification
Routes of Entry
Skin Contact May cause skin sensitization
Skin Absorption May cause skin sensitization
Eye Contact None known
Inhalation Toxic by inhalation May cause respiratory sensitization
Ingestion Harmful if swallowed
[Emergency Overview]
Warning! May be harmful if swallowed, may cause sensitization to skin and respiratory tract. May cause
allergic respiratory and skin reaction.
WHMIS Symbols
[Potential Health Effects]
Skin and respiratory sensitization
Section 4-First Aid Measures
Skin Contact Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes.
Eye Contact Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid immediately.
Inhalation Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen.
Ingestion Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or
symptoms occur.
Section 5-Fire Fighting Measures
Flammable Nonflammable
Means of Extinction Any
Flashpoint (oC) and Method Not tested
Upper Flammable Limit (% by volume) Not tested
Lower Flammable Limit (% by volume) Not tested
Autoignition Temperature (oC) Not tested
Explosion Data 鈥? Sensitivity to Impact Not tested
Explosion Data 鈥? Sensitivity to Static Discharge Not tested
Hazardous Combustion Products Not tested
NFPA Health: 1 Fire: 0 Stability: 0
Section 6-Accidental Release Measures
Leak and Spill Procedures
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material,
then place into a suitable clean, dry, closed container for disposal.
Section 7-Handling and Storage
Handling Procedures and Wash thoroughly after handling. Wash hands before eating. Use with adequate
Equipment ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly
closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Version 1 Page 1 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1953
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?3/Cy鈩?5
AMBION, INC.
Catalog #:1797
Cy5鈩? foil pack
Material Safety Data Sheet
Storage Requirements Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect
against physical damage. Isolate from incompatible substances. Containers of
this material may be hazardous when empty since they retain product residues
(dust, solids); observe all warnings and precautions listed for the product.
Section 8-Exposure Control/Personal Protection
Exposure Limits
ACGIH TLV Not tested
OSHA PEL Not tested
Other (specify) N.A.
Engineering Controls (specific)
General Facilities storing or utilizing this material should be equipped with an eyewash
facility and a safety shower. Use adequate ventilation to keep airborne
concentrations low.
Local Exhaust A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation, A Manual of Recommended Practices, most recent
edition, for details.
Other N.A.
Personal Protective Equipment (specific)
Gloves Synthetic gloves
Respirator A respiratory protection program that meets OSHA's 29 CFR 1910.134 and
ANSI Z88.2 requirements or European Standard EN 149 must be followed
whenever workplace conditions warrant a respirator's use.
Eye Wear appropriate protective eyeglasses or chemical safety goggles as described
by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European
Standard EN166. Maintain eye wash fountain and quick-drench facilities in work
area.
Footwear Closed toe shoes
Clothing Wear appropriate protective clothing to prevent skin exposure.
Other N.A.
Section 9-Physical and Chemical Properties
Physical State Solid
Odor and Appearance Odorless / Purple
Odor Threshold (ppm) N.A.
Specific Gravity N.A.
Vapor Density (Air=1) N.A.
Vapor Pressure (mmHg) N.A.
Evaporation Rate N.A.
Boiling Point (oC) N.A.
Freezing Point (oC) N.A.
pH N.A.
Coefficient of Water/Oil Distribution N.A.
[Solubility in Water] Soluble in hot water, cold water
Section 10-Stability and Reactivity
Chemical Stability Stable
Incompatible with other substances Not tested
Reactivity Not tested
Hazardous Decomposition Products Not tested
Section 11-Toxicological Information
Acute Effects Not tested
Chronic Effects Not tested
Irritancy of Product Not tested
Skin Sensitization Yes
Respiratory Sensitization Yes
Carcinogenicity
IARC (1,2A, or 2B) Not tested
ACGIH (A1, A2, or A3) Not tested
Version 1 Page 2 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1953
Revision Date: NA
Amino Allyl MessageAmp鈩? II Cy鈩?3/Cy鈩?5
AMBION, INC.
Catalog #:1797
Cy5鈩? foil pack
Material Safety Data Sheet
Reproductive Toxicity Not tested
Teratogenicity Not tested
Embryotoxicity Not tested
Mutagenicity Not tested
Name of Synergistic Not tested
Products/Effects
Section 12-Ecological Information
Aquatic Toxicity Not tested
Section 13-Disposal Considerations
Waste Disposal Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
Section 14-Transport Information
Special Shipping Information
PIN Not listed
TDG Not listed
[DOT] Not listed
[IMO] Not listed
[ICAO] Not listed
Section 15-Regulatory Information
[WHMIS Classification]
[OSHA] Not listed
[SARA] Not listed
[TSCA] Not listed
Section 16-Other Information
This bulletin is for your guidance and is based upon information and tests believed to be reliable. Ambion makes no
guarantee of the accuracy or completeness of the data and shall not be liable for any damages thereto. The data are
offered solely for your consideration, investigation, and verification. These suggestions should not be confused with
state, municipal, or insurance requirements, or with national safety codes and constitute no warranty. Any use of
these data and information must be determined by the user to be in accordance with applicable federal, state, and local
regulations.
Version 1 Page 3 of 3 Printed: 11/8/2004
Created:110504 QC Form: 1953
Revision Date: NA
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #:1753
Product/Component Name: T7 Oligo(dT) Primer
Catalog Number: 5710G3
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/28/2004
Created Date:082604 QC Form 1718
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #:1753
Product/Component Name: Nuclease-free Water
Catalog Number: 9914G
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/29/2004
Created Date:082604 QC Form 1729
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #:1753
Product/Component Name: Nuclease-free Water
Catalog Number: 9914G1
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/28/2004
Created Date:082604 QC Form 1729
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #:1753
Product/Component Name: Wash Buffer
Catalog Number: 9913G22
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/28/2004
Created Date:082604 QC Form 1735
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #: 1753
Product/Component Name: aaUTP Solution
Catalog Number: 8437G1
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/28/2004
Created Date:082604 QC Form 1726
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #:1753
Product/Component Name: dNTP Mix
Catalog Number: 8243G5
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/28/2004
Created Date:082604 QC Form
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #:1753
Product/Component Name: UTP Solution
Catalog Number: 8142G3
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/28/2004
Created Date:082604 QC Form 1725
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #:1753
Product/Component Name: ATP, CTP, GTP Mix
Catalog Number: 8060G1
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/28/2004
Created Date:082604 QC Form 1727
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #:1753
Product/Component Name: Control RNA
Catalog Number: 7852G1
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/28/2004
Created Date:082604 QC Form 1730
SAFETY STATEMENT
This document is only available in English.
1. Identification of the substance/preparation and company/undertaking
鈩?
Product/Kit Name: Amino Allyl MessageAmp II aRNA Amplification Kit
Catalog #:1753
Product/Component Name: Second Round Primers
Catalog Number: 5722G11
Supplier: Ambion, Inc.
Emergency Telephone Numbers:
USA: 1-800-888-8804
Europe: +44 (0) 1480 373 020
2. Composition/ information on ingredients
Substance/Preparation:
To the present knowledge of Ambion, Inc., this product does not contain any hazardous
ingredients in quantities requiring reporting in this section, in accordance with EU
regulations or National regulations.
To Ambion鈥檚 knowledge this substance/preparation is not classified as hazardous
according to EU, US, or any other known national regulations.
9. Physical and chemical properties
Physical State: Liquid
Color: Colorless
16. Other information:
To the best of Ambion鈥檚 knowledge, the information contained herein is accurate.
However, Ambion, Inc. does not assume any liability whatsoever for the accuracy or
completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All
materials may present unknown hazards and should be used with caution.
This is not an MSDS. According to EU and US regulations we are not required to supply
an MSDS for a product, which is not classified as hazardous.
Version# 1 Revision Date: N.A. Page 1 of 1 Printed:10/28/2004
Created Date:082604 QC Form 1728
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